{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T22:51:30Z","timestamp":1790635890469,"version":"4.1.0"},"reference-count":32,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T00:00:00Z","timestamp":1634083200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Age-related macular degeneration (AMD) is an eye disease that is characterized by damage to the central part of the retina, the macula, and that affects millions of people worldwide. At an advanced stage, a blind spot grows in the center of vision, severely handicapping patients with this degenerative condition. Despite therapeutic advances thanks to the use of anti-VEGF, many resistance mechanisms have been found to accentuate the visual deficit. In the present study, we explored whether supplementation with Resvega\u00ae, a nutraceutical formulation composed of omega-3 fatty acids and resveratrol, a well-known polyphenol in grapes, was able to counteract laser-induced choroidal neovascularization (CNV) in mice. We highlight that Resvega\u00ae significantly reduced CNV in mice compared with supplementations containing omega-3 or resveratrol alone. Moreover, a proteomic approach confirmed that Resvega\u00ae could counteract the progression of AMD through a pleiotropic effect targeting key regulators of neoangiogenesis in retina cells in vivo. These events were associated with an accumulation of resveratrol metabolites within the retina. Therefore, a supplementation of omega-3\/resveratrol could improve the management or slow the progression of AMD in patients with this condition.<\/jats:p>","DOI":"10.3390\/ijms222011023","type":"journal-article","created":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T21:36:15Z","timestamp":1634160975000},"page":"11023","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["RESVEGA, a Nutraceutical Omega-3\/Resveratrol Supplementation, Reduces Angiogenesis in a Preclinical Mouse Model of Choroidal Neovascularization"],"prefix":"10.3390","volume":"22","author":[{"given":"Flavie","family":"Courtaut","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Bourgogne Franche-Comt\u00e9, 21000 Dijon, France"},{"name":"INSERM Research Center U1231\u2014Cancer and Adaptive Immune Response Team, Bioactive Molecules and Health Research Group, 21000 Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginie","family":"Aires","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Bourgogne Franche-Comt\u00e9, 21000 Dijon, France"},{"name":"INSERM Research Center U1231\u2014Cancer and Adaptive Immune Response Team, Bioactive Molecules and Health Research Group, 21000 Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3401-8079","authenticated-orcid":false,"given":"Niyazi","family":"Acar","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Bourgogne Franche-Comt\u00e9, 21000 Dijon, France"},{"name":"Centre des Sciences du Go\u00fbt et de l\u2019Alimentation, AgroSup Dijon, CNRS, INRAE, Eye and Nutrition Research Group, 21000 Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lionel","family":"Bretillon","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Bourgogne Franche-Comt\u00e9, 21000 Dijon, France"},{"name":"Centre des Sciences du Go\u00fbt et de l\u2019Alimentation, AgroSup Dijon, CNRS, INRAE, Eye and Nutrition Research Group, 21000 Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4832-6793","authenticated-orcid":false,"given":"Ida Chiara","family":"Guerrera","sequence":"additional","affiliation":[{"name":"Proteomics Platform Necker, Universit\u00e9 de Paris\u2014Structure F\u00e9d\u00e9rative de Recherche Necker, INSERM US24\/CNRS UMS3633, 75015 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cerina","family":"Chhuon","sequence":"additional","affiliation":[{"name":"Proteomics Platform Necker, Universit\u00e9 de Paris\u2014Structure F\u00e9d\u00e9rative de Recherche Necker, INSERM US24\/CNRS UMS3633, 75015 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Paul","family":"Pais de Barros","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Bourgogne Franche-Comt\u00e9, 21000 Dijon, France"},{"name":"INSERM Research Center U1231\u2014Cancer and Adaptive Immune Response Team, Bioactive Molecules and Health Research Group, 21000 Dijon, France"},{"name":"INSERM Research Center U1231-Lipidomic Analytical Platform, 21000 Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7551-1129","authenticated-orcid":false,"given":"C\u00e9line","family":"Olmiere","sequence":"additional","affiliation":[{"name":"Laboratoires Thea, 12 Rue Louis-Bl\u00e9riot, 63000 Clermont-Ferrand, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Delmas","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Bourgogne Franche-Comt\u00e9, 21000 Dijon, France"},{"name":"INSERM Research Center U1231\u2014Cancer and Adaptive Immune Response Team, Bioactive Molecules and Health Research Group, 21000 Dijon, France"},{"name":"Centre Anticanc\u00e9reux Georges Fran\u00e7ois Leclerc, 21000 Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,10,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1016\/S0140-6736(12)60282-7","article-title":"Age-related macular degeneration","volume":"379","author":"Lim","year":"2012","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"483034","DOI":"10.1155\/2012\/483034","article-title":"Development of Anti-VEGF Therapies for Intraocular Use: A Guide for Clinicians","volume":"2012","author":"Keane","year":"2012","journal-title":"J. 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