{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:05:29Z","timestamp":1790805929651,"version":"4.1.0"},"reference-count":176,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2021,9,30]],"date-time":"2021-09-30T00:00:00Z","timestamp":1632960000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Two small leucine-rich proteoglycans (SLRP), decorin and biglycan, play important roles in structural\u2013functional integrity of the placenta and fetal membranes, and their alterations can result in several pregnancy-associated diseases. In this review, we briefly discuss normal placental structure and functions, define and classify SLRPs, and then focus on two SLRPs, decorin (DCN) and biglycan (BGN). We discuss the consequences of deletions\/mutations of DCN and BGN. We then summarize DCN and BGN expression in the pregnant uterus, myometrium, decidua, placenta, and fetal membranes. Actions of these SLRPs as ligands are then discussed in the context of multiple binding partners in the extracellular matrix and cell surface (receptors), as well as their alterations in pathological pregnancies, such as preeclampsia, fetal growth restriction, and preterm premature rupture of membranes. Lastly, we raise some unanswered questions as food for thought.<\/jats:p>","DOI":"10.3390\/ijms221910584","type":"journal-article","created":{"date-parts":[[2021,9,30]],"date-time":"2021-09-30T10:22:42Z","timestamp":1632997362000},"page":"10584","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Roles of Two Small Leucine-Rich Proteoglycans Decorin and Biglycan in Pregnancy and Pregnancy-Associated Diseases"],"prefix":"10.3390","volume":"22","author":[{"given":"Chidambra D.","family":"Halari","sequence":"first","affiliation":[{"name":"Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, ON N6A 5C1, Canada"},{"name":"Children\u2019s Health Research Institute (CHRI), Schulich School of Medicine and Dentistry, The University of Western Ontario, London, ON N6A 5C1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0968-689X","authenticated-orcid":false,"given":"Michael","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, ON N6A 5C1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6405-9584","authenticated-orcid":false,"given":"Peeyush K.","family":"Lala","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, ON N6A 5C1, Canada"},{"name":"Children\u2019s Health Research Institute (CHRI), Schulich School of Medicine and Dentistry, The University of Western Ontario, London, ON N6A 5C1, Canada"},{"name":"Department of Oncology, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, ON N6A 5C1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1093\/biolre\/ioy049","article-title":"Hemochorial placentation: Development, function, and adaptations","volume":"99","author":"Soares","year":"2018","journal-title":"Biol. Reprod."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"S64","DOI":"10.1016\/j.placenta.2007.01.007","article-title":"Human Early Placental Development: Potential Roles of the Endometrial Glands","volume":"28","author":"Burton","year":"2007","journal-title":"Placenta"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.placenta.2015.01.002","article-title":"Tracking nutrient transfer at the human maternofetal interface from 4 weeks to term","volume":"36","author":"Jones","year":"2015","journal-title":"Placenta"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/0165-0378(88)90028-9","article-title":"Expression of the proliferation markers Ki67 and transferrin receptor by human trophoblast populations","volume":"14","author":"Bulmer","year":"1988","journal-title":"J. Reprod. Immunol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1016\/S0002-9440(10)64648-2","article-title":"A Repertoire of Cell Cycle Regulators Whose Expression Is Coordinated with Human Cytotrophoblast Differentiation","volume":"157","author":"Genbacev","year":"2000","journal-title":"Am. J. Pathol."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Lala, P.K., Nandi, P., Hadi, A., and Halari, C. (2021). A crossroad between placental and tumor biology: What have we learnt?. Placenta, 12.","DOI":"10.1016\/j.placenta.2021.03.003"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.placenta.2020.10.003","article-title":"Transient loss of endothelial cells in human spiral artery remodelling during early pregnancy: Challenging the dogma","volume":"101","author":"Bulmer","year":"2020","journal-title":"Placenta"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/s00418-018-1699-0","article-title":"Human trophoblast invasion: New and unexpected routes and functions","volume":"150","author":"Moser","year":"2018","journal-title":"Histochem. Cell Biol."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Huppertz, B. (2019). Traditional and New Routes of Trophoblast Invasion and Their Implications for Pregnancy Diseases. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21010289"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1093\/humrep\/14.2.496","article-title":"Are human placental bed giant cells merely aggregates of small mononuclear trophoblast cells? An ultrastructural and immunocytochemical study","volume":"14","author":"AlLamki","year":"1999","journal-title":"Hum. Reprod."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.matbio.2015.02.003","article-title":"Proteoglycan form and function: A comprehensive nomenclature of proteoglycans","volume":"42","author":"Iozzo","year":"2015","journal-title":"Matrix Biol. J. Int. Soc. Matrix Biol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0076-6879(10)80001-1","article-title":"Auxiliary and Autonomous Proteoglycan Signaling Networks","volume":"480","author":"Elfenbein","year":"2010","journal-title":"Methods Enzymol."},{"key":"ref_13","unstructured":"Varki, A., Cummings, R.D., Esko, J.D., Stanley, P., Hart, G.W., Aebi, M., Darvill, A.G., Kinoshita, T., Packer, N.H., and Prestegard, J.H. (2017). Proteoglycans and Sulfated Glycosaminoglycans. Essentials of Glycobiology, Cold Spring Harbor Laboratory Press. [3rd ed.]. Chapter 17."