{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T23:14:08Z","timestamp":1792624448183,"version":"4.5.0"},"reference-count":111,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2021,10,24]],"date-time":"2021-10-24T00:00:00Z","timestamp":1635033600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003130","name":"Research Foundation - Flanders","doi-asserted-by":"publisher","award":["G0B2219N"],"award-info":[{"award-number":["G0B2219N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004040","name":"KU Leuven","doi-asserted-by":"publisher","award":["C14\/18\/086"],"award-info":[{"award-number":["C14\/18\/086"]}],"id":[{"id":"10.13039\/501100004040","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The non-selective cation channel TRPA1 is best known as a broadly-tuned sensor expressed in nociceptive neurons, where it plays key functions in chemo-, thermo-, and mechano-sensing. However, in this review we illustrate how this channel is expressed also in cells of the immune system. TRPA1 has been detected, mainly with biochemical techniques, in eosinophils, mast cells, macrophages, dendritic cells, T cells, and B cells, but not in neutrophils. Functional measurements, in contrast, remain very scarce. No studies have been reported in basophils and NK cells. TRPA1 in immune cells has been linked to arthritis (neutrophils), anaphylaxis and atopic dermatitis (mast cells), atherosclerosis, renal injury, cardiac hypertrophy and inflammatory bowel disease (macrophages), and colitis (T cells). The contribution of TRPA1 to immunity is dual: as detector of cell stress, tissue injury, and exogenous noxious stimuli it leads to defensive responses, but in conditions of aberrant regulation it contributes to the exacerbation of inflammatory conditions. Future studies should aim at characterizing the functional properties of TRPA1 in immune cells, an essential step in understanding its roles in inflammation and its potential as therapeutic target.<\/jats:p>","DOI":"10.3390\/ijms222111460","type":"journal-article","created":{"date-parts":[[2021,10,24]],"date-time":"2021-10-24T22:06:16Z","timestamp":1635113176000},"page":"11460","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":73,"title":["TRPA1 Expression and Pathophysiology in Immune Cells"],"prefix":"10.3390","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1055-327X","authenticated-orcid":false,"given":"Robbe","family":"Naert","sequence":"first","affiliation":[{"name":"Laboratory of Ion Channel Research, Department of Cellular and Molecular Medicine, KU Leuven, VIB Center for Brain & Disease Research, 3000 Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6951-8321","authenticated-orcid":false,"given":"Alejandro","family":"L\u00f3pez-Requena","sequence":"additional","affiliation":[{"name":"Laboratory of Ion Channel Research, Department of Cellular and Molecular Medicine, KU Leuven, VIB Center for Brain & Disease Research, 3000 Leuven, Belgium"},{"name":"Ablynx, Technologiepark 21, 9052 Zwijnaarde, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3124-138X","authenticated-orcid":false,"given":"Karel","family":"Talavera","sequence":"additional","affiliation":[{"name":"Laboratory of Ion Channel Research, Department of Cellular and Molecular Medicine, KU Leuven, VIB Center for Brain & Disease Research, 3000 Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,10,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1038\/nri2152","article-title":"Calcium signalling in lymphocyte activation and disease","volume":"7","author":"Feske","year":"2007","journal-title":"Nat. Rev. Immunol."},{"key":"ref_2","first-page":"143","article-title":"Role of Calcium Signaling in B Cell Activation and Biology","volume":"393","author":"Baba","year":"2016","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/ni1548","article-title":"\u2018Tuning\u2019 of type I interferon-induced Jak-STAT1 signaling by calcium-dependent kinases in macrophages","volume":"9","author":"Wang","year":"2008","journal-title":"Nat. Immunol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.ceca.2019.01.003","article-title":"CRAC channel regulation of innate immune cells in health and disease","volume":"78","author":"Clemens","year":"2019","journal-title":"Cell Calcium"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Nilius, B., and Flockerzi, V. (2014). Preface. Mammalian Transient Receptor Potential (TRP) Cation Channels, Springer.","DOI":"10.1007\/978-3-642-54215-2"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"3529","DOI":"10.1096\/fj.10-178483","article-title":"Dendritic cell maturation and chemotaxis is regulated by TRPM2-mediated lysosomal Ca2+ release","volume":"25","author":"Lange","year":"2011","journal-title":"FASEB J."