{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T03:04:32Z","timestamp":1771556672140,"version":"3.50.1"},"reference-count":42,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2021,9,11]],"date-time":"2021-09-11T00:00:00Z","timestamp":1631318400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL130082"],"award-info":[{"award-number":["R01HL130082"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013759","name":"Commonwealth Health Research Board","doi-asserted-by":"publisher","award":["207-12-21"],"award-info":[{"award-number":["207-12-21"]}],"id":[{"id":"10.13039\/100013759","id-type":"DOI","asserted-by":"publisher"}]},{"name":"University of Virginia George A. Beller, M.D. Research Award","award":["n\/a"],"award-info":[{"award-number":["n\/a"]}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32HL007849"],"award-info":[{"award-number":["T32HL007849"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32AI078875"],"award-info":[{"award-number":["T32AI078875"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32HL007849-21A1"],"award-info":[{"award-number":["T32HL007849-21A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Global hypothermia prolongs survival in rats with intraabdominal feculent sepsis by inhibiting inflammatory responses. We hypothesized that topical neck cooling (TNC) has similar benefits. Septic shock was induced by cecal ligation and incision (CLI) in Sprague Dawley rats. Rats were randomized to sham laparotomy, control with CLI, CLI with TNC, or vagotomy at the gastroesophageal junction before CLI and TNC. Two more groups underwent peritoneal washout with and without TNC two hours after CLI. TNC significantly lowered neck skin temperature (16.7 \u00b1 1.4 vs. 30.5 \u00b1 0.6 \u00b0C, p &lt; 0.05) while maintaining core body normothermia. TNC rats recovered from anesthesia 70 min earlier than the control (p &lt; 0.05). Three hours following CLI, the control and vagotomy with TNC groups had significantly more splenic contraction, fewer circulating leukocytes and higher plasma IL-1\u03b2, IL-10 and TNF-\u03b1 levels than TNC rats (p &lt; 0.05). TNC prolonged survival duration after CLI by a median of four hours vs. control (p &lt; 0.05), but no benefit was seen if vagotomy preceded TNC. Peritoneal washout alone increased survival by 3 h (9.2 (7.8\u201310.5) h). Survival duration increased dramatically with TNC preceding washout, to a 56% survival rate (&gt;10 days). TNC significantly prolonged the survival of rats with severe intraabdominal sepsis by inhibiting systemic proinflammatory responses by activating vagal anti-inflammatory pathways.<\/jats:p>","DOI":"10.3390\/ijms22189828","type":"journal-article","created":{"date-parts":[[2021,9,12]],"date-time":"2021-09-12T21:45:57Z","timestamp":1631483157000},"page":"9828","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Topical Neck Cooling Prolongs Survival of Rats with Intra-Abdominal Feculent Sepsis by Activation of the Vagus Nerve"],"prefix":"10.3390","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3660-3917","authenticated-orcid":false,"given":"Aimee Y.","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Surgery, University of Virginia Health System, Charlottesville, VA 22903, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine M.","family":"Marsh","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Virginia Health System, Charlottesville, VA 22903, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9859-9917","authenticated-orcid":false,"given":"Radhika","family":"Rastogi","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Virginia Health System, Charlottesville, VA 22903, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Di","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Virginia Health System, Charlottesville, VA 22903, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric J.","family":"Charles","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Virginia Health System, Charlottesville, VA 22903, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irving L.","family":"Kron","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Virginia Health System, Charlottesville, VA 22903, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8155-2661","authenticated-orcid":false,"given":"Robert G.","family":"Sawyer","sequence":"additional","affiliation":[{"name":"Department of Surgery, Western Michigan University Medical School, Kalamazoo, MI 49008, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zequan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Virginia Health System, Charlottesville, VA 22903, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"16045","DOI":"10.1038\/nrdp.2016.45","article-title":"Sepsis and Septic Shock","volume":"2","author":"Hotchkiss","year":"2016","journal-title":"Nat. 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