{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T15:09:18Z","timestamp":1789571358425,"version":"build-2803163510"},"reference-count":255,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2021,10,15]],"date-time":"2021-10-15T00:00:00Z","timestamp":1634256000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004281","name":"National Science Center","doi-asserted-by":"publisher","award":["2019\/35\/O\/NZ5\/02502"],"award-info":[{"award-number":["2019\/35\/O\/NZ5\/02502"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>One of the most common chronic liver disorders, affecting mainly people in Western countries, is nonalcoholic fatty liver disease (NAFLD). Unfortunately, its pathophysiological mechanism is not fully understood, and no dedicated treatment is available. Simple steatosis can lead to nonalcoholic steatohepatitis and even to fibrosis, cancer, and cirrhosis of the liver. NAFLD very often occurs in parallel with type 2 diabetes mellitus and in obese people. Furthermore, it is much more likely to develop in patients with metabolic syndrome (MS), whose criteria include abdominal obesity, elevated blood triacylglycerol level, reduced high-density lipoprotein cholesterol level, increased blood pressure, and high fasting glucose. An important phenomenon in MS is also insulin resistance (IR), which is very common in NAFLD. Liver IR and NAFLD development are linked through an interaction between the accumulation of free fatty acids, hepatic inflammation, and increased oxidative stress. The liver is particularly exposed to elevated levels of reactive oxygen species due to a large number of mitochondria in hepatocytes. In these organelles, the main DNA repair pathway is base excision repair (BER). The present article will illustrate how impairment of BER may be related to the development of NAFLD.<\/jats:p>","DOI":"10.3390\/ijms222011128","type":"journal-article","created":{"date-parts":[[2021,10,15]],"date-time":"2021-10-15T13:35:47Z","timestamp":1634304947000},"page":"11128","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":201,"title":["The Interplay between Insulin Resistance, Inflammation, Oxidative Stress, Base Excision Repair and Metabolic Syndrome in Nonalcoholic Fatty Liver Disease"],"prefix":"10.3390","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8140-3853","authenticated-orcid":false,"given":"Sylwia","family":"Ziolkowska","sequence":"first","affiliation":[{"name":"Department of Medical Biochemistry, Medical University of Lodz, 92-215 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agata","family":"Binienda","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, 92-215 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maciej","family":"Jab\u0142kowski","sequence":"additional","affiliation":[{"name":"Department of Infectious and Liver Diseases, Medical University of Lodz, 91-347 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6052-3557","authenticated-orcid":false,"given":"Janusz","family":"Szemraj","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Medical University of Lodz, 92-215 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5146-5225","authenticated-orcid":false,"given":"Piotr","family":"Czarny","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Medical University of Lodz, 92-215 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,10,15]]},"reference":[{"key":"ref_1","first-page":"9","article-title":"Non alcoholic fatty liver disease and metabolic syndrome","volume":"13","author":"Paschos","year":"2009","journal-title":"Hippokratia"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"846","DOI":"10.4254\/wjh.v7.i6.846","article-title":"Non-alcoholic fatty liver disease: The diagnosis and management","volume":"7","year":"2015","journal-title":"World J. Hepatol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"421","DOI":"10.4103\/ijem.IJEM_585_17","article-title":"Nonalcoholic Fatty Liver Disease and Type 2 Diabetes Mellitus","volume":"22","author":"Dharmalingam","year":"2018","journal-title":"Indian J. Endocrinol. Metab."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.3748\/wjg.v20.i7.1756","article-title":"Dietary habits and behaviors associated with nonalcoholic fatty liver disease","volume":"20","author":"Yasutake","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1242\/dmm.001180","article-title":"A comprehensive definition for metabolic syndrome","volume":"2","author":"Huang","year":"2009","journal-title":"Dis. Model. Mech."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1016\/j.metabol.2015.12.012","article-title":"The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD)","volume":"65","author":"Buzzetti","year":"2016","journal-title":"Metabolism."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.bj.2017.06.007","article-title":"The etiology of oxidative stress in insulin resistance","volume":"40","author":"Hurrle","year":"2017","journal-title":"Biomed. J."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"9547613","DOI":"10.1155\/2018\/9547613","article-title":"Role of Oxidative Stress in Pathophysiology of Nonalcoholic Fatty Liver Disease","volume":"2018","author":"Masarone","year":"2018","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1089\/dna.2017.3653","article-title":"The Influence of Hepatitis C Virus Therapy on the DNA Base Excision Repair System of Peripheral Blood Mononuclear Cells","volume":"36","author":"Czarny","year":"2017","journal-title":"DNA Cell Biol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.mce.2015.02.018","article-title":"Metabolic syndrome and nonalcoholic fatty liver disease: Is insulin resistance the link?","volume":"418","author":"Asrih","year":"2015","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1111\/j.1365-2559.2006.02416.x","article-title":"Histological assessment of non-alcoholic fatty liver disease","volume":"49","year":"2006","journal-title":"Histopathology"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.diabet.2012.11.002","article-title":"Non-alcoholic fatty liver disease and insulin resistance: From bench to bedside","volume":"39","author":"Gariani","year":"2013","journal-title":"Diabetes Metab."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/S1665-2681(19)30879-8","article-title":"The prevalence of nonalcoholic fatty liver disease in the Americas","volume":"13","author":"Arrese","year":"2014","journal-title":"Ann. Hepatol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1002\/hep.20701","article-title":"Design and validation of a histological scoring system for nonalcoholic fatty liver disease","volume":"41","author":"Kleiner","year":"2005","journal-title":"Hepatology"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Yang, J., Fern\u00e1ndez-Galilea, M., Mart\u00ednez-Fern\u00e1ndez, L., Gonz\u00e1lez-Muniesa, P., P\u00e9rez-Ch\u00e1vez, A., Mart\u00ednez, J.A., and Moreno-Aliaga, M.J. (2019). Oxidative Stress and Non-Alcoholic Fatty Liver Disease: Effects of Omega-3 Fatty Acid Supplementation. Nutrients, 11.","DOI":"10.3390\/nu11040872"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1055\/s-2007-985075","article-title":"Definitive diagnosis and assessment of risk for nonalcoholic fatty liver disease in children and adolescents","volume":"27","author":"Schwimmer","year":"2007","journal-title":"Semin. Liver Dis."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e036663","DOI":"10.1136\/bmjopen-2019-036663","article-title":"Prevalence trends in non-alcoholic fatty liver disease at the global, regional and national levels, 1990\u20132017: A population-based observational study","volume":"10","author":"Ge","year":"2020","journal-title":"BMJ Open"},{"key":"ref_18","first-page":"282","article-title":"Nonalcoholic Fatty Liver Disease: Clinical Features and Pathogenesis","volume":"2","author":"Basaranoglu","year":"2006","journal-title":"Gastroenterol. Hepatol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1053\/jhep.2003.50193","article-title":"Nonalcoholic steatohepatitis: Summary of an AASLD Single Topic Conference","volume":"37","author":"Caldwell","year":"2003","journal-title":"Hepatology"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"3928","DOI":"10.2174\/1381612826666200521133307","article-title":"The Relevance of Noninvasive Tools To Assess Fibrosis in Non-Alcoholic Fatty Liver Disease","volume":"26","author":"Pennisi","year":"2020","journal-title":"Curr. Pharm. Des."},{"key":"ref_21","first-page":"2082","article-title":"Comparison of MAFLD and NAFLD diagnostic criteria in real world","volume":"40","author":"Lin","year":"2020","journal-title":"Liver Int. Off. J. Int. Assoc. Study Liver"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.jhep.2019.06.021","article-title":"The global epidemiology of NAFLD and NASH in patients with type 2 diabetes: A systematic review and meta-analysis","volume":"71","author":"Younossi","year":"2019","journal-title":"J. Hepatol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1038\/ng.257","article-title":"Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease","volume":"40","author":"Romeo","year":"2008","journal-title":"Nat. Genet."