{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:37:09Z","timestamp":1790775429092,"version":"4.1.0"},"reference-count":51,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2021,9,14]],"date-time":"2021-09-14T00:00:00Z","timestamp":1631577600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003329","name":"Ministry of Economy, Industry and Competitiveness","doi-asserted-by":"publisher","award":["SAF2016-77096-R"],"award-info":[{"award-number":["SAF2016-77096-R"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Approximately 25% of colorectal cancer (CRC) patients develop peritoneal metastasis, a condition associated with a bleak prognosis. The CRC peritoneal dissemination cascade involves the shedding of cancer cells from the primary tumor, their transport through the peritoneal cavity, their adhesion to the peritoneal mesothelial cells (PMCs) that line all peritoneal organs, and invasion of cancer cells through this mesothelial cell barrier and underlying stroma to establish new metastatic foci. Exosomes produced by cancer cells have been shown to influence many processes related to cancer progression and metastasis. In epithelial ovarian cancer these extracellular vesicles (EVs) have been shown to favor different steps of the peritoneal dissemination cascade by changing the functional phenotype of cancer cells and PMCs. Little is currently known, however, about the roles played by exosomes in the pathogenesis and peritoneal metastasis cascade of CRC and especially about the molecules that mediate their interaction and uptake by target PMCs and tumor cells. We isolated exosomes by size\u2212exclusion chromatography from CRC cells and performed cell-adhesion assays to immobilized exosomes in the presence of blocking antibodies against surface proteins and measured the uptake of fluorescently-labelled exosomes. We report here that the interaction between integrin \u03b15\u03b21 on CRC cells (and PMCs) and its ligand ADAM17 on exosomes mediated the binding and uptake of CRC-derived exosomes. Furthermore, this process was negatively regulated by the expression of tetraspanin CD9 on exosomes.<\/jats:p>","DOI":"10.3390\/ijms22189938","type":"journal-article","created":{"date-parts":[[2021,9,14]],"date-time":"2021-09-14T23:34:11Z","timestamp":1631662451000},"page":"9938","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Cellular Integrin \u03b15\u03b21 and Exosomal ADAM17 Mediate the Binding and Uptake of Exosomes Produced by Colorectal Carcinoma Cells"],"prefix":"10.3390","volume":"22","author":[{"given":"Beatriz","family":"Carde\u00f1es","sequence":"first","affiliation":[{"name":"Centre for Molecular Biology \u201cSevero Ochoa\u201d (CSIC-UAM), Cell-Cell Communication & Inflammation Unit, 28049 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Clares","sequence":"additional","affiliation":[{"name":"Centre for Molecular Biology \u201cSevero Ochoa\u201d 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Molecular Biology \u201cSevero Ochoa\u201d (CSIC-UAM), Cell-Cell Communication & Inflammation Unit, 28049 Madrid, Spain"},{"name":"Department of Molecular Biology, Faculty of Sciences, Universidad Aut\u00f3noma de Madrid, 28049 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7377-1581","authenticated-orcid":false,"given":"Alvaro","family":"Torres-Gomez","sequence":"additional","affiliation":[{"name":"Department of Immunology, Ophthalmology and Otorhinolaryngology, School of Medicine, Universidad Complutense de Madrid, 28040 Madrid, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Hospital 12 de Octubre (i+12), 28041 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Sainz de la Cuesta","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Hospital Universitario Quironsalud Madrid, 28223 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8466-1022","authenticated-orcid":false,"given":"Esther M.","family":"Lafuente","sequence":"additional","affiliation":[{"name":"Department of Immunology, Ophthalmology and Otorhinolaryngology, School of Medicine, Universidad Complutense de Madrid, 28040 Madrid, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Hospital 12 de Octubre (i+12), 28041 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0976-9719","authenticated-orcid":false,"given":"Manuel","family":"L\u00f3pez-Cabrera","sequence":"additional","affiliation":[{"name":"Centre for Molecular Biology \u201cSevero Ochoa\u201d (CSIC-UAM), Cell-Cell Communication & Inflammation Unit, 28049 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7484-2866","authenticated-orcid":false,"given":"Mar\u00eda","family":"Y\u00e1\u00f1ez-M\u00f3","sequence":"additional","affiliation":[{"name":"Centre for Molecular Biology \u201cSevero Ochoa\u201d (CSIC-UAM), Cell-Cell Communication & Inflammation Unit, 28049 Madrid, Spain"},{"name":"Department of Molecular Biology, Faculty of Sciences, Universidad Aut\u00f3noma de Madrid, 28049 Madrid, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Hospital La Princesa, 28006 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8767-060X","authenticated-orcid":false,"given":"Carlos","family":"Caba\u00f1as","sequence":"additional","affiliation":[{"name":"Centre for Molecular Biology \u201cSevero Ochoa\u201d (CSIC-UAM), Cell-Cell Communication & Inflammation Unit, 28049 Madrid, Spain"},{"name":"Department of Immunology, Ophthalmology 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