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1038\/ni.1648","article-title":"The calcium-activated nonselective cation channel TRPM4 is essential for the migration but not the maturation of dendritic cells","volume":"9","author":"Barbet","year":"2008","journal-title":"Nat. Immunol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"eaak9573","DOI":"10.1126\/sciimmunol.aak9573","article-title":"Lysosome signaling controls the migration of dendritic cells","volume":"2","author":"Bretou","year":"2017","journal-title":"Sci. Immunol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1126\/science.1098845","article-title":"TRPM4 regulates calcium oscillations after T cell activation","volume":"306","author":"Launay","year":"2004","journal-title":"Science"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2836","DOI":"10.4049\/jimmunol.1000880","article-title":"Trpm4 differentially regulates Th1 and Th2 function by altering calcium signaling and NFAT localization","volume":"185","author":"Weber","year":"2010","journal-title":"J. Immunol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"7325","DOI":"10.1074\/jbc.274.11.7325","article-title":"An ankyrin-like protein with transmembrane domains is specifically lost after oncogenic transformation of human fibroblasts","volume":"274","author":"Jaquemar","year":"1999","journal-title":"J. Biol. Chem."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1007\/978-3-642-54215-2_23","article-title":"TRPA1","volume":"222","author":"Zygmunt","year":"2014","journal-title":"Handb. Exp. Pharm."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1152\/physrev.00005.2019","article-title":"Mammalian Transient Receptor Potential TRPA1 Channels: From Structure to Disease","volume":"100","author":"Talavera","year":"2020","journal-title":"Physiol. Rev."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1523\/JNEUROSCI.5614-06.2007","article-title":"Emergence of functional sensory subtypes as defined by transient receptor potential channel expression","volume":"27","author":"Alqatari","year":"2007","journal-title":"J. Neurosci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1002\/cne.22238","article-title":"Expression of transient receptor potential ankyrin 1 (TRPA1) in the rat trigeminal sensory afferents and spinal dorsal horn","volume":"518","author":"Kim","year":"2010","journal-title":"J. Comp. Neurol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.cbi.2013.08.012","article-title":"Functional expression of the transient receptor potential channel TRPA1, a sensor for toxic lung inhalants, in pulmonary epithelial cells","volume":"206","author":"Demmel","year":"2013","journal-title":"Chem.-Biol. Interact."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1073\/pnas.1215555110","article-title":"UV light phototransduction activates transient receptor potential A1 ion channels in human melanocytes","volume":"110","author":"Bellono","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1038\/jid.2009.58","article-title":"Non-neuronal expression of transient receptor potential type A1 (TRPA1) in human skin","volume":"129","author":"Atoyan","year":"2009","journal-title":"J. Investig. Dermatol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1146\/annurev.physiol.68.040204.101406","article-title":"Permeation and selectivity of TRP channels","volume":"68","author":"Owsianik","year":"2006","journal-title":"Annu. Rev. Physiol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/S0896-6273(04)00150-3","article-title":"Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin","volume":"41","author":"Bandell","year":"2004","journal-title":"Neuron"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/nature02282","article-title":"Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1","volume":"427","author":"Jordt","year":"2004","journal-title":"Nature"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"12248","DOI":"10.1073\/pnas.0505356102","article-title":"Pungent products from garlic activate the sensory ion channel TRPA1","volume":"102","author":"Bautista","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.cell.2006.02.023","article-title":"TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents","volume":"124","author":"Bautista","year":"2006","journal-title":"Cell"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1172\/JCI34192","article-title":"TRPA1 is a major oxidant sensor in murine airway sensory neurons","volume":"118","author":"Bessac","year":"2008","journal-title":"J. Clin. Invest."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1007\/978-3-319-05161-1_3","article-title":"TRPs as chemosensors (ROS, RNS, RCS, gasotransmitters)","volume":"223","author":"Shimizu","year":"2014","journal-title":"Handb. Exp. Pharm."