},{"key":"ref_14","first-page":"2484","article-title":"Insulin-Like Growth Factor-Binding Protein 1 Stimulates Human Trophoblast Migration by Signaling through \u03b15\u03b21 Integrin via Mitogen-Activated Protein Kinase Pathway","volume":"86","author":"Gleeson","year":"2001","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1111\/febs.12210","article-title":"Lumican effects in the control of tumour progression and their links with metalloproteinases and integrins","volume":"280","author":"Maquart","year":"2013","journal-title":"FEBS J."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"12212","DOI":"10.1074\/jbc.M011290200","article-title":"Expression Pattern and Gene Characterization of Asporin: A newly discovered member of the leucine-rich repeat protein family","volume":"276","author":"Henry","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"107R","DOI":"10.1093\/glycob\/cwf065","article-title":"Mice deficient in small leucine-rich proteoglycans: Novel in vivo models for osteoporosis, osteoarthritis, Ehlers-Danlos syndrome, muscular dystrophy, and corneal diseases","volume":"12","author":"Ameye","year":"2002","journal-title":"Glycobiology"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.matbio.2010.01.001","article-title":"The role of small leucine-rich proteoglycans in collagen fibrillogenesis","volume":"29","author":"Kalamajski","year":"2010","journal-title":"Matrix Biol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2084","DOI":"10.4161\/cc.20316","article-title":"Small leucine-rich proteoglycans orchestrate receptor crosstalk during inflammation","volume":"11","author":"Moreth","year":"2012","journal-title":"Cell Cycle"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.ajpath.2012.04.029","article-title":"Decorin: A guardian from the matrix","volume":"181","author":"Neill","year":"2012","journal-title":"Am. J. Pathol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"21305","DOI":"10.1074\/jbc.R800020200","article-title":"Biological Functions of the Small Leucine-rich Proteoglycans: From Genetics to Signal Transduction","volume":"283","author":"Schaefer","year":"2008","journal-title":"J. Biol. Chem."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.1002\/ijc.23930","article-title":"Tumor microenvironment: Modulation by decorin and related molecules harboring leucine-rich tandem motifs","volume":"123","author":"Goldoni","year":"2008","journal-title":"Int. J. Cancer"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.gde.2011.12.002","article-title":"Small leucine-rich proteoglycans, at the crossroad of cancer growth and inflammation","volume":"22","author":"Schaefer","year":"2012","journal-title":"Curr. Opin. Genet. Dev."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"141","DOI":"10.3109\/10409239709108551","article-title":"The Family of the Small Leucine-Rich Proteoglycans: Key Regulators of Matrix Assembly and Cellular Growth","volume":"32","author":"Iozzo","year":"1997","journal-title":"Crit. Rev. Biochem. Mol. Biol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.jsb.2006.01.016","article-title":"Structural correlations in the family of small leucine-rich repeat proteins and proteoglycans","volume":"155","author":"McEwan","year":"2006","journal-title":"J. Struct. Biol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"25639","DOI":"10.1074\/jbc.270.43.25639","article-title":"The Primary Structure of a Basic Leucine-rich Repeat Protein, PRELP, Found in Connective Tissues","volume":"270","author":"Bengtsson","year":"1995","journal-title":"J. Biol. Chem."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"12201","DOI":"10.1074\/jbc.M010932200","article-title":"Identification and Characterization of Asporin: A novel member of the leucine-rich repeat protein family closely related to decorin and biglycan","volume":"276","author":"Lorenzo","year":"2001","journal-title":"J. Biol. Chem."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"28543","DOI":"10.1074\/jbc.M109.047076","article-title":"The Tyrosine Sulfate-rich Domains of the LRR Proteins Fibromodulin and Osteoadherin Bind Motifs of Basic Clusters in a Variety of Heparin-binding Proteins, Including Bioactive Factors","volume":"284","author":"Tillgren","year":"2009","journal-title":"J. Biol. Chem."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1167\/iovs.04-0804","article-title":"Congenital Stromal Dystrophy of the Cornea Caused by a Mutation in the Decorin Gene","volume":"46","author":"Bredrup","year":"2005","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.exer.2010.05.008","article-title":"Focus on Molecules: Decorin","volume":"92","author":"Chen","year":"2011","journal-title":"Exp. Eye Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"21547","DOI":"10.1016\/S0021-9258(17)31839-2","article-title":"The structure of a 38-kDa leucine-rich protein (chondroadherin) isolated from bovine cartilage","volume":"269","author":"Neame","year":"1994","journal-title":"J. Biol. Chem."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/81619","article-title":"Mutations in NYX, encoding the leucine-rich proteoglycan nyctalopin, cause X-linked complete congenital stationary night blindness","volume":"26","author":"Naylor","year":"2000","journal-title":"Nat. Genet."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1038\/81627","article-title":"The complete form of X-linked congenital stationary night blindness is caused by mutations in a gene encoding a leucine-rich repeat protein","volume":"26","author":"Pusch","year":"2000","journal-title":"Nat. Genet."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.devcel.2004.08.014","article-title":"Tsukushi Functions as an Organizer Inducer by Inhibition of BMP Activity in Cooperation with Chordin","volume":"7","author":"Ohta","year":"2004","journal-title":"Dev. Cell"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1096\/fj.03-0899com","article-title":"The small leucine-rich proteoglycan biglycan modulates BMP-4-induced osteoblast differentiation","volume":"18","author":"Chen","year":"2004","journal-title":"FASEB J."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1038\/sj.emboj.7600615","article-title":"Biglycan is a new extracellular component of the Chordin\u2013BMP4 signaling pathway","volume":"24","author":"Moreno","year":"2005","journal-title":"EMBO J."