{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T02:27:52Z","timestamp":1760236072722,"version":"build-2065373602"},"reference-count":66,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2021,10,18]],"date-time":"2021-10-18T00:00:00Z","timestamp":1634515200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["315817 (2021)"],"award-info":[{"award-number":["315817 (2021)"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"name":"DGAPA-PAPIIT-UNAM","award":["IA209720 to JEO and IN226519 to LIT"],"award-info":[{"award-number":["IA209720 to JEO and IN226519 to LIT"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>A close connection between inflammation and the risk of developing colon cancer has been suggested in the last few years. It has been estimated that patients diagnosed with some types of inflammatory bowel disease, such as ulcerative colitis or Crohn\u2019s disease, have up to a 30% increased risk of developing colon cancer. However, there is also evidence showing that the activation of anti-inflammatory pathways, such as the IL-4 receptor-mediated pathway, may favor the development of colon tumors. Using an experimental model of colitis-associated colon cancer (CAC), we found that the decrease in tumor development in global IL4R\u03b1 knockout mice (IL4R\u03b1KO) was apparently associated with an inflammatory response mediated by the infiltration of M1 macrophages (F480+TLR2+STAT1+) and iNOS expression in colon tissue. However, when we developed mice with a specific deletion of IL4R\u03b1 in macrophages (LysMcreIL4R\u03b1\u2212\/lox mice) and subjected them to CAC, it was found that despite presenting a large infiltration of M1 macrophages into the colon, these mice were as susceptible to colon-tumorigenesis as WT mice. These data suggest that in the tumor microenvironment the absence of IL4R\u03b1 expression on macrophages, as well as the recruitment of M1 macrophages, may not be directly associated with resistance to developing colon tumors. Therefore, it is possible that IL4R\u03b1 expression in other cell types, such as colonic epithelial cells, could have an important role in promoting the development of colitis-associated colon tumorigenesis.<\/jats:p>","DOI":"10.3390\/ijms222011204","type":"journal-article","created":{"date-parts":[[2021,10,19]],"date-time":"2021-10-19T22:52:47Z","timestamp":1634683967000},"page":"11204","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Recruitment of M1 Macrophages May Not Be Critical for Protection against Colitis-Associated Tumorigenesis"],"prefix":"10.3390","volume":"22","author":[{"given":"Itzel","family":"Medina-Andrade","sequence":"first","affiliation":[{"name":"Laboratorio Nacional en Salud FES-Iztacala, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Av. De los Barrios 1, Los Reyes Iztacala, Tlalnepantla 54090, Estado de M\u00e9xico, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonadab E.","family":"Olgu\u00edn","sequence":"additional","affiliation":[{"name":"Laboratorio Nacional en Salud FES-Iztacala, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Av. De los Barrios 1, Los Reyes Iztacala, Tlalnepantla 54090, Estado de M\u00e9xico, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Guerrero-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Laboratorio Nacional en Salud FES-Iztacala, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Av. De los Barrios 1, Los Reyes Iztacala, Tlalnepantla 54090, Estado de M\u00e9xico, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jossael A.","family":"Espinosa","sequence":"additional","affiliation":[{"name":"Laboratorio Nacional en Salud FES-Iztacala, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Av. De los Barrios 1, Los Reyes Iztacala, Tlalnepantla 54090, Estado de M\u00e9xico, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Gardu\u00f1o-Javier","sequence":"additional","affiliation":[{"name":"Laboratorio Nacional en Salud FES-Iztacala, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Av. De los Barrios 1, Los Reyes Iztacala, Tlalnepantla 54090, Estado de M\u00e9xico, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria","family":"Hern\u00e1ndez-G\u00f3mez","sequence":"additional","affiliation":[{"name":"Laboratorio Nacional en Salud FES-Iztacala, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Av. De los Barrios 1, Los Reyes Iztacala, Tlalnepantla 54090, Estado de M\u00e9xico, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2200-9706","authenticated-orcid":false,"given":"Felipe","family":"Vaca-Paniagua","sequence":"additional","affiliation":[{"name":"Laboratorio Nacional en Salud FES-Iztacala, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Av. De los Barrios 1, Los Reyes Iztacala, Tlalnepantla 54090, Estado de M\u00e9xico, Mexico"},{"name":"Unidad de Biomedicina, Facultad de Estudios Superiores (FES)-Iztacala, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Av. De los Barrios 1, Los Reyes Iztacala, Tlalnepantla 54090, Estado de M\u00e9xico, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2911-9390","authenticated-orcid":false,"given":"Miriam","family":"Rodr\u00edguez-Sosa","sequence":"additional","affiliation":[{"name":"Laboratorio Nacional en Salud FES-Iztacala, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Av. De los Barrios 1, Los Reyes Iztacala, Tlalnepantla 54090, Estado de M\u00e9xico, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis I.","family":"Terrazas","sequence":"additional","affiliation":[{"name":"Laboratorio Nacional en Salud FES-Iztacala, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Av. De los Barrios 1, Los Reyes Iztacala, Tlalnepantla 54090, Estado de M\u00e9xico, Mexico"},{"name":"Unidad de Biomedicina, Facultad de Estudios Superiores (FES)-Iztacala, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Av. De los Barrios 1, Los Reyes Iztacala, Tlalnepantla 54090, Estado de M\u00e9xico, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,10,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0092-8674(00)81683-9","article-title":"The hallmarks of cancer","volume":"100","author":"Hanahan","year":"2000","journal-title":"Cell"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"3839","DOI":"10.3748\/wjg.v18.i29.3839","article-title":"Colorectal cancer in inflammatory bowel disease: What is the real magnitude of the risk?","volume":"18","author":"Dyson","year":"2012","journal-title":"World J. 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