{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T18:56:05Z","timestamp":1792090565309,"version":"4.4.0"},"reference-count":234,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2021,11,3]],"date-time":"2021-11-03T00:00:00Z","timestamp":1635897600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Nuclear factor erythroid-2 related factor 2 (Nrf2) is a transcription factor that controls cellular defense responses against toxic and oxidative stress by modulating the expression of genes involved in antioxidant response and drug detoxification. In addition to maintaining redox homeostasis, Nrf2 is also involved in various cellular processes including metabolism and inflammation. Nrf2 activity is tightly regulated at the transcriptional, post-transcriptional and post-translational levels, which allows cells to quickly respond to pathological stress. In the present review, we describe the molecular mechanisms underlying the transcriptional regulation of Nrf2. We also focus on the impact of Nrf2 in cardiac ischemia\u2013reperfusion injury, a condition that stimulates the overproduction of reactive oxygen species. Finally, we analyze the protective effect of several natural and synthetic compounds that induce Nrf2 activation and protect against ischemia\u2013reperfusion injury in the heart and other organs, and their potential clinical application.<\/jats:p>","DOI":"10.3390\/ijms222111939","type":"journal-article","created":{"date-parts":[[2021,11,3]],"date-time":"2021-11-03T17:59:38Z","timestamp":1635962378000},"page":"11939","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":66,"title":["The Antioxidant Transcription Factor Nrf2 in Cardiac Ischemia\u2013Reperfusion Injury"],"prefix":"10.3390","volume":"22","author":[{"given":"Ana","family":"Mata","sequence":"first","affiliation":[{"name":"Centro de Biolog\u00eda Molecular \u201cSevero Ochoa\u201d (CSIC\/UAM), 28049 Madrid, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Princesa (IIS-IP), 28006 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"Cadenas","sequence":"additional","affiliation":[{"name":"Centro de Biolog\u00eda Molecular \u201cSevero Ochoa\u201d (CSIC\/UAM), 28049 Madrid, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Princesa (IIS-IP), 28006 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,11,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1042\/BST20160108","article-title":"Understanding and Preventing Mitochondrial Oxidative Damage","volume":"44","author":"Murphy","year":"2016","journal-title":"Biochem. Soc. Trans."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"R453","DOI":"10.1016\/j.cub.2014.03.034","article-title":"ROS Function in Redox Signaling and Oxidative Stress","volume":"24","author":"Schieber","year":"2014","journal-title":"Curr. Biol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.freeradbiomed.2018.01.024","article-title":"ROS and Redox Signaling in Myocardial Ischemia-Reperfusion Injury and Cardioprotection","volume":"117","author":"Cadenas","year":"2018","journal-title":"Free Radic. Biol. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"4184","DOI":"10.1128\/MCB.15.8.4184","article-title":"Cloning and Characterization of a Novel Erythroid Cell-Derived CNC Family Transcription Factor Heterodimerizing with the Small Maf Family Proteins","volume":"15","author":"Itoh","year":"1995","journal-title":"Mol. Cell Biol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"9926","DOI":"10.1073\/pnas.91.21.9926","article-title":"Isolation of NF-E2-Related Factor 2 (Nrf2), a NF-E2-like Basic Leucine Zipper Transcriptional Activator That Binds to the Tandem NF-E2\/AP1 Repeat of the Beta-Globin Locus Control Region","volume":"91","author":"Moi","year":"1994","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"11371","DOI":"10.1073\/pnas.90.23.11371","article-title":"Cloning of Nrf1, an NF-E2-Related Transcription Factor, by Genetic Selection in Yeast","volume":"90","author":"Chan","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"6443","DOI":"10.1074\/jbc.274.10.6443","article-title":"Molecular Cloning and Functional Characterization of a New Cap\u2019n\u2019 Collar Family Transcription Factor Nrf3","volume":"274","author":"Kobayashi","year":"1999","journal-title":"J. Biol. Chem."