{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:07:43Z","timestamp":1791497263684,"version":"4.3.4"},"reference-count":95,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T00:00:00Z","timestamp":1634083200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Thematic Excellence Program 2020 - Institutional Excellence Sub- programme of the Min-istry for Innovation and Technology in Hungary, within the framework of the second the-matic programme of the University of P\u00e9cs ELKH-PTE Human Reproduction Scientific R","award":["2020"],"award-info":[{"award-number":["2020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The most recent studies of progesterone research provide remarkable insights into the physiological role and clinical importance of this hormone. Although the name progesterone itself means \u201cpromoting gestation\u201d, this steroid hormone is far more than a gestational agent. Progesterone is recognized as a key physiological component of not only the menstrual cycle and pregnancy but also as an essential steroidogenic precursor of other gonadal and non-gonadal hormones such as aldosterone, cortisol, estradiol, and testosterone. Based on current findings, progesterone and novel progesterone-based drugs have many important functions, including contraception, treatment of dysfunctional uterine bleeding, immune response, and prevention of cancer. Considering the above, reproduction and life are not possible without progesterone; thus, a better understanding of this essential molecule could enable safe and effective use of this hormone in many clinical conditions.<\/jats:p>","DOI":"10.3390\/ijms222011039","type":"journal-article","created":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T21:36:15Z","timestamp":1634160975000},"page":"11039","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":115,"title":["Key to Life: Physiological Role and Clinical Implications of Progesterone"],"prefix":"10.3390","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2890-5824","authenticated-orcid":false,"given":"Bernadett","family":"Nagy","sequence":"first","affiliation":[{"name":"National Laboratory for Human Reproduction, University of P\u00e9cs, 7624 P\u00e9cs, Hungary"},{"name":"Department of Obstetrics and Gynecology, Medical School, University of P\u00e9cs, 7624 P\u00e9cs, Hungary"},{"name":"MTA-PTE Human Reproduction Scientific Research Group, University of P\u00e9cs, 7624 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00falia","family":"Szekeres-Barth\u00f3","sequence":"additional","affiliation":[{"name":"National Laboratory for Human Reproduction, University of P\u00e9cs, 7624 P\u00e9cs, Hungary"},{"name":"MTA-PTE Human Reproduction Scientific Research Group, University of P\u00e9cs, 7624 P\u00e9cs, Hungary"},{"name":"Szent\u00e1gothai Research Center, University of P\u00e9cs, 7624 P\u00e9cs, Hungary"},{"name":"Department of Medical Biology, Medical School, University of P\u00e9cs, 7624 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e1bor L.","family":"Kov\u00e1cs","sequence":"additional","affiliation":[{"name":"National Laboratory for Human Reproduction, University of P\u00e9cs, 7624 P\u00e9cs, Hungary"},{"name":"Szent\u00e1gothai Research Center, University of P\u00e9cs, 7624 P\u00e9cs, Hungary"},{"name":"Department of Laboratory Medicine, Medical School, University of P\u00e9cs, 7624 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Endre","family":"Sulyok","sequence":"additional","affiliation":[{"name":"National Laboratory for Human Reproduction, University of P\u00e9cs, 7624 P\u00e9cs, Hungary"},{"name":"Doctoral School of Health Sciences, Faculty of Health Sciences, University of P\u00e9cs, 7624 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e1lint","family":"Farkas","sequence":"additional","affiliation":[{"name":"National Laboratory for Human Reproduction, University of P\u00e9cs, 7624 P\u00e9cs, Hungary"},{"name":"Department of Obstetrics and Gynecology, Medical School, University of P\u00e9cs, 7624 P\u00e9cs, Hungary"},{"name":"MTA-PTE Human Reproduction Scientific Research Group, University of P\u00e9cs, 7624 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1kos","family":"V\u00e1rnagy","sequence":"additional","affiliation":[{"name":"National Laboratory for Human Reproduction, University of P\u00e9cs, 7624 P\u00e9cs, Hungary"},{"name":"Department of Obstetrics and Gynecology, Medical School, University of P\u00e9cs, 7624 P\u00e9cs, Hungary"},{"name":"MTA-PTE Human Reproduction Scientific Research Group, University of P\u00e9cs, 7624 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viola","family":"V\u00e9rtes","sequence":"additional","affiliation":[{"name":"National Laboratory for Human Reproduction, University of P\u00e9cs, 7624 P\u00e9cs, Hungary"},{"name":"Department of Obstetrics and Gynecology, Medical School, University of P\u00e9cs, 7624 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K\u00e1lm\u00e1n","family":"Kov\u00e1cs","sequence":"additional","affiliation":[{"name":"National 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