{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T00:09:13Z","timestamp":1788566953238,"version":"build-2803163510"},"reference-count":64,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006747","name":"Fondazione Cassa di Risparmio di Verona Vicenza Belluno e Ancona","doi-asserted-by":"publisher","award":["2017-0604"],"award-info":[{"award-number":["2017-0604"]}],"id":[{"id":"10.13039\/501100006747","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Neural precursors (NPs) present in the hippocampus can be modulated by several neurogenic stimuli, including environmental enrichment (EE) acting through BDNF-TrkB signaling. We have recently identified NPs in meninges; however, the meningeal niche response to pro-neurogenic stimuli has never been investigated. To this aim, we analyzed the effects of EE exposure on NP distribution in mouse brain meninges. Following neurogenic stimuli, although we did not detect modification of the meningeal cell number and proliferation, we observed an increased number of neural precursors in the meninges. A lineage tracing experiment suggested that EE-induced \u03b23-Tubulin+ immature neuronal cells present in the meninges originated, at least in part, from GLAST+ radial glia cells. To investigate the molecular mechanism responsible for meningeal reaction to EE exposure, we studied the BDNF-TrkB interaction. Treatment with ANA-12, a TrkB non-competitive inhibitor, abolished the EE-induced meningeal niche changes. Overall, these data showed, for the first time, that EE exposure induced meningeal niche remodeling through TrkB-mediated signaling. Fluoxetine treatment further confirmed the meningeal niche response, suggesting it may also respond to other pharmacological neurogenic stimuli. A better understanding of the neurogenic stimuli modulation for meninges may be useful to improve the effectiveness of neurodegenerative and neuropsychiatric treatments.<\/jats:p>","DOI":"10.3390\/ijms221910657","type":"journal-article","created":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T10:55:40Z","timestamp":1633085740000},"page":"10657","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Environmental Enrichment Induces Meningeal Niche Remodeling through TrkB-Mediated Signaling"],"prefix":"10.3390","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0867-8433","authenticated-orcid":false,"given":"Stefania","family":"Zorzin","sequence":"first","affiliation":[{"name":"Section of Pharmacology, Department of Diagnostic and Public Health, University of Verona, 37134 Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7482-3251","authenticated-orcid":false,"given":"Andrea","family":"Corsi","sequence":"additional","affiliation":[{"name":"Section of Pharmacology, Department of Diagnostic and Public Health, University of Verona, 37134 Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Ciarpella","sequence":"additional","affiliation":[{"name":"Section of Pharmacology, Department of Diagnostic and Public Health, University of Verona, 37134 Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela","family":"Bottani","sequence":"additional","affiliation":[{"name":"Section of Pharmacology, Department of Diagnostic and Public Health, University of Verona, 37134 Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sissi","family":"Dolci","sequence":"additional","affiliation":[{"name":"Section of Pharmacology, Department of Diagnostic and Public Health, University of Verona, 37134 Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2996-2903","authenticated-orcid":false,"given":"Giorgio","family":"Malpeli","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, University of Verona, 37134 Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annachiara","family":"Pino","sequence":"additional","affiliation":[{"name":"Section of Pharmacology, Department of Diagnostic and Public Health, University of Verona, 37134 Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Amenta","sequence":"additional","affiliation":[{"name":"Laboratory of Cell Metabolism and Regenerative Medicine, Department of Medical Biotechnology and Translational Medicine, University of Milan, 20129 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2195-4973","authenticated-orcid":false,"given":"Guido Franceso","family":"Fumagalli","sequence":"additional","affiliation":[{"name":"Section of Pharmacology, Department of Diagnostic and Public Health, University of Verona, 37134 Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiano","family":"Chiamulera","sequence":"additional","affiliation":[{"name":"Section of Pharmacology, Department of Diagnostic and Public Health, University of Verona, 37134 Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2028-3012","authenticated-orcid":false,"given":"Francesco","family":"Bifari","sequence":"additional","affiliation":[{"name":"Laboratory of Cell Metabolism and Regenerative Medicine, Department of Medical Biotechnology and Translational Medicine, University of Milan, 20129 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6627-1263","authenticated-orcid":false,"given":"Ilaria","family":"Decimo","sequence":"additional","affiliation":[{"name":"Section of Pharmacology, Department of Diagnostic and Public Health, University of Verona, 37134 Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,10,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e351","DOI":"10.1038\/tp.2013.128","article-title":"Social interaction plays a critical role in neurogenesis and recovery after stroke","volume":"4","author":"Venna","year":"2014","journal-title":"Transl. 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