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"33248","DOI":"10.1074\/jbc.M301299200","article-title":"Podocan, a Novel Small Leucine-rich Repeat Protein Expressed in the Sclerotic Glomerular Lesion of Experimental HIV-associated Nephropathy","volume":"278","author":"Ross","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"R79","DOI":"10.1186\/ar2453","article-title":"Fragmentation of decorin, biglycan, lumican and keratocan is elevated in degenerate human meniscus, knee and hip articular cartilages compared with age-matched macroscopically normal and control tissues","volume":"10","author":"Melrose","year":"2008","journal-title":"Arthritis Res. Ther."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1093\/molehr\/gaaa058","article-title":"Decorin production by the human decidua: Role in decidual cell maturation","volume":"26","author":"Halari","year":"2020","journal-title":"Mol. Hum. Reprod."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/0143-4004(95)90110-8","article-title":"Localization of transforming growth factor \u03b2 and its natural inhibitor decorin in the human placenta and decidua throughout gestation","volume":"16","author":"Lysiak","year":"1995","journal-title":"Placenta"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1139\/o92-135","article-title":"Mechanisms of placental invasion of the uterus and their control","volume":"70","author":"Graham","year":"1992","journal-title":"Biochem. Cell Biol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1095\/biolreprod67.2.681","article-title":"Control of Proliferation, Migration, and Invasiveness of Human Extravillous Trophoblast by Decorin, a Decidual Product","volume":"67","author":"Xu","year":"2002","journal-title":"Biol. Reprod."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"6187","DOI":"10.1210\/en.2008-0780","article-title":"Decorin-Mediated Inhibition of Proliferation and Migration of the Human Trophoblast via Different Tyrosine Kinase Receptors","volume":"149","author":"Iacob","year":"2008","journal-title":"Endocrinology"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1210\/me.2010-0426","article-title":"Decorin Is a Novel VEGFR-2-Binding Antagonist for the Human Extravillous Trophoblast","volume":"25","author":"Khan","year":"2011","journal-title":"Mol. Endocrinol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1095\/biolreprod.111.097881","article-title":"Mechanisms in Decorin Regulation of Vascular Endothelial Growth Factor-Induced Human Trophoblast Migration and Acquisition of Endothelial Phenotype","volume":"87","author":"Lala","year":"2012","journal-title":"Biol. Reprod."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1111\/aji.12449","article-title":"Restraint of Trophoblast Invasion of the Uterus by Decorin: Role in Pre-eclampsia","volume":"75","author":"Nandi","year":"2016","journal-title":"Am. J. Reprod. Immunol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"361.e1","DOI":"10.1016\/j.ajog.2016.03.020","article-title":"Decorin over-expression by decidual cells in preeclampsia: A potential blood biomarker","volume":"215","author":"Siddiqui","year":"2016","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1080\/19336918.2015.1106669","article-title":"Mechanisms of trophoblast migration, endometrial angiogenesis in preeclampsia: The role of decorin","volume":"10","author":"Lala","year":"2016","journal-title":"Cell Adhes. Migr."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-018-27119-4","article-title":"Human trophoblast stem cell self-renewal and differentiation: Role of decorin","volume":"8","author":"Nandi","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1006\/bbrc.2002.6370","article-title":"Asb4, Ata3, and Dcn Are Novel Imprinted Genes Identified by High-Throughput Screening Using RIKEN cDNA Microarray","volume":"290","author":"Mizuno","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"6623","DOI":"10.1073\/pnas.0511031103","article-title":"Limited evolutionary conservation of imprinting in the human placenta","volume":"103","author":"Monk","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.anireprosci.2010.11.012","article-title":"Expression and genomic imprinting of DCN, PON2 and PEG3 genes in porcine placenta","volume":"123","author":"Zhou","year":"2011","journal-title":"Anim. Reprod. Sci."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.placenta.2014.06.366","article-title":"Spatial and temporal changes of Decorin, Type I collagen and Fibronectin expression in normal and clone bovine placenta","volume":"35","author":"Guillomot","year":"2014","journal-title":"Placenta"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1007\/s10719-018-9834-7","article-title":"Preliminary results of the placental decorin profile in bovine pregnancy and parturition","volume":"35","author":"Franczyk","year":"2018","journal-title":"Glycoconj. J."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1080\/03008200600883138","article-title":"Change in Decorin during Aging of Rat Placenta","volume":"47","author":"Batbayal","year":"2006","journal-title":"Connect. Tissue Res."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1006\/abio.1995.9949","article-title":"Identification of Glycosaminoglycans Using High-Performance Liquid Chromatography on a Hydroxyapatite Column","volume":"232","author":"Narita","year":"1995","journal-title":"Anal. Biochem."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1136\/jcp.49.11.916","article-title":"Increase in the relative level of type V collagen during development and ageing of the placenta","volume":"49","author":"Iwahashi","year":"1996","journal-title":"J. Clin. Pathol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1210\/er.2014-1045","article-title":"Cyclic Decidualization of the Human Endometrium in Reproductive Health and Failure","volume":"35","author":"Gellersen","year":"2014","journal-title":"Endocr. Rev."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1055\/s-2007-991042","article-title":"Decidualization of the Human Endometrium: Mechanisms, Functions, and Clinical Perspectives","volume":"25","author":"Gellersen","year":"2007","journal-title":"Semin. Reprod. Med."