{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T17:39:52Z","timestamp":1781977192267,"version":"3.54.5"},"reference-count":42,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2021,9,25]],"date-time":"2021-09-25T00:00:00Z","timestamp":1632528000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003407","name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","award":["PRIN-2017249YEF"],"award-info":[{"award-number":["PRIN-2017249YEF"]}],"id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The protection of metals from atmospheric corrosion is a task of primary importance for many applications and many different products have been used, sometimes being toxic and harmful for health and the environment. In order to overcome drawbacks due to toxicity of the corrosion inhibitors and harmful organic solvents and to ensure long-lasting protection, new organic compounds have been proposed and their corrosion inhibition properties have been investigated. In this work, we describe the use of a new environment-friendly anticorrosive coating that takes advantage of the synergism between an eco-friendly bio-polymer matrix and an amino acid. The corrosion inhibition of a largely used Copper-based (Cu-based) alloy against the chloride-induced indoor atmospheric attack was studied using chitosan (CH) as a biopolymer and l-Cysteine (Cy) as an amino acid. To evaluate the protective efficacy of the coatings, tailored accelerated corrosion tests were carried out on bare and coated Cu-based alloys, further, the nature of the protective film formed on the Cu-based alloy surface was analyzed by Fourier-transformed infrared spectroscopy (FTIR) while the surface modifications due to the corrosion treatments were investigated by optical microscopy (OM). The evaluation tests reveal that the Chitosan\/l-Cysteine (CH\/Cy) coatings exhibit good anti-corrosion properties against chloride attack whose efficiency increases with a minimum amount of Cy of 0.25 mg\/mL.<\/jats:p>","DOI":"10.3390\/ijms221910321","type":"journal-article","created":{"date-parts":[[2021,9,27]],"date-time":"2021-09-27T04:55:33Z","timestamp":1632718533000},"page":"10321","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Synergistic Inhibition Effect of Chitosan and L-Cysteine for the Protection of Copper-Based Alloys against Atmospheric Chloride-Induced Indoor Corrosion"],"prefix":"10.3390","volume":"22","author":[{"given":"Elena","family":"Messina","sequence":"first","affiliation":[{"name":"Istituto per lo Studio dei Materiali Nanostrutturati-Consiglio Nazionale delle Ricerche, Area della Ricerca CNR-Montelibretti, via Salaria km 29.3, 00015 Monterotondo, RM, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0757-1805","authenticated-orcid":false,"given":"Chiara","family":"Giuliani","sequence":"additional","affiliation":[{"name":"Istituto per lo Studio dei Materiali Nanostrutturati-Consiglio Nazionale delle Ricerche, Area della Ricerca CNR-Montelibretti, via Salaria km 29.3, 00015 Monterotondo, RM, Italy"},{"name":"Division Sustainable Materials, ENEA, C.R. Casaccia, Via Anguillarese 301, S. M. Di Galeria, 00123 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianna","family":"Pascucci","sequence":"additional","affiliation":[{"name":"Istituto per lo Studio dei Materiali Nanostrutturati-Consiglio Nazionale delle Ricerche, Area della Ricerca CNR-Montelibretti, via Salaria km 29.3, 00015 Monterotondo, RM, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Riccucci","sequence":"additional","affiliation":[{"name":"Istituto per lo Studio dei Materiali Nanostrutturati-Consiglio Nazionale delle Ricerche, Area della Ricerca CNR-Montelibretti, via Salaria km 29.3, 00015 Monterotondo, RM, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Paola","family":"Staccioli","sequence":"additional","affiliation":[{"name":"Istituto per lo Studio dei Materiali Nanostrutturati-Consiglio Nazionale delle Ricerche, Area della Ricerca CNR-Montelibretti, via Salaria km 29.3, 00015 Monterotondo, RM, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Albini","sequence":"additional","affiliation":[{"name":"Istituto per lo Studio dei Materiali Nanostrutturati-Consiglio Nazionale delle Ricerche, Area della Ricerca CNR-Montelibretti, via Salaria km 29.3, 00015 Monterotondo, RM, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6955-8828","authenticated-orcid":false,"given":"Gabriella","family":"Di Carlo","sequence":"additional","affiliation":[{"name":"Istituto per lo Studio dei Materiali Nanostrutturati-Consiglio Nazionale delle Ricerche, Area della Ricerca CNR-Montelibretti, via Salaria km 29.3, 00015 Monterotondo, RM, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"4189","DOI":"10.1016\/S0013-4686(02)00436-X","article-title":"Evaluation of non-toxic corrosion inhibitors for copper in sulphuric acid","volume":"47","author":"Gazivoda","year":"2002","journal-title":"Electrochim. Acta"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1002\/maco.200390050","article-title":"Copper corrosion inhibition by fast green, fuchsin acid and basic compounds in citric acid solution","volume":"54","author":"Cano","year":"2003","journal-title":"Mater. Corros."