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0378-1119(88)90577-X","article-title":"Molecular characterization of the patatin multigene family of potato","volume":"62","author":"Mignery","year":"1988","journal-title":"Gene"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"6969","DOI":"10.3748\/wjg.v19.i41.6969","article-title":"PNPLA3 I148M polymorphism and progressive liver disease","volume":"19","author":"Dongiovanni","year":"2013","journal-title":"World J. Gastroenterol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.jhep.2014.02.030","article-title":"Carriage of the PNPLA3 rs738409 C >G polymorphism confers an increased risk of non-alcoholic fatty liver disease associated hepatocellular carcinoma","volume":"61","author":"Liu","year":"2014","journal-title":"J. Hepatol."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Pennisi, G., Celsa, C., Giammanco, A., Spatola, F., and Petta, S. (2019). The Burden of Hepatocellular Carcinoma in Non-Alcoholic Fatty Liver Disease: Screening Issue and Future Perspectives. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20225613"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/s41575-019-0212-0","article-title":"Genetic contributions to NAFLD: Leveraging shared genetics to uncover systems biology","volume":"17","author":"Eslam","year":"2020","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Simoes, I.C.M., Karkucinska-wieckowska, A., Janikiewicz, J., Szymanska, S., Pronicki, M., Dobrzyn, P., Dabrowski, M., Dobrzyn, A., Oliveira, P.J., and Zischka, H. (2020). Western diet causes obesity-induced nonalcoholic fatty liver disease development by differentially compromising the autophagic response. Antioxidants, 9.","DOI":"10.3390\/antiox9100995"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.bbrc.2015.04.092","article-title":"Fat and carbohydrate in western diet contribute differently to hepatic lipid accumulation","volume":"461","author":"Wu","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12944-017-0551-1","article-title":"Free fatty acids profile among lean, overweight and obese non-alcoholic fatty liver disease patients: A case\u2014Control study","volume":"16","author":"Feng","year":"2017","journal-title":"Lipids Health Dis."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/S1262-3636(07)70061-7","article-title":"Contribution of hepatic de novo lipogenesis and reesterification of plasma non esterified fatty acids to plasma triglyceride synthesis during non-alcoholic fatty liver disease","volume":"29","author":"Diraison","year":"2003","journal-title":"Diabetes Metab."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1053\/j.gastro.2013.11.049","article-title":"Increased De novo Lipogenesis Is a Distinct Characteristic of Individuals With Nonalcoholic Fatty Liver Disease","volume":"146","author":"Lambert","year":"2014","journal-title":"Gastroenterology"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"35832","DOI":"10.1074\/jbc.274.50.35832","article-title":"Sterol regulatory element-binding protein-1 as a key transcription factor for nutritional induction of lipogenic enzyme genes","volume":"274","author":"Shimano","year":"1999","journal-title":"J. Biol. Chem."},{"key":"ref_35","first-page":"72","article-title":"SREBP-1c transcription factor and lipid homeostasis: Clinical perspective","volume":"68","author":"Foufelle","year":"2007","journal-title":"Horm. Res."},{"key":"ref_36","first-page":"1","article-title":"Carbohydrate sensing through the transcription factor ChREBP","volume":"10","author":"Postic","year":"2019","journal-title":"Front. Genet."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"3760","DOI":"10.1128\/MCB.19.5.3760","article-title":"ADD1\/SREBP-1c Is Required in the Activation of Hepatic Lipogenic Gene Expression by Glucose","volume":"19","author":"Foretz","year":"1999","journal-title":"Mol. Cell. Biol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"9520","DOI":"10.1074\/jbc.M111421200","article-title":"Diminished hepatic response to fasting\/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1c","volume":"277","author":"Liang","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0031812","article-title":"Liver-specific expression of transcriptionally active srebp-1c is associated with fatty liver and increased visceral fat mass","volume":"7","author":"Knebel","year":"2012","journal-title":"PLoS ONE"},{"key":"ref_40","first-page":"351","article-title":"Re-evaluation of fatty acid metabolism-related gene expression in nonalcoholic fatty liver disease","volume":"20","author":"Kohjima","year":"2007","journal-title":"Int. J. Mol. Med."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"7281","DOI":"10.1073\/pnas.0401516101","article-title":"From The Cover: Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysis","volume":"101","author":"Iizuka","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Kato, T., Iizuka, K., Takao, K., Horikawa, Y., Kitamura, T., and Takeda, J. (2018). ChREBP-knockout mice show sucrose intolerance and fructose malabsorption. Nutrients, 10.","DOI":"10.20944\/preprints201802.0005.v1"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1152\/ajpendo.2002.282.1.E46","article-title":"Increased hepatic lipogenesis but decreased expression of lipogenic gene in adipose tissue in human obesity","volume":"282","author":"Diraison","year":"2002","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"3486","DOI":"10.2337\/diabetes.51.12.3486","article-title":"Mechanisms of the triglyceride- and cholesterol-lowering effect of fenofibrate in hyperlipidemic type 2 diabetic patients","volume":"51","author":"Forcheron","year":"2002","journal-title":"Diabetes"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.2337\/db06-0200","article-title":"Liver-specific inhibition of ChREBP improves hepatic steatosis and insulin resistance in ob\/ob mice","volume":"55","author":"Dentin","year":"2006","journal-title":"Diabetes"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"2176","DOI":"10.1172\/JCI41636","article-title":"The lipogenic transcription factor ChREBP dissociates hepatic steatosis from insulin resistance in mice and humans","volume":"122","author":"Benhamed","year":"2012","journal-title":"J. Clin. Invest."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"8552","DOI":"10.1073\/pnas.0603115103","article-title":"Liver-specific deletion of acetyl-CoA carboxylase 1 reduces hepatic triglyceride accumulation without affecting glucose homeostasis","volume":"103","author":"Mao","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1042\/bst0301086","article-title":"Peroxisome proliferator-activated receptors and the regulation of mammalian lipid metabolism","volume":"30","author":"Smith","year":"2002","journal-title":"Biochem. Soc. Trans."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1002\/hep.20170","article-title":"Administration of the Potent PPAR\u03b1 Agonist, Wy-14,643, Reverses Nutritional Fibrosis and Steatohepatitis in Mice","volume":"39","author":"Ip","year":"2004","journal-title":"Hepatology"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1053\/jhep.2003.50307","article-title":"Central role of PPAR\u03b1-dependent hepatic lipid turnover in dietary steatohepatitis in mice","volume":"38","author":"Ip","year":"2003","journal-title":"Hepatology"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1111\/j.1440-1746.2011.06939.x","article-title":"Peroxisome proliferator-activated receptor-\u03b1 agonist, Wy 14643, improves metabolic indices, steatosis and ballooning in diabetic mice with non-alcoholic steatohepatitis","volume":"27","author":"Larter","year":"2012","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"16638","DOI":"10.1074\/jbc.275.22.16638","article-title":"Peroxisome proliferator-activated receptor \u03b1 activators improve insulin sensitivity and reduce adiposity","volume":"275","author":"Gervois","year":"2000","journal-title":"J. Biol. Chem."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1172\/JCI11497","article-title":"PPARalpha deficiency reduces insulin resistance and atherosclerosis in apoE-null mice","volume":"107","author":"Tordjman","year":"2001","journal-title":"J. Clin. Invest."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Vancells Lujan, P., Vi\u00f1as Esmel, E., and Sacanella Meseguer, E. (2021). Overview of non-alcoholic fatty liver disease (Nafld) and the role of sugary food consumption and other dietary components in its development. Nutrients, 13.","DOI":"10.3390\/nu13051442"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Hydes, T., Alam, U., and Cuthbertson, D.J. (2021). The Impact of Macronutrient Intake on Non-alcoholic Fatty Liver Disease (NAFLD): Too Much Fat, Too Much Carbohydrate, or Just Too Many Calories?. Front. Nutr., 8.","DOI":"10.3389\/fnut.2021.640557"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"5018","DOI":"10.3390\/nu6115018","article-title":"The influence of dietary fat on liver fat accumulation","volume":"6","author":"Green","year":"2014","journal-title":"Nutrients"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"619","DOI":"10.4254\/wjh.v11.i8.619","article-title":"Prolonged high-fat-diet feeding promotes non-alcoholic fatty liver disease and alters gut microbiota in mice","volume":"11","author":"Enos","year":"2019","journal-title":"World J. Hepatol."