{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:55:56Z","timestamp":1791233756071,"version":"4.1.0"},"reference-count":101,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2021,10,28]],"date-time":"2021-10-28T00:00:00Z","timestamp":1635379200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Research and Innovation in Romania","award":["PN 19.29.02.01"],"award-info":[{"award-number":["PN 19.29.02.01"]}]},{"name":"Ministry of Research and Innovation in Romania","award":["CNFISFDI-2021-0300"],"award-info":[{"award-number":["CNFISFDI-2021-0300"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Increasing evidence suggests that the gut microbiota and the brain are closely connected via the so-called gut\u2013brain axis. Small intestinal bacterial overgrowth (SIBO) is a gut dysbiosis in which the small intestine is abundantly colonized by bacteria that are typically found in the colon. Though not a disease, it may result in intestinal symptoms caused by the accumulation of microbial gases in the intestine. Intestinal inflammation, malabsorption and vitamin imbalances may also develop. SIBO can be eradicated by one or several courses of antibiotics but reappears if the predisposing condition persists. Parkinson\u2019s disease (PD) is a common neurodegenerative proteinopathy for which disease modifying interventions are not available. Sporadic forms may start in the gut years before the development of clinical features. Increased gastrointestinal transit time is present in most people with PD early during the course of the disease, predisposing to gut dysbiosis, including SIBO. The role that gut dysbiosis may play in the etiopathogenesis of PD is not fully understood yet. Here, we discuss the possibility that SIBO could contribute to the progression of PD, by promoting or preventing neurodegeneration, thus being a potential target for treatments aiming at slowing down the progression of PD. The direct symptomatic impact of SIBO and its impact on symptomatic medication are also briefly discussed.<\/jats:p>","DOI":"10.3390\/ijms222111663","type":"journal-article","created":{"date-parts":[[2021,10,28]],"date-time":"2021-10-28T23:51:36Z","timestamp":1635465096000},"page":"11663","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Small Intestinal Bacterial Overgrowth as Potential Therapeutic Target in Parkinson\u2019s Disease"],"prefix":"10.3390","volume":"22","author":[{"given":"Adela","family":"D\u0103n\u0103u","sequence":"first","affiliation":[{"name":"Department of Clinical Neurosciences, Colentina Clinical Hospital, Neurology Division, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5356-1096","authenticated-orcid":false,"given":"Laura","family":"Dumitrescu","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences, Colentina Clinical Hospital, Neurology Division, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonia","family":"Lefter","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences, Colentina Clinical Hospital, Neurology Division, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delia","family":"Tulb\u0103","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences, Colentina Clinical Hospital, Neurology Division, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4826-2598","authenticated-orcid":false,"given":"Bogdan Ovidiu","family":"Popescu","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences, Carol Davila University of Medicine and Pharmacy, 030167 Bucharest, Romania"},{"name":"Laboratory of Neurosciences and Experimental Myology, Victor Babe\u0219 National Institute of Pathology, 050096 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,10,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1016\/S1474-4422(18)30355-7","article-title":"The burden of Parkinson\u2019s disease: A worldwide perspective","volume":"17","author":"Rocca","year":"2018","journal-title":"Lancet Neurol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1002\/mds.26424","article-title":"MDS clinical diagnostic criteria for Parkinson\u2019s disease","volume":"30","author":"Postuma","year":"2015","journal-title":"Mov. 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