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"242","DOI":"10.5006\/0010-9312-32.6.242","article-title":"Erosion-Corrosion of Copper-Nickel Alloys in Sea Water and Other Aqueous Environments\u2014A Literature Review","volume":"32","author":"Syrett","year":"1976","journal-title":"Corrosion"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"410","DOI":"10.5006\/1.3585271","article-title":"Whitney Award Lecture: Inhibitors-An Old Remedy for a New Challenge","volume":"47","author":"Trabanelli","year":"1991","journal-title":"Corrosion"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"314","DOI":"10.5006\/1.3277563","article-title":"Studies of Benzotriazole and Tolytriazole as Inhibitors for Copper Corrosion in Deionized Water","volume":"59","author":"Yu","year":"2003","journal-title":"Corrosion"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"4339","DOI":"10.1016\/S0013-4686(02)00486-3","article-title":"Quantitative characterization of protective films grown on copper in the presence of different triazole derivate inhibitors","volume":"47","author":"Qafsaoui","year":"2002","journal-title":"Electrochim. Acta"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"3483","DOI":"10.1149\/1.2221114","article-title":"Rotating Ring-Disk Electrode Studies of Cu-Zn Alloy electrodissolution in 1M HCl Effect of Benzotriazole","volume":"140","author":"Agostinho","year":"1993","journal-title":"J. Electrochem. Soc."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/0010-938X(82)90056-7","article-title":"The corrosion inhibition of copper by benzimidazole","volume":"22","author":"Lewis","year":"1982","journal-title":"Corros. Sci."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1016\/S0010-938X(96)00094-7","article-title":"Tetrazole derivates as corrosion inhibitors for copper in chloride solutions","volume":"38","author":"Zucchi","year":"1996","journal-title":"Corros. Sci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"3325","DOI":"10.1016\/j.matlet.2008.02.068","article-title":"Some amino acids as corrosion inhibitors for copper in nitric acid solution","volume":"62","author":"Barouni","year":"2008","journal-title":"Mater. Lett."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.1002\/ejic.201501161","article-title":"Amino Acid Interleaved Layred Double Hydroxides as Promising Hybrid Materials for Corrosion Inhibition","volume":"2016","author":"Stimpfling","year":"2016","journal-title":"Eur. J. Inorg. Chem."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1007\/s10800-007-9297-1","article-title":"Some environmentally friendly formulations as inhibitors for mild steel corrosion in sulphuric and solution","volume":"37","author":"Morad","year":"2007","journal-title":"J. Appl. Electrochem."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1007\/s10800-005-4745-2","article-title":"Effect of amino acids containing sulphur on the corrosion of mild steel in phosphoric acid solution containing Cl\u2212, F\u2212, and Fe3+ ions: Behavior under polarization conditions","volume":"35","author":"Morad","year":"2005","journal-title":"J. Appl. Electrochem."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1007\/s10800-008-9595-2","article-title":"Corrosion Inhibition of mild steel in sulfamic acid solution by S-containing amino acids","volume":"38","author":"Morad","year":"2008","journal-title":"J. Appl. Electrochem."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1023\/A:1018490727290","article-title":"Inhibitory effect of amino acids on Al pitting corrosion in 0.1 M NaCl","volume":"27","author":"Moussa","year":"1997","journal-title":"J. Appl. Electrochem."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/j.electacta.2007.07.076","article-title":"Effect of 2-amino-3mercaptopropanoic acid (cysteine) on the corrosion behaviour of low carbon steel in surphuric acid","volume":"53","author":"Oguzie","year":"2007","journal-title":"Electrochim. Acta"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/j.corsci.2007.11.031","article-title":"Inhibitory effect of some amino acids on corrosion of Pb-Ca-Sn allo in sulfuric acid solution","volume":"50","author":"Kiani","year":"2008","journal-title":"Corros. Sci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.jallcom.2007.04.293","article-title":"Corrosion control of vanadium in aqueous solutions by amino acids","volume":"459","author":"Helal","year":"2008","journal-title":"J. Alloys Compd."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.apsusc.2004.12.016","article-title":"The inhibition effect of some amino acids towards the corrosion of aluminum in 1 M HCl + 1 M H2SO4 solution","volume":"249","author":"Ghasemi","year":"2005","journal-title":"Appl. Surf. Sci."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"4182","DOI":"10.1016\/j.electacta.2005.11.037","article-title":"Corrosion control of Cu-Ni alloys in neutral chloride solutions by amino acids","volume":"51","author":"Badawy","year":"2006","journal-title":"Electrochim. Acta"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1016\/S0010-938X(02)00020-3","article-title":"Tryptophan as copper corrosion inhibitor in 0.5 M aerated sulfuric acid","volume":"44","author":"Moretti","year":"2002","journal-title":"Corros. Sci."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/S0022-0728(01)00649-0","article-title":"Characterisation of gold electrodes modified with self-assembled monolayers of L-Cysteine for the adsorptive stripping analysis of copper","volume":"516","author":"Yang","year":"2001","journal-title":"J. Electroanal. Chem."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"7811","DOI":"10.1016\/j.electacta.2007.02.053","article-title":"Evaluation of cysteine as environmentally friendl corrosion inhibitor for copper in neutral and acidic chloride solutions","volume":"52","author":"Ismail","year":"2007","journal-title":"Electrochim. Acta"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1381-5148(00)00038-9","article-title":"A review of chitin and chitosan applications","volume":"46","year":"2000","journal-title":"React. Funct. Polym."