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/nchembio.146","article-title":"Zinc activates damage-sensing TRPA1 ion channels","volume":"5","author":"Hu","year":"2009","journal-title":"Nat. Chem. Biol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1152\/japplphysiol.01371.2009","article-title":"Heavy metals zinc, cadmium, and copper stimulate pulmonary sensory neurons via direct activation of TRPA1","volume":"108","author":"Gu","year":"2010","journal-title":"J. Appl. Physiol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1186\/1744-8069-9-7","article-title":"Involvement of TRPA1 activation in acute pain induced by cadmium in mice","volume":"9","author":"Miura","year":"2013","journal-title":"Mol. Pain"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"9874","DOI":"10.1523\/JNEUROSCI.2221-07.2007","article-title":"Bimodal action of menthol on the transient receptor potential channel TRPA1","volume":"27","author":"Karashima","year":"2007","journal-title":"J. Neurosci."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1038\/nn.2379","article-title":"Nicotine activates the chemosensory cation channel TRPA1","volume":"12","author":"Talavera","year":"2009","journal-title":"Nat. Neurosci."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1038\/bjp.2008.85","article-title":"Thymol and related alkyl phenols activate the hTRPA1 channel","volume":"153","author":"Lee","year":"2008","journal-title":"Br. J. Pharm."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1097\/ALN.0b013e3181d94e00","article-title":"Pungent general anesthetics activate transient receptor potential-A1 to produce hyperalgesia and neurogenic bronchoconstriction","volume":"112","author":"Eilers","year":"2010","journal-title":"Anesthesiology"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Eberhardt, M., Stueber, T., de la Roche, J., Herzog, C., Leffler, A., Reeh, P.W., and Kistner, K. (2017). TRPA1 and TRPV1 are required for lidocaine-evoked calcium influx and neuropeptide release but not cytotoxicity in mouse sensory neurons. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0188008"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"3125","DOI":"10.1038\/ncomms4125","article-title":"TRPA1 channels mediate acute neurogenic inflammation and pain produced by bacterial endotoxins","volume":"5","author":"Meseguer","year":"2014","journal-title":"Nat. Commun."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"13133","DOI":"10.7554\/eLife.13133","article-title":"Gustatory-mediated avoidance of bacterial lipopolysaccharides via TRPA1 activation in Drosophila","volume":"5","author":"Soldano","year":"2016","journal-title":"eLife"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.ceca.2018.04.004","article-title":"Differential effects of lipopolysaccharide on mouse sensory TRP channels","volume":"73","author":"Boonen","year":"2018","journal-title":"Cell Calcium"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Boonen, B., Alpizar, Y.A., Meseguer, V.M., and Talavera, K. (2018). TRP Channels as Sensors of Bacterial Endotoxins. Toxins, 10.","DOI":"10.3390\/toxins10080326"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Startek, J.B., and Talavera, K. (2020). Lipid Raft Destabilization Impairs Mouse TRPA1 Responses to Cold and Bacterial Lipopolysaccharides. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21113826"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"e46084","DOI":"10.7554\/eLife.46084","article-title":"Mouse TRPA1 function and membrane localization are modulated by direct interactions with cholesterol","volume":"8","author":"Startek","year":"2019","journal-title":"eLife"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/S0092-8674(03)00158-2","article-title":"ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures","volume":"112","author":"Story","year":"2003","journal-title":"Cell"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.brainres.2007.05.047","article-title":"Cold sensitivity of recombinant TRPA1 channels","volume":"1160","author":"Sawada","year":"2007","journal-title":"Brain Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1073\/pnas.0808487106","article-title":"TRPA1 acts as a cold sensor in vitro and in vivo","volume":"106","author":"Karashima","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"16901","DOI":"10.1073\/pnas.1412689111","article-title":"Human TRPA1 is intrinsically cold- and chemosensitive with and without its N-terminal ankyrin repeat domain","volume":"111","author":"Moparthi","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"28763","DOI":"10.1038\/srep28763","article-title":"Human TRPA1 is a heat sensor displaying intrinsic