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/S0301-2115(01)00476-6","article-title":"Changes of the uterine proteoglycan distribution at term pregnancy and during labour","volume":"100","author":"Hjelm","year":"2002","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_61","first-page":"223","article-title":"Binucleate and polyploid cells in the decidua of the mouse","volume":"31","author":"Ansell","year":"1974","journal-title":"J. Embryol. Exp. Morphol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1002\/aja.1001860411","article-title":"Diameter increase of collagen fibrils of the mouse endometrium during decidualization","volume":"186","author":"Zorn","year":"1989","journal-title":"Am. J. Anat."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1002\/jemt.20265","article-title":"Arrangement and fine structure of collagen fibrils in the decidualized mouse endometrium","volume":"69","author":"Carbone","year":"2006","journal-title":"Microsc. Res. Tech."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1083\/jcb.136.3.729","article-title":"Targeted Disruption of Decorin Leads to Abnormal Collagen Fibril Morphology and Skin Fragility","volume":"136","author":"Danielson","year":"1997","journal-title":"J. Cell Biol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1111\/j.1469-7580.2009.01170.x","article-title":"Collagen fibril organization in the pregnant endometrium of decorin-deficient mice","volume":"216","author":"Sanches","year":"2010","journal-title":"J. Anat."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1083\/jcb.151.4.779","article-title":"Differential Expression of Lumican and Fibromodulin Regulate Collagen Fibrillogenesis in Developing Mouse Tendons","volume":"151","author":"Ezura","year":"2000","journal-title":"J. Cell Biol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1002\/jcb.20776","article-title":"Decorin regulates assembly of collagen fibrils and acquisition of biomechanical properties during tendon development","volume":"98","author":"Zhang","year":"2006","journal-title":"J. Cell. Biochem."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1471-0528.2005.00575.x","article-title":"The epidemiology of preterm labour","volume":"112","author":"Steer","year":"2005","journal-title":"BJOG"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1136\/bmj.2.5515.682","article-title":"Ehlers-Danlos syndrome: Associated with prematurity and premature rupture of foetal membranes; possible increase in incidence","volume":"2","author":"Barabas","year":"1966","journal-title":"Br. Med. J."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/S0929-6646(09)60187-X","article-title":"Clinical Features of Ehlers-Danlos Syndrome","volume":"105","author":"Yen","year":"2006","journal-title":"J. Formos. Med. Assoc."},{"key":"ref_71","first-page":"436","article-title":"Glycosaminoglycan-free small proteoglycan core protein is secreted by fibroblasts from a patient with a syndrome resembling progeroid","volume":"41","author":"Kresse","year":"1987","journal-title":"Am. J. Hum. Genet."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1073\/pnas.87.4.1342","article-title":"A genetic defect in the biosynthesis of dermatan sulfate proteoglycan: Galactosyltransferase I deficiency in fibroblasts from a patient with a progeroid syndrome","volume":"87","author":"Quentin","year":"1990","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.matbio.2013.07.005","article-title":"Ehlers\u2013Danlos syndrome: A showcase of conditions that lead to understanding matrix biology","volume":"33","author":"Byers","year":"2014","journal-title":"Matrix Biol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.1161\/CIRCULATIONAHA.106.653980","article-title":"Biglycan Deficiency Causes Spontaneous Aortic Dissection and Rupture in Mice","volume":"115","author":"Heegaard","year":"2007","journal-title":"Circulation"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/path.2516","article-title":"Syndromic and non-syndromic aneurysms of the human ascending aorta share activation of the Smad2 pathway","volume":"218","author":"Gomez","year":"2009","journal-title":"J. Pathol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.matbio.2013.12.006","article-title":"Biglycan and decorin differentially regulate signaling in the fetal membranes","volume":"35","author":"Wu","year":"2014","journal-title":"Matrix Biol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/0028-2243(93)90086-R","article-title":"Different biomechanical properties of human fetal membranes obtained before and after delivery","volume":"48","author":"Helmig","year":"1993","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/0028-2243(89)90028-2","article-title":"The concentration of collagen and the collagenolytic activity in the amnion and the chorion","volume":"31","author":"Halaburt","year":"1989","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1067\/mob.2001.110294","article-title":"Proteoglycans and hyaluronan in human fetal membranes","volume":"184","author":"Meinert","year":"2001","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.placenta.2006.09.006","article-title":"Labour Induces Increased Concentrations of Biglycan and Hyaluronan in Human Fetal Membranes","volume":"28","author":"Meinert","year":"2007","journal-title":"Placenta"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.jsgi.2005.12.010","article-title":"Fetal Membranes from Term VAginal Deliveries Have a Zone of Weakness Exhibiting Characteristics of Apoptosis and Remodeling","volume":"13","author":"Pandey","year":"2006","journal-title":"J. Soc. Gynecol. Investig."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/j.placenta.2006.01.002","article-title":"The Physiology of Fetal Membrane Rupture: Insight Gained from the Determination of Physical Properties","volume":"27","author":"Moore","year":"2006","journal-title":"Placenta"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1093\/molehr\/5.9.880","article-title":"Expression of cyclo-oxygenase types-1 and -2 in human myometrium throughout pregnancy","volume":"5","author":"Slater","year":"1999","journal-title":"Mol. Hum. Reprod."