{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T15:23:50Z","timestamp":1790522630743,"version":"4.1.0"},"reference-count":273,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2021,10,24]],"date-time":"2021-10-24T00:00:00Z","timestamp":1635033600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The neurons secreting oxytocin (OXY) and vasopressin (AVP) are located mainly in the supraoptic, paraventricular, and suprachiasmatic nucleus of the brain. Oxytocinergic and vasopressinergic projections reach several regions of the brain and the spinal cord. Both peptides are released from axons, soma, and dendrites and modulate the excitability of other neuroregulatory pathways. The synthesis and action of OXY and AVP in the peripheral organs (eye, heart, gastrointestinal system) is being investigated. The secretion of OXY and AVP is influenced by changes in body fluid osmolality, blood volume, blood pressure, hypoxia, and stress. Vasopressin interacts with three subtypes of receptors: V1aR, V1bR, and V2R whereas oxytocin activates its own OXTR and V1aR receptors. AVP and OXY receptors are present in several regions of the brain (cortex, hypothalamus, pons, medulla, and cerebellum) and in the peripheral organs (heart, lungs, carotid bodies, kidneys, adrenal glands, pancreas, gastrointestinal tract, ovaries, uterus, thymus). Hypertension, myocardial infarction, and coexisting factors, such as pain and stress, have a significant impact on the secretion of oxytocin and vasopressin and on the expression of their receptors. The inappropriate regulation of oxytocin and vasopressin secretion during ischemia, hypoxia\/hypercapnia, inflammation, pain, and stress may play a significant role in the pathogenesis of cardiovascular diseases.<\/jats:p>","DOI":"10.3390\/ijms222111465","type":"journal-article","created":{"date-parts":[[2021,10,24]],"date-time":"2021-10-24T22:06:16Z","timestamp":1635113176000},"page":"11465","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Complementary Role of Oxytocin and Vasopressin in Cardiovascular Regulation"],"prefix":"10.3390","volume":"22","author":[{"given":"Ewa","family":"Szczepanska-Sadowska","sequence":"first","affiliation":[{"name":"Laboratory of Centre for Preclinical Research, Chair and Department of Experimental and Clinical Physiology, Medical University of Warsaw, 02-091 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7221-8103","authenticated-orcid":false,"given":"Agnieszka","family":"Wsol","sequence":"additional","affiliation":[{"name":"Laboratory of Centre for Preclinical Research, Chair and Department of Experimental and Clinical Physiology, Medical University of Warsaw, 02-091 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3872-291X","authenticated-orcid":false,"given":"Agnieszka","family":"Cudnoch-Jedrzejewska","sequence":"additional","affiliation":[{"name":"Laboratory of Centre for Preclinical Research, Chair and Department of Experimental and Clinical Physiology, Medical University of Warsaw, 02-091 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3535-715X","authenticated-orcid":false,"given":"Tymoteusz","family":"\u017bera","sequence":"additional","affiliation":[{"name":"Laboratory of Centre for Preclinical Research, Chair and Department of Experimental and Clinical Physiology, Medical University of Warsaw, 02-091 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,10,24]]},"reference":[{"key":"ref_1","first-page":"40","article-title":"Chemistry of the Neurohypophysial Hormones","volume":"Volume 23","author":"Boissonnas","year":"1968","journal-title":"Handbook of Experimental Pharmakologie"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.biopsych.2015.08.008","article-title":"Oxytocin pathway genes: Evolutionary ancient system impacting on human affiliation, sociality, and psychopathology","volume":"79","author":"Feldman","year":"2016","journal-title":"Biol. Psychiatry"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1152\/physrev.2001.81.2.629","article-title":"The oxytocin receptor system: Structure, function, and regulation","volume":"81","author":"Gimpl","year":"2001","journal-title":"Physiol. Rev."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1113\/expphysiol.2013.072561","article-title":"Physiology of invertebrate oxytocin and vasopressin neuropeptides","volume":"99","author":"Gruber","year":"2014","journal-title":"Exp. Physiol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1111\/j.1365-2826.2010.01989.x","article-title":"Performance, properties and plasticity of identified oxytocin and vasopressin neurones in vitro","volume":"22","author":"Armstrong","year":"2010","journal-title":"J. Neuroendocrinol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.neuroscience.2013.08.048","article-title":"Immunohistochemical localization of oxytocin receptors in human brain","volume":"253","author":"Boccia","year":"2013","journal-title":"Neuroscience"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/BF00224932","article-title":"Intra- and extrahypothalamic vasopressin and oxytocin pathways in the rat. Pathways to the limbic system, medulla oblongata and spinal cord","volume":"192","author":"Buijs","year":"1978","journal-title":"Cell Tissue Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"T173","DOI":"10.1530\/JOE-15-0087","article-title":"60 YEARS OF NEUROENDOCRINOLOGY: The posterior pituitary, from Geoffrey Harris to our present understanding","volume":"226","author":"Leng","year":"2015","journal-title":"J. Endocrinol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1016\/0300-9084(88)90185-X","article-title":"Structure, processing and evolution of the neurohypophysial hormone-neurophysin precursors","volume":"70","author":"Acher","year":"1988","journal-title":"Biochimie"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1373\/clinchem.2005.060038","article-title":"Assay for the measurement of copeptin, a stable peptide derived from the precursor of vasopressin","volume":"52","author":"Morgenthaler","year":"2006","journal-title":"Clin. Chem."},{"key":"ref_11","first-page":"10","article-title":"The role of copeptin as a diagnostic and prognostic biomarker for risk stratification in the emergency department","volume":"20","author":"Nickel","year":"2012","journal-title":"BMC Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"614145","DOI":"10.1155\/2015\/614145","article-title":"Copeptin testing in acute myocardial infarction: Ready for routine use?","volume":"2015","author":"Reinstadler","year":"2015","journal-title":"Dis. Markers"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1007\/s12264-017-0120-7","article-title":"Genes Related to Oxytocin and Arginine-Vasopressin Pathways: Associations with Autism Spectrum Disorders","volume":"33","author":"Zhang","year":"2017","journal-title":"Neurosci. Bull."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1111\/joim.12645","article-title":"Vasopressin: Physiology, assessment and osmosensation","volume":"282","author":"Bankir","year":"2017","journal-title":"J. Intern Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1159\/000446200","article-title":"Vasopressin at central levels and consequences of dehydration","volume":"68","author":"Bichet","year":"2016","journal-title":"Ann. Nutr. Metab."},{"key":"ref_16","first-page":"1","article-title":"Neurohypophysis. Structure and Function","volume":"Volume 23","author":"Bergmann","year":"1968","journal-title":"Handbook of Experimental Pharmakologie"},{"key":"ref_17","first-page":"15","article-title":"Tests of posterior pituitary function","volume":"26","author":"Ball","year":"2003","journal-title":"J. Endocrinol. Investig."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"R452","DOI":"10.1152\/ajpregu.00217.2010","article-title":"Oxytocin release in magnocellular nuclei: Neurochemical mediators and functional significance during gestation","volume":"299","author":"Bealer","year":"2010","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1093\/ckj\/sfu050","article-title":"Central vasopressin: Dendritic and axonal secretion and renal actions","volume":"7","author":"Bichet","year":"2014","journal-title":"Clin. Kidney J."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s11302-013-9396-x","article-title":"Purinergic signalling in endocrine organs","volume":"10","author":"Burnstock","year":"2014","journal-title":"Purinergic. Signal."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2726","DOI":"10.1523\/JNEUROSCI.23-07-02726.2003","article-title":"Somatodendritic secretion in oxytocin neurons is upregulated during the female reproductive cycle","volume":"23","author":"Wierda","year":"2003","journal-title":"J. Neurosci."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0169-328X(03)00137-2","article-title":"Local synthesis of the rat Vasopressin precursor in dendrites of in vitro cultured nerve cells","volume":"114","author":"Mohr","year":"2003","journal-title":"Brain Res. Mol. Brain Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1590\/S0100-879X2002000900011","article-title":"Nitrergic modulation of vasopressin, oxytocin and atrial natriuretic peptide secretion in response to sodium intake and hypertonic blood volume expansion","volume":"35","author":"Ventura","year":"2002","journal-title":"Braz. J. Med. Biol. Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1080\/17470919.2016.1156570","article-title":"Selective localization of oxytocin receptors and vasopressin 1a receptors in the human brainstem","volume":"12","author":"Freeman","year":"2017","journal-title":"Soc. Neurosci."