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ZIKV is an arbovirus of the Flaviviridae family, and its infection during development has been associated with central nervous system (CNS) malformations, including microcephaly, through the targeting of neural stem\/progenitor cells (NSCs\/NPCs). This finding has led various groups to evaluate ZIKV\u2019s effects against glioblastoma stem cells (GSCs), supposedly responsible for GBM onset, progression, and therapy resistance. While preliminary data support ZIKV tropism toward GSCs, a more accurate study of ZIKV mechanisms of action is fundamental in order to launch ZIKV-based clinical trials for GBM patients.<\/jats:p>","DOI":"10.3390\/ijms222010996","type":"journal-article","created":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T06:38:41Z","timestamp":1634107121000},"page":"10996","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Zika Virus: A New Therapeutic Candidate for Glioblastoma Treatment"],"prefix":"10.3390","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7194-7918","authenticated-orcid":false,"given":"Maria Giovanna","family":"Francipane","sequence":"first","affiliation":[{"name":"Fondazione Ri.MED, 90133 Palermo, Italy"},{"name":"McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9980-4505","authenticated-orcid":false,"given":"Bruno","family":"Douradinha","sequence":"additional","affiliation":[{"name":"Fondazione Ri.MED, 90133 Palermo, Italy"},{"name":"Department of Research, Istituto di Ricovero e Cura a Carattere Scientifico\u2014Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione (IRCCS ISMETT), 90127 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9318-6606","authenticated-orcid":false,"given":"Cinzia Maria","family":"Chinnici","sequence":"additional","affiliation":[{"name":"Fondazione Ri.MED, 90133 Palermo, Italy"},{"name":"Department of Research, Istituto di Ricovero e Cura a Carattere Scientifico\u2014Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione (IRCCS ISMETT), 90127 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Russelli","sequence":"additional","affiliation":[{"name":"Department of Research, Istituto di Ricovero e Cura a Carattere Scientifico\u2014Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione (IRCCS ISMETT), 90127 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1994-8005","authenticated-orcid":false,"given":"Pier Giulio","family":"Conaldi","sequence":"additional","affiliation":[{"name":"Department of Research, Istituto di Ricovero e Cura a Carattere Scientifico\u2014Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione (IRCCS ISMETT), 90127 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7710-4735","authenticated-orcid":false,"given":"Gioacchin","family":"Iannolo","sequence":"additional","affiliation":[{"name":"Department of Research, Istituto di Ricovero e Cura a Carattere Scientifico\u2014Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione (IRCCS ISMETT), 90127 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,10,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1056\/NEJMra0708126","article-title":"Malignant gliomas in adults","volume":"359","author":"Wen","year":"2008","journal-title":"N. 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