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1111\/j.1600-0897.2004.00143.x","article-title":"Differential Expression and Localization of Decorin in Human Choriodecidual Membrane during Preterm and Term Pregnancy","volume":"51","author":"Ogita","year":"2004","journal-title":"Am. J. Reprod. Immunol."},{"key":"ref_85","first-page":"217","article-title":"Changed proteoglycan metabolism in human cervix immediately after spontaneous vaginal delivery","volume":"81","author":"Norman","year":"1993","journal-title":"Obstet. Gynecol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/S0002-9378(00)70329-2","article-title":"Further evidence of a decorin-collagen interaction in the disruption of cervical collagen fibers during rat gestation","volume":"182","author":"Leppert","year":"2000","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"C199","DOI":"10.1152\/ajpcell.2000.278.1.C199","article-title":"Characterization of decorin mRNA in pregnant intrauterine tissues of the ewe and regulation by steroids","volume":"278","author":"Wu","year":"2000","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/1477-7827-9-22","article-title":"Modulation of small leucine-rich proteoglycans (SLRPs) expression in the mouse uterus by estradiol and progesterone","volume":"9","author":"Salgado","year":"2011","journal-title":"Reprod. Biol. Endocrinol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1530\/rep.0.1250585","article-title":"Small leucine-rich proteoglycans (SLRPs) in uterine tissues during pregnancy in mice","volume":"125","author":"Aplin","year":"2003","journal-title":"Reproduction"},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Glasser, S.R., Aplin, J.D., Giudice, L.C., and Tabibzadeh, S. (2002). Female sex steroid hormone regulation of cell proliferation in the endometrium. The Endometrium, Taylor & Francis.","DOI":"10.3109\/9780203219034"},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Wu, Z., Aron, A.W., Macksoud, E.E., Iozzo, R., Hai, C.-M., and Lechner, B.E. (2012). Uterine Dysfunction in Biglycan and Decorin Deficient Mice Leads to Dystocia during Parturition. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0029627"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1530\/REP-10-0387","article-title":"A mouse model of spontaneous preterm birth based on the genetic ablation of biglycan and decorin","volume":"142","author":"Calmus","year":"2011","journal-title":"Reproduction"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"10129","DOI":"10.1073\/pnas.91.21.10129","article-title":"Stromal-epithelial interaction mediates steroidal regulation of metalloproteinase expression in human endometrium","volume":"91","author":"Osteen","year":"1994","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/1477-7827-2-66","article-title":"Comparison in gene expression of secretory human endometrium using laser microdissection","volume":"2","author":"Yanaihara","year":"2004","journal-title":"Reprod. Biol. Endocrinol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1016\/j.fertnstert.2004.11.032","article-title":"Differences in gene expression in the proliferative human endometrium","volume":"83","author":"Yanaihara","year":"2005","journal-title":"Fertil. Steril."},{"key":"ref_96","first-page":"217","article-title":"Small leucine rich proteoglycans are differently distributed in normal and pathological endometrium","volume":"29","author":"Lucariello","year":"2015","journal-title":"In Vivo"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1152\/physiolgenomics.00061.2001","article-title":"Gene induction and categorical reprogramming during in vitro human endometrial fibroblast decidualization","volume":"7","author":"Brar","year":"2001","journal-title":"Physiol. Genom."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1095\/biolreprod.106.053058","article-title":"Autocrine Prolactin Inhibits Human Uterine Decidualization: A Novel Role for Prolactin","volume":"76","author":"Eyal","year":"2007","journal-title":"Biol. Reprod."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"9636","DOI":"10.1074\/jbc.274.14.9636","article-title":"Fibromodulin-null Mice Have Abnormal Collagen Fibrils, Tissue Organization, and Altered Lumican Deposition in Tendon","volume":"274","author":"Svensson","year":"1999","journal-title":"J. Biol. Chem."},{"key":"ref_100","first-page":"3365","article-title":"Corneal opacity in lumican-null mice: Defects in collagen fibril structure and packing in the posterior stroma","volume":"41","author":"Chakravarti","year":"2000","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1002\/dvdy.20868","article-title":"Collagen fibril assembly during postnatal development and dysfunctional regulation in the lumican-deficient murine cornea","volume":"235","author":"Chakravarti","year":"2006","journal-title":"Dev. Dyn."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"8888","DOI":"10.1074\/jbc.M806590200","article-title":"Genetic Evidence for the Coordinated Regulation of Collagen Fibrillogenesis in the Cornea by Decorin and Biglycan","volume":"284","author":"Zhang","year":"2009","journal-title":"J. Biol. Chem."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1080\/00016340802460313","article-title":"Differences in heparan sulfate production in cervical fibroblast cultures from women undergoing term and preterm delivery","volume":"87","author":"Dubicke","year":"2008","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"253","DOI":"10.3109\/03008207.2015.1023432","article-title":"The absence of the embryo in the pseudopregnant uterus alters the deposition of some ECM molecules during decidualization in mice","volume":"56","author":"Covarrubias","year":"2015","journal-title":"Connect. Tissue Res."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/1477-7827-2-54","article-title":"Microarray profiling of progesterone-regulated endometrial genes during the rhesus monkey secretory phase","volume":"2","author":"Ace","year":"2004","journal-title":"Reprod. Biol. Endocrinol."