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Freeman, S.M., and Young, L.J. (2016). Comparative Perspectives on Oxytocin and Vasopressin Receptor Research in Rodents and Primates: Translational Implications. J. Neuroendocrinol., 28.","DOI":"10.1111\/jne.12382"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/0006-8993(82)90745-4","article-title":"The influence of the paraventriculo-spinal pathway, and oxytocin and vasopressin on sympathetic preganglionic neurones","volume":"251","author":"Gilbey","year":"1982","journal-title":"Brain Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"H1549","DOI":"10.1152\/ajpheart.00808.2015","article-title":"Oxytocin neuron activation prevents hypertension that occurs with chronic intermittent hypoxia\/hypercapnia in rats","volume":"310","author":"Jameson","year":"2016","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1007\/s002210050717","article-title":"Terminals of paraventricular spinal neurones are closely associated with adrenal medullary sympathetic preganglionic neurones: Immunocytochemical evidence for vasopressin as a possible neurotransmitter in this pathway","volume":"126","author":"Motawei","year":"1999","journal-title":"Exp. Brain Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1111\/j.1365-2826.2011.02241.x","article-title":"The hypothalamic-neurohypophyseal system: From genome to physiology","volume":"24","author":"Murphy","year":"2012","journal-title":"J. Neuroendocrinol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/0006-8993(85)90630-4","article-title":"Vasopressin-mediated slow EPSPs in a mammalian sympathetic ganglion","volume":"339","author":"Peters","year":"1985","journal-title":"Brain Res."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Pi\u00f1ol, R.A., Jameson, H., Popratiloff, A., Lee, N.H., and Mendelowitz, D. (2014). Visualization of oxytocin release that mediates paired pulse facilitation in hypothalamic pathways to brainstem autonomic neurons. PLoS ONE., 9.","DOI":"10.1371\/journal.pone.0112138"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"e22875","DOI":"10.1002\/ajp.22875","article-title":"Oxytocin- and arginine vasopressin-containing fibers in the cortex of humans, chimpanzees, and rhesus macaques","volume":"80","author":"Rogers","year":"2018","journal-title":"Am. J. Primatol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1046\/j.1365-2826.1999.00332.x","article-title":"Localization of vasopressin (V1a) receptor binding and mRNA in the rhesus monkey brain","volume":"11","author":"Young","year":"1999","journal-title":"J. Neuroendocrinol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"11704","DOI":"10.1073\/pnas.94.21.11704","article-title":"Oxytocin releases atrial natriuretic peptide by combining with oxytocin receptors in the heart","volume":"94","author":"Gutkowska","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"14558","DOI":"10.1073\/pnas.95.24.14558","article-title":"Rat heart: A site of oxytocin production and action","volume":"95","author":"Jankowski","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.peptides.2017.12.019","article-title":"Oxytocin is present in islets and plays a role in beta-cell function and survival","volume":"100","author":"Mohan","year":"2018","journal-title":"Peptides"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1159\/000108655","article-title":"Vasopressin receptor mRNA expression in the human gastrointestinal tract","volume":"40","author":"Monstein","year":"2008","journal-title":"Eur. Surg. Res."},{"key":"ref_38","first-page":"3254","article-title":"Endogenous arginine vasopressin-positive retinal cells in arginine vasopressin-eGFP transgenic rats identified by immunohistochemistry and reverse transcriptase-polymerase chain reaction","volume":"17","author":"Moritoh","year":"2011","journal-title":"Mol. Vis."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1161\/01.RES.66.3.710","article-title":"Attenuation of vasopressin-mediated coronary constriction and myocardial depression in the hypoxic heart","volume":"66","author":"Boyle","year":"1990","journal-title":"Circ. Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"R982","DOI":"10.1152\/ajpregu.00543.2016","article-title":"Acute hypoxia activates neuroendocrine, but not presympathetic, neurons in the paraventricular nucleus of the hypothalamus: Differential role of nitric oxide","volume":"312","author":"Coldren","year":"2017","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1590\/S0100-879X2000001000001","article-title":"Role of the hypothalamic pituitary adrenal axis in the control of the response to stress and infection","volume":"33","author":"McCann","year":"2000","journal-title":"Braz. J. Med. Biol. Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"R1167","DOI":"10.1152\/ajpregu.00244.2018","article-title":"Hypoxia activates a neuropeptidergic pathway from the paraventricular nucleus of the hypothalamus to the nucleus tractus solitarii","volume":"315","author":"Ruyle","year":"2018","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"R59","DOI":"10.1152\/ajpregu.00772.2005","article-title":"Intravenous 6-hydroxydopamine attenuates vasopressin and oxytocin secretion stimulated by hemorrhage and hypotension but not hyperosmolality in rats","volume":"291","author":"Stocker","year":"2006","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s11906-018-0823-9","article-title":"Dysregulation of the Renin-Angiotensin System and the Vasopressinergic System Interactions in Cardiovascular Disorders","volume":"20","author":"Czarzasta","year":"2018","journal-title":"Curr. Hypertens. Rep."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"306","DOI":"10.2174\/1389200218666170119145900","article-title":"Vasopressin and Related Peptides; Potential Value in Diagnosis, Prognosis and Treatment of Clinical Disorders","volume":"18","author":"Zera","year":"2017","journal-title":"Curr. Drug Metab."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1254\/jphs.08R15FM","article-title":"New topics in vasopressin receptors and approach to novel drugs: Effects of vasopressin receptor on regulations of hormone secretion and metabolisms of glucose, fat, and protein","volume":"109","author":"Tanoue","year":"2009","journal-title":"J. Pharmacol. Sci."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.yhbeh.2011.12.014","article-title":"The contributions of oxytocin and vasopressin pathway genes to human behavior","volume":"61","author":"Ebstein","year":"2012","journal-title":"Horm. Behav."},{"key":"ref_48","first-page":"815","article-title":"Serotonergic involvement in stress-induced vasopressin and oxytocin secretion","volume":"147","author":"Knigge","year":"2002","journal-title":"Eur. J. Endocrinol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0079-6123(08)00412-3","article-title":"Endogenous modulators of synaptic transmission: Cannabinoid regulation in the supraoptic nucleus","volume":"170","author":"McDonald","year":"2008","journal-title":"Prog. Brain Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1111\/j.1365-2826.2011.02268.x","article-title":"Diverse roles of G-protein coupled receptors in the regulation of neurohypophyseal hormone secretion","volume":"24","author":"Sladek","year":"2012","journal-title":"J. Neuroendocrinol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.neuron.2012.09.025","article-title":"Neuromodulation by oxytocin and vasopressin","volume":"76","author":"Stoop","year":"2012","journal-title":"Neuron"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1210\/er.2009-0009","article-title":"The effects of opioids and opioid analogs on animal and human endocrine systems","volume":"31","author":"Vuong","year":"2010","journal-title":"Endocr. Rev."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"3071","DOI":"10.2174\/138161210793292474","article-title":"Ligand-based peptide design and combinatorial peptide libraries to target G protein-coupled receptors","volume":"16","author":"Gruber","year":"2010","journal-title":"Curr. Pharm. Des."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"8772","DOI":"10.1074\/jbc.271.15.8772","article-title":"Different single receptor domains determine the distinct G protein coupling profiles of members of the vasopressin receptor family","volume":"271","author":"Liu","year":"1996","journal-title":"J. Biol. Chem."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/j.1749-6632.1995.tb44688.x","article-title":"Molecular biology of vasopressin receptors","volume":"771","author":"Lolait","year":"1995","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"8048","DOI":"10.1128\/MCB.24.18.8048-8054.2004","article-title":"Heterotrimeric G proteins of the Gq\/11 family are crucial for the induction of maternal behavior in mice","volume":"24","author":"Wettschureck","year":"2004","journal-title":"Mol. Cell Biol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"6129","DOI":"10.1096\/fj.201902982R","article-title":"PKA-independent vasopressin signaling in renal collecting duct","volume":"34","author":"Datta","year":"2020","journal-title":"FASEB J."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"F931","DOI":"10.1152\/ajprenal.00604.2013","article-title":"The physiological and pathophysiological functions of renal and extrarenal vasopressin V2 receptors","volume":"306","author":"Juul","year":"2014","journal-title":"Am. J. Physiol. Renal. Physiol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1002\/ajmg.1320600303","article-title":"Polymorphism and genetic mapping of the human oxytocin receptor gene on chromosome 3","volume":"60","author":"Michelini","year":"1995","journal-title":"Am. J. Med. Genet."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1006\/geno.1996.0055","article-title":"Structure, sequence, expression, and chromosomal localization of the human V1a vasopressin receptor gene","volume":"31","author":"Thibonnier","year":"1996","journal-title":"Genomics"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1093\/hmg\/2.10.1746-a","article-title":"A polymorphism in the coding region of the vasopressin type 2 receptor (AVPR2) gene","volume":"2","author":"Friedman","year":"1993","journal-title":"Hum. Mol. Genet."