{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T12:22:13Z","timestamp":1764937333864,"version":"build-2065373602"},"reference-count":54,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T00:00:00Z","timestamp":1635120000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003606","name":"Korea Foundation","doi-asserted-by":"publisher","award":["KMDF_PR_20200901-0237,1711138501"],"award-info":[{"award-number":["KMDF_PR_20200901-0237,1711138501"]}],"id":[{"id":"10.13039\/501100003606","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Korea Health Technology R&amp;D Project through the Korea Health Industry Development Institute (KHIDI)","award":["HI20C2114"],"award-info":[{"award-number":["HI20C2114"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Our aim was to investigate the bone regeneration capacity of powder-type biphasic ceramic scaffold (BCP powder), block-type BCP (BCP block), and collagen-added block-type BCP (BCP collagen) with different concentrations of recombinant human bone morphogenetic protein 2 (rhBMP-2) in an animal model. Four rabbits were assigned to each of the following groups: no graft + rhBMP-2 (0.1\/0.2 mg\/mL), BCP powder + rhBMP-2 (0.1\/0.2 mg\/mL), BCP block + rhBMP-2 (0.1\/0.2 mg\/mL), and BCP collagen + rhBMP-2 (0.1\/0.2 mg\/mL), i.e., a total of 32 rabbits. Polycarbonate tubes (\u03a6 7 mm \u00d7 5 mm) for supporting scaffolds were fixed into a 7 mm round border. Subsequently, 0.1 mL of rhBMP-2 solutions with different concentrations was injected into the tubes. Both radiological and histomorphometric analyses showed that osteogenesis was not enhanced by increasing the concentration of rhBMP-2 in all groups at both 3 and 6 weeks. Radiological analysis showed that bone formation was higher in the BCP collagen group than in the BCP powder and BCP block groups at both rhBMP-2 concentrations at 3 weeks. rhBMP-2 enhanced bone formation; however, as the concentration increased, bone formation could not be enhanced infinitely. Collagen-added alloplastic graft material may be useful for mediating rapid bone formation in initial stages.<\/jats:p>","DOI":"10.3390\/ijms222111485","type":"journal-article","created":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T21:40:21Z","timestamp":1635198021000},"page":"11485","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Enhanced Bone Regeneration in Variable-Type Biphasic Ceramic Phosphate Scaffolds Using rhBMP-2"],"prefix":"10.3390","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4083-7721","authenticated-orcid":false,"given":"Ho-Kyung","family":"Lim","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Korea University Guro Hospital, Seoul 08308, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8222-2971","authenticated-orcid":false,"given":"Ik-Jae","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Oral & Maxillofacial Surgery, School of Dentistry, Seoul National University, Seoul 03080, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6192-1530","authenticated-orcid":false,"given":"Sung-Woon","family":"On","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Dentistry, Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Hwaseong 18450, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9061-0552","authenticated-orcid":false,"given":"Seok-Jin","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head & Neck Surgery, Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Hwaseong 18450, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4446-6772","authenticated-orcid":false,"given":"Byoung-Eun","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Dentistry, Sacred Heart Hospital, Hallym University College of Medicine, Anyang 14068, Korea"},{"name":"Graduate School of Clinical Dentistry, Hallym University, Chuncheon 24252, Korea"},{"name":"Research Center of Clinical Dentistry, Clinical Dentistry Graduate School, Hallym University, Chuncheon 24252, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6916-0489","authenticated-orcid":false,"given":"Soung-Min","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Oral & Maxillofacial Surgery, School of Dentistry, Seoul National University, Seoul 03080, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8843-545X","authenticated-orcid":false,"given":"Jong-Ho","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Oral & Maxillofacial Surgery, School of Dentistry, Seoul National University, Seoul 03080, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0739-7971","authenticated-orcid":false,"given":"Soo-Hwan","family":"Byun","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Dentistry, Sacred Heart Hospital, Hallym University College of Medicine, Anyang 14068, Korea"},{"name":"Graduate School of Clinical Dentistry, Hallym University, Chuncheon 24252, Korea"},{"name":"Research Center of Clinical Dentistry, Clinical Dentistry Graduate School, Hallym University, Chuncheon 24252, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,10,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1016\/j.ijom.2010.07.008","article-title":"A comparison of autogenous bone graft combined with deproteinized bovine bone and autogenous bone graft alone for treatment of alveolar cleft","volume":"39","author":"Thuaksuban","year":"2010","journal-title":"Int. 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