},{"key":"ref_106","first-page":"673","article-title":"The small proteoglycan biglycan is associated with thick collagen fibrils in the mouse decidua","volume":"49","author":"Zorn","year":"2003","journal-title":"Cell Mol. Biol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"2388","DOI":"10.1021\/bm0603746","article-title":"Fibrillogenesis of Collagen Types I, II, and III with Small Leucine-Rich Proteoglycans Decorin and Biglycan","volume":"7","author":"Douglas","year":"2006","journal-title":"Biomacromolecules"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1042\/bj2230587","article-title":"Specific inhibition of type I and type II collagen fibrillogenesis by the small proteoglycan of tendon","volume":"223","author":"Vogel","year":"1984","journal-title":"Biochem. J."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"2164","DOI":"10.1016\/S0006-3495(97)78247-X","article-title":"Self-assembly of collagen fibers. Influence of fibrillar alignment and decorin on mechanical properties","volume":"73","author":"Pins","year":"1997","journal-title":"Biophys. J."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.matbio.2013.04.004","article-title":"Effects of decorin proteoglycan on fibrillogenesis, ultrastructure, and mechanics of type I collagen gels","volume":"32","author":"Reese","year":"2013","journal-title":"Matrix Biol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1002\/(SICI)1097-4644(19971001)67:1<75::AID-JCB8>3.0.CO;2-T","article-title":"Decorin inhibits cell attachment to thrombospondin-1 by binding to a KKTR-dependent cell adhesive site present within the N-terminal domain of thrombospondin-1","volume":"67","author":"Merle","year":"1997","journal-title":"J. Cell Biochem."},{"key":"ref_112","first-page":"47","article-title":"Interactions between thrombospondin and the small proteoglycan decorin: Interference with cell attachment","volume":"59","author":"Vischer","year":"1992","journal-title":"Eur. J. Cell Biol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1083\/jcb.104.6.1683","article-title":"Interaction of small dermatan sulfate proteoglycan from fibroblasts with fibronectin","volume":"104","author":"Schmidt","year":"1987","journal-title":"J. Cell Biol."},{"key":"ref_114","first-page":"10","article-title":"Influence of decorin on fibroblast adhesion to fibronectin","volume":"54","author":"Schmidt","year":"1991","journal-title":"Eur. J. Cell Biol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1042\/bj3020527","article-title":"Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor \u03b2","volume":"302","author":"Hildebrand","year":"1994","journal-title":"Biochem. J."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/346281a0","article-title":"Negative regulation of transforming growth factor-\u03b2 by the proteoglycan decorin","volume":"346","author":"Yamaguchi","year":"1990","journal-title":"Nature"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/S0945-053X(00)00097-4","article-title":"Influence of decorin expression on transforming growth factor-\u03b2-mediated collagen gel retraction and biglycan induction","volume":"19","author":"Markmann","year":"2000","journal-title":"Matrix Biol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/360361a0","article-title":"Natural inhibitor of transforming growth factor-\u03b2 protects against scarring in experimental kidney disease","volume":"360","author":"Border","year":"1992","journal-title":"Nature"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"L1327","DOI":"10.1152\/ajplung.2001.280.6.L1327","article-title":"Proteoglycans decorin and biglycan differentially modulate TGF-\u03b2-mediated fibrotic responses in the lung","volume":"280","author":"Kolb","year":"2001","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1042\/bj3220809","article-title":"Degradation of decorin by matrix metalloproteinases: Identification of the cleavage sites, kinetic analyses and transforming growth factor-\u03b21 release","volume":"322","author":"Imai","year":"1997","journal-title":"Biochem. J."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"4489","DOI":"10.1074\/jbc.274.8.4489","article-title":"Decorin Is a Biological Ligand for the Epidermal Growth Factor Receptor","volume":"274","author":"Iozzo","year":"1999","journal-title":"J. Biol. Chem."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"35671","DOI":"10.1074\/jbc.M205317200","article-title":"Decorin Binds to a Narrow Region of the Epidermal Growth Factor (EGF) Receptor, Partially Overlapping but Distinct from the EGF-binding Epitope","volume":"277","author":"Santra","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1172\/JCI846","article-title":"Decorin suppresses tumor cell growth by activating the epidermal growth factor receptor","volume":"101","author":"Moscatello","year":"1998","journal-title":"J. Clin. Investig."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"32468","DOI":"10.1074\/jbc.M503833200","article-title":"Decorin Evokes Protracted Internalization and Degradation of the Epidermal Growth Factor Receptor via Caveolar Endocytosis","volume":"280","author":"Zhu","year":"2005","journal-title":"J. Biol. Chem."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"32879","DOI":"10.1074\/jbc.M005609200","article-title":"Sustained Down-regulation of the Epidermal Growth Factor Receptor by Decorin: A mechanism for controlling tumor growth in vivo","volume":"275","author":"Santra","year":"2000","journal-title":"J. Biol. Chem."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"15767","DOI":"10.1074\/jbc.M500451200","article-title":"Decorin, a Novel Player in the Insulin-like Growth Factor System","volume":"280","author":"Iozzo","year":"2005","journal-title":"J. Biol. Chem."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1083\/jcb.200901129","article-title":"Decorin is a novel antagonistic ligand of the Met receptor","volume":"185","author":"Goldoni","year":"2009","journal-title":"J. Cell Biol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"5492","DOI":"10.1074\/jbc.M111.283499","article-title":"Decorin Antagonizes the Angiogenic Network: Concurrent inhibition of Met, hypoxia inducible factor 1\u03b1, vascular endothelial growth factor A, and induction of thrombos-pondin-1 and TIMP3","volume":"287","author":"Neill","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"27935","DOI":"10.1074\/jbc.M414320200","article-title":"Peptides Derived from Human Decorin Leucine-rich Repeat 5 Inhibit Angiogenesis","volume":"280","author":"Sulochana","year":"2005","journal-title":"J. Biol. Chem."