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1006\/jmcc.2000.1108","article-title":"Study of V(1)-vascular vasopressin receptor gene microsatellite polymorphisms in human essential hypertension","volume":"32","author":"Thibonnier","year":"2000","journal-title":"J. Mol. Cell Cardiol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"380","DOI":"10.3389\/fpsyt.2019.00380","article-title":"Systematic Review of Literature on Single-Nucleotide Polymorphisms Within the Oxytocin and Vasopressin Receptor Genes in the Development of Social Cognition Dysfunctions in Individuals Suffering From Autism Spectrum Disorder","volume":"10","author":"Siwiec","year":"2019","journal-title":"Front. Psychiatry"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1615\/CritRevNeurobiol.v10.i1.60","article-title":"Vasopressin and oxytocin receptors in the central nervous system","volume":"10","author":"Barberis","year":"1996","journal-title":"Crit. Rev. Neurobiol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"919","DOI":"10.3389\/fnins.2018.00919","article-title":"Dynamic Modulation of Mouse Locus Coeruleus Neurons by Vasopressin 1a and 1b Receptors","volume":"12","author":"Kelly","year":"2018","journal-title":"Front. Neurosci."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/S0361-9230(02)00943-7","article-title":"Differential expression of vasopressin V1a and V1b receptors mRNA in the brain of renin transgenic TGR(mRen2)27 and Sprague-Dawley rats","volume":"59","author":"Kumosa","year":"2003","journal-title":"Brain Res. Bull."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"3303","DOI":"10.1113\/JP274178","article-title":"Vasopressin V1a receptors mediate the hypertensive effects of [Pyr(1)]apelin-13 in the rat rostral ventrolateral medulla","volume":"595","author":"Griffiths","year":"2017","journal-title":"J. Physiol."},{"key":"ref_68","first-page":"725","article-title":"Altered expression of angiotensin AT1a and vasopressin V1a receptors and nitric oxide synthase mRNA in the brain of rats with renovascular hypertension","volume":"55","author":"Jackiewicz","year":"2004","journal-title":"J. Physiol. Pharmacol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"6783","DOI":"10.1073\/pnas.92.15.6783","article-title":"Extrapituitary expression of the rat V1b vasopressin receptor gene","volume":"92","author":"Lolait","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1210\/endo.131.1.1535312","article-title":"Distribution of V1a and V2 vasopressin receptor messenger ribonucleic acids in rat liver, kidney, pituitary and brain","volume":"131","author":"Ostrowski","year":"1992","journal-title":"Endocrinology"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"5015","DOI":"10.1210\/endo.139.12.6382","article-title":"Comparative distribution of vasopressin V1b and oxytocin receptor messenger ribonucleic acids in brain","volume":"139","author":"Vaccari","year":"1998","journal-title":"Endocrinology"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/j.neuroscience.2006.08.040","article-title":"The vasopressin 1b receptor is prominent in the hippocampal area CA2 where it is unaffected by restraint stress or adrenalectomy","volume":"143","author":"Young","year":"2006","journal-title":"Neuroscience"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"H2262","DOI":"10.1152\/ajpheart.01320.2006","article-title":"Functional arginine vasopressin system in early heart maturation","volume":"293","author":"Gutkowska","year":"2007","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/0006-8993(88)90108-4","article-title":"Vasopressin-stimulated turnover of phosphatidylinositol in the decentralised superior cervical ganglion of the rat","volume":"455","author":"Horn","year":"1988","journal-title":"Brain Res."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"5335","DOI":"10.1073\/pnas.83.14.5335","article-title":"Biochemical and electrophysiological evidence of functional vasopressin receptors in the rat superior cervical ganglion","volume":"83","author":"Kiraly","year":"1986","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_76","first-page":"805","article-title":"Expression of heart oxytocin receptor and its mRNA in two rat strains with different activity of HPA axis","volume":"32","author":"Klenerova","year":"2011","journal-title":"Neuro Endocrinol. Lett."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"3065","DOI":"10.1111\/bph.12635","article-title":"Oxytocin inhibits the activity of acid-sensing ion channels through the vasopressin, V1A receptor in primary sensory neurons","volume":"171","author":"Qiu","year":"2014","journal-title":"Br. J. Pharmacol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.peptides.2018.03.004","article-title":"Vasopressin V1a receptors are present in the carotid body and contribute to the control of breathing in male Sprague-Dawley rats","volume":"102","author":"Zera","year":"2018","journal-title":"Peptides"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1002\/nau.23830","article-title":"Aging increases the expression of vasopressin receptors in both the kidney and urinary bladder","volume":"38","author":"Birder","year":"2019","journal-title":"Neurourol. Urodyn."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/B978-0-12-820683-6.00017-8","article-title":"Differential diagnosis of familial diabetes insipidus","volume":"181","author":"Robertson","year":"2021","journal-title":"Handb. Clin. Neurol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"4057","DOI":"10.1039\/D0SC05501H","article-title":"Nature-inspired dimerization as a strategy to modulate neuropeptide pharmacology exemplified with vasopressin and oxytocin","volume":"12","author":"Dekan","year":"2021","journal-title":"Chem. Sci."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1111\/j.0953-8194.2004.01188.x","article-title":"Homo- and hetero-dimeric complex formations of the human oxytocin receptor","volume":"16","author":"Devost","year":"2004","journal-title":"J. Neuroendocrinol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.mce.2017.01.034","article-title":"Advances in the role of oxytocin receptors in human parturition","volume":"449","author":"Kim","year":"2017","journal-title":"Mol. Cell Endocrinol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1210\/me.2011-1202","article-title":"V1b and CRHR1 receptor heterodimerization mediates synergistic biological actions of vasopressin and CRH","volume":"26","author":"Murat","year":"2012","journal-title":"Mol. Endocrinol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1210\/me.2002-0222","article-title":"Oxytocin and vasopressin V1a and V2 receptors form constitutive homo- and heterodimers during biosynthesis","volume":"17","author":"Terrillon","year":"2003","journal-title":"Mol. Endocrinol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1017\/S0022029917000097","article-title":"Molecular characterisation, genetic variability and detection of a functional polymorphism influencing the promoter activity of OXT gene in goat and sheep","volume":"84","author":"Cosenza","year":"2017","journal-title":"J. Dairy Res."},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Pauciullo, A., Ogah, D.M., Iannaccone, M., Erhardt, G., Di Stasio, L., and Cosenza, G. (2018). Genetic characterization of the oxytocin-neurophysin I gene (OXT) and its regulatory regions analysis in domestic Old and New World camelids. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0195407"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"10236","DOI":"10.1016\/S0021-9258(17)39236-0","article-title":"The human vasopressin gene is linked to the oxytocin gene and is selectively expressed in a cultured lung cancer cell line","volume":"260","author":"Sausville","year":"1985","journal-title":"J. Biol. Chem."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/0306-4522(89)90091-2","article-title":"Dendrites of hypothalamic magnocellular neurons release neurohypophysial peptides by exocytosis","volume":"32","author":"Pow","year":"1989","journal-title":"Neuroscience"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1111\/jne.12112","article-title":"Annexin A1 complex mediates oxytocin vesicle transport","volume":"25","author":"Makani","year":"2013","journal-title":"J. Neuroendocrinol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s00441-018-2960-5","article-title":"Diversity of central oxytocinergic projections","volume":"375","author":"Jirikowski","year":"2019","journal-title":"Cell Tissue Res."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1146\/annurev.ne.17.030194.001251","article-title":"Synaptic vesicles and exocytosis","volume":"17","author":"Jahn","year":"1994","journal-title":"Annu. Rev. Neurosci."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0166-2236(92)90053-B","article-title":"Distribution and functional significance of the Ptype, voltage-dependent Ca2+ channels in the mammalian central nervous system","volume":"15","author":"Sugimori","year":"1992","journal-title":"Trends Neurosci."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.tem.2005.02.002","article-title":"Ca2+-regulated exocytosis and SNARE function","volume":"16","author":"Stojilkovic","year":"2005","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1111\/j.1365-2826.2011.02237.x","article-title":"Expression of exocytosis proteins in rat supraoptic nucleus neurones","volume":"24","author":"Tobin","year":"2012","journal-title":"J. Neuroendocrinol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1038\/nature23484","article-title":"The primed SNARE-complexin-synaptotagmin complex for neuronal exocytosis","volume":"548","author":"Zhou","year":"2017","journal-title":"Nature"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/S0166-2236(96)10034-5","article-title":"Calcium-channel subtypes in the somata and axon terminals of magnocellular neurosecretory cells","volume":"19","author":"Fisher","year":"1996","journal-title":"Trends Neurosci."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1152\/jn.1996.76.2.977","article-title":"Pharmacological dissection of high-voltage-activated Ca2+ current types in acutely dissociated rat supraoptic magnocellular neurons","volume":"76","author":"Foehring","year":"1996","journal-title":"J. Neurophysiol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/0006-8993(92)90685-3","article-title":"Does the release of vasopressin within the supraoptic nucleus of the rat brain depend upon changes in osmolality and Ca2+\/K+?","volume":"576","author":"Ludwig","year":"1992","journal-title":"Brain Res."