{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T02:22:53Z","timestamp":1760235773581,"version":"build-2065373602"},"reference-count":68,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2021,9,23]],"date-time":"2021-09-23T00:00:00Z","timestamp":1632355200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2011\/50629-7"],"award-info":[{"award-number":["2011\/50629-7"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Chronic myeloid leukemia (CML), a hematopoietic neoplasm arising from the fusion of BCR (breakpoint cluster region) gene on chromosome 22 to the ABL (Abelson leukemia virus) gene on chromosome 9 (BCR-ABL1 oncogene), originates from a small population of leukemic stem cells with extensive capacity for self-renewal and an inflammatory microenvironment. Currently, CML treatment is based on tyrosine kinase inhibitors (TKIs). However, allogeneic hematopoietic stem cell transplantation (HSCT-allo) is currently the only effective treatment of CML. The difficulty of finding a compatible donor and high rates of morbidity and mortality limit transplantation treatment. Despite the safety and efficacy of TKIs, patients can develop resistance. Thus, microRNAs (miRNAs) play a prominent role as biomarkers and post-transcriptional regulators of gene expression. The aim of this study was to analyze the miRNA profile in CML patients who achieved cytogenetic remission after treatment with both HSCT-allo and TKI. Expression analyses of the 758 miRNAs were performed using reverse transcription quantitative polymerase chain reaction (RT-qPCR). Bioinformatics tools were used for data analysis. We detected miRNA profiles using their possible target genes and target pathways. MiR-125a-3p stood out among the downregulated miRNAs, showing an interaction network with 52 target genes. MiR-320b was the only upregulated miRNA, with an interaction network of 26 genes. The results are expected to aid future studies of miRNAs, residual leukemic cells, and prognosis in CML.<\/jats:p>","DOI":"10.3390\/ijms221910216","type":"journal-article","created":{"date-parts":[[2021,9,23]],"date-time":"2021-09-23T09:59:15Z","timestamp":1632391155000},"page":"10216","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["MiR-125a-3p and MiR-320b Differentially Expressed in Patients with Chronic Myeloid Leukemia Treated with Allogeneic Hematopoietic Stem Cell Transplantation and Imatinib Mesylate"],"prefix":"10.3390","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8373-3191","authenticated-orcid":false,"given":"Juliana R. B.","family":"Martins","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Botucatu Medical School, S\u00e3o Paulo State University (FMB-UNESP), Botucatu 18618-687, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonardo N.","family":"Moraes","sequence":"additional","affiliation":[{"name":"Department of Bioprocesses and Biotechnology, School of Agriculture, S\u00e3o Paulo State University (FCA-UNESP), Botucatu 18610-034, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4803-0933","authenticated-orcid":false,"given":"Sarah S.","family":"Cury","sequence":"additional","affiliation":[{"name":"Department of Structural and Functional Biology, Institute of Biosciences, S\u00e3o Paulo State University (IBB-UNESP), Botucatu 18618-970, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliana","family":"Capannacci","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Botucatu Medical School, S\u00e3o Paulo State University (FMB-UNESP), Botucatu 18618-687, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4901-7714","authenticated-orcid":false,"given":"Robson Francisco","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Department of Structural and Functional Biology, Institute of Biosciences, S\u00e3o Paulo State University (IBB-UNESP), Botucatu 18618-970, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4014-0660","authenticated-orcid":false,"given":"C\u00e9lia Regina","family":"Nogueira","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Botucatu Medical School, S\u00e3o Paulo State University (FMB-UNESP), Botucatu 18618-687, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Newton Key","family":"Hokama","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Botucatu Medical School, S\u00e3o Paulo State University (FMB-UNESP), Botucatu 18618-687, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3474-4422","authenticated-orcid":false,"given":"Paula O. M.","family":"Hokama","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Botucatu Medical School, S\u00e3o Paulo State University (FMB-UNESP), Botucatu 18618-687, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1053\/j.seminhematol.2010.07.001","article-title":"Chronic Myeloid Leukemia: A Historical Perspective","volume":"47","author":"Goldman","year":"2010","journal-title":"Semin. 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