{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T18:36:20Z","timestamp":1768588580633,"version":"3.49.0"},"reference-count":43,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T00:00:00Z","timestamp":1631145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011019","name":"Nemzeti Kutat\u00e1si Fejleszt\u00e9si \u00e9s Innov\u00e1ci\u00f3s Hivatal","doi-asserted-by":"publisher","award":["OTKA FK-124571"],"award-info":[{"award-number":["OTKA FK-124571"]}],"id":[{"id":"10.13039\/501100011019","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011019","name":"Nemzeti Kutat\u00e1si Fejleszt\u00e9si \u00e9s Innov\u00e1ci\u00f3s Hivatal","doi-asserted-by":"publisher","award":["OTKA K-124983"],"award-info":[{"award-number":["OTKA K-124983"]}],"id":[{"id":"10.13039\/501100011019","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003825","name":"Magyar Tudom\u00e1nyos Akad\u00e9mia","doi-asserted-by":"publisher","award":["J\u00e1nos Bolyai Research Scholarship"],"award-info":[{"award-number":["J\u00e1nos Bolyai Research Scholarship"]}],"id":[{"id":"10.13039\/501100003825","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Mesoporous aerogel microparticles are promising drug delivery systems. However, their in vivo biodistribution pathways and health effects are unknown. Suspensions of fluorescein-labeled silica\u2013gelatin hybrid aerogel microparticles were injected into the peritoneum (abdominal cavity) of healthy mice in concentrations of 52 and 104 mg kg\u22121 in a 3-week-long acute toxicity experiment. No physiological dysfunctions were detected, and all mice were healthy. An autopsy revealed that the aerogel microparticles were not present at the site of injection in the abdominal cavity at the end of the experiment. The histological study of the liver, spleen, kidneys, thymus and lymphatic tissues showed no signs of toxicity. The localization of the aerogel microparticles in the organs was studied by fluorescence microscopy. Aerogel microparticles were not detected in any of the abdominal organs, but they were clearly visible in the cortical part of the parathymic lymph nodes, where they accumulated. The accumulation of aerogel microparticles in parathymic lymph nodes in combination with their absence in the reticuloendothelial system organs, such as the liver or spleen, suggests that the microparticles entered the lymphatic circulation. This biodistribution pathway could be exploited to design passive targeting drug delivery systems for flooding metastatic pathways of abdominal cancers that spread via the lymphatic circulation.<\/jats:p>","DOI":"10.3390\/ijms22189756","type":"journal-article","created":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T12:20:37Z","timestamp":1631190037000},"page":"9756","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Mesoporous Aerogel Microparticles Injected into the Abdominal Cavity of Mice Accumulate in Parathymic Lymph Nodes"],"prefix":"10.3390","volume":"22","author":[{"given":"G\u00e1bor","family":"Kir\u00e1ly","sequence":"first","affiliation":[{"name":"Department of Molecular Biotechnology and Microbiology, University of Debrecen, Egyetem t\u00e9r 1, H-4032 Debrecen, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John Chinonso","family":"Egu","sequence":"additional","affiliation":[{"name":"MTA-DE ELKH Homogeneous Catalysis and Reaction Mechanisms Research Group, Department of Inorganic and Analytical Chemistry, University of Debrecen, Egyetem t\u00e9r 1, H-4032 Debrecen, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zolt\u00e1n","family":"Hargitai","sequence":"additional","affiliation":[{"name":"Department of Pathology, Ken\u00e9zy University Hospital, University of Debrecen, 2-28 Bart\u00f3k B\u00e9la Street, H-4031 Debrecen, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilona","family":"Kov\u00e1cs","sequence":"additional","affiliation":[{"name":"Department of Pathology, Ken\u00e9zy University Hospital, University of Debrecen, 2-28 Bart\u00f3k B\u00e9la Street, H-4031 Debrecen, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4467-2912","authenticated-orcid":false,"given":"Istv\u00e1n","family":"F\u00e1bi\u00e1n","sequence":"additional","affiliation":[{"name":"MTA-DE ELKH Homogeneous Catalysis and Reaction Mechanisms Research Group, Department of Inorganic and Analytical Chemistry, University of Debrecen, Egyetem t\u00e9r 1, H-4032 Debrecen, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2422-6106","authenticated-orcid":false,"given":"J\u00f3zsef","family":"Kalm\u00e1r","sequence":"additional","affiliation":[{"name":"MTA-DE ELKH Homogeneous Catalysis and Reaction Mechanisms Research Group, Department of Inorganic and Analytical Chemistry, University of Debrecen, Egyetem t\u00e9r 1, H-4032 Debrecen, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1906-0188","authenticated-orcid":false,"given":"G\u00e1bor","family":"Szem\u00e1n-Nagy","sequence":"additional","affiliation":[{"name":"Department of Molecular Biotechnology and Microbiology, University of Debrecen, Egyetem t\u00e9r 1, H-4032 Debrecen, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Garcia-Gonzalez, C.A., Budtova, T., Duraes, L., Erkey, C., Del Gaudio, P., Gurikov, P., Koebel, M., Liebner, F., Neagu, M., and Smirnova, I. 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