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"e12856","DOI":"10.1111\/jne.12856","article-title":"Somato-dendritic vasopressin and oxytocin secretion in endocrine and autonomic regulation","volume":"32","author":"Brown","year":"2020","journal-title":"J. Neuroendocrinol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1002\/cne.903410405","article-title":"Noradrenergic innervation of vasopressin- and oxytocin-containing neurons in the hypothalamic paraventricular nucleus of the macaque monkey: Quantitative analysis using double-label immunohistochemistry and confocal laser microscopy","volume":"341","author":"Ginsberg","year":"1994","journal-title":"J. Comp. Neurol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1006\/frne.2001.0226","article-title":"Oxytocin-secreting neurons: A physiological model of morphological neuronal and glial plasticity in the adult hypothalamus","volume":"23","author":"Theodosis","year":"2002","journal-title":"Front. Neuroendocrinol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"6207","DOI":"10.1073\/pnas.110137497","article-title":"Oxytocin and its receptors are synthesized in the rat vasculature","volume":"97","author":"Jankowski","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/0167-0115(93)90215-T","article-title":"Oxytocin, a male intragonadal hormone","volume":"45","author":"Nicholson","year":"1993","journal-title":"Regul. Pept."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"3652068","DOI":"10.1155\/2016\/3652068","article-title":"Increased Activity of the Intracardiac Oxytocinergic System in the Development of Postinfarction Heart Failure","volume":"2016","author":"Wsol","year":"2016","journal-title":"Biomed Res. Int."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1210\/endo.140.3.6546","article-title":"Human vascular endothelial cells express oxytocin receptors","volume":"140","author":"Thibonnier","year":"1999","journal-title":"Endocrinology"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0006-8993(00)02464-1","article-title":"A single social defeat experience selectively stimulates the release of oxytocin, but not vasopressin, within the septal brain area of male rats","volume":"872","author":"Ebner","year":"2000","journal-title":"Brain Res."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1530\/ror.0.0010013","article-title":"Oxytocin: Cellular and molecular approaches in medicine and research","volume":"1","author":"Ivell","year":"1996","journal-title":"Rev. Reprod."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1152\/physrev.00031.2017","article-title":"The Oxytocin Receptor: From Intracellular Signaling to Behavior","volume":"98","author":"Jurek","year":"2018","journal-title":"Physiol. Rev."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0083-6729(05)71002-5","article-title":"Regulation of oxytocin secretion","volume":"71","author":"Leng","year":"2005","journal-title":"Vitam. Horm."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0006-8993(97)01159-1","article-title":"Stress increases oxytocin release within the hypothalamic paraventricular nucleus","volume":"781","author":"Nishioka","year":"1998","journal-title":"Brain Res."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1111\/j.1365-2826.2010.01957.x","article-title":"Increased sensitivity of monoamine release in the supraoptic nucleus in late pregnancy: Region- and stimulus-dependent responses","volume":"22","author":"Tobin","year":"2010","journal-title":"J. Neuroendocrinol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/S0169-328X(02)00525-9","article-title":"Estrogen receptor-beta regulates transcript levels for oxytocin and arginine vasopressin in the hypothalamic paraventricular nucleus of male mice","volume":"109","author":"Nomura","year":"2002","journal-title":"Brain Res. Mol. Brain Res."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1046\/j.1365-2826.2003.01061.x","article-title":"Oxytocin, but not oxytocin receptor, is regulated by oestrogen receptor beta in the female mouse hypothalamus","volume":"15","author":"Patisaul","year":"2003","journal-title":"J. Neuroendocrinol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.1210\/en.2011-1002","article-title":"The ER\u03b2 ligand 5\u03b1-androstane, 3\u03b2,17\u03b2-diol (3\u03b2-diol) regulates hypothalamic oxytocin (Oxt) gene expression","volume":"153","author":"Sharma","year":"2012","journal-title":"Endocrinology"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1210\/endo.139.4.5873","article-title":"Regulation of vasopressin synthesis and release by area postrema in rats","volume":"139","author":"Arima","year":"1998","journal-title":"Endocrinology"},{"key":"ref_117","first-page":"510","article-title":"Oxytocin and vasopressin receptor gene polymorphisms: Role in social and psychiatric traits","volume":"9","author":"Moreno","year":"2016","journal-title":"Front. Neurosci."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.brainres.2014.01.021","article-title":"Oxytocin and vasopressin systems in genetic syndromes and neurodevelopmental disorders","volume":"1580","author":"Francis","year":"2014","journal-title":"Brain Res."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"567","DOI":"10.3389\/fnins.2017.00567","article-title":"Social Context, Stress, Neuropsychiatric Disorders, and the Vasopressin 1b Receptor","volume":"11","author":"Caldwell","year":"2017","journal-title":"Front. Neurosci."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.autneu.2007.04.002","article-title":"Body water balance and body temperature in vasopressin V1b receptor knockout mice","volume":"136","author":"Daikoku","year":"2007","journal-title":"Auton. Neurosci."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s11906-018-0811-0","article-title":"Vasopressin, Central Autonomic Control and Blood Pressure Regulation","volume":"20","author":"Murphy","year":"2018","journal-title":"Curr. Hypertens. Rep."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1002\/pchj.102","article-title":"The arginine vasopressin V1b receptor gene and prosociality: Mediation role of emotional empathy","volume":"4","author":"Wu","year":"2015","journal-title":"Psych J."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1590\/1414-431X20132788","article-title":"Mapping and signaling of neural pathways involved in the regulation of hydromineral homeostasis","volume":"46","author":"Ruginsk","year":"2013","journal-title":"Braz. J. Med. Biol. Res."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"R447","DOI":"10.1152\/ajpregu.00520.2013","article-title":"Supraoptic oxytocin and vasopressin neurons function as glucose and metabolic sensors","volume":"306","author":"Song","year":"2014","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_125","first-page":"432","article-title":"Control of central release of vasopressin","volume":"79","author":"Gray","year":"1984","journal-title":"J. Physiol. (Paris)"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1007\/BF00581562","article-title":"Plasma and cerebrospinal fluid vasopressin and osmolality in relation to thirst","volume":"400","author":"Gray","year":"1984","journal-title":"Pflugers. Arch."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1038\/sj.ki.5002788","article-title":"Contribution of TRPV channels to osmosensory transduction, thirst, and vasopressin release","volume":"73","author":"Ciura","year":"2008","journal-title":"Kidney Int."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"e12826","DOI":"10.1111\/jne.12826","article-title":"Advances in the neurophysiology of magnocellular neuroendocrine cells","volume":"32","author":"Tasker","year":"2020","journal-title":"J. Neuroendocrinol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"e13259","DOI":"10.14814\/phy2.13259","article-title":"Osmotic activation of a Ca(2+)-dependent phospholipase C pathway that regulates N TRPV1-mediated currents in rat supraoptic neurons","volume":"5","author":"Bansal","year":"2017","journal-title":"Physiol. Rep."},{"key":"ref_130","first-page":"14","article-title":"Vasopressin & Oxytocin in Control of the Cardiovascular System: An Updated Review","volume":"18","author":"Murphy","year":"2020","journal-title":"Curr. Neuropharmacol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/S0301-0082(98)00072-0","article-title":"Physiological pathways regulating the activity of magnocellular neurosecretory cells","volume":"57","author":"Leng","year":"1999","journal-title":"Prog. Neurobiol."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/0361-9230(85)90209-6","article-title":"The periventricular anteroventral third ventricle (AV3V): Its relationship with the subfornical organ and neural systems involved in maintaining body fluid homeostasis","volume":"15","author":"Johnson","year":"1985","journal-title":"Brain Res. Bull."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1152\/physrev.00017.2003","article-title":"Neuroendocrine control of body fluid metabolism","volume":"84","author":"Elias","year":"2004","journal-title":"Physiol. Rev."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.neuron.2010.12.028","article-title":"The molecular and cellular identity of peripheral osmoreceptors","volume":"69","author":"Lechner","year":"2011","journal-title":"Neuron"},{"key":"ref_135","first-page":"3","article-title":"Influence of low- and high-pressure baroreflexes on vasopressin release in humans","volume":"121","author":"Norsk","year":"1989","journal-title":"Acta Endocrinol. (Copenh.)"},{"key":"ref_136","first-page":"F321","article-title":"Osmotic and nonosmotic control of vasopressin release","volume":"236","author":"Schrier","year":"1979","journal-title":"Am. J. Physiol."