{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T16:47:38Z","timestamp":1785257258282,"version":"3.55.0"},"reference-count":42,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2021,10,20]],"date-time":"2021-10-20T00:00:00Z","timestamp":1634688000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>We have previously reported that vision decline was not associated with amyloidogenesis processing in aging C57BL\/6J wild-type (WT) mice and in a mouse model of Alzheimer\u2019s disease, the APPswe\/PS1\u0394E9 transgenic mouse model (APP\/PS1). This conclusion was drawn using middle-aged (10\u201313 months old) mice. Here, we hypothesized that compared with hippocampal and cortical neurons, the weak amyloidogenic activity of retinal neurons may result in a detectable release of amyloid \u03b2 (A\u03b2) only in aged mice, i.e., between 14 and 24 months of age. The aim of the present study was thus to follow potential activity changes in the amyloidogenic and nonamyloidogenic pathways of young (4 months) and old (20\u201324 months) WT and APP\/PS1 mice. Our results showed that in spite of retinal activity loss reported by electroretinogram (ERG) recordings, the level of amyloid beta precursor protein (APP) and its derivatives did not significantly vary in the eyes of old vs. young mice. Strikingly, the ectopic expression of human APPswe in APP\/PS1 mice did not allow us to detect A\u03b2 monomers at 23 months. In contrast, A\u03b2 was observed in hippocampal and cortical tissues at this age but not at 4 months of life. In contrast, optic nerve transection-induced retinal ganglion cell injury significantly affected the level of retinal APP and the secretion of soluble APP alpha in the vitreous. Collectively, these results suggest that the amyloidogenic and nonamyloidogenic pathways are not involved in visual function decline in aging mice. In WT and APP\/PS1 mice, it is proposed that retinal neurons do not have the capacity to secrete A\u03b2 in contrast with other cortical and hippocampal neurons.<\/jats:p>","DOI":"10.3390\/ijms222111344","type":"journal-article","created":{"date-parts":[[2021,10,20]],"date-time":"2021-10-20T21:29:46Z","timestamp":1634765386000},"page":"11344","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Lack of Amyloidogenic Activity Is Persistent in Old WT and APPswe\/PS1\u0394E9 Mouse Retinae"],"prefix":"10.3390","volume":"22","author":[{"given":"Sandrine","family":"Joly","sequence":"first","affiliation":[{"name":"Centre de Recherche du CHU de Qu\u00e9bec-Universit\u00e9 Laval and Department of Molecular Medicine, Faculty of Medicine, Universit\u00e9 Laval, Quebec, QC G1V 4G2, Canada"},{"name":"Department of Ophthalmology, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e9a","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Centre de Recherche du CHU de Qu\u00e9bec-Universit\u00e9 Laval and Department of Molecular Medicine, Faculty of Medicine, Universit\u00e9 Laval, Quebec, QC G1V 4G2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Pernet","sequence":"additional","affiliation":[{"name":"Centre de Recherche du CHU de Qu\u00e9bec-Universit\u00e9 Laval and Department of Molecular Medicine, Faculty of Medicine, Universit\u00e9 Laval, Quebec, QC G1V 4G2, Canada"},{"name":"Department of Neurology, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,10,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1097\/01.OPX.0000153162.05903.4C","article-title":"The Glenn A. 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