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1038\/362722a0","article-title":"Erythroid Transcription Factor NF-E2 Is a Haematopoietic-Specific Basic-Leucine Zipper Protein","volume":"362","author":"Andrews","year":"1993","journal-title":"Nature"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"6083","DOI":"10.1128\/MCB.16.11.6083","article-title":"Bach Proteins Belong to a Novel Family of BTB-Basic Leucine Zipper Transcription Factors That Interact with MafK and Regulate Transcription through the NF-E2 Site","volume":"16","author":"Oyake","year":"1996","journal-title":"Mol. Cell Biol."},{"key":"ref_10","first-page":"3299","article-title":"The Cap\u2019n\u2019Collar Basic Leucine Zipper Transcription Factor Nrf2 (NF-E2 P45-Related Factor 2) Controls Both Constitutive and Inducible Expression of Intestinal Detoxification and Glutathione Biosynthetic Enzymes","volume":"61","author":"McMahon","year":"2001","journal-title":"Cancer Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"11632","DOI":"10.1016\/S0021-9258(18)99004-6","article-title":"The Antioxidant Responsive Element. Activation by Oxidative Stress and Identification of the DNA Consensus Sequence Required for Functional Activity","volume":"266","author":"Rushmore","year":"1991","journal-title":"J. Biol. Chem."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1042\/bj20030754","article-title":"Identification of a Novel Nrf2-Regulated Antioxidant Response Element (ARE) in the Mouse NAD(P)H:Quinone Oxidoreductase 1 Gene: Reassessment of the ARE Consensus Sequence","volume":"374","author":"Nioi","year":"2003","journal-title":"Biochem. J."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.tibs.2014.02.002","article-title":"The Nrf2 Regulatory Network Provides an Interface between Redox and Intermediary Metabolism","volume":"39","author":"Hayes","year":"2014","journal-title":"Trends Biochem. Sci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"192","DOI":"10.2741\/4384","article-title":"Nuclear Factor Erythroid-2 Related Factor 2 (Nrf2)-Mediated Protein Quality Control in Cardiomyocytes","volume":"21","author":"Cui","year":"2016","journal-title":"Front. Biosci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.freeradbiomed.2020.03.023","article-title":"Beyond Repression of Nrf2: An Update on Keap1","volume":"157","author":"Kopacz","year":"2020","journal-title":"Free Radic. Biol. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1152\/physiolgenomics.00041.2017","article-title":"Nrf2 at the Heart of Oxidative Stress and Cardiac Protection","volume":"50","author":"Chen","year":"2018","journal-title":"Physiol. Genom."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"8309698","DOI":"10.1155\/2018\/8309698","article-title":"Nrf2 Deficiency Unmasks the Significance of Nitric Oxide Synthase Activity for Cardioprotection","volume":"2018","author":"Erkens","year":"2018","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1161\/ATVBAHA.110.210906","article-title":"NF-E2-Related Factor 2 Promotes Atherosclerosis by Effects on Plasma Lipoproteins and Cholesterol Transport That Overshadow Antioxidant Protection","volume":"31","author":"Barajas","year":"2011","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"722","DOI":"10.3389\/fphys.2020.00722","article-title":"The Dark Side of Nrf2 in the Heart","volume":"11","author":"Zang","year":"2020","journal-title":"Front. Physiol."},{"key":"ref_20","first-page":"5196","article-title":"Identification of Nrf2-Regulated Genes Induced by the Chemopreventive Agent Sulforaphane by Oligonucleotide Microarray","volume":"62","author":"Thimmulappa","year":"2002","journal-title":"Cancer Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"12029","DOI":"10.1074\/jbc.M211558200","article-title":"Identification of the NF-E2-Related Factor-2-Dependent Genes Conferring Protection against Oxidative Stress in Primary Cortical Astrocytes Using Oligonucleotide Microarray Analysis","volume":"278","author":"Lee","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1093\/toxsci\/kfr183","article-title":"Beneficial Role of Nrf2 in Regulating NADPH Generation and Consumption","volume":"123","author":"Wu","year":"2011","journal-title":"Toxicol. Sci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"3029","DOI":"10.1016\/j.febslet.2005.04.058","article-title":"Role of Nrf2 Signaling in Regulation of Antioxidants and Phase 2 Enzymes in Cardiac Fibroblasts: Protection against Reactive Oxygen and Nitrogen Species-Induced Cell Injury","volume":"579","author":"Zhu","year":"2005","journal-title":"FEBS Lett."