},{"key":"ref_137","first-page":"264","article-title":"The Logic of Carotid Body Connectivity to the Brain","volume":"34","author":"Zera","year":"2019","journal-title":"Physiology (Bethesda)"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1523\/JNEUROSCI.04-02-00474.1984","article-title":"Tonic vasomotor control by the rostral ventrolateral medulla: Effect of electrical or chemical stimulation of the area containing C1 adrenaline neurons on arterial pressure, heart rate, and plasma catecholamines and vasopressin","volume":"4","author":"Ross","year":"1984","journal-title":"J. Neurosci."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"3810","DOI":"10.1523\/JNEUROSCI.4343-13.2014","article-title":"Transcription factor CREB3L1 regulates vasopressin gene expression in the rat hypothalamus","volume":"34","author":"Greenwood","year":"2014","journal-title":"J. Neurosci."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1046\/j.1365-2826.1998.00225.x","article-title":"Activation by systemic angiotensin II of neurochemically identified neurons in rat hypothalamic paraventricular nucleus","volume":"10","author":"Dawson","year":"1998","journal-title":"J. Neuroendocrinol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1006\/exnr.2001.7779","article-title":"Neurotransmitter\/neuropeptide interactions in the regulation of neurohypophyseal hormone release","volume":"171","author":"Sladek","year":"2001","journal-title":"Exp. Neurol."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"e12686","DOI":"10.1111\/jne.12686","article-title":"Nitric oxide acutely modulates hypothalamic and neurohypophyseal carbon monoxide and hydrogen sulphide production to control vasopressin, oxytocin and atrial natriuretic peptide release in rats","volume":"31","author":"Coletti","year":"2019","journal-title":"J. Neuroendocrinol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1139\/y87-324","article-title":"Atrial peptides and the renal response to hypervolemia in nephrotic rats","volume":"65","author":"Keeler","year":"1987","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1113\/expphysiol.2007.037911","article-title":"Central nitric oxide blocks vasopressin, oxytocin and atrial natriuretic peptide release and antidiuretic and natriuretic responses induced by central angiotensin II in conscious rats","volume":"92","author":"Reis","year":"2007","journal-title":"Exp. Physiol."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1111\/jne.12325","article-title":"Localisation of 11\u03b2-Hydroxysteroid Dehydrogenase Type 2 in Mineralocorticoid Receptor Expressing Magnocellular Neurosecretory Neurones of the Rat Supraoptic and Paraventricular Nuclei","volume":"27","author":"Haque","year":"2015","journal-title":"J. Neuroendocrinol."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1159\/000081314","article-title":"Mineralocorticoid treatment upregulates the hypothalamic vasopressinergic system of spontaneously hypertensive rats","volume":"80","author":"Pietranera","year":"2004","journal-title":"Neuroendocrinology"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.yfrne.2007.08.005","article-title":"Estrogen receptors: Their roles in regulation of vasopressin release for maintenance of fluid and electrolyte homeostasis","volume":"29","author":"Sladek","year":"2008","journal-title":"Front. Neuroendocrinol."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/1749-4877.12467","article-title":"Density-induced social stress alters oxytocin and vasopressin activities in the brain of a small rodent species","volume":"16","author":"Huang","year":"2021","journal-title":"Integr. Zool."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1111\/j.1365-2826.2008.01711.x","article-title":"The neuroendocrinology of stress: A never ending story","volume":"20","author":"Lightman","year":"2008","journal-title":"J. Neuroendocrinol."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1172\/JCI117121","article-title":"Studies of the secretion of corticotropin-releasing factor and arginine vasopressin into the hypophysial-portal circulation of the conscious sheep. II. The central noradrenergic and neuropeptide Y pathways cause immediate and prolonged hypothalamic-pituitary-adrenal activation. Potential involvement in the pseudo-Cushing\u2019s syndrome of endogenous depression and anorexia nervosa","volume":"93","author":"Liu","year":"1994","journal-title":"J. Clin. Investig."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"e12972","DOI":"10.1111\/jne.12972","article-title":"Impact of chronic variable stress on neuroendocrine hypothalamus and pituitary in male and female C57BL\/6J mice","volume":"33","author":"Nair","year":"2021","journal-title":"J. Neuroendocrinol."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1111\/j.1460-9568.2006.05045.x","article-title":"Effects of early life stress on adult male aggression and hypothalamic vasopressin and serotonin","volume":"24","author":"Veenema","year":"2006","journal-title":"Eur. J. Neurosci."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/sj.npp.1300290","article-title":"Alterations in central neuropeptide expression, release, and receptor binding in rats bred for high anxiety: Critical role of vasopressin","volume":"29","author":"Wigger","year":"2004","journal-title":"Neuropsychopharmacology"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1152\/ajplegacy.1974.226.1.155","article-title":"Plasma ADH increase and osmotic thirst suppression elicited by preoptic heating in the dog","volume":"226","year":"1974","journal-title":"Am. J. Physiol."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.neuron.2008.02.013","article-title":"TRPV1 gene required for thermosensory transduction and anticipatory secretion from vasopressin neurons during hyperthermia","volume":"58","author":"Ciura","year":"2008","journal-title":"Neuron"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1042\/cs0680035","article-title":"Altered neuropeptide concentrations in spontaneously hypertensive rats: Cause or consequence?","volume":"68","author":"Gaida","year":"1985","journal-title":"Clin. Sci. (Lond.)"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1113\/expphysiol.2009.049262","article-title":"Brainstem oxytocinergic modulation of heart rate control in rats: Effects of hypertension and exercise training","volume":"94","author":"Felix","year":"2009","journal-title":"Exp. Physiol."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1161\/01.HYP.0000175812.03322.59","article-title":"Hypertension and exercise training differentially affect oxytocin and oxytocin receptor expression in the brain","volume":"46","author":"Martins","year":"2005","journal-title":"Hypertension"},{"key":"ref_159","first-page":"303","article-title":"Vasopressin and oxytocin gene expression in the supraoptic and paraventricular nucleus of the spontaneously hypertensive rat (SHR) during development of hypertension","volume":"464","author":"Burbach","year":"1988","journal-title":"Brain Res."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/j.1748-1716.2010.02134.x","article-title":"Downregulation of oxytocin receptors in right ventricle of rats with monocrotaline-induced pulmonary hypertension","volume":"200","author":"Broderick","year":"2010","journal-title":"Acta Physiol. (Oxf.)"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"R98","DOI":"10.1186\/cc7930","article-title":"Low-dose vasopressin infusion results in increased mortality and cardiac dysfunction following ischemia-reperfusion injury in mice","volume":"13","author":"Indrambarya","year":"2009","journal-title":"Crit. Care"},{"key":"ref_162","first-page":"739","article-title":"Expression of oxytocin receptor in the rat superior cervical ganglion after myocardial infarction","volume":"11","author":"Yu","year":"2018","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/B978-0-12-820107-7.00003-3","article-title":"Central and peripheral release of oxytocin: Relevance of neuroendocrine and neurotransmitter actions for physiology and behavior","volume":"180","author":"Althammer","year":"2021","journal-title":"Handb. Clin. Neurol."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.neuroscience.2017.09.041","article-title":"Oxytocin and Pain Perception: From Animal Models to Human Research","volume":"387","author":"Boll","year":"2018","journal-title":"Neuroscience"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1016\/j.celrep.2017.10.063","article-title":"Oxytocin Modulates Nociception as an Agonist of Pain-Sensing TRPV1","volume":"21","author":"Nersesyan","year":"2017","journal-title":"Cell Rep."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"102046","DOI":"10.1016\/j.npep.2020.102046","article-title":"Differential role of specific cardiovascular neuropeptides in pain regulation: Relevance to cardiovascular diseases","volume":"81","author":"Sadowski","year":"2020","journal-title":"Neuropeptides"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.neuroscience.2019.02.027","article-title":"Neuropathic Pain Up-Regulates Hypothalamo-Neurohypophysial and Hypothalamo-Spinal Oxytocinergic Pathways in Oxytocin-Monomeric Red Fluorescent Protein 1 Transgenic Rat","volume":"406","author":"Nishimura","year":"2019","journal-title":"Neuroscience"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.npep.2016.03.003","article-title":"Oxytocin in hypothalamic supraoptic nucleus is transferred to the caudate nucleus to influence pain modulation","volume":"58","author":"Pan","year":"2016","journal-title":"Neuropeptides"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1111\/j.1749-6632.1995.tb44681.x","article-title":"Vasopressin and oxytocin in stress","volume":"771","author":"Jezova","year":"1995","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_170","first-page":"124","article-title":"Effects of acute stressors on the expression of oxytocin receptor mRNA in hearts of rats with different activity of HPA axis","volume":"33","author":"Skopek","year":"2012","journal-title":"Neuro Endocrinol. Lett."