},{"key":"ref_58","first-page":"1","article-title":"Western diet induces severe nonalcoholic steatohepatitis, ductular reaction, and hepatic fibrosis in liver CGI-58 knockout mice","volume":"10","author":"Yang","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Perdomo, C.M., Fr\u00fchbeck, G., and Escalada, J. (2019). Impact of nutritional changes on nonalcoholic fatty liver disease. Nutrients, 11.","DOI":"10.3390\/nu11030677"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.jdiacomp.2014.10.005","article-title":"A biochemical view: Increase in polyunsaturated fatty acid \u03c9-6\/\u03c9-3 ratio in relation to hepatic steatosis in patients with non-alcoholic fatty liver disease","volume":"29","author":"Sertoglu","year":"2015","journal-title":"J. Diabetes Complications"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.clnu.2017.01.006","article-title":"Non-alcoholic fatty liver disease and its treatment with n-3 polyunsaturated fatty acids","volume":"37","author":"Calder","year":"2018","journal-title":"Clin. Nutr."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.jnutbio.2017.09.017","article-title":"Dietary omega-3 and omega-6 polyunsaturated fatty acids modulate hepatic pathology","volume":"52","author":"Khadge","year":"2018","journal-title":"J. Nutr. Biochem."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/j.jhep.2018.01.019","article-title":"Fructose and sugar: A major mediator of non-alcoholic fatty liver disease","volume":"68","author":"Jensen","year":"2018","journal-title":"J. Hepatol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"2434","DOI":"10.1210\/jc.2014-3678","article-title":"Effect of a high-fructose weight-maintaining diet on lipogenesis and liver fat","volume":"100","author":"Schwarz","year":"2015","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Chen, H., Wang, J., Li, Z., Kei Lam, C.W., Xiao, Y., Wu, Q., and Zhang, W. (2019). Consumption of sugar-sweetened beverages has a dose-dependent effect on the risk of non-alcoholic fatty liver disease: An updated systematic review and dose-response meta-analysis. Int. J. Environ. Res. Public Health, 16.","DOI":"10.3390\/ijerph16122192"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1093\/qjmed\/hcv172","article-title":"Associations of sugar- and artificially sweetened soda with nonalcoholic fatty liver disease: A systematic review and meta-analysis","volume":"109","author":"Wijarnpreecha","year":"2016","journal-title":"QJM"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"727","DOI":"10.3945\/ajcn.112.038695","article-title":"Effect of short-term carbohydrate overfeeding and long-term weight loss on liver fat in overweight humans","volume":"96","author":"Sevastianova","year":"2012","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.immuni.2010.05.007","article-title":"Alternative activation of macrophages: Mechanism and functions","volume":"32","author":"Gordon","year":"2010","journal-title":"Immunity"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/nature05485","article-title":"Inflammation and metabolic disorders","volume":"444","author":"Hotamisligil","year":"2006","journal-title":"Nature"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.atherosclerosis.2015.01.001","article-title":"A concise review of non-alcoholic fatty liver disease","volume":"239","author":"Than","year":"2015","journal-title":"Atherosclerosis"},{"key":"ref_71","first-page":"1175","article-title":"Role of Kupffer cells in host defense and liver disease","volume":"26","author":"Bilzer","year":"2006","journal-title":"Liver Int. Off. J. Int. Assoc. Study Liver"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1002\/hep.26607","article-title":"M2 Kupffer cells promote M1 Kupffer cell apoptosis: A protective mechanism against alcoholic and nonalcoholic fatty liver disease","volume":"59","author":"Wan","year":"2014","journal-title":"Hepatology"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1002\/hep.26754","article-title":"Macrophage plasticity and polarization in liver homeostasis and pathology","volume":"59","author":"Sica","year":"2014","journal-title":"Hepatology"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.it.2004.09.015","article-title":"The chemokine system in diverse forms of macrophage activation and polarization","volume":"25","author":"Mantovani","year":"2004","journal-title":"Trends Immunol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1038\/ni.1937","article-title":"Macrophage plasticity and interaction with lymphocyte subsets: Cancer as a paradigm","volume":"11","author":"Biswas","year":"2010","journal-title":"Nat. Immunol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1002\/hep.24524","article-title":"Cannabinoid CB2 receptors protect against alcoholic liver disease by regulating Kupffer cell polarization in mice","volume":"54","author":"Louvet","year":"2011","journal-title":"Hepatology"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1172\/JCI24335","article-title":"CCR2 modulates inflammatory and metabolic effects of high-fat feeding","volume":"116","author":"Weisberg","year":"2006","journal-title":"J. Clin. Invest."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1053\/j.gastro.2009.03.053","article-title":"Antifibrotic effects of CXCL9 and its receptor CXCR3 in livers of mice and humans","volume":"137","author":"Wasmuth","year":"2009","journal-title":"Gastroenterology"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.2337\/db11-1506","article-title":"CCR5 plays a critical role in obesity-induced adipose tissue inflammation and insulin resistance by regulating both macrophage recruitment and M1\/M2 status","volume":"61","author":"Kitade","year":"2012","journal-title":"Diabetes"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"727","DOI":"10.3748\/wjg.v18.i8.727","article-title":"Role of cytokines and chemokines in non-alcoholic fatty liver disease","volume":"18","author":"Braunersreuther","year":"2012","journal-title":"World J. Gastroenterol."},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Kitade, H., Chen, G., Ni, Y., and Ota, T. (2017). Nonalcoholic Fatty Liver Disease and Insulin Resistance: New Insights and Potential New Treatments. Nutrients, 9.","DOI":"10.3390\/nu9040387"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/nm1166","article-title":"Local and systemic insulin resistance resulting from hepatic activation of IKK-\u03b2 and NF-\u03baB","volume":"11","author":"Cai","year":"2005","journal-title":"Nat. Med."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1111\/j.1572-0241.2004.40009.x","article-title":"Hepatocyte apoptosis, expression of death receptors, and activation of NF-kappaB in the liver of nonalcoholic and alcoholic steatohepatitis patients","volume":"99","author":"Ribeiro","year":"2004","journal-title":"Am. J. Gastroenterol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.3748\/wjg.v20.i7.1768","article-title":"Role of endoplasmic reticulum stress in the pathogenesis of nonalcoholic fatty liver disease","volume":"20","author":"Zhang","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1210\/en.2005-0570","article-title":"Saturated fatty acids promote endoplasmic reticulum stress and liver injury in rats with hepatic steatosis","volume":"147","author":"Wang","year":"2006","journal-title":"Endocrinology"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1097\/BOR.0b013e3283588dbb","article-title":"The role of endoplasmic reticulum stress and the unfolded protein response in fibrosis","volume":"24","author":"Lenna","year":"2012","journal-title":"Curr. Opin. Rheumatol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/nrm2199","article-title":"Signal integration in the endoplasmic reticulum unfolded protein response","volume":"8","author":"Ron","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1097\/MCO.0b013e32834778d4","article-title":"Endoplasmic reticulum stress and glucose homeostasis","volume":"14","author":"Wagner","year":"2011","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1016\/j.cell.2010.02.034","article-title":"Endoplasmic reticulum stress and the inflammatory basis of metabolic disease","volume":"140","author":"Hotamisligil","year":"2010","journal-title":"Cell"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.biocel.2005.09.018","article-title":"Coordination of ER and oxidative stress signaling: The PERK\/Nrf2 signaling pathway","volume":"38","author":"Cullinan","year":"2006","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"20108","DOI":"10.1074\/jbc.M314219200","article-title":"PERK-dependent