U-shaped thermosensitivity","volume":"6","author":"Moparthi","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.neuron.2006.03.042","article-title":"TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction","volume":"50","author":"Kwan","year":"2006","journal-title":"Neuron"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"102255","DOI":"10.1016\/j.ceca.2020.102255","article-title":"Human TRPA1 is an inherently mechanosensitive bilayer-gated ion channel","volume":"91","author":"Moparthi","year":"2020","journal-title":"Cell Calcium"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"7145","DOI":"10.1074\/jbc.M609600200","article-title":"TRPA1 is differentially modulated by the amphipathic molecules trinitrophenol and chlorpromazine","volume":"282","author":"Hill","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s00424-011-1069-4","article-title":"Primary alcohols activate human TRPA1 channel in a carbon chain length-dependent manner","volume":"463","author":"Komatsu","year":"2012","journal-title":"Eur. J. Physiol."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Startek, J.B., Milici, A., Naert, R., Segal, A., Alpizar, Y.A., Voets, T., and Talavera, K. (2021). The Agonist Action of Alkylphenols on TRPA1 Relates to Their Effects on Membrane Lipid Order: Implications for TRPA1-Mediated Chemosensation. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22073368"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"12010","DOI":"10.1038\/s41598-018-30534-2","article-title":"Differential interactions of bacterial lipopolysaccharides with lipid membranes: Implications for TRPA1-mediated chemosensation","volume":"8","author":"Startek","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Startek, J.B., Boonen, B., Talavera, K., and Meseguer, V. (2019). TRP Channels as Sensors of Chemically-Induced Changes in Cell Membrane Mechanical Properties. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20020371"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"4151","DOI":"10.1113\/JP270935","article-title":"TRPA1 channels: Molecular sentinels of cellular stress and tissue damage","volume":"594","author":"Viana","year":"2016","journal-title":"J. Physiol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/1744-8069-4-48","article-title":"HC-030031, a TRPA1 selective antagonist, attenuates inflammatory- and neuropathy-induced mechanical hypersensitivity","volume":"4","author":"Eid","year":"2008","journal-title":"Mol. Pain"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/1744-8069-3-40","article-title":"A role of TRPA1 in mechanical hyperalgesia is revealed by pharmacological inhibition","volume":"3","author":"Petrus","year":"2007","journal-title":"Mol. Pain"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1016\/j.pain.2011.01.049","article-title":"Selective blockade of TRPA1 channel attenuates pathological pain without altering noxious cold sensation or body temperature regulation","volume":"152","author":"Chen","year":"2011","journal-title":"Pain"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"L\u00f3pez-Requena, A., Boonen, B., Van Gerven, L., Hellings, P.W., Alpizar, Y.A., and Talavera, K. (2017). Roles of Neuronal TRP Channels in Neuroimmune Interactions. Neurobiology of TRP Channels, CRC Press.","DOI":"10.4324\/9781315152837-15"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"9099","DOI":"10.1073\/pnas.0900591106","article-title":"A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthma","volume":"106","author":"Caceres","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1016\/j.cellsig.2005.12.009","article-title":"TRPA1 is a substrate for de-ubiquitination by the tumor suppressor CYLD","volume":"18","author":"Stokes","year":"2006","journal-title":"Cell. Signal."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"53","DOI":"10.3389\/fphar.2017.00053","article-title":"Transient Receptor Potential Ankyrin 1 Channel Expression on Peripheral Blood Leukocytes from Rheumatoid Arthritic Patients and Correlation with Pain and Disability","volume":"8","author":"Pereira","year":"2017","journal-title":"Front. Pharmacol."