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1016\/j.freeradbiomed.2007.03.018","article-title":"Upregulation of Thioredoxin System via Nrf2-Antioxidant Responsive Element Pathway in Adaptive-Retinal Neuroprotection in Vivo and in Vitro","volume":"42","author":"Tanito","year":"2007","journal-title":"Free Radic. Biol. Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1093\/carcin\/bgp176","article-title":"Characterization of the Cancer Chemopreventive NRF2-Dependent Gene Battery in Human Keratinocytes: Demonstration That the KEAP1-NRF2 Pathway, and Not the BACH1-NRF2 Pathway, Controls Cytoprotection against Electrophiles as Well as Redox-Cycling Compounds","volume":"30","author":"MacLeod","year":"2009","journal-title":"Carcinogenesis"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s10549-011-1536-9","article-title":"Transcriptomic and Proteomic Profiling of KEAP1 Disrupted and Sulforaphane-Treated Human Breast Epithelial Cells Reveals Common Expression Profiles","volume":"132","author":"Agyeman","year":"2012","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"5171","DOI":"10.1073\/pnas.0813132106","article-title":"Bilirubin and Glutathione Have Complementary Antioxidant and Cytoprotective Roles","volume":"106","author":"Sedlak","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1002\/hep.21831","article-title":"Oxidative and Electrophilic Stress Induces Multidrug Resistance-Associated Protein Transporters via the Nuclear Factor-E2-Related Factor-2 Transcriptional Pathway","volume":"46","author":"Maher","year":"2007","journal-title":"Hepatology"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1006\/bbrc.1997.6943","article-title":"An Nrf2\/Small Maf Heterodimer Mediates the Induction of Phase II Detoxifying Enzyme Genes through Antioxidant Response Elements","volume":"236","author":"Itoh","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1242\/bio.20134853","article-title":"Nrf2 Impacts Cellular Bioenergetics by Controlling Substrate Availability for Mitochondrial Respiration","volume":"2","author":"Baird","year":"2013","journal-title":"Biol. Open"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1038\/s41419-018-0436-x","article-title":"The Mitochondrially Targeted Antioxidant MitoQ Protects the Intestinal Barrier by Ameliorating Mitochondrial DNA Damage via the Nrf2\/ARE Signaling Pathway","volume":"9","author":"Hu","year":"2018","journal-title":"Cell Death Dis."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2883","DOI":"10.1128\/MCB.22.9.2883-2892.2002","article-title":"Enhanced Expression of the Transcription Factor Nrf2 by Cancer Chemopreventive Agents: Role of Antioxidant Response Element-like Sequences in the Nrf2 Promoter","volume":"22","author":"Kwak","year":"2002","journal-title":"Mol. Cell Biol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"3765","DOI":"10.1038\/onc.2012.388","article-title":"Nrf2 Is Controlled by Two Distinct \u03b2-TrCP Recognition Motifs in Its Neh6 Domain, One of Which Can Be Modulated by GSK-3 Activity","volume":"32","author":"Chowdhry","year":"2013","journal-title":"Oncogene"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1128\/MCB.01204-10","article-title":"SCF\/{beta}-TrCP Promotes Glycogen Synthase Kinase 3-Dependent Degradation of the Nrf2 Transcription Factor in a Keap1-Independent Manner","volume":"31","author":"Rada","year":"2011","journal-title":"Mol. Cell Biol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"3486","DOI":"10.1128\/MCB.00180-12","article-title":"Structural and Functional Characterization of Nrf2 Degradation by the Glycogen Synthase Kinase 3\/\u03b2-TrCP Axis","volume":"32","author":"Rada","year":"2012","journal-title":"Mol. Cell Biol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2877","DOI":"10.1074\/jbc.275.4.2877","article-title":"Homodimer of Two F-Box Proteins BetaTrCP1 or BetaTrCP2 Binds to IkappaBalpha for Signal-Dependent Ubiquitination","volume":"275","author":"Suzuki","year":"2000","journal-title":"J. Biol. Chem."