activation of Nrf2 contributes to redox homeostasis and cell survival following endoplasmic reticulum stress","volume":"279","author":"Cullinan","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.jhep.2010.11.005","article-title":"Endoplasmic reticulum stress in liver disease","volume":"54","author":"Malhi","year":"2011","journal-title":"J. Hepatol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/nature01137","article-title":"A central role for JNK in obesity and insulin resistance","volume":"420","author":"Hirosumi","year":"2002","journal-title":"Nature"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1126\/science.1103160","article-title":"Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes","volume":"306","author":"Ozcan","year":"2004","journal-title":"Science"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1126\/science.1079817","article-title":"TRB3: A tribbles homolog that inhibits Akt\/PKB activation by insulin in liver","volume":"300","author":"Du","year":"2003","journal-title":"Science"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1002\/hep.21614","article-title":"CCAAT\/enhancing binding protein beta deletion in mice attenuates inflammation, endoplasmic reticulum stress, and lipid accumulation in diet-induced nonalcoholic steatohepatitis","volume":"45","author":"Rahman","year":"2007","journal-title":"Hepatology"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1038\/oby.2008.217","article-title":"Chromium alleviates glucose intolerance, insulin resistance, and hepatic ER stress in obese mice","volume":"16","author":"Sreejayan","year":"2008","journal-title":"Obesity"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1053\/j.gastro.2007.10.039","article-title":"Activation and Dysregulation of the Unfolded Protein Response in Nonalcoholic Fatty Liver Disease","volume":"134","author":"Puri","year":"2008","journal-title":"Gastroenterology"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1093\/ps\/79.7.961","article-title":"Human requirement for N-3 polyunsaturated fatty acids","volume":"79","author":"Simopoulos","year":"2000","journal-title":"Poult. Sci."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"144","DOI":"10.3164\/jcbn.08-251","article-title":"Ascorbic Acid in Human Seminal Plasma: Determination and Its Relationship to Sperm Quality","volume":"45","author":"Colagar","year":"2009","journal-title":"J. Clin. Biochem. Nutr."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1080\/17461391.2019.1571114","article-title":"Mechanisms of beneficial effects of exercise training on non-alcoholic fatty liver disease (NAFLD): Roles of oxidative stress and inflammation","volume":"19","author":"Farzanegi","year":"2019","journal-title":"Eur. J. Sport Sci."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"R453","DOI":"10.1016\/j.cub.2014.03.034","article-title":"ROS function in redox signaling and oxidative stress","volume":"24","author":"Schieber","year":"2014","journal-title":"Curr. Biol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.freeradbiomed.2016.04.001","article-title":"Mitochondrial generation of superoxide and hydrogen peroxide as the source of mitochondrial redox signaling","volume":"100","author":"Brand","year":"2016","journal-title":"Free Radic. Biol. Med."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.redox.2014.02.006","article-title":"Hydrogen peroxide sensing, signaling and regulation of transcription factors","volume":"2","author":"Marinho","year":"2014","journal-title":"Redox Biol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1172\/JCI21625","article-title":"Increased oxidative stress in obesity and its impact on metabolic syndrome","volume":"114","author":"Furukawa","year":"2004","journal-title":"J. Clin. Invest."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.4254\/wjh.v7.i10.1325","article-title":"Oxidative stress: New insights on the association of non-alcoholic fatty liver disease and atherosclerosis","volume":"7","author":"Polimeni","year":"2015","journal-title":"World J. Hepatol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"12467","DOI":"10.1074\/jbc.M114.554162","article-title":"Insulin and metabolic stress stimulate multisite serine\/threonine phosphorylation of insulin receptor substrate 1 and inhibit tyrosine phosphorylation","volume":"289","author":"Qiu","year":"2014","journal-title":"J. Biol. Chem."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1210\/en.2014-1757","article-title":"Peripheral insulin resistance and impaired insulin signaling contribute to abnormal glucose metabolism in preterm baboons","volume":"156","author":"Blanco","year":"2015","journal-title":"Endocrinology"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1074\/jbc.M113.533240","article-title":"Prolonged insulin stimulation down-regulates GLUT4 through oxidative stress-mediated retromer inhibition by a protein kinase CK2-dependent mechanism in 3T3-L1 adipocytes","volume":"289","author":"Ma","year":"2014","journal-title":"J. Biol. Chem."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"71","DOI":"10.4161\/21541248.2014.989789","article-title":"Crossroads of PI3K and Rac pathways","volume":"6","author":"Campa","year":"2015","journal-title":"Small GTPases"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/j.freeradbiomed.2010.12.005","article-title":"Oxidative stress and the etiology of insulin resistance and type 2 diabetes","volume":"51","author":"Henriksen","year":"2011","journal-title":"Free Radic. Biol. Med."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1002\/jcp.22847","article-title":"NADPH oxidase-derived superoxide anion-induced apoptosis is mediated via the JNK-dependent activation of NF-\u03baB in cardiomyocytes exposed to high glucose","volume":"227","author":"Tsai","year":"2012","journal-title":"J. Cell. Physiol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.clinbiochem.2012.03.024","article-title":"Role of mitochondria in nonalcoholic fatty liver disease--from origin to propagation","volume":"45","author":"Grattagliano","year":"2012","journal-title":"Clin. Biochem."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/S0168-8278(99)80033-6","article-title":"Mitochondrial abnormalities in non-alcoholic steatohepatitis","volume":"31","author":"Caldwell","year":"1999","journal-title":"J. Hepatol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1042\/cs0900307","article-title":"beta-Oxidation in human alcoholic and non-alcoholic hepatic steatosis","volume":"90","author":"Eaton","year":"1996","journal-title":"Clin. Sci."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1002\/hep.26226","article-title":"Mitochondrial adaptations and dysfunctions in nonalcoholic fatty liver disease","volume":"58","author":"Begriche","year":"2013","journal-title":"Hepatology"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.cld.2009.07.009","article-title":"Role of Insulin Resistance and Lipotoxicity in Non-Alcoholic Steatohepatitis","volume":"13","author":"Cusi","year":"2009","journal-title":"Clin. Liver Dis."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s10545-008-0841-x","article-title":"Valproic acid metabolism and its effects on mitochondrial fatty acid oxidation: A review","volume":"31","author":"Silva","year":"2008","journal-title":"J. Inherit. Metab. Dis."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"852","DOI":"10.7150\/ijbs.19370","article-title":"Emerging roles of SIRT1 in fatty liver diseases","volume":"13","author":"Ding","year":"2017","journal-title":"Int. J. Biol. Sci."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"472","DOI":"10.7150\/ijbs.10809","article-title":"Stem cell transplantation upregulates Sirt1 and antioxidant expression, ameliorating fatty liver in type 2 diabetic mice","volume":"11","author":"Li","year":"2015","journal-title":"Int. J. Biol. Sci."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1042\/BJ20100791","article-title":"Fatty liver is associated with reduced SIRT3 activity and mitochondrial protein hyperacetylation","volume":"433","author":"Kendrick","year":"2011","journal-title":"Biochem. J."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1002\/hep.28245","article-title":"Eliciting the mitochondrial unfolded protein response by nicotinamide adenine dinucleotide repletion reverses fatty liver disease in mice","volume":"63","author":"Gariani","year":"2016","journal-title":"Hepatology"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1038\/s41418-020-0491-6","article-title":"Inhibition of the mitochondrial citrate carrier, Slc25a1, reverts steatosis, glucose intolerance, and inflammation in preclinical models of NAFLD\/NASH","volume":"27","author":"Tan","year":"2020","journal-title":"Cell Death Differ."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"689042","DOI":"10.3389\/fmed.2021.689042","article-title":"Role of Carnitine in Non-alcoholic Fatty Liver Disease and Other Related Diseases: An Update","volume":"8","author":"Li","year":"2021","journal-title":"Front. Med."