},{"key":"ref_60","first-page":"69","article-title":"The role of Ca2+ in (-)-menthol-induced human promyelocytic leukemia HL-60 cell death","volume":"20","author":"Lu","year":"2006","journal-title":"In Vivo"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Groot-Kormelink, P.J., Fawcett, L., Wright, P.D., Gosling, M., and Kent, T.C. (2012). Quantitative GPCR and ion channel transcriptomics in primary alveolar macrophages and macrophage surrogates. BMC Immunol., 13.","DOI":"10.1186\/1471-2172-13-57"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"5371","DOI":"10.4049\/jimmunol.1300300","article-title":"TRPA1-dependent pruritus in IL-13-induced chronic atopic dermatitis","volume":"191","author":"Oh","year":"2013","journal-title":"J. Immunol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"245","DOI":"10.4193\/Rhin17.108","article-title":"Upregulation of extraneuronal TRPV1 expression in chronic rhinosinusitis with nasal polyps","volume":"56","author":"Kneif","year":"2018","journal-title":"Rhinology"},{"key":"ref_64","first-page":"94","article-title":"An Exploration of Charge Compensating Ion Channels across the Phagocytic Vacuole of Neutrophils","volume":"8","author":"Foote","year":"2017","journal-title":"Front. Pharmacol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1093\/nar\/30.1.207","article-title":"Gene Expression Omnibus: NCBI gene expression and hybridization array data repository","volume":"30","author":"Edgar","year":"2002","journal-title":"Nucleic Acids Res."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"964","DOI":"10.3389\/fphar.2019.00964","article-title":"TRPA1 Ion Channel Determines Beneficial and Detrimental Effects of GYY4137 in Murine Serum-Transfer Arthritis","volume":"10","author":"Nemes","year":"2019","journal-title":"Front. Pharmacol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.4049\/jimmunol.167.3.1601","article-title":"Essential role of neutrophils in the initiation and progression of a murine model of rheumatoid arthritis","volume":"167","author":"Wipke","year":"2001","journal-title":"J. Immunol."},{"key":"ref_68","first-page":"1","article-title":"Transient receptor potential ankyrin 1 (TRPA1) receptor is involved in chronic arthritis: In vivo study using TRPA1-deficient mice","volume":"18","author":"Boros","year":"2016","journal-title":"Arthritis Res. Ther."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.ceca.2013.02.001","article-title":"Knockout of the Trpc1 gene reveals that TRPC1 can promote recovery from anaphylaxis by negatively regulating mast cell TNF-\u03b1 production","volume":"53","author":"Medic","year":"2013","journal-title":"Cell Calcium"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1007\/s00424-013-1219-y","article-title":"TRPM2 contributes to antigen-stimulated Ca2+ influx in mucosal mast cells","volume":"465","author":"Oda","year":"2013","journal-title":"Eur. J. Physiol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"2959","DOI":"10.4049\/jimmunol.2000149","article-title":"A Rapid Shift from Chronic Hyperoxia to Normoxia Induces Systemic Anaphylaxis via Transient Receptor Potential Ankyrin 1 Channels on Mast Cells","volume":"205","author":"Matsuda","year":"2020","journal-title":"J. Immunol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1016\/j.jaci.2013.12.024","article-title":"IgE-mediated mast cell responses are inhibited by thymol-mediated, activation-induced cell death in skin inflammation","volume":"133","author":"Wechsler","year":"2014","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1164\/rccm.201208-1358OC","article-title":"Crucial role of transient receptor potential ankyrin 1 and mast cells in induction of nonallergic airway hyperreactivity in mice","volume":"187","author":"Hox","year":"2013","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"5024","DOI":"10.4049\/jimmunol.181.7.5024","article-title":"Secretogranin III directs secretory vesicle biogenesis in mast cells in a manner dependent upon interaction with chromogranin A","volume":"181","author":"Prasad","year":"2008","journal-title":"J. Immunol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"e13166","DOI":"10.14814\/phy2.13166","article-title":"Orai and TRPC channel characterization in Fc \u03b5 RI-mediated calcium signaling and mediator secretion in human mast cells","volume":"5","author":"Wajdner","year":"2017","journal-title":"Physiol. Rep."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-019-55133-7","article-title":"Validation of antibodies for the specific detection of human TRPA1","volume":"9","author":"Virk","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.ejphar.2013.07.029","article-title":"Mechanisms involved in abdominal nociception induced by either TRPV1 or TRPA1 stimulation of rat peritoneum","volume":"714","author":"Trevisan","year":"2013","journal-title":"Eur. J. Pharmacol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.bbrc.2011.11.014","article-title":"Suppression of phospholipase C\u03b31 phosphorylation by cinnamaldehyde inhibits antigen-induced extracellular calcium influx and degranulation in mucosal mast cells","volume":"416","author":"Wang","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1097\/ACI.0b013e3283036a90","article-title":"Understanding the mechanisms of anaphylaxis","volume":"8","author":"Peavy","year":"2008","journal-title":"Curr. Opin. Allergy