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"ra75","DOI":"10.1126\/scisignal.2001868","article-title":"Signaling by the Matrix Proteoglycan Decorin Controls Inflammation and Cancer Through PDCD4 and MicroRNA-21","volume":"4","author":"Merline","year":"2011","journal-title":"Sci. Signal."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1172\/JCI115579","article-title":"An anticoagulant dermatan sulfate proteoglycan circulates in the pregnant woman and her fetus","volume":"89","author":"Andrew","year":"1992","journal-title":"J. Clin. Investig."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0049-3848(98)00035-8","article-title":"Anticoagulant Dermatan Sulfate Proteoglycan (Decorin) in the Term Human Placenta","volume":"90","author":"Delorme","year":"1998","journal-title":"Thromb. Res."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1002\/mrd.22488","article-title":"Compensatory fetal membrane mechanisms between biglycan and decorin in inflammation","volume":"82","author":"Horgan","year":"2015","journal-title":"Mol. Reprod. Dev."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1095\/biolreprod.114.121236","article-title":"Altered Decorin and Smad Expression in Human Fetal Membranes in PPROM","volume":"91","author":"Horgan","year":"2014","journal-title":"Biol. Reprod."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.placenta.2014.05.009","article-title":"Altered decorin leads to disrupted endothelial cell function: A possible mechanism in the pathogenesis of fetal growth restriction?","volume":"35","author":"Chui","year":"2014","journal-title":"Placenta"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/cr.2008.302","article-title":"Signaling cross-talk between TGF-\u03b2\/BMP and other pathways","volume":"19","author":"Guo","year":"2008","journal-title":"Cell Res."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"3920","DOI":"10.1016\/S0021-9258(18)53560-2","article-title":"Interaction of heparin cofactor II with biglycan and decorin","volume":"268","author":"Whinna","year":"1993","journal-title":"J. Biol. Chem."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1172\/JCI23755","article-title":"The matrix component biglycan is proinflammatory and signals through Toll-like receptors 4 and 2 in macrophages","volume":"115","author":"Schaefer","year":"2005","journal-title":"J. Clin. Investig."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"4251","DOI":"10.1172\/JCI42213","article-title":"The proteoglycan biglycan regulates expression of the B cell chemoattractant CXCL13 and aggravates murine lupus nephritis","volume":"120","author":"Moreth","year":"2010","journal-title":"J. Clin. Investig."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.matbio.2014.01.010","article-title":"Biglycan-triggered TLR-2- and TLR-4-signaling exacerbates the pathophysiology of ischemic acute kidney injury","volume":"35","author":"Moreth","year":"2014","journal-title":"Matrix Biol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.matbio.2013.12.003","article-title":"De novo expression of circulating biglycan evokes an innate inflammatory tissue response via MyD88\/TRIF pathways","volume":"35","author":"Beckmann","year":"2014","journal-title":"Matrix Biol."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1016\/j.molonc.2016.08.002","article-title":"Biglycan stimulates VEGF expression in endothelial cells by activating the TLR signaling pathway","volume":"10","author":"Hu","year":"2016","journal-title":"Mol. Oncol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"24035","DOI":"10.1074\/jbc.M109.014266","article-title":"Biglycan, a Danger Signal That Activates the NLRP3 Inflammasome via Toll-like and P2X Receptors","volume":"284","author":"Babelova","year":"2009","journal-title":"J. Biol. Chem."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.matbio.2015.12.005","article-title":"Bimodal role of NADPH oxidases in the regulation of biglycan-triggered IL-1\u03b2 synthesis","volume":"49","author":"Hsieh","year":"2016","journal-title":"Matrix Biol."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1007\/s43032-020-00192-9","article-title":"Serum Decorin and Biglycan as Potential Biomarkers to Predict PPROM in Early Gestation","volume":"27","author":"Underhill","year":"2020","journal-title":"Reprod. Sci."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.ydbio.2004.09.022","article-title":"Excess biglycan causes eyelid malformation by perturbing muscle development and TGF-\u03b1 signaling","volume":"277","author":"Hayashi","year":"2005","journal-title":"Dev. Biol."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.matbio.2013.12.004","article-title":"Biglycan modulates angiogenesis and bone formation during fracture healing","volume":"35","author":"Berendsen","year":"2014","journal-title":"Matrix Biol."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"4059","DOI":"10.3109\/14767058.2016.1154942","article-title":"Placental levels of total oxidative and anti-oxidative status, ADAMTS-12 and decorin in early- and late-onset severe preeclampsia","volume":"29","author":"Daglar","year":"2016","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"201629","DOI":"10.1155\/2015\/201629","article-title":"Decorin-Mediated Inhibition of Human Trophoblast Cells Proliferation, Migration, and Invasion and Promotion of ApoptosisIn Vitro","volume":"2015","author":"Zou","year":"2015","journal-title":"BioMed Res. Int."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.placenta.2019.08.084","article-title":"Placental and serum levels of human Klotho in severe preeclampsia: A potential sensitive biomarker","volume":"85","author":"Cilingir","year":"2019","journal-title":"Placenta"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1081\/PRG-120021060","article-title":"Subclassification of Preeclampsia","volume":"22","author":"Magee","year":"2003","journal-title":"Hypertens. Pregnancy"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"141","DOI":"10.3109\/09513590.2013.860125","article-title":"Decorin: A possible marker for fetal growth restriction","volume":"30","author":"Caglar","year":"2014","journal-title":"Gynecol. Endocrinol."