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1172\/JCI23621","article-title":"Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease","volume":"115","author":"Donnelly","year":"2005","journal-title":"J. Clin. Invest."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1002\/hep.21655","article-title":"Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis","volume":"45","author":"Yamaguchi","year":"2007","journal-title":"Hepatology"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"E484","DOI":"10.1152\/ajpendo.00492.2015","article-title":"Lipotoxicity in steatohepatitis occurs despite an increase in tricarboxylic acid cycle activity","volume":"310","author":"Patterson","year":"2016","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"14205","DOI":"10.3748\/wjg.v20.i39.14205","article-title":"Oxidative stress, cardiolipin and mitochondrial dysfunction in nonalcoholic fatty liver disease","volume":"20","author":"Paradies","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.tem.2010.06.005","article-title":"Insulin signaling meets mitochondria in metabolism","volume":"21","author":"Cheng","year":"2010","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"S103","DOI":"10.2337\/diabetes.53.2007.S103","article-title":"Mitochondrial diabetes: Molecular mechanisms and clinical presentation","volume":"53","author":"Maassen","year":"2004","journal-title":"Diabetes"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1053\/jhep.2003.50095","article-title":"Hepatic cytochrome P450 2E1 activity in nondiabetic patients with nonalcoholic steatohepatitis","volume":"37","author":"Chalasani","year":"2003","journal-title":"Hepatology"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1016\/S0016-5085(96)70028-8","article-title":"Increased hepatocyte CYP2E1 expression in a rat nutritional model of hepatic steatosis with inflammation","volume":"111","author":"Weltman","year":"1996","journal-title":"Gastroenterology"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"81","DOI":"10.4067\/S0716-97602008000100010","article-title":"Study of cytochrome P450 2E1 and its allele variants in liver injury of nondiabetic, nonalcoholic steatohepatitis obese women","volume":"41","author":"Varela","year":"2008","journal-title":"Biol. Res."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"18528","DOI":"10.1074\/jbc.M109.099333","article-title":"Specific contribution of methionine and choline in nutritional nonalcoholic steatohepatitis: Impact on mitochondrial S-adenosyl-L-methionine and glutathione","volume":"285","author":"Caballero","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1097\/MPG.0000000000000279","article-title":"A 4-polymorphism risk score predicts steatohepatitis in children with nonalcoholic fatty liver disease","volume":"58","author":"Nobili","year":"2014","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1097\/00000441-200512000-00004","article-title":"Epidemiology of the metabolic syndrome","volume":"330","author":"Reynolds","year":"2005","journal-title":"Am. J. Med. Sci."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.1161\/CIRCULATIONAHA.105.169404","article-title":"Diagnosis and management of the metabolic syndrome: An American Heart Association\/National Heart, Lung, and Blood Institute Scientific Statement","volume":"112","author":"Grundy","year":"2005","journal-title":"Circulation"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1373\/clinchem.2008.105254","article-title":"Why a cluster is truly a cluster: Insulin resistance and cardiovascular disease","volume":"54","author":"Reaven","year":"2008","journal-title":"Clin. Chem."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"13","DOI":"10.3132\/dvdr.2007.001","article-title":"The insulin resistance syndrome: Physiological considerations","volume":"4","author":"Kashyap","year":"2007","journal-title":"Diabetes Vasc. Dis. Res."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1172\/JCI10842","article-title":"Obesity and insulin resistance","volume":"106","author":"Kahn","year":"2000","journal-title":"J. Clin. Invest."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1161\/CIRCRESAHA.107.151621","article-title":"Adiposity and cardiovascular disorders: Disturbance of the regulatory system consisting of humoral and neuronal signals","volume":"101","author":"Katagiri","year":"2007","journal-title":"Circ. Res."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1210\/jc.2006-1819","article-title":"Review: Insulin and endothelin: An interplay contributing to hypertension development?","volume":"92","author":"Sarafidis","year":"2007","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1016\/j.ultrasmedbio.2015.01.020","article-title":"Effects of steatosis on hepatic hemodynamics in patients with metabolic syndrome","volume":"41","author":"Soresi","year":"2015","journal-title":"Ultrasound Med. Biol."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.2337\/diabetes.50.8.1844","article-title":"Nonalcoholic fatty liver disease: A feature of the metabolic syndrome","volume":"50","author":"Marchesini","year":"2001","journal-title":"Diabetes"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"3490","DOI":"10.1210\/jc.2007-0482","article-title":"Liver fat in the metabolic syndrome","volume":"92","author":"Kotronen","year":"2007","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"722","DOI":"10.7326\/0003-4819-143-10-200511150-00009","article-title":"The metabolic syndrome as a predictor of nonalcoholic fatty liver disease","volume":"143","author":"Hamaguchi","year":"2005","journal-title":"Ann. Intern. Med."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1053\/j.gastro.2019.11.312","article-title":"MAFLD: A Consensus-Driven Proposed Nomenclature for Metabolic Associated Fatty Liver Disease","volume":"158","author":"Eslam","year":"2020","journal-title":"Gastroenterology"},{"key":"ref_148","doi-asserted-by":"crossref","unstructured":"EASL, EASD, and EASO (2016). EASL-EASD-EASO Clinical Practice Guidelines for the Management of Non-Alcoholic Fatty Liver Disease. Obes. Facts, 9, 65\u201390.","DOI":"10.1159\/000443344"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.jhep.2020.03.039","article-title":"A new definition for metabolic dysfunction-associated fatty liver disease: An international expert consensus statement","volume":"73","author":"Eslam","year":"2020","journal-title":"J. Hepatol."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1038\/ajg.2011.400","article-title":"Ultrasonographically detected non-alcoholic fatty liver disease is an independent predictor for identifying patients with insulin resistance in non-obese, non-diabetic middle-aged Asian adults","volume":"107","author":"Sinn","year":"2012","journal-title":"Am. J. Gastroenterol."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"789","DOI":"10.3346\/jkms.2008.23.5.789","article-title":"Impact of visceral fat on the metabolic syndrome and nonalcoholic fatty liver disease","volume":"23","author":"Jeong","year":"2008","journal-title":"J. Korean Med. Sci."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1007\/s00535-006-1790-5","article-title":"Visceral fat accumulation and insulin resistance are important factors in nonalcoholic fatty liver disease","volume":"41","author":"Eguchi","year":"2006","journal-title":"J. Gastroenterol."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"12587","DOI":"10.1073\/pnas.0705408104","article-title":"The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome","volume":"104","author":"Petersen","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/nature13478","article-title":"The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes","volume":"510","author":"Perry","year":"2014","journal-title":"Nature"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1038\/oby.2009.224","article-title":"Relationship between body fat mass and free fatty acid kinetics in men and women","volume":"17","author":"Mittendorfer","year":"2009","journal-title":"Obesity"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1007\/s11906-009-0026-5","article-title":"Update on the metabolic syndrome: Hypertension","volume":"11","author":"Reynolds","year":"2009","journal-title":"Curr. Hypertens. Rep."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1097\/MOL.0b013e3282ff5e55","article-title":"Hepatic triglyceride synthesis and nonalcoholic fatty liver disease","volume":"19","author":"Choi","year":"2008","journal-title":"Curr. Opin. Lipidol."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.livres.2018.02.002","article-title":"The role of adipose tissue in fatty liver diseases","volume":"2","author":"Parker","year":"2018","journal-title":"Liver Res."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.jceh.2015.02.002","article-title":"The Riddle of Nonalcoholic Fatty Liver Disease: Progression From Nonalcoholic Fatty Liver to Nonalcoholic Steatohepatitis","volume":"5","author":"Sharma","year":"2015","journal-title":"J. Clin. Exp. Hepatol."