Clin. Immunol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/S0140-6736(15)00149-X","article-title":"Atopic dermatitis","volume":"387","author":"Weidinger","year":"2016","journal-title":"Lancet"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/bph.12120","article-title":"The cannabinoid TRPA1 agonist cannabichromene inhibits nitric oxide production in macrophages and ameliorates murine colitis","volume":"169","author":"Romano","year":"2013","journal-title":"Br. J. Pharmacol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.phrs.2016.07.045","article-title":"Pure \u0394 9-tetrahydrocannabivarin and a Cannabis sativa extract with high content in \u0394 9-tetrahydrocannabivarin inhibit nitrite production in murine peritoneal macrophages","volume":"113","author":"Romano","year":"2016","journal-title":"Pharmacol. Res."},{"key":"ref_83","first-page":"1","article-title":"Schwann cell TRPA1 mediates neuroinflammation that sustains macrophage-dependent neuropathic pain in mice","volume":"8","author":"Nassini","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Kun, J., Szitter, I., Kem\u00e9ny, A., Perkecz, A., Kereskai, L., Poh\u00f3czky, K., Vincze, A., G\u00f3di, S., Szab\u00f3, I., and Szolcs\u00e1nyi, J. (2014). Upregulation of the transient receptor potential ankyrin 1 ion channel in the inflamed human and mouse colon and its protective roles. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0108164"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"812","DOI":"10.7150\/ijbs.15229","article-title":"Transient Receptor Potential Ankyrin 1 Channel Involved in Atherosclerosis and Macrophage-Foam Cell Formation","volume":"12","author":"Zhao","year":"2016","journal-title":"Int. J. Biol. Sci."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1136\/thoraxjnl-2014-205467","article-title":"Role of transient receptor potential and pannexin channels in cigarette smoke-triggered ATP release in the lung","volume":"69","author":"Baxter","year":"2014","journal-title":"Thorax"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.surg.2015.03.065","article-title":"TRPA1 mediates the effects of hypothermia on the monocyte inflammatory response","volume":"158","author":"Billeter","year":"2015","journal-title":"Surgery"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1016\/j.febslet.2013.03.027","article-title":"Transient receptor potential vanilloid-2 mediates the effects of transient heat shock on endocytosis of human monocyte-derived dendritic cells","volume":"587","author":"Papp","year":"2013","journal-title":"FEBS Lett."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s11010-020-03818-3","article-title":"Transient receptor potential ankyrin 1 contributes to the ATP-elicited oxidative stress and inflammation in THP-1-derived macrophage","volume":"473","author":"Tian","year":"2020","journal-title":"Mol. Cell. Biochem."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1600474","DOI":"10.1002\/mnfr.201600474","article-title":"Nonivamide, a capsaicin analogue, exhibits anti-inflammatory properties in peripheral blood mononuclear cells and U-937 macrophages","volume":"61","author":"Walker","year":"2017","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1744806917705564","DOI":"10.1177\/1744806917705564","article-title":"Local upregulation of transient receptor potential ankyrin 1 and transient receptor potential vanilloid 1 ion channels in rectosigmoid deep infiltrating endometriosis","volume":"13","author":"Bohonyi","year":"2017","journal-title":"Mol. Pain"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/odi.12593","article-title":"TRPA1 receptor is upregulated in human oral lichen planus","volume":"23","author":"Kun","year":"2017","journal-title":"Oral Dis."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.fct.2007.07.016","article-title":"Cinnamaldehyde inhibits pro-inflammatory cytokines secretion from monocytes\/macrophages through suppression of intracellular signaling","volume":"46","author":"Chao","year":"2008","journal-title":"Food Chem. Toxicol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1165\/rcmb.2007-0130OC","article-title":"Alpha,beta-unsaturated aldehydes in cigarette smoke release inflammatory mediators from human macrophages","volume":"37","author":"Facchinetti","year":"2007","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"7700","DOI":"10.1021\/jf020751f","article-title":"Suppression effect of Cinnamomum cassia bark-derived component on nitric oxide synthase","volume":"50","author":"Lee","year":"2002","journal-title":"J. Agric. Food Chem."