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"117","DOI":"10.3109\/10253890.2013.872620","article-title":"Oxytocin differently regulates pressor responses to stress in WKY and SHR rats: The role of central oxytocin and V1a receptors","volume":"17","author":"Wsol","year":"2014","journal-title":"Stress"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"R160","DOI":"10.1152\/ajpregu.00050.2019","article-title":"Impaired hypotensive effects of centrally acting oxytocin in SHR and WKY rats exposed to chronic mild stress","volume":"318","author":"Wsol","year":"2020","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1055\/s-0029-1234081","article-title":"Comparison of vasopressin and oxytocin expressions in the hypothalamo-neurohypophysial system of patients with chronic heart failure","volume":"42","author":"Sivukhina","year":"2010","journal-title":"Horm. Metab. Res."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1093\/hmg\/ddz014","article-title":"Sex differences in gene expression in response to ischemia in the human left ventricular myocardium","volume":"28","author":"Stone","year":"2019","journal-title":"Hum. Mol. Genet."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"I93","DOI":"10.1161\/01.HYP.3.3_Pt_2.I93","article-title":"Vasopressin elevation in essential hypertension and increased responsiveness to sodium intake","volume":"3","author":"Cowley","year":"1981","journal-title":"Hypertension"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"250","DOI":"10.2174\/18715303113136660042","article-title":"Role of central and peripheral chemoreceptors in vasopressin secretion control","volume":"13","author":"Iovino","year":"2013","journal-title":"Endocr. Metab. Immune Disord. Drug Targets"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0079-6123(02)39023-X","article-title":"The central vasopressinergic system in experimental left ventricular hypertrophy and dysfunction","volume":"139","author":"Muders","year":"2002","journal-title":"Prog. Brain Res."},{"key":"ref_178","first-page":"348","article-title":"Central cardiovascular effects of vasotocin, oxytocin and vasopressin in conscious rats","volume":"228","author":"Feuerstein","year":"1984","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_179","first-page":"R786","article-title":"Differential regulation of central vasopressin in transgenic rats harboring the mouse Ren-2 gene","volume":"267","author":"Moriguchi","year":"1994","journal-title":"Am. J. Physiol."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"E273","DOI":"10.1152\/ajpendo.00407.2011","article-title":"Epithelial Na\u207a sodium channels in magnocellular cells of the rat supraoptic and paraventricular nuclei","volume":"302","author":"Teruyama","year":"2012","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"R1787","DOI":"10.1152\/ajpregu.00063.2005","article-title":"Distribution of epithelial sodium channels and mineralocorticoid receptors in cardiovascular regulatory centers in rat brain","volume":"289","author":"Amin","year":"2005","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S0895-7061(98)00177-0","article-title":"Central vasopressin is modulated by chronic blockade of the renin-angiotensin system in experimental left ventricular hypertrophy","volume":"12","author":"Muders","year":"1999","journal-title":"Am. J. Hypertens."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/0002-9378(94)90285-2","article-title":"Endocrinologic and biophysical responses to prolonged (24-hour) hypoxemia in fetal goats","volume":"171","author":"Fujimori","year":"1994","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_184","first-page":"E453","article-title":"Vasopressin, ACTH, and corticosteroids during hypercapnia and graded hypoxia in dogs","volume":"244","author":"Raff","year":"1983","journal-title":"Am. J. Physiol."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"R1112","DOI":"10.1152\/ajpregu.00280.2013","article-title":"Acute systemic hypoxia activates hypothalamic paraventricular nucleus-projecting catecholaminergic neurons in the caudal ventrolateral medulla","volume":"305","author":"King","year":"2013","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.3109\/10641969709083208","article-title":"Excitatory amino acid receptors in the paraventricular hypothalamic nucleus mediate pressor response induced by carotid body chemoreceptor stimulation in rats","volume":"19","author":"Kubo","year":"1997","journal-title":"Clin. Exp. Hypertens."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.exger.2010.08.023","article-title":"HPA axis responsiveness to stress: Implications for healthy aging","volume":"46","author":"Aguilera","year":"2011","journal-title":"Exp. Gerontol."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"13182","DOI":"10.1523\/JNEUROSCI.2624-09.2009","article-title":"Exaggerated response of a vasopressin-enhanced green fluorescent protein transgene to nociceptive stimulation in the rat","volume":"29","author":"Suzuki","year":"2009","journal-title":"J. Neurosci."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"H639","DOI":"10.1152\/ajpheart.00484.2019","article-title":"The role of oxytocin and vasopressin in the pathophysiology of heart failure in pregnancy and in fetal and neonatal life","volume":"318","author":"Wsol","year":"2020","journal-title":"Am. J. Physiol. Heart. Circ. Physiol."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.neulet.2006.10.049","article-title":"Arginine vasopressin in periaqueductal gray, which relates to antinociception, comes from hypothalamic paraventricular nucleus in the rat","volume":"412","author":"Yang","year":"2007","journal-title":"Neurosci. Lett."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.regpep.2007.01.006","article-title":"Arginine vasopressin induces periaqueductal gray release of enkephalin and endorphin relating to pain modulation in the rat","volume":"142","author":"Yang","year":"2007","journal-title":"Regul. Pept."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.npep.2009.06.003","article-title":"Norepinephrine regulates arginine vasopressin secretion in hypothalamic paraventricular nucleus relating with pain modulation","volume":"43","author":"Yang","year":"2009","journal-title":"Neuropeptides"},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0002-9343(88)90206-9","article-title":"Neuroendocrine changes in acute myocardial infarction","volume":"84","author":"McAlpine","year":"1988","journal-title":"Am. J. Med."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1016\/S0735-1097(83)80040-0","article-title":"Increased plasma arginine vasopressin levels in patients with congestive heart failure","volume":"1","author":"Goldsmith","year":"1983","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1161\/CIRCULATIONAHA.106.685503","article-title":"C-terminal provasopressin (copeptin) as a novel and prognostic marker in acute myocardial infarction: Leicester Acute Myocardial Infarction Peptide (LAMP) study","volume":"115","author":"Khan","year":"2007","journal-title":"Circulation"},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1136\/heartjnl-2013-303975","article-title":"Association of copeptin with myocardial infarct size and myocardial function after ST segment elevation myocardial infarction","volume":"99","author":"Reinstadler","year":"2013","journal-title":"Heart"},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1056\/NEJM198107303050506","article-title":"Radioimmunoassay of plasma arginine vasopressin in hyponatremic patients with congestive heart failure","volume":"305","author":"Szatalowicz","year":"1981","journal-title":"N. Engl. J. Med."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0079-6123(08)00417-2","article-title":"Oxytocin receptors: Ligand binding, signalling and cholesterol dependence","volume":"170","author":"Gimpl","year":"2008","journal-title":"Prog. Brain Res."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.jash.2008.04.004","article-title":"Oxytocin revisited: It is also a cardiovascular hormone","volume":"2","author":"Gutkowska","year":"2008","journal-title":"J. Am. Soc. Hypertens."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s00395-009-0076-5","article-title":"Anti-inflammatory effect of oxytocin in rat myocardial infarction","volume":"105","author":"Jankowski","year":"2010","journal-title":"Basic. Res. Cardiol."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/0166-2236(83)90221-7","article-title":"Vasopressin and oxytocin in the mammalian brain and spinal cord","volume":"6","author":"Sofroniew","year":"1983","journal-title":"Trends Neurosci."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1097\/00001756-199803300-00031","article-title":"Estrogen receptor alpha is essential for induction of oxytocin receptor by estrogen","volume":"9","author":"Young","year":"1998","journal-title":"Neuroreport"},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/j.psyneuen.2007.06.015","article-title":"Effects of an acute stressor on blood pressure and heart rate in rats pretreated with intracerebroventricular oxytocin injections","volume":"32","author":"Petersson","year":"2007","journal-title":"Psychoneuroendocrinology"},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/S0031-9384(96)00261-2","article-title":"Oxytocin causes a long-term decrease of blood pressure in female and male rats","volume":"60","author":"Petersson","year":"1996","journal-title":"Physiol. Behav."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0165-1838(99)00061-2","article-title":"Oxytocin enhances the effects of clonidine on blood pressure and locomotor activity in rats","volume":"78","author":"Petersson","year":"1999","journal-title":"J. Auton. Nerv. Syst."