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1002\/mnfr.200700289","article-title":"Polyunsaturated fatty acids, inflammatory processes and inflammatory bowel diseases","volume":"52","author":"Calder","year":"2008","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"18J","DOI":"10.1016\/S0002-9149(03)00612-X","article-title":"Insulin resistance, inflammation, and the prediabetic state","volume":"92","author":"Haffner","year":"2003","journal-title":"Am. J. Cardiol."},{"key":"ref_162","doi-asserted-by":"crossref","unstructured":"Rogero, M.M., and Calder, P.C. (2018). Obesity, Inflammation, Toll-Like Receptor 4 and Fatty Acids. Nutrients, 10.","DOI":"10.3390\/nu10040432"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.18632\/aging.101288","article-title":"Toll-like receptor 4 (TLR4) deficient mice are protected from adipose tissue inflammation in aging","volume":"9","author":"Ghosh","year":"2017","journal-title":"Aging"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"2595","DOI":"10.2337\/db08-0038","article-title":"Elevated toll-like receptor 4 expression and signaling in muscle from insulin-resistant subjects","volume":"57","author":"Reyna","year":"2008","journal-title":"Diabetes"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.tem.2010.08.007","article-title":"Toll-like receptors: Linking inflammation to metabolism","volume":"22","year":"2011","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_166","first-page":"264","article-title":"Higher levels of serum uric acid influences hepatic damage in patients with non-alcoholic fatty liver disease (NAFLD)","volume":"111","author":"Aller","year":"2019","journal-title":"Rev. Esp. Enfermedades Dig. Organo Of. la Soc. Esp. Patol. Dig."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"422","DOI":"10.3945\/ajcn.115.118695","article-title":"Serum aminotransferases in nonalcoholic fatty liver disease are a signature of liver metabolic perturbations at the amino acid and Krebs cycle level","volume":"103","author":"Sookoian","year":"2016","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/0016-5085(94)90235-6","article-title":"Nonalcoholic steatohepatitis: An expanded clinical entity","volume":"107","author":"Bacon","year":"1994","journal-title":"Gastroenterology"},{"key":"ref_169","first-page":"1688","article-title":"Elevated serum ferritin is associated with increased mortality in non-alcoholic fatty liver disease after 16 years of follow-up","volume":"36","author":"Nasr","year":"2016","journal-title":"Liver Int. Off. J. Int. Assoc. Study Liver"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1177\/002215540104900508","article-title":"The role of 15-lipoxygenase in disruption of the peroxisomal membrane and in programmed degradation of peroxisomes in normal rat liver","volume":"49","author":"Yokota","year":"2001","journal-title":"J. Histochem. Cytochem. Off. J. Histochem. Soc."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/j.jhep.2011.05.008","article-title":"Iron in fatty liver and in the metabolic syndrome: A promising therapeutic target","volume":"55","author":"Dongiovanni","year":"2011","journal-title":"J. Hepatol."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.niox.2005.04.009","article-title":"Chronic iron overload enhances inducible nitric oxide synthase expression in rat liver","volume":"13","author":"Cornejo","year":"2005","journal-title":"Nitric Oxide Biol. Chem."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"E1140","DOI":"10.1152\/ajpendo.00620.2009","article-title":"Iron restriction improves type 2 diabetes mellitus in Otsuka Long-Evans Tokushima fatty rats","volume":"298","author":"Minamiyama","year":"2010","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1002\/dmrr.2513","article-title":"Prevention of type 2 diabetes mellitus: Is it feasible?","volume":"30","author":"Palermo","year":"2014","journal-title":"Diabetes. Metab. Res. Rev."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"11070","DOI":"10.1073\/pnas.0504978102","article-title":"Obesity alters gut microbial ecology","volume":"102","author":"Ley","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1053\/j.gastro.2012.06.031","article-title":"Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome","volume":"143","author":"Vrieze","year":"2012","journal-title":"Gastroenterology"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.2337\/db08-1637","article-title":"Butyrate improves insulin sensitivity and increases energy expenditure in mice","volume":"58","author":"Gao","year":"2009","journal-title":"Diabetes"},{"key":"ref_178","doi-asserted-by":"crossref","unstructured":"Mattace Raso, G., Simeoli, R., Russo, R., Iacono, A., Santoro, A., Paciello, O., Ferrante, M.C., Canani, R.B., Calignano, A., and Meli, R. (2013). Effects of sodium butyrate and its synthetic amide derivative on liver inflammation and glucose tolerance in an animal model of steatosis induced by high fat diet. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0068626"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"16","DOI":"10.21037\/tgh.2019.09.08","article-title":"Epidemiology of non-alcoholic and alcoholic fatty liver diseases","volume":"5","author":"Mitra","year":"2020","journal-title":"Transl. Gastroenterol. Hepatol."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.soard.2014.06.015","article-title":"Liver disease in the morbidly obese: A review of 1000 consecutive patients undergoing weight loss surgery","volume":"11","author":"Subichin","year":"2015","journal-title":"Surg. Obes. Relat. Dis. Off. J. Am. Soc. Bariatr. Surg."},{"key":"ref_181","doi-asserted-by":"crossref","unstructured":"Van Vliet-Ostaptchouk, J.V., Nuotio, M.-L., Slagter, S.N., Doiron, D., Fischer, K., Foco, L., Gaye, A., G\u00f6gele, M., Heier, M., and Hiekkalinna, T. (2014). The prevalence of metabolic syndrome and metabolically healthy obesity in Europe: A collaborative analysis of ten large cohort studies. BMC Endocr. Disord., 14.","DOI":"10.1186\/1472-6823-14-9"},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1002\/hep.510300604","article-title":"Independent predictors of liver fibrosis in patients with nonalcoholic steatohepatitis","volume":"30","author":"Angulo","year":"1999","journal-title":"Hepatology"},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1381\/096089203322190853","article-title":"Hepatic steatosis in patients undergoing bariatric surgery and its relationship to body mass index and co-morbidities","volume":"13","author":"Moretto","year":"2003","journal-title":"Obes. Surg."},{"key":"ref_184","first-page":"107","article-title":"The liver in consecutive patients with morbid obesity: A clinical, morphological, and biochemical study","volume":"8","author":"Andersen","year":"1984","journal-title":"Int. J. Obes."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/ng.3714","article-title":"Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance","volume":"49","author":"Lotta","year":"2017","journal-title":"Nat. Genet."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1002\/hep.23567","article-title":"Nonobese population in a developing country has a high prevalence of nonalcoholic fatty liver and significant liver disease","volume":"51","author":"Das","year":"2010","journal-title":"Hepatology"},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s13098-020-00570-y","article-title":"NAFLD as a continuum: From obesity to metabolic syndrome and diabetes","volume":"12","author":"Valerio","year":"2020","journal-title":"Diabetol. Metab. Syndr."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1007\/s00125-016-3933-4","article-title":"Adipose tissue plasticity: How fat depots respond differently to pathophysiological cues","volume":"59","author":"Pellegrinelli","year":"2016","journal-title":"Diabetologia"},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"e00300","DOI":"10.14309\/ctg.0000000000000300","article-title":"Implications of Abdominal Adipose Tissue Distribution on Nonalcoholic Fatty Liver Disease and Metabolic Syndrome: A Chinese General Population Study","volume":"12","author":"Chiyanika","year":"2021","journal-title":"Clin. Transl. Gastroenterol."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"R25","DOI":"10.1530\/JOE-13-0201","article-title":"Inflammation as a potential link between nonalcoholic fatty liver disease and insulin resistance","volume":"218","author":"Asrih","year":"2013","journal-title":"J. Endocrinol."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/nm.2277","article-title":"Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin","volume":"17","author":"Holland","year":"2011","journal-title":"Nat. Med."