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.ijbiomac.2012.12.044","article-title":"Chitosan as a green inhibitor for copper corrosion in acidic medium","volume":"55","year":"2013","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.porgcoat.2015.03.008","article-title":"Chitosan as a smart coating for corrosion protection of aluminum alloy 2024: A review","volume":"89","author":"Carneiro","year":"2015","journal-title":"Prog. Org. Coat."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"3843","DOI":"10.1007\/s10570-017-1381-z","article-title":"Chitosan as an eco-friendly inhibitor for copper corrosion in acidic medium: Protocol and characterization","volume":"24","author":"Jmiai","year":"2017","journal-title":"Cellulose"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.porgcoat.2018.05.002","article-title":"Chitosan-based coating for corrosion protection of copper-based alloys: A promising more sustainable approach for cultural heritage applications","volume":"122","author":"Giuliani","year":"2018","journal-title":"Progr. Org. Coat."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"7380","DOI":"10.1002\/anie.201713234","article-title":"Long-Lasting Efficacy of Coatings for Bronze Artwork Conservation: The Key Role of Layered Double Hydroxide Nanocarriers in Protecting Corrosion Inhibitors from Photodegradation","volume":"57","author":"Buonocore","year":"2018","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2474","DOI":"10.1016\/j.saa.2004.09.012","article-title":"L-Cysteine: Neutron spectroscopy, Raman, IR and ab initio study","volume":"61","author":"Leciejewicz","year":"2005","journal-title":"Spectrochim. Acta Part A Mol. Biomol. Spectrosc."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.electacta.2013.01.047","article-title":"Voltammetry of nitrobenzene wit cysteine and other acids in DMSO. Implication for the biological reactivity of reduced nitroaromatics with thiols","volume":"92","author":"Andres","year":"2013","journal-title":"Electrochim. Acta"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/S0032-3861(02)00879-0","article-title":"A novel method for immobilization of chitosan onto nonporous glass beads through a 1,3-thiazolidine linker","volume":"44","author":"Liu","year":"2003","journal-title":"Polymer"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"3569","DOI":"10.1016\/S0032-3861(00)00713-8","article-title":"An infrared investigation in relation with chitin and chitosan characterization","volume":"42","author":"Brugnerotto","year":"2001","journal-title":"Polymer"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"084004","DOI":"10.1088\/0022-3727\/49\/8\/084004","article-title":"FTIR spectroscopy of cysteine as a ready-to-use method for the investigation of plasma-induced chemical modification of macromolecules","volume":"49","author":"Kogelheide","year":"2016","journal-title":"J. Phys. D Appl. Phys."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.chemphys.2013.04.020","article-title":"Assignment of the vibrational spectrum of L-Cysteine","volume":"424","author":"Parker","year":"2013","journal-title":"Chem. Phys."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.polymdegradstab.2008.09.009","article-title":"Degradation of poly(ethylene terephthalate)\/clay nanocomposites during melt extrusion: Effect of clay catalysis and chain extension","volume":"94","author":"Xu","year":"2009","journal-title":"Polym. Degrad. Stab."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1007\/s00339-006-3550-z","article-title":"Large scale investigation of chemical composition, structure and corrosion mechanism of bronze archeological artefacts from Mediterranean basin","volume":"83","author":"Ingo","year":"2006","journal-title":"Appl. Phys. A"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1016\/S0010-938X(00)00135-9","article-title":"The Inhibition effect of amino acids and hydroxy carboxylic acids on pitting corrosion of aluminum alloy 7075","volume":"43","author":"Bereket","year":"2001","journal-title":"Corros. Sci."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1007\/s10800-005-4741-6","article-title":"Enviromentally safe corrosion inhibition of the Cu-Ni alloys in acid sulfate solutions","volume":"35","author":"Badawy","year":"2005","journal-title":"J. Appl. Electrochem."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.corsci.2015.04.018","article-title":"The inhibition effect and mechanism of L-cysteine on the corrosion of bronze covered with a CuCl patina","volume":"97","author":"Wang","year":"2015","journal-title":"Corros. Sci."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1007\/s00339-006-3533-0","article-title":"Combined use of SEM-EDS, OM and XRD for the characterisation of corrosion products grown on silver Roman coins","volume":"83","author":"Ingo","year":"2006","journal-title":"Appl. Phys. A Mater. Sci. Process."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1002\/sia.1311","article-title":"Contribution of surface analytical techniques for the microchemical study of archaeological artefacts","volume":"34","author":"Ingo","year":"2002","journal-title":"Surf. Interface Anal."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/22\/19\/10321\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:04:50Z","timestamp":1760166290000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/22\/19\/10321"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,25]]},"references-count":42,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2021,10]]}},"alternative-id":["ijms221910321"],"URL":"https:\/\/doi.org\/10.3390\/ijms221910321","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,25]]}}}