{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T19:22:49Z","timestamp":1784748169893,"version":"3.55.0"},"reference-count":256,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2021,9,18]],"date-time":"2021-09-18T00:00:00Z","timestamp":1631923200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["N142005001 and N172002001"],"award-info":[{"award-number":["N142005001 and N172002001"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018617","name":"Liaoning Revitalization Talents Program","doi-asserted-by":"publisher","award":["XLYC1807001"],"award-info":[{"award-number":["XLYC1807001"]}],"id":[{"id":"10.13039\/501100018617","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31870140"],"award-info":[{"award-number":["31870140"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Fungal infections have become a major health concern, given that invasive infections by Candida, Cryptococcus, and Aspergillus species have led to millions of mortalities. Conventional antifungal drugs including polyenes, echinocandins, azoles, allylamins, and antimetabolites have been used for decades, but their limitations include off-target toxicity, drug-resistance, poor water solubility, low bioavailability, and weak tissue penetration, which cannot be ignored. These drawbacks have led to the emergence of novel antifungal therapies. In this review, we discuss the nanosystems that are currently utilized for drug delivery and the application of antifungal therapies.<\/jats:p>","DOI":"10.3390\/ijms221810104","type":"journal-article","created":{"date-parts":[[2021,9,21]],"date-time":"2021-09-21T08:04:23Z","timestamp":1632211463000},"page":"10104","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Striking Back against Fungal Infections: The Utilization of Nanosystems for Antifungal Strategies"],"prefix":"10.3390","volume":"22","author":[{"given":"Wei","family":"Du","sequence":"first","affiliation":[{"name":"College of Life and Health Sciences, Northeastern University, Shenyang 110015, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiru","family":"Gao","sequence":"additional","affiliation":[{"name":"College of Life and Health Sciences, Northeastern University, Shenyang 110015, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Life and Health Sciences, Northeastern University, Shenyang 110015, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sixiang","family":"Sai","sequence":"additional","affiliation":[{"name":"School of Medicine, Binzhou Medical University, Yantai 264003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9195-2255","authenticated-orcid":false,"given":"Chen","family":"Ding","sequence":"additional","affiliation":[{"name":"College of Life and Health Sciences, Northeastern University, Shenyang 110015, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,18]]},"reference":[{"key":"ref_1","unstructured":"(2019). 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