{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T10:50:01Z","timestamp":1780397401738,"version":"3.54.1"},"reference-count":149,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2021,9,21]],"date-time":"2021-09-21T00:00:00Z","timestamp":1632182400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Cancers are a major challenge to health worldwide. Spinel ferrites have attracted attention due to their broad theranostic applications. This study aimed at investigating the antimicrobial, antibiofilm, and anticancer activities of ebselen (Eb) and cerium-nanoparticles (Ce-NPs) in the form of ZnCexFe2\u2212XO4 on human breast and colon cancer cell lines. Bioassays of the cytotoxic concentrations of Eb and ZnCexFe2\u2212XO4, oxidative stress and inflammatory milieu, autophagy, apoptosis, related signalling effectors, the distribution of cells through the cell-cycle phases, and the percentage of cells with apoptosis were evaluated in cancer cell lines. Additionally, the antimicrobial and antibiofilm potential have been investigated against different pathogenic microbes. The ZOI, and MIC results indicated that ZnCexFe2\u2212XO4; X = 0.06 specimen reduced the activity of a wide range of bacteria and unicellular fungi at low concentration including P. aeruginosa (9.5 mm; 6.250 \u00b5g\/mL), S. aureus (13.2 mm; 0.390 \u00b5g\/mL), and Candida albicans (13.5 mm; 0.195 \u00b5g\/mL). Reaction mechanism determination indicated that after ZnCexFe2\u2212xO4; X = 0.06 treatment, morphological differences in S.aureus were apparent with complete lysis of bacterial cells, a concomitant decrease in the viable number, and the growth of biofilm was inhibited. The combination of Eb with ZFO or ZnCexFe2\u2212XO4 with \u03b3-radiation exposure showed marked anti-proliferative efficacy in both cell lines, through modulating the oxidant\/antioxidant machinery imbalance, restoring the fine-tuning of redox status, and promoting an anti-inflammatory milieu to prevent cancer progression, which may be a valuable therapeutic approach to cancer therapy and as a promising antimicrobial agent to reduce the pathogenic potential of the invading microbes.<\/jats:p>","DOI":"10.3390\/ijms221810171","type":"journal-article","created":{"date-parts":[[2021,9,21]],"date-time":"2021-09-21T22:34:01Z","timestamp":1632263641000},"page":"10171","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Influence of Ce3+ Substitution on Antimicrobial and Antibiofilm Properties of ZnCexFe2\u2212xO4 Nanoparticles (X = 0.0, 0.02, 0.04, 0.06, and 0.08) Conjugated with Ebselen and Its Role Subsidised with \u03b3-Radiation in Mitigating Human TNBC and Colorectal Adenocarcinoma Proliferation In Vitro"],"prefix":"10.3390","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7091-8955","authenticated-orcid":false,"given":"Mohamed K.","family":"Abdel-Rafei","sequence":"first","affiliation":[{"name":"Radiation Biology Department, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), Cairo 11787, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0073-7347","authenticated-orcid":false,"given":"Noura M.","family":"Thabet","sequence":"additional","affiliation":[{"name":"Radiation Biology Department, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), Cairo 11787, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7708-9646","authenticated-orcid":false,"given":"M. I. A.","family":"Abdel Maksoud","sequence":"additional","affiliation":[{"name":"Materials Science Lab., Radiation Physics Department, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), Cairo 11787, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9408-9178","authenticated-orcid":false,"given":"M.","family":"Abd Elkodous","sequence":"additional","affiliation":[{"name":"Department of Electrical and Electronic Information Engineering, Toyohashi University of Technology, 1-1 Hibarigaoka, Tempaku-cho, Toyohashi 441-8580, Aichi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Go","family":"Kawamura","sequence":"additional","affiliation":[{"name":"Department of Electrical and Electronic Information Engineering, Toyohashi University of Technology, 1-1 Hibarigaoka, Tempaku-cho, Toyohashi 441-8580, Aichi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6493-1205","authenticated-orcid":false,"given":"Atsunori","family":"Matsuda","sequence":"additional","affiliation":[{"name":"Department of Electrical and Electronic Information Engineering, Toyohashi University of Technology, 1-1 Hibarigaoka, Tempaku-cho, Toyohashi 441-8580, Aichi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. H.","family":"Ashour","sequence":"additional","affiliation":[{"name":"Materials Science Lab., Radiation Physics Department, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), Cairo 11787, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed I.","family":"El-Batal","sequence":"additional","affiliation":[{"name":"Drug Microbiology Lab., Drug Radiation Research Department, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), Cairo 11787, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5410-7936","authenticated-orcid":false,"given":"Gharieb S.","family":"El-Sayyad","sequence":"additional","affiliation":[{"name":"Drug Microbiology Lab., Drug Radiation Research Department, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), Cairo 11787, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"6884","DOI":"10.1007\/s11664-017-5729-9","article-title":"Electrical Properties and Dipole Relaxation Behavior of Zinc-Substituted Cobalt Ferrite","volume":"46","author":"Supriya","year":"2017","journal-title":"J. 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