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1016\/S1097-2765(03)00234-X","article-title":"Structure of a Beta-TrCP1-Skp1-Beta-Catenin Complex: Destruction Motif Binding and Lysine Specificity of the SCF(Beta-TrCP1) Ubiquitin Ligase","volume":"11","author":"Wu","year":"2003","journal-title":"Mol. Cell"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"6379","DOI":"10.1073\/pnas.0305902101","article-title":"Small Maf Proteins Serve as Transcriptional Cofactors for Keratinocyte Differentiation in the Keap1-Nrf2 Regulatory Pathway","volume":"101","author":"Motohashi","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Fuse, Y., and Kobayashi, M. (2017). Conservation of the Keap1-Nrf2 System: An Evolutionary Journey through Stressful Space and Time. Molecules, 22.","DOI":"10.3390\/molecules22030436"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1046\/j.1365-2443.2001.00469.x","article-title":"Two Domains of Nrf2 Cooperatively Bind CBP, a CREB Binding Protein, and Synergistically Activate Transcription","volume":"6","author":"Katoh","year":"2001","journal-title":"Genes Cells"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"3097","DOI":"10.1158\/0008-5472.CAN-12-3386","article-title":"RXR\u03b1 Inhibits the NRF2-ARE Signaling Pathway through a Direct Interaction with the Neh7 Domain of NRF2","volume":"73","author":"Wang","year":"2013","journal-title":"Cancer Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1042\/BST20150011","article-title":"Dual Regulation of Transcription Factor Nrf2 by Keap1 and by the Combined Actions of \u03b2-TrCP and GSK-3","volume":"43","author":"Hayes","year":"2015","journal-title":"Biochem. Soc. Trans."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1089\/ars.2017.7342","article-title":"Transcriptional Regulation by Nrf2","volume":"29","author":"Tonelli","year":"2018","journal-title":"Antioxid. Redox Signal."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"20340","DOI":"10.1074\/jbc.M412081200","article-title":"Transcriptional Regulation of NF-E2 P45-Related Factor (NRF2) Expression by the Aryl Hydrocarbon Receptor-Xenobiotic Response Element Signaling Pathway: Direct Cross-Talk between Phase I and II Drug-Metabolizing Enzymes","volume":"280","author":"Miao","year":"2005","journal-title":"J. Biol. Chem."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1093\/toxsci\/kfp168","article-title":"Cross-Talk between Transcription Factors AhR and Nrf2: Lessons for Cancer Chemoprevention from Dioxin","volume":"111","author":"Hayes","year":"2009","journal-title":"Toxicol. Sci."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"33142","DOI":"10.1074\/jbc.M002319200","article-title":"Suppression of Rat Thromboxane Synthase Gene Transcription by Peroxisome Proliferator-Activated Receptor Gamma in Macrophages via an Interaction with NRF2","volume":"275","author":"Ikeda","year":"2000","journal-title":"J. Biol. Chem."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"3701","DOI":"10.1158\/0008-5472.CAN-03-3924","article-title":"Transactivation of the PPAR-Responsive Enhancer Module in Chemopreventive Glutathione S-Transferase Gene by the Peroxisome Proliferator-Activated Receptor-Gamma and Retinoid X Receptor Heterodimer","volume":"64","author":"Park","year":"2004","journal-title":"Cancer Res."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"5188","DOI":"10.1182\/blood-2012-04-422121","article-title":"The High Nrf2 Expression in Human Acute Myeloid Leukemia Is Driven by NF-\u039aB and Underlies Its Chemo-Resistance","volume":"120","author":"Rushworth","year":"2012","journal-title":"Blood"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"15244","DOI":"10.1074\/jbc.M113.540633","article-title":"Transcription Factors NRF2 and NF-\u039aB Are Coordinated Effectors of the Rho Family, GTP-Binding Protein RAC1 during Inflammation","volume":"289","author":"Cuadrado","year":"2014","journal-title":"J. Biol. Chem."