{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T12:50:20Z","timestamp":1784119820259,"version":"3.55.0"},"reference-count":254,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T00:00:00Z","timestamp":1634083200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Structural and Investment Funds; Operational Program Research, Development and Education","award":["CZ.02.1.01\/0.0\/0.0\/16_019\/0000785"],"award-info":[{"award-number":["CZ.02.1.01\/0.0\/0.0\/16_019\/0000785"]}]},{"DOI":"10.13039\/100007397","name":"Charles University in Prague","doi-asserted-by":"publisher","award":["PROGRES Q28"],"award-info":[{"award-number":["PROGRES Q28"]}],"id":[{"id":"10.13039\/100007397","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Interleukin-6 (IL-6) is a highly potent cytokine involved in multiple biological processes. It was previously reported to play a distinct role in inflammation, autoimmune and psychiatric disorders, ageing and various types of cancer. Furthermore, it is understood that IL-6 and its signaling pathways are substantial players in orchestrating the cancer microenvironment. Thus, they appear to be potential targets in anti-tumor therapy. The aim of this article is to elucidate the role of IL-6 in the tumor ecosystem and to review the possible therapeutic approaches in head and neck cancer.<\/jats:p>","DOI":"10.3390\/ijms222011027","type":"journal-article","created":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T21:36:15Z","timestamp":1634160975000},"page":"11027","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["IL-6 in the Ecosystem of Head and Neck Cancer: Possible Therapeutic Perspectives"],"prefix":"10.3390","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0222-9944","authenticated-orcid":false,"given":"Michal","family":"\u0160panko","sequence":"first","affiliation":[{"name":"Institute of Anatomy, First Faculty of Medicine, Charles University, 12800 Prague, Czech Republic"},{"name":"Department of Stomatology, First Faculty of Medicine, Charles University and General University Hospital in Prague, 12801 Prague, Czech 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