{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T17:04:00Z","timestamp":1773248640661,"version":"3.50.1"},"reference-count":65,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2021,9,4]],"date-time":"2021-09-04T00:00:00Z","timestamp":1630713600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["SAF2011-30396"],"award-info":[{"award-number":["SAF2011-30396"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Universidad de Le\u00f3n, Spain","award":["Programa 463A.3.01"],"award-info":[{"award-number":["Programa 463A.3.01"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Excess aldosterone promotes pathological remodeling of the heart and imbalance in cardiac ion homeostasis of sodium, potassium and calcium. Novel treatment with proanthocyanidins in aldosterone-treated rats has resulted in downregulation of cardiac SGK1, the main genomic aldosterone-induced intracellular mediator of ion handling. It therefore follows that proanthocyanidins could be modulating cardiac ion homeostasis in aldosterone-treated rats. Male Wistar rats received aldosterone (1 mg kg\u22121 day\u22121) +1% NaCl for three weeks. Half of the animals in each group were simultaneously treated with the proanthocyanidins-rich extract (80% w\/w) (PRO80, 5 mg kg\u22121 day\u22121). PRO80 prevented cardiac hypertrophy and decreased calcium content. Expression of ion channels (ROMK, NHE1, NKA and NCX1) and calcium transient mediators (CAV1.2, pCaMKII and oxCaMKII) were reduced by PRO80 treatment in aldosterone-treated rats. To conclude, our data indicate that PRO80 may offer an alternative treatment to conventional MR-blockade in the prevention of aldosterone-induced cardiac pathology.<\/jats:p>","DOI":"10.3390\/ijms22179602","type":"journal-article","created":{"date-parts":[[2021,9,6]],"date-time":"2021-09-06T13:15:56Z","timestamp":1630934156000},"page":"9602","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Proanthocyanidins Maintain Cardiac Ionic Homeostasis in Aldosterone-Induced Hypertension and Heart Failure"],"prefix":"10.3390","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2960-6175","authenticated-orcid":false,"given":"Natalia","family":"de las Heras","sequence":"first","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, Plaza Ram\u00f3n y Cajal, s\/n. Universidad Complutense, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6779-009X","authenticated-orcid":false,"given":"Adri\u00e1n","family":"Galiana","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, Plaza Ram\u00f3n y Cajal, s\/n. Universidad Complutense, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Ballesteros","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, Plaza Ram\u00f3n y Cajal, s\/n. Universidad Complutense, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Olivares-\u00c1lvaro","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, Plaza Ram\u00f3n y Cajal, s\/n. Universidad Complutense, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter J.","family":"Fuller","sequence":"additional","affiliation":[{"name":"Centre for Endocrinology and Metabolism, Hudson Institute of Medical Research, Clayton, VIC 3168, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vicente","family":"Lahera","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, Plaza Ram\u00f3n y Cajal, s\/n. Universidad Complutense, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1904-6194","authenticated-orcid":false,"given":"Beatriz","family":"Mart\u00edn-Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, Plaza Ram\u00f3n y Cajal, s\/n. Universidad Complutense, 28040 Madrid, Spain"},{"name":"Department of Molecular Biology, Faculty of Biology, Universidad de Le\u00f3n, Campus de Vegazana s\/n, 24071 Le\u00f3n, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/s41371-020-0360-2","article-title":"Structural determinants of activation of the mineralocorticoid receptor: An evolutionary perspective","volume":"35","author":"Fuller","year":"2021","journal-title":"J. Hum. Hypertens."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1210\/jc.2015-4061","article-title":"The Management of Primary Aldosteronism: Case Detection, Diagnosis, and Treatment: An Endocrine Society Clinical Practice Guideline","volume":"101","author":"Funder","year":"2016","journal-title":"J. Clin. Endocrinol. 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