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"100704","DOI":"10.1016\/j.jbc.2021.100704","article-title":"Sp1 Is a Substrate of Keap1 and Regulates the Activity of CRL4AWDR23 Ubiquitin Ligase toward Nrf2","volume":"296","author":"Siswanto","year":"2021","journal-title":"J. Biol. Chem."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"41692","DOI":"10.18632\/oncotarget.6150","article-title":"Mutant P53 Confers Chemoresistance in Non-Small Cell Lung Cancer by Upregulating Nrf2","volume":"6","author":"Tung","year":"2015","journal-title":"Oncotarget"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/nature10189","article-title":"Oncogene-Induced Nrf2 Transcription Promotes ROS Detoxification and Tumorigenesis","volume":"475","author":"DeNicola","year":"2011","journal-title":"Nature"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1002\/iub.314","article-title":"C-Myc Is a Nrf2-Interacting Protein That Negatively Regulates Phase II Genes through Their Electrophile Responsive Elements","volume":"62","author":"Levy","year":"2010","journal-title":"IUBMB Life"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1084\/jem.20121337","article-title":"BRCA1 Interacts with Nrf2 to Regulate Antioxidant Signaling and Cell Survival","volume":"210","author":"Gorrini","year":"2013","journal-title":"J. Exp. Med."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.abb.2016.10.010","article-title":"Keap1 as the Redox Sensor of the Antioxidant Response","volume":"617","author":"Sihvola","year":"2017","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.abb.2016.08.005","article-title":"Keap1, the Cysteine-Based Mammalian Intracellular Sensor for Electrophiles and Oxidants","volume":"617","author":"Kostov","year":"2017","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"11908","DOI":"10.1073\/pnas.172398899","article-title":"Direct Evidence That Sulfhydryl Groups of Keap1 Are the Sensors Regulating Induction of Phase 2 Enzymes That Protect against Carcinogens and Oxidants","volume":"99","author":"Holtzclaw","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.abb.2004.10.012","article-title":"Evolutionary Conserved N-Terminal Domain of Nrf2 Is Essential for the Keap1-Mediated Degradation of the Protein by Proteasome","volume":"433","author":"Katoh","year":"2005","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"13291","DOI":"10.1074\/jbc.R900010200","article-title":"The Nrf2-Antioxidant Response Element Signaling Pathway and Its Activation by Oxidative Stress","volume":"284","author":"Nguyen","year":"2009","journal-title":"J. Biol. Chem."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.1074\/jbc.M209195200","article-title":"Degradation of Transcription Factor Nrf2 via the Ubiquitin-Proteasome Pathway and Stabilization by Cadmium","volume":"278","author":"Stewart","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"7511","DOI":"10.1128\/MCB.00753-07","article-title":"Different Electrostatic Potentials Define ETGE and DLG Motifs as Hinge and Latch in Oxidative Stress Response","volume":"27","author":"Tong","year":"2007","journal-title":"Mol. Cell Biol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"42769","DOI":"10.1074\/jbc.M206911200","article-title":"Phosphorylation of Nrf2 at Ser-40 by Protein Kinase C Regulates Antioxidant Response Element-Mediated Transcription","volume":"277","author":"Huang","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_63","first-page":"40","article-title":"GSK-3: Functional Insights from Cell Biology and Animal Models","volume":"4","author":"Woodgett","year":"2011","journal-title":"Front. Mol. Neurosci."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1101\/gad.238246.114","article-title":"Hrd1 Suppresses Nrf2-Mediated Cellular Protection during Liver Cirrhosis","volume":"28","author":"Wu","year":"2014","journal-title":"Genes Dev."