{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T06:52:13Z","timestamp":1787727133413,"version":"build-2784847793"},"reference-count":39,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2021,9,7]],"date-time":"2021-09-07T00:00:00Z","timestamp":1630972800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"This study was funded by the Korea Polar Research Institute.","award":["PE21150"],"award-info":[{"award-number":["PE21150"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Chemical investigation of the Antarctic fungi Pleosporales sp. SF-7343 revealed four known secondary fungal metabolites: alternate C (1), altenusin (2), alternariol (3), and altenuene (4). The compound structures were identified primarily by NMR and MS analyses. Atopic dermatitis, an inflammatory disease, is driven by the abnormal activation of T helper (Th) 2 cells and barrier dysfunction. We attempted to identify the anti-inflammatory components of SF-7343. Initial screening showed that compounds 1 and 3 inhibited the secretion of interleukin-8 and -6 in tumor necrosis factor-\u03b1\/interferon-\u03b3-treated HaCaT cells, and these compounds also showed inhibitory effects on CCL5 and CCL22. Compounds 1 and 3 also downregulated the protein expression levels of intercellular adhesion molecule-1 and upregulated the expression of filaggrin and involcurin. The mechanism study results showed that compounds 1 and 3 inhibited nuclear translocation of nuclear factor-kappa B p65 and the phosphorylation of STAT1 and STAT3. Compound 1, but not compound 3, significantly promoted the expression of heme oxygenase (HO)-1. The effects of compound 1 were partly reversed by co-treatment with a HO-1 inhibitor, tin protoporphyrin IX. Taken together, this study demonstrates the potential value of Antarctic fungal strain SF-7343 isolates as a bioresource for bioactive compounds to prevent skin inflammation.<\/jats:p>","DOI":"10.3390\/ijms22189674","type":"journal-article","created":{"date-parts":[[2021,9,7]],"date-time":"2021-09-07T10:24:25Z","timestamp":1631010265000},"page":"9674","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Anti-Inflammatory Effects of Metabolites from Antarctic Fungal Strain Pleosporales sp. SF-7343 in HaCaT Human Keratinocytes"],"prefix":"10.3390","volume":"22","author":[{"given":"Linsha","family":"Dong","sequence":"first","affiliation":[{"name":"College of Pharmacy, Chosun University, Dong-gu, Gwangju 61452, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye Jin","family":"Kim","sequence":"additional","affiliation":[{"name":"Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University, Iksan 54538, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thao Quyen","family":"Cao","sequence":"additional","affiliation":[{"name":"Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University, Iksan 54538, Korea"},{"name":"Hanbang Cardio-Renal Syndrome Research Center, Wonkwang University, Iksan 54538, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiming","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Chosun University, Dong-gu, Gwangju 61452, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hwan","family":"Lee","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Chosun University, Dong-gu, Gwangju 61452, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wonmin","family":"Ko","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Chosun University, Dong-gu, Gwangju 61452, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youn-Chul","family":"Kim","sequence":"additional","affiliation":[{"name":"Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University, Iksan 54538, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Hak","family":"Sohn","sequence":"additional","affiliation":[{"name":"College of Medical and Life Sciences, Silla University, Busan 46958, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tai Kyoung","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Polar Life Sciences, Korea Polar Research Institute, Incheon 21990, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joung Han","family":"Yim","sequence":"additional","affiliation":[{"name":"Division of Polar Life Sciences, Korea Polar Research Institute, Incheon 21990, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9234-7567","authenticated-orcid":false,"given":"Dong-Sung","family":"Lee","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Chosun University, Dong-gu, Gwangju 61452, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyuncheol","family":"Oh","sequence":"additional","affiliation":[{"name":"Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University, Iksan 54538, Korea"},{"name":"Hanbang Cardio-Renal Syndrome Research Center, Wonkwang University, Iksan 54538, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/S0140-6736(15)00149-X","article-title":"Atopic dermatitis","volume":"10023","author":"Weidinger","year":"2016","journal-title":"Lancet"},{"key":"ref_2","first-page":"293","article-title":"Atopic dermatitis in children","volume":"35","author":"Lyons","year":"2016","journal-title":"Immunol. 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