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"H1223","DOI":"10.1152\/ajpheart.00774.2001","article-title":"Oxytocin does not directly affect vascular tone in vessels from nonpregnant and pregnant rats","volume":"282","author":"Miller","year":"2002","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"9550","DOI":"10.1073\/pnas.152302499","article-title":"Oxytocin induces differentiation of P19 embryonic stem cells to cardiomyocytes","volume":"99","author":"Paquin","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.pathophys.2016.03.003","article-title":"Oxytocin decreases diurnal and nocturnal arterial blood pressure in the conscious unrestrained spontaneously hypertensive rat","volume":"23","author":"Gutkowska","year":"2016","journal-title":"Pathophysiology"},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0165-1838(97)00040-4","article-title":"Oxytocin decreases blood pressure in male but not in female spontaneously hypertensive rats","volume":"66","author":"Petersson","year":"1997","journal-title":"J. Auton. Nerv. Syst."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S1566-0702(02)00134-0","article-title":"Postnatal oxytocin treatment and postnatal stroking of rats reduce blood pressure in adulthood","volume":"99","author":"Holst","year":"2002","journal-title":"Auton. Neurosci."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.neulet.2008.05.091","article-title":"Postnatal oxytocin treatment of spontaneously hypertensive male rats decreases blood pressure and body weight in adulthood","volume":"440","author":"Petersson","year":"2008","journal-title":"Neurosci. Lett."},{"key":"ref_212","first-page":"85446","article-title":"Increased oxytocinergic system activity in the cardiac muscle in spontaneously hypertensive SHR rats","volume":"2019","author":"Wsol","year":"2019","journal-title":"Arch. Med. Sci."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.peptides.2012.08.001","article-title":"The role of nitric oxide, reactive oxygen species, and protein kinase C in oxytocin-induced cardioprotection in ischemic rat heart","volume":"37","author":"Faghihi","year":"2012","journal-title":"Peptides"},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"H265","DOI":"10.1152\/ajpheart.00487.2009","article-title":"Cardiac oxytocin receptor blockade stimulates adverse cardiac remodeling in ovariectomized spontaneously hypertensive rats","volume":"299","author":"Jankowski","year":"2010","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_215","doi-asserted-by":"crossref","unstructured":"Jankowski, M., Broderick, T.L., and Gutkowska, J. (2016). Oxytocin and cardioprotection in diabetes and obesity. BMC Endocr. Disord., 16.","DOI":"10.1186\/s12902-016-0110-1"},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.3389\/fpsyg.2020.02139","article-title":"The Role of Oxytocin in Cardiovascular Protection","volume":"11","author":"Jankowski","year":"2020","journal-title":"Front. Psychol."},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"261","DOI":"10.4149\/gpb_2012_030","article-title":"Prolonged oxytocin treatment in rats affects intracellular signaling and induces myocardial protection against infarction","volume":"31","author":"Ondrejcakova","year":"2012","journal-title":"Gen. Physiol. Biophys."},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.peptides.2016.10.001","article-title":"RISK pathway is involved in oxytocin postconditioning in isolated rat heart","volume":"86","author":"Polshekan","year":"2016","journal-title":"Peptides"},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.peptides.2018.04.002","article-title":"The SAFE pathway is involved in the postconditioning mechanism of oxytocin in isolated rat heart","volume":"111","author":"Polshekan","year":"2019","journal-title":"Peptides"},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.mce.2015.04.028","article-title":"Molecular mechanisms underlying oxytocin-induced cardiomyocyte protection from simulated ischemia-reperfusion","volume":"412","author":"Menaouar","year":"2015","journal-title":"Mol. Cell Endocrinol."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"517","DOI":"10.3109\/10253890802687688","article-title":"Central oxytocin modulation of acute stress-induced cardiovascular responses after myocardial infarction in the rat","volume":"12","author":"Wsol","year":"2009","journal-title":"Stress"},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1093\/cvr\/cvx084","article-title":"Chronic activation of hypothalamic oxytocin neurons improves cardiac function during left ventricular hypertrophy-induced heart failure","volume":"113","author":"Garrott","year":"2017","journal-title":"Cardiovasc. Res."},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"4725","DOI":"10.1113\/jphysiol.2009.176461","article-title":"Downregulation of oxytocin and natriuretic peptides in diabetes: Possible implications in cardiomyopathy","volume":"587","author":"Gutkowska","year":"2009","journal-title":"J. Physiol."},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1210\/en.2014-1718","article-title":"Oxytocin treatment prevents the cardiomyopathy observed in obese diabetic male db\/db mice","volume":"156","author":"Plante","year":"2015","journal-title":"Endocrinology"},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.cardfail.2018.05.004","article-title":"Cardiac-Specific Overexpression of Oxytocin Receptor Leads to Cardiomyopathy in Mice","volume":"24","author":"Jung","year":"2018","journal-title":"J. Card Fail."},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1097\/ALN.0b013e31829416dd","article-title":"Changes in blood pressure and cardiac output during cesarean delivery: The effects of oxytocin and carbetocin compared with placebo","volume":"119","author":"Rosseland","year":"2013","journal-title":"Anesthesiology"},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1093\/bja\/aen071","article-title":"Signs of myocardial ischaemia after injection of oxytocin: A randomized double-blind comparison of oxytocin and methylergometrine during Caesarean section","volume":"100","author":"Biber","year":"2008","journal-title":"Br. J. Anaesth."},{"key":"ref_228","doi-asserted-by":"crossref","unstructured":"Kemp, A.H., Quintana, D.S., Kuhnert, R.L., Griffiths, K., Hickie, I.B., and Guastella, A.J. (2012). Oxytocin increases heart rate variability in humans at rest: Implications for social approach-related motivation and capacity for social engagement. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0044014"},{"key":"ref_229","first-page":"H751","article-title":"Chronic intravenous administration of V1 arginine vasopressin agonist results in sustained hypertension","volume":"267","author":"Cowley","year":"1994","journal-title":"Am. J. Physiol."},{"key":"ref_230","first-page":"349","article-title":"Vasopressin V1a, V1b and V2 receptors mRNA in the kidney and heart of the renin transgenic TGR(mRen2)27 and Sprague Dawley rats","volume":"53","author":"Luszczyk","year":"2002","journal-title":"J. Physiol. Pharmacol."},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.4155\/fmc.12.108","article-title":"Exploring bioactive peptides from natural sources for oxytocin and vasopressin drug discovery","volume":"4","author":"Gruber","year":"2012","journal-title":"Future Med. Chem."},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1210\/endo.136.3.7867583","article-title":"Vasopressin stimulates steroid secretion in human adrenal glands: Comparison with angiotensin-II effect","volume":"136","author":"Guillon","year":"1995","journal-title":"Endocrinology"},{"key":"ref_233","first-page":"R1217","article-title":"Prolonged stimulation of intrarenal V1 vasopressin receptors results in sustained hypertension","volume":"267","author":"Stepniakowski","year":"1994","journal-title":"Am. J. Physiol."},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S1569-9048(02)00131-3","article-title":"Paraventricular vasopressin-containing neurons project to brain stem and spinal cord respiratory-related sites","volume":"133","author":"Kc","year":"2002","journal-title":"Respir. Physiol. Neurobiol."},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"R213","DOI":"10.1152\/ajpregu.00245.2020","article-title":"V(1a) and V(1b) vasopressin receptors within the paraventricular nucleus contribute to hypertension in male rats exposed to chronic mild unpredictable stress","volume":"320","author":"Komnenov","year":"2021","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1113\/expphysiol.2006.034082","article-title":"The role of supraspinal vasopressin and glutamate neurones in an increase in renal sympathetic activity in response to mild haemorrhage in the rat","volume":"91","author":"Yang","year":"2006","journal-title":"Exp. Physiol."},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1097\/00005344-200007000-00005","article-title":"[Arg8]-vasopressin-induced responses on coronary and mesenteric arteries of rats with myocardial infarction: The effects of V1a- and V2-receptor antagonists","volume":"36","author":"Lankhuizen","year":"2000","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0014-2999(01)01092-5","article-title":"Vascular and renal effects of vasopressin and its antagonists in conscious rats with chronic myocardial infarction; evidence for receptor shift","volume":"423","author":"Lankhuizen","year":"2001","journal-title":"Eur. J. Pharmacol."},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"2098","DOI":"10.1016\/j.jtcvs.2018.05.090","article-title":"Enhanced coronary arteriolar contraction to vasopressin in patients with diabetes after cardiac surgery","volume":"156","author":"Sellke","year":"2018","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1472-8206.1995.tb00260.x","article-title":"Effects of SR 49059, a non-peptide antagonist of vasopressin V1a receptors, on vasopressin-induced coronary vasoconstriction in conscious rabbits","volume":"9","author":"Villanova","year":"1995","journal-title":"Fundam. Clin. Pharmacol."},{"key":"ref_241","first-page":"H415","article-title":"Vasopressin-induced pulmonary vasodilation in rats","volume":"257","author":"Walker","year":"1989","journal-title":"Am. J. Physiol."},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"F1418","DOI":"10.1152\/ajprenal.00358.2006","article-title":"Downregulation of vasopressin V2 receptor promoter activity via V1a receptor pathway","volume":"292","author":"Izumi","year":"2007","journal-title":"Am. J. Physiol. Renal. Physiol."