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1210\/endo.130.1.1727716","article-title":"Tumor necrosis factor impairs insulin action on peripheral glucose disposal and hepatic glucose output","volume":"130","author":"Lang","year":"1992","journal-title":"Endocrinology"},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.2337\/diabetes.51.6.1876","article-title":"Altered Tumor Necrosis Factor-\u03b1 (TNF-\u03b1) Processing in Adipocytes and Increased Expression of Transmembrane TNF-\u03b1 in Obesity","volume":"51","author":"Xu","year":"2002","journal-title":"Diabetes"},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S1043-2760(03)00024-9","article-title":"The adipocyte in insulin resistance: Key molecules and the impact of the thiazolidinediones","volume":"14","author":"Arner","year":"2003","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1038\/39335","article-title":"Protection from obesity-induced insulin resistance in mice lacking TNF-\u03b1 function","volume":"389","author":"Uysal","year":"1997","journal-title":"Nature"},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1111\/j.1572-0241.2007.01774.x","article-title":"Increased hepatic and circulating interleukin-6 levels in human nonalcoholic steatohepatitis","volume":"103","author":"Wieckowska","year":"2008","journal-title":"Am. J. Gastroenterol."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1038\/labinvest.2010.75","article-title":"Blockade of interleukin-6 signaling enhances hepatic steatosis but improves liver injury in methionine choline-deficient diet-fed mice","volume":"90","author":"Yamaguchi","year":"2010","journal-title":"Lab. Investig."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1053\/jhep.2002.33684","article-title":"Leptin is required for fibrogenic responses induced by thioacetamide in the murine liver","volume":"36","author":"Honda","year":"2002","journal-title":"Hepatology"},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1038\/sj.ijo.0802142","article-title":"Leptin: A review of its peripheral actions and interactions","volume":"26","author":"Margetic","year":"2002","journal-title":"Int. J. Obes. Relat. Metab. Disord. J. Int. Assoc. Study Obes."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.metabol.2018.11.014","article-title":"Obesity and nonalcoholic fatty liver disease: From pathophysiology to therapeutics","volume":"92","author":"Polyzos","year":"2019","journal-title":"Metabolism"},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"8152","DOI":"10.1002\/jcp.27603","article-title":"Insulin resistance: Review of the underlying molecular mechanisms","volume":"234","author":"Yaribeygi","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"9488","DOI":"10.3748\/wjg.v22.i43.9488","article-title":"Nonalcoholic fatty liver disease\u2014A multisystem disease?","volume":"22","author":"Mikolasevic","year":"2016","journal-title":"World J. Gastroenterol."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"154299","DOI":"10.1016\/j.metabol.2020.154299","article-title":"Metabolic liver disease in diabetes\u2014From mechanisms to clinical trials","volume":"111S","author":"Dewidar","year":"2020","journal-title":"Metabolism."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.2337\/dc14-1239","article-title":"Clinical Model for NASH and Advanced Fibrosis in Adult Patients With Diabetes and NAFLD: Guidelines for Referral in NAFLD","volume":"38","author":"Bazick","year":"2015","journal-title":"Diabetes Care"},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/nrgastro.2016.147","article-title":"NAFLD and diabetes mellitus","volume":"14","author":"Tilg","year":"2017","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_206","first-page":"181","article-title":"Nonalcoholic fatty liver disease: A precursor of the metabolic syndrome","volume":"47","author":"Lonardo","year":"2015","journal-title":"Dig. Liver Dis. Off. J. Ital. Soc. Gastroenterol. Ital. Assoc. Study Liver"},{"key":"ref_207","first-page":"997","article-title":"Epidemiological modifiers of non-alcoholic fatty liver disease: Focus on high-risk groups","volume":"47","author":"Lonardo","year":"2015","journal-title":"Dig. Liver Dis. Off. J. Ital. Soc. Gastroenterol. Ital. Assoc. Study Liver"},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"e8179","DOI":"10.1097\/MD.0000000000008179","article-title":"Prevalence of nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus: A meta-analysis","volume":"96","author":"Dai","year":"2017","journal-title":"Medicine"},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/apt.13405","article-title":"Non-invasive screening of diabetics in primary care for NAFLD and advanced fibrosis by MRI and MRE","volume":"43","author":"Doycheva","year":"2016","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1136\/gutjnl-2015-309265","article-title":"Screening diabetic patients for non-alcoholic fatty liver disease with controlled attenuation parameter and liver stiffness measurements: A prospective cohort study","volume":"65","author":"Kwok","year":"2016","journal-title":"Gut"},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/nrgastro.2013.41","article-title":"Progression of NAFLD to diabetes mellitus, cardiovascular disease or cirrhosis","volume":"10","author":"Anstee","year":"2013","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/nrgastro.2013.175","article-title":"Noninvasive evaluation of NAFLD","volume":"10","author":"Castera","year":"2013","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1002\/hep.20466","article-title":"Prevalence of hepatic steatosis in an urban population in the United States: Impact of ethnicity","volume":"40","author":"Browning","year":"2004","journal-title":"Hepatology"},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1002\/hep.21327","article-title":"Long-term follow-up of patients with NAFLD and elevated liver enzymes","volume":"44","author":"Ekstedt","year":"2006","journal-title":"Hepatology"},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"226","DOI":"10.3803\/EnM.2019.34.3.226","article-title":"Nonalcoholic Fatty Liver Disease and Diabetes: An Epidemiological Perspective","volume":"34","author":"Rhee","year":"2019","journal-title":"Endocrinol. Metab."},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1016\/j.metabol.2016.01.001","article-title":"Non-alcoholic fatty liver disease and diabetes","volume":"65","author":"Hazlehurst","year":"2016","journal-title":"Metabolism."},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1016\/j.jhep.2016.01.014","article-title":"Type 2 diabetes and risk of hospital admission or death for chronic liver diseases","volume":"64","author":"Wild","year":"2016","journal-title":"J. Hepatol."},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.jhep.2017.09.021","article-title":"Hypertension, diabetes, atherosclerosis and NASH: Cause or consequence?","volume":"68","author":"Lonardo","year":"2018","journal-title":"J. Hepatol."},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1016\/j.jhep.2014.11.034","article-title":"Evidence of NAFLD progression from steatosis to fibrosing-steatohepatitis using paired biopsies: Implications for prognosis and clinical management","volume":"62","author":"McPherson","year":"2015","journal-title":"J. Hepatol."},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1038\/ajg.2009.67","article-title":"NAFLD as a risk factor for the development of diabetes and the metabolic syndrome: An eleven-year follow-up study","volume":"104","author":"Adams","year":"2009","journal-title":"Am. J. Gastroenterol."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"877","DOI":"10.3389\/fphar.2019.00877","article-title":"NAFLD and Diabetes: Two Sides of the Same Coin? Rationale for Gene-Based Personalized NAFLD Treatment","volume":"10","author":"Xia","year":"2019","journal-title":"Front. Pharmacol."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1002\/hep.22429","article-title":"Risk of severe liver disease in nonalcoholic fatty liver disease with normal aminotransferase levels: A role for insulin resistance and diabetes","volume":"48","author":"Fracanzani","year":"2008","journal-title":"Hepatology"},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1002\/oby.21182","article-title":"Assessment of liver fat content using quantitative ultrasonography to evaluate risks for metabolic diseases","volume":"23","author":"Xia","year":"2015","journal-title":"Obesity"},{"key":"ref_224","doi-asserted-by":"crossref","unstructured":"Palmer, C.N.A., Maglio, C., Pirazzi, C., Burza, M.A., Adiels, M., Burch, L., Donnelly, L.A., Colhoun, H., Doney, A.S., and Dillon, J.F. (2012). Paradoxical lower serum triglyceride levels and higher type 2 diabetes mellitus susceptibility in obese individuals with the PNPLA3 148M variant. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0039362"},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.clinre.2012.06.014","article-title":"PNPLA3, a genetic marker of progressive liver disease, still hiding its metabolic function?","volume":"37","author":"Dubuquoy","year":"2013","journal-title":"Clin. Res. Hepatol. Gastroenterol."