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S0024-3205(02)01685-5","article-title":"Effect of naturally occurring organosulfur compounds on nitric oxide production in lipopolysaccharide-activated macrophages","volume":"71","author":"Ippoushi","year":"2002","journal-title":"Life Sci."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.cell.2011.04.005","article-title":"Macrophages in the pathogenesis of atherosclerosis","volume":"145","author":"Moore","year":"2011","journal-title":"Cell"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.atherosclerosis.2020.04.004","article-title":"TRPA1 regulates macrophages phenotype plasticity and atherosclerosis progression","volume":"301","author":"Wang","year":"2020","journal-title":"Atherosclerosis"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s00232-019-00104-2","article-title":"Transient Receptor Potential Ankyrin 1 Contributes to Lysophosphatidylcholine-Induced Intracellular Calcium Regulation and THP-1-Derived Macrophage Activation","volume":"253","author":"Tian","year":"2020","journal-title":"J. Membr. Biol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"F623","DOI":"10.1152\/ajprenal.00069.2019","article-title":"Knockout of TRPA1 exacerbates angiotensin II-induced kidney injury","volume":"317","author":"Ma","year":"2019","journal-title":"Am. J. Physiol.-Ren. Physiol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1093\/ajh\/hpaa162","article-title":"Knockout of Trpa1 Exacerbates Renal Ischemia-Reperfusion Injury with Classical Activation of Macrophages","volume":"34","author":"Ma","year":"2021","journal-title":"Am. J. Hypertens."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.ebiom.2018.08.022","article-title":"TRPA1 inhibition ameliorates pressure overload-induced cardiac hypertrophy and fibrosis in mice","volume":"36","author":"Wang","year":"2018","journal-title":"EBioMedicine"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1097\/MIB.0b013e3182a69dca","article-title":"The role of macrophages and dendritic cells in the initiation of inflammation in IBD","volume":"20","author":"Steinbach","year":"2014","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1136\/gutjnl-2015-310710","article-title":"The TRPA1 ion channel is expressed in CD4+ T cells and restrains T-cell-mediated colitis through inhibition of TRPV1","volume":"66","author":"Bertin","year":"2017","journal-title":"Gut"},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Naert, R., L\u00f3pez-Requena, A., Voets, T., Talavera, K., and Alpizar, Y.A. (2019). Expression and Functional Role of TRPV4 in Bone Marrow-Derived CD11c + Cells. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20143378"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"BSR20191437","DOI":"10.1042\/BSR20191437","article-title":"Transient receptor potential ankyrin1 channel is endogenously expressed in T cells and is involved in immune functions","volume":"39","author":"Sahoo","year":"2019","journal-title":"Biosci. Rep."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1080\/09273948.2016.1231330","article-title":"TRPV1 Antagonist Suppresses Allergic Conjunctivitis in a Murine Model","volume":"26","author":"Kwon","year":"2018","journal-title":"Ocul. Immunol. Inflamm."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1016\/j.jid.2018.02.040","article-title":"TRPA1 Acts in a Protective Manner in Imiquimod-Induced Psoriasiform Dermatitis in Mice","volume":"138","author":"Kodji","year":"2018","journal-title":"J. Investig. Dermatol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1189\/jlb.1RI0614-293R","article-title":"The signaling symphony: T cell receptor tunes cytokine-mediated T cell differentiation","volume":"97","author":"Huang","year":"2015","journal-title":"J. Leukoc. Biol."},{"key":"ref_110","unstructured":"Glenmark Pharmaceuticals, S.A. (2012). A Phase II, 4 Week Randomized, Double-Blind, Parallel Group, Placebo Controlled Proof of Concept Study to Evaluate Efficacy, Safety and Tolerability of GRC 17536 in Patients with Painful Diabetic Neuropathy, Glenmark Pharmaceuticals S.A."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1007\/s00424-020-02397-y","article-title":"TRPA1 gene variants hurting our feelings","volume":"472","author":"Naert","year":"2020","journal-title":"Eur. J. Physiol."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/22\/21\/11460\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:22:22Z","timestamp":1760167342000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/22\/21\/11460"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,24]]},"references-count":111,"journal-issue":{"issue":"21","published-online":{"date-parts":[[2021,11]]}},"alternative-id":["ijms222111460"],"URL":"https:\/\/doi.org\/10.3390\/ijms222111460","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,24]]}}}