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1071\/RD09240","article-title":"Decorin expression is decreased in human idiopathic fetal growth restriction","volume":"22","author":"Swan","year":"2010","journal-title":"Reprod. Fertil. Dev."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1097\/00001703-200004000-00009","article-title":"Fetal growth","volume":"12","author":"Mongelli","year":"2000","journal-title":"Curr. Opin. Obstet. Gynecol."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.placenta.2016.07.008","article-title":"Decorin expression is decreased in first trimester placental tissue from pregnancies with small for gestation age infants at birth","volume":"45","author":"Murthi","year":"2016","journal-title":"Placenta"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1159\/000055945","article-title":"Pre-Eclampsia-Associated Differential Expression of Proteoglycans in the Umbilical Cord Arteries","volume":"69","author":"Gogiel","year":"2001","journal-title":"Pathobiology"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1515\/jpme.1993.21.6.491","article-title":"Collagen of umbilical cord arteries and its alterations in EPH-gestosis","volume":"21","author":"Bankowski","year":"1993","journal-title":"J. Pe\u00e9rinat. Med."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.ejogrb.2006.10.003","article-title":"Pre-eclampsia-associated alterations in decorin, biglycan and versican of the umbilical cord vein wall","volume":"134","author":"Gogiel","year":"2007","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/j.ajog.2005.02.029","article-title":"Extracellular matrix changes in the umbilical arteries of growth-restricted fetuses","volume":"192","author":"Kinzler","year":"2005","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.placenta.2014.05.004","article-title":"Chorioamniontis in preterm delivery is associated with degradation of decorin and biglycan and depletion of hyaluronan in fetal membranes","volume":"35","author":"Meinert","year":"2014","journal-title":"Placenta"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.tjog.2017.12.004","article-title":"Serum decorin measurement in prediction of the risk for preterm birth","volume":"57","author":"Atalay","year":"2018","journal-title":"Taiwan J. Obstet. Gynecol."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0140-6736(08)60074-4","article-title":"Epidemiology and causes of preterm birth","volume":"371","author":"Goldenberg","year":"2008","journal-title":"Lancet"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/0002-9378(91)90447-Y","article-title":"Microbiologic causes and neonatal outcomes associated with chorioamnion infection","volume":"165","author":"Hillier","year":"1991","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_164","first-page":"1","article-title":"Small leucine-rich proteoglycans (SLRPs) in the endometrium of polycystic ovary syndrome women: A pilot study","volume":"10","author":"Soares","year":"2017","journal-title":"J. Ovarian Res."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.steroids.2007.10.003","article-title":"Dienogest is a selective progesterone receptor agonist in transactivation analysis with potent oral endometrial activity due to its efficient pharmacokinetic profile","volume":"73","author":"Sasagawa","year":"2008","journal-title":"Steroids"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.maturitas.2008.11.011","article-title":"Reprint of Pharmacological profile of progestins","volume":"61","year":"2008","journal-title":"Maturitas"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"865","DOI":"10.2165\/00002512-200421130-00004","article-title":"New Progestogens: A review of their effects in perimenopausal and postmenopausal women","volume":"21","year":"2004","journal-title":"Drugs Aging"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1530\/JOE-14-0393","article-title":"Decorin induced by progesterone plays a crucial role in suppressing endometriosis","volume":"223","author":"Ono","year":"2014","journal-title":"J. Endocrinol."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1111\/his.12304","article-title":"Decorin and biglycan immunolocalization in non-villous structures of healthy and pathological human placentas","volume":"64","author":"Borbely","year":"2014","journal-title":"Histopathology"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.addr.2015.10.016","article-title":"Decorin as a multivalent therapeutic agent against cancer","volume":"97","author":"Neill","year":"2016","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.placenta.2020.01.007","article-title":"Biomarkers of abnormally invasive placenta","volume":"91","author":"Youssef","year":"2020","journal-title":"Placenta"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/j.placenta.2010.05.009","article-title":"Placental Biglycan Expression Is Decreased in Human Idiopathic Fetal Growth Restriction","volume":"31","author":"Murthi","year":"2010","journal-title":"Placenta"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1161\/ATVBAHA.117.309422","article-title":"Expression of Biglycan in First Trimester Chorionic Villous Sampling Placental Samples and Altered Function in Telomerase-Immortalized Microvascular Endothelial Cells","volume":"37","author":"Chui","year":"2017","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"C1","DOI":"10.1152\/ajpcell.1993.264.1.C1","article-title":"Uterine contraction and physiological mechanisms of modulation","volume":"264","author":"Wray","year":"1993","journal-title":"Am. J. Physiol."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1159\/000109218","article-title":"Ehlers-Danlos Type IV in Pregnancy: A case report and a literature review","volume":"23","author":"Erez","year":"2008","journal-title":"Fetal Diagn. Ther."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1034\/j.1600-0412.2002.810403.x","article-title":"Pregnancy and the Ehlers-Danlos syndrome: A retrospective study in a Dutch population","volume":"81","author":"Lind","year":"2002","journal-title":"Acta Obstet. Gynecol. 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