},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1467-789X.2009.00623.x","article-title":"Subcutaneous and visceral adipose tissue: Structural and functional differences","volume":"11","author":"Ibrahim","year":"2010","journal-title":"Obes. Rev. an Off. J. Int. Assoc. Study Obes."},{"key":"ref_227","doi-asserted-by":"crossref","unstructured":"Wr\u00f3blewski, A., Strycharz, J., \u015awiderska, E., Balcerczyk, A., Szemraj, J., Drzewoski, J., and \u015aliwi\u0144ska, A. (2021). Chronic and Transient Hyperglycemia Induces Changes in the Expression Patterns of IL6 and ADIPOQ Genes and Their Associated Epigenetic Modifications in Differentiating Human Visceral Adipocytes. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22136964"},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/s41575-018-0082-x","article-title":"The role of macrophages in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis","volume":"16","author":"Kazankov","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1172\/JCI121842","article-title":"STING-mediated inflammation in Kupffer cells contributes to progression of nonalcoholic steatohepatitis","volume":"129","author":"Yu","year":"2019","journal-title":"J. Clin. Invest."},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"632","DOI":"10.2337\/dc15-1876","article-title":"Metabolic Impact of Nonalcoholic Steatohepatitis in Obese Patients With Type 2 Diabetes","volume":"39","author":"Lomonaco","year":"2016","journal-title":"Diabetes Care"},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.atherosclerosis.2011.02.043","article-title":"Diet, commensals and the intestine as sources of pathogen-associated molecular patterns in atherosclerosis, type 2 diabetes and non-alcoholic fatty liver disease","volume":"216","author":"Erridge","year":"2011","journal-title":"Atherosclerosis"},{"key":"ref_232","first-page":"9072","article-title":"Non-alcoholic fatty liver disease and type 2 diabetes mellitus: The liver disease of our age?","volume":"20","author":"Firneisz","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"532","DOI":"10.3389\/fphys.2019.00532","article-title":"Mitochondrial (Dys)function and Insulin Resistance: From Pathophysiological Molecular Mechanisms to the Impact of Diet","volume":"10","author":"Sergi","year":"2019","journal-title":"Front. Physiol."},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.cld.2017.08.010","article-title":"Nonalcoholic Fatty Liver Disease and Metabolic Syndrome","volume":"22","author":"Kim","year":"2018","journal-title":"Clin. Liver Dis."},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"340476","DOI":"10.1155\/2013\/340476","article-title":"Mitochondrial dysfunction in metabolic syndrome and asthma","volume":"2013","author":"Mabalirajan","year":"2013","journal-title":"J. Allergy"},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1172\/JCI37048","article-title":"Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans","volume":"119","author":"Anderson","year":"2009","journal-title":"J. Clin. Invest."},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"a012641","DOI":"10.1101\/cshperspect.a012641","article-title":"The maintenance of mitochondrial DNA integrity--critical analysis and update","volume":"5","author":"Alexeyev","year":"2013","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"3","DOI":"10.2174\/1874467211205010003","article-title":"Overview of base excision repair biochemistry","volume":"5","author":"Kim","year":"2012","journal-title":"Curr. Mol. Pharmacol."},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1002\/em.22087","article-title":"Mechanisms of DNA damage, repair, and mutagenesis","volume":"58","author":"Chatterjee","year":"2017","journal-title":"Environ. Mol. Mutagen."},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.pnpbp.2017.06.036","article-title":"The interplay between inflammation, oxidative stress, DNA damage, DNA repair and mitochondrial dysfunction in depression","volume":"80","author":"Czarny","year":"2018","journal-title":"Prog. Neuro Psychopharmacol. Biol. Psychiatry"},{"key":"ref_241","doi-asserted-by":"crossref","unstructured":"Sampath, H., Vartanian, V., Rollins, M.R., Sakumi, K., Nakabeppu, Y., and Lloyd, R.S. (2012). 8-Oxoguanine DNA glycosylase (OGG1) deficiency increases susceptibility to obesity and metabolic dysfunction. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0051697"},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"e0181687","DOI":"10.1371\/journal.pone.0181687","article-title":"8-oxoguanine DNA glycosylase (OGG1) deficiency elicits coordinated changes in lipid and mitochondrial metabolism in muscle","volume":"12","author":"Vartanian","year":"2017","journal-title":"PLoS ONE"},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.dnarep.2017.11.008","article-title":"8-oxoguanine DNA glycosylase (Ogg1) controls hepatic gluconeogenesis","volume":"61","author":"Scheffler","year":"2018","journal-title":"DNA Repair"},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"14886","DOI":"10.1038\/s41598-018-33151-1","article-title":"The DNA Repair Protein OGG1 Protects Against Obesity by Altering Mitochondrial Energetics in White Adipose Tissue","volume":"8","author":"Komakula","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_245","doi-asserted-by":"crossref","unstructured":"Komakula, S.S.B., Blaze, B., Ye, H., Dobrzyn, A., and Sampath, H. (2021). A Novel Role for the DNA Repair Enzyme 8-Oxoguanine DNA Glycosylase in Adipogenesis. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22031152"},{"key":"ref_246","doi-asserted-by":"crossref","first-page":"102667","DOI":"10.1016\/j.dnarep.2019.102667","article-title":"Roles of OGG1 in transcriptional regulation and maintenance of metabolic homeostasis","volume":"81","author":"Sampath","year":"2019","journal-title":"DNA Repair"},{"key":"ref_247","doi-asserted-by":"crossref","first-page":"E724","DOI":"10.1152\/ajpendo.00387.2010","article-title":"Variable penetrance of metabolic phenotypes and development of high-fat diet-induced adiposity in NEIL1-deficient mice","volume":"300","author":"Sampath","year":"2011","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_248","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1073\/pnas.0507444103","article-title":"The metabolic syndrome resulting from a knockout of the NEIL1 DNA glycosylase","volume":"103","author":"Vartanian","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"G1070","DOI":"10.1152\/ajpgi.00228.2004","article-title":"Oxidative DNA damage and DNA repair enzyme expression are inversely related in murine models of fatty liver disease","volume":"287","author":"Gao","year":"2004","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_250","doi-asserted-by":"crossref","unstructured":"Hsiao, P.-J., Hsieh, T.-J., Kuo, K.-K., Hung, W.-W., Tsai, K.-B., Yang, C.-H., Yu, M.-L., and Shin, S.-J. (2008). Pioglitazone retrieves hepatic antioxidant DNA repair in a mice model of high fat diet. BMC Mol. Biol., 9.","DOI":"10.1186\/1471-2199-9-82"},{"key":"ref_251","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.mrfmmm.2011.11.001","article-title":"Decreased nucleotide excision repair in steatotic livers associates with myeloperoxidase-immunoreactivity","volume":"736","author":"Schults","year":"2012","journal-title":"Mutat. Res."},{"key":"ref_252","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1002\/jat.3117","article-title":"The effect of a methyl-deficient diet on the global DNA methylation and the DNA methylation regulatory pathways","volume":"35","author":"Takumi","year":"2015","journal-title":"J. Appl. Toxicol."},{"key":"ref_253","doi-asserted-by":"crossref","unstructured":"Cioffi, F., Senese, R., Lasala, P., Ziello, A., Mazzoli, A., Crescenzo, R., Liverini, G., Lanni, A., Goglia, F., and Iossa, S. (2017). Fructose-Rich Diet Affects Mitochondrial DNA Damage and Repair in Rats. Nutrients, 9.","DOI":"10.3390\/nu9040323"},{"key":"ref_254","doi-asserted-by":"crossref","first-page":"3170","DOI":"10.1016\/j.bbadis.2017.08.017","article-title":"Growth arrest and DNA damage-inducible 45\u03b1 protects against nonalcoholic steatohepatitis induced by methionine- and choline-deficient diet","volume":"1863","author":"Tanaka","year":"2017","journal-title":"Biochim. Biophys. Acta. Mol. Basis Dis."},{"key":"ref_255","first-page":"949","article-title":"Comparative analysis of the expression profiles of genes related to the Gadd45\u03b1 signaling pathway in four kinds of liver diseases","volume":"35","author":"Yang","year":"2020","journal-title":"Histol. Histopathol."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/22\/20\/11128\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:15:28Z","timestamp":1760166928000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/22\/20\/11128"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,15]]},"references-count":255,"journal-issue":{"issue":"20","published-online":{"date-parts":[[2021,10]]}},"alternative-id":["ijms222011128"],"URL":"https:\/\/doi.org\/10.3390\/ijms222011128","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,15]]}}}