{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T15:55:10Z","timestamp":1792511710351,"version":"4.5.0"},"reference-count":153,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2021,10,17]],"date-time":"2021-10-17T00:00:00Z","timestamp":1634428800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["4R00AG055701-03"],"award-info":[{"award-number":["4R00AG055701-03"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007558","name":"Rutgers, The State University of New Jersey","doi-asserted-by":"publisher","award":["StartUp package"],"award-info":[{"award-number":["StartUp package"]}],"id":[{"id":"10.13039\/100007558","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Alzheimer\u2019s Disease (AD) is the most common neurodegenerative disorder in our society, as the population ages, its incidence is expected to increase in the coming decades. The etiopathology of this disease still remains largely unclear, probably because of the highly complex and multifactorial nature of AD. However, the presence of mitochondrial dysfunction has been broadly described in AD neurons and other cellular populations within the brain, in a wide variety of models and organisms, including post-mortem humans. Mitochondria are complex organelles that play a crucial role in a wide range of cellular processes, including bioenergetics. In fact, in mammals, including humans, the main source of cellular ATP is the oxidative phosphorylation (OXPHOS), a process that occurs in the mitochondrial electron transfer chain (ETC). The last enzyme of the ETC, and therefore the ulterior generator of ATP, is the ATP synthase. Interestingly, in mammalian cells, the ATP synthase can also degrade ATP under certain conditions (ATPase), which further illustrates the crucial role of this enzyme in the regulation of cellular bioenergetics and metabolism. In this collaborative review, we aim to summarize the knowledge of the presence of dysregulated ATP synthase, and of other components of mammalian mitochondrial bioenergetics, as an early event in AD. This dysregulation can act as a trigger of the dysfunction of the organelle, which is a clear component in the etiopathology of AD. Consequently, the pharmacological modulation of the ATP synthase could be a potential strategy to prevent mitochondrial dysfunction in AD.<\/jats:p>","DOI":"10.3390\/ijms222011185","type":"journal-article","created":{"date-parts":[[2021,10,17]],"date-time":"2021-10-17T23:05:47Z","timestamp":1634511947000},"page":"11185","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":72,"title":["ATP Synthase and Mitochondrial Bioenergetics Dysfunction in Alzheimer\u2019s Disease"],"prefix":"10.3390","volume":"22","author":[{"given":"Somya","family":"Patro","sequence":"first","affiliation":[{"name":"Department of Biology, College of Arts and Sciences, Rutgers University, Camden, NJ 08103, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0939-3715","authenticated-orcid":false,"given":"Sujay","family":"Ratna","sequence":"additional","affiliation":[{"name":"Department of Biology, College of Arts and Sciences, Rutgers University, Camden, NJ 08103, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4673-7254","authenticated-orcid":false,"given":"Hianny A.","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Biology, College of Arts and Sciences, Rutgers University, Camden, NJ 08103, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew T.","family":"Ebenezer","sequence":"additional","affiliation":[{"name":"Department of Biology, College of Arts and Sciences, Rutgers University, Camden, NJ 08103, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dillon S.","family":"Ferguson","sequence":"additional","affiliation":[{"name":"Department of Biology, College of Arts and Sciences, Rutgers University, Camden, NJ 08103, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanpreet","family":"Kaur","sequence":"additional","affiliation":[{"name":"Department of Biology, College of Arts and Sciences, Rutgers University, Camden, NJ 08103, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brendan C.","family":"McIntyre","sequence":"additional","affiliation":[{"name":"Department of Biology, College of Arts and Sciences, Rutgers University, Camden, NJ 08103, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Snow","sequence":"additional","affiliation":[{"name":"Department of Biology, College of Arts and Sciences, Rutgers University, Camden, NJ 08103, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8105-1701","authenticated-orcid":false,"given":"Maria E.","family":"Solesio","sequence":"additional","affiliation":[{"name":"Department of Biology, College of Arts and Sciences, Rutgers University, Camden, NJ 08103, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,10,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1002\/alz.12328","article-title":"2021 Alzheimer\u2019s disease facts and figures","volume":"17","author":"Association","year":"2021","journal-title":"Alzheimers Dement."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"3443","DOI":"10.1093\/brain\/awy264","article-title":"Atrophy subtypes in prodromal Alzheimer\u2019s disease are associated with cognitive decline","volume":"141","author":"Dicks","year":"2018","journal-title":"Brain"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1002\/ana.25621","article-title":"Hospitalization, Alzheimer\u2019s Disease and Related Neuropathologies, and Cognitive Decline","volume":"86","author":"James","year":"2019","journal-title":"Ann. 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