},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"2339","DOI":"10.1172\/JCI116838","article-title":"Different localization and regulation of two types of vasopressin receptor messenger RNA in microdissected rat nephron segments using reverse transcription polymerase chain reaction","volume":"92","author":"Terada","year":"1993","journal-title":"J. Clin. Investig."},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1038\/ki.2009.319","article-title":"Vasopressin regulation of blood pressure and volume: Findings from V1a receptor-deficient mice","volume":"76","author":"Aoyagi","year":"2009","journal-title":"Kidney Int."},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1681\/ASN.2010050468","article-title":"Aldosterone requires vasopressin V1a receptors on intercalated cells to mediate acid-base homeostasis","volume":"22","author":"Izumi","year":"2011","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_246","doi-asserted-by":"crossref","first-page":"R979","DOI":"10.1152\/ajpregu.00520.2001","article-title":"Cytokine-mediated downregulation of vasopressin V(1A) receptors during acute endotoxemia in rats","volume":"282","author":"Bucher","year":"2002","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_247","doi-asserted-by":"crossref","first-page":"4136","DOI":"10.1210\/en.2006-1633","article-title":"Pharmacological and physiological characterization of d[Leu4, Lys8]vasopressin, the first V1b-selective agonist for rat vasopressin\/oxytocin receptors","volume":"148","author":"Pena","year":"2007","journal-title":"Endocrinology"},{"key":"ref_248","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S0014-2999(00)00465-9","article-title":"Evidence that atypical vasopressin V(2) receptor in inner medulla of kidney is V(1B) receptor","volume":"401","author":"Saito","year":"2000","journal-title":"Eur. J. Pharmacol."},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1113\/expphysiol.2014.084426","article-title":"Haemodynamic and renal sympathetic responses to V1b vasopressin receptor activation within the paraventricular nucleus","volume":"100","author":"Toomasian","year":"2015","journal-title":"Exp. Physiol."},{"key":"ref_250","doi-asserted-by":"crossref","first-page":"19S","DOI":"10.1111\/j.1469-445X.2000.tb00004.x","article-title":"Regulation of vasopressin V1b receptors in the anterior pituitary gland of the rat","volume":"85","author":"Aguilera","year":"2000","journal-title":"Exp. Physiol."},{"key":"ref_251","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1124\/mol.65.3.623","article-title":"Vasopressin stimulates insulin release from islet cells through V1b receptors: A combined pharmacological\/knockout approach","volume":"65","author":"Oshikawa","year":"2004","journal-title":"Mol. Pharmacol."},{"key":"ref_252","doi-asserted-by":"crossref","first-page":"F305","DOI":"10.1152\/ajprenal.00081.2021","article-title":"Characterization of a functional V(1B) vasopressin receptor in the male rat kidney: Evidence for cross talk between V(1B) and V(2) receptor signaling pathways","volume":"321","author":"Bouby","year":"2021","journal-title":"Am. J. Physiol. Renal. Physiol."},{"key":"ref_253","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1055\/s-2007-1018962","article-title":"Interaction between effects of insulin and vasopressin on renal excretion of water and sodium in rats","volume":"14","author":"Brzezinski","year":"1982","journal-title":"Horm. Metab. Res."},{"key":"ref_254","doi-asserted-by":"crossref","first-page":"933","DOI":"10.3390\/jcm4050933","article-title":"Hyponatremia Associated with Heart Failure: Pathological Role of Vasopressin-Dependent Impaired Water Excretion","volume":"4","author":"Ishikawa","year":"2015","journal-title":"J. Clin. Med."},{"key":"ref_255","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1111\/nep.13465","article-title":"Salt, water and nephron: Mechanisms of action and link to hypertension and chronic kidney disease","volume":"23","author":"Qian","year":"2018","journal-title":"Nephrology (Carlton)"},{"key":"ref_256","first-page":"333","article-title":"The regulation of vasopressin function in health and disease","volume":"33","author":"Robertson","year":"1976","journal-title":"Recent Prog. Horm. Res."},{"key":"ref_257","doi-asserted-by":"crossref","first-page":"F284","DOI":"10.1152\/ajprenal.00360.2015","article-title":"Vasopressin\/V2 receptor stimulates renin synthesis in the collecting duct","volume":"310","author":"Gonzalez","year":"2016","journal-title":"Am. J. Physiol. Renal. Physiol."},{"key":"ref_258","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.semnephrol.2008.03.009","article-title":"Vasopressin and aquaporin 2 in clinical disorders of water homeostasis","volume":"28","author":"Schrier","year":"2008","journal-title":"Semin Nephrol."},{"key":"ref_259","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1038\/ki.2010.276","article-title":"Vasopressin regulation of renal sodium excretion","volume":"78","author":"Stockand","year":"2010","journal-title":"Kidney Int."},{"key":"ref_260","doi-asserted-by":"crossref","first-page":"F438","DOI":"10.1152\/ajprenal.00158.2005","article-title":"Aldosterone increases urine production and decreases apical AQP2 expression in rats with diabetes insipidus","volume":"290","author":"Nielsen","year":"2006","journal-title":"Am. J. Physiol. Renal. Physiol."},{"key":"ref_261","doi-asserted-by":"crossref","first-page":"F1547","DOI":"10.1152\/ajprenal.00461.2012","article-title":"Congestive heart failure in rats is associated with increased collecting duct vasopressin sensitivity and vasopressin type 2 receptor reexternalization","volume":"305","author":"Torp","year":"2013","journal-title":"Am. J. Physiol. Renal. Physiol."},{"key":"ref_262","doi-asserted-by":"crossref","first-page":"223S","DOI":"10.1111\/j.1469-445X.2000.tb00027.x","article-title":"Control of the renal medullary circulation by vasopressin V1 and V2 receptors in the rat","volume":"85","author":"Cowley","year":"2000","journal-title":"Exp. Physiol."},{"key":"ref_263","doi-asserted-by":"crossref","first-page":"11255","DOI":"10.1074\/jbc.M610769200","article-title":"Arginine vasopressin-mediated cardiac differentiation: Insights into the role of its receptors and nitric oxide signaling","volume":"282","author":"Gassanov","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref_264","doi-asserted-by":"crossref","first-page":"137","DOI":"10.3109\/08037059409101533","article-title":"Vasopressin and a nonpeptide antidiuretic hormone receptor antagonist (OPC-31260)","volume":"3","author":"Burrell","year":"1994","journal-title":"Blood Press."},{"key":"ref_265","first-page":"852","article-title":"Selective vasopressin, angiotensin II, or dual receptor blockade with developing congestive heart failure","volume":"293","author":"Clair","year":"2000","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_266","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.npep.2014.07.004","article-title":"Altered expression of V1a receptors mRNA in the brain and kidney after myocardial infarction and chronic stress","volume":"48","author":"Milik","year":"2014","journal-title":"Neuropeptides"},{"key":"ref_267","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1038\/jcbfm.2014.24","article-title":"Water deprivation induces neurovascular and cognitive dysfunction through vasopressin-induced oxidative stress","volume":"34","author":"Faraco","year":"2014","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_268","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.jacc.2013.09.032","article-title":"Increased vasopressin 1A receptor expression in failing human hearts","volume":"63","author":"Zhu","year":"2014","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_269","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1001\/jama.297.12.1332","article-title":"Short-term clinical effects of tolvaptan, an oral vasopressin antagonist, in patients hospitalized for heart failure: The EVEREST Clinical Status Trials. Efficacy of Vasopressin Antagonism in Heart Failure Outcome Study with Tolvaptan (EVEREST) Investigators","volume":"297","author":"Gheorghiade","year":"2007","journal-title":"JAMA"},{"key":"ref_270","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1016\/j.jacc.2007.01.091","article-title":"Multicenter, randomized, double-blind, placebo-controlled study on the effect of oral tolvaptan on left ventricular dilation and function in patients with heart failure and systolic dysfunction","volume":"49","author":"Udelson","year":"2007","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_271","doi-asserted-by":"crossref","first-page":"1753944720977741","DOI":"10.1177\/1753944720977741","article-title":"Vasopressin antagonism in heart failure: A review of the hemodynamic studies and major clinical trials","volume":"15","author":"Urbach","year":"2021","journal-title":"Ther. Adv. Cardiovasc. Dis."},{"key":"ref_272","doi-asserted-by":"crossref","first-page":"3599","DOI":"10.1093\/eurheartj\/ehab368","article-title":"2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure","volume":"42","author":"McDonagh","year":"2021","journal-title":"Eur. Heart J."},{"key":"ref_273","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.cardfail.2020.10.007","article-title":"Dual Vasopressin Receptor Antagonism to Improve Congestion in Patients With Acute Heart Failure: Design of the AVANTI Trial","volume":"27","author":"Goldsmith","year":"2021","journal-title":"J. Card Fail."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/22\/21\/11465\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:22:27Z","timestamp":1760167347000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/22\/21\/11465"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,24]]},"references-count":273,"journal-issue":{"issue":"21","published-online":{"date-parts":[[2021,11]]}},"alternative-id":["ijms222111465"],"URL":"https:\/\/doi.org\/10.3390\/ijms222111465","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,24]]}}}