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"21258","DOI":"10.1074\/jbc.M109.084590","article-title":"CR6-Interacting Factor 1 (CRIF1) Regulates NF-E2-Related Factor 2 (NRF2) Protein Stability by Proteasome-Mediated Degradation","volume":"285","author":"Kang","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"2658","DOI":"10.1128\/MCB.01639-08","article-title":"Acetylation of Nrf2 by P300\/CBP Augments Promoter-Specific DNA Binding of Nrf2 during the Antioxidant Response","volume":"29","author":"Sun","year":"2009","journal-title":"Mol. Cell Biol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"14569","DOI":"10.1074\/jbc.M112.437392","article-title":"Trafficking of the Transcription Factor Nrf2 to Promyelocytic Leukemia-Nuclear Bodies: Implications for Degradation of NRF2 in the Nucleus","volume":"288","author":"Malloy","year":"2013","journal-title":"J. Biol. Chem."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1042\/BST20140317","article-title":"NRF2 and MicroRNAs: New but Awaited Relations","volume":"43","author":"Kurinna","year":"2015","journal-title":"Biochem. Soc. Trans."},{"key":"ref_69","first-page":"1233","article-title":"Role of MicroRNAs in the Regulation of Redox-Dependent Processes","volume":"84","author":"Kalinina","year":"2019","journal-title":"Biochemistry"},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"W\u0142odarski, A., Strycharz, J., Wr\u00f3blewski, A., Kasznicki, J., Drzewoski, J., and \u015aliwi\u0144ska, A. (2020). The Role of MicroRNAs in Metabolic Syndrome-Related Oxidative Stress. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21186902"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.cell.2009.01.002","article-title":"MicroRNAs: Target Recognition and Regulatory Functions","volume":"136","author":"Bartel","year":"2009","journal-title":"Cell"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/s41580-018-0059-1","article-title":"Regulation of MicroRNA Biogenesis and Its Crosstalk with Other Cellular Pathways","volume":"20","author":"Treiber","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","article-title":"MicroRNAs: Genomics, Biogenesis, Mechanism, and Function","volume":"116","author":"Bartel","year":"2004","journal-title":"Cell"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1016\/j.febslet.2012.05.016","article-title":"The NRF2-Related Interactome and Regulome Contain Multifunctional Proteins and Fine-Tuned Autoregulatory Loops","volume":"586","author":"Papp","year":"2012","journal-title":"FEBS Lett."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1007\/s10549-011-1604-1","article-title":"MiR-28 Regulates Nrf2 Expression through a Keap1-Independent Mechanism","volume":"129","author":"Yang","year":"2011","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.toxlet.2014.05.020","article-title":"Hydrogen Peroxide Responsive MiR153 Targets Nrf2\/ARE Cytoprotection in Paraquat Induced Dopaminergic Neurotoxicity","volume":"228","author":"Narasimhan","year":"2014","journal-title":"Toxicol. Lett."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1158\/1541-7786.MCR-13-0246-T","article-title":"The Impact of MiRNA-Based Molecular Diagnostics and Treatment of NRF2-Stabilized Tumors","volume":"12","author":"Yamamoto","year":"2014","journal-title":"Mol. Cancer Res."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1093\/carcin\/bgt026","article-title":"MicroRNA-93 Regulates NRF2 Expression and Is Associated with Breast Carcinogenesis","volume":"34","author":"Singh","year":"2013","journal-title":"Carcinogenesis"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"4338","DOI":"10.1182\/blood-2009-04-214817","article-title":"MicroRNA MiR-144 Modulates Oxidative Stress Tolerance and Associates with Anemia Severity in Sickle Cell Disease","volume":"116","author":"Sangokoya","year":"2010","journal-title":"Blood"},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Narasimhan, M., Patel, D., Vedpathak, D., Rathinam, M., Henderson, G., and Mahimainathan, L. (2012). Identification of Novel MicroRNAs in Post-Transcriptional Control of Nrf2 Expression and Redox Homeostasis in Neuronal, SH-SY5Y Cells. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0051111"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"H292","DOI":"10.1152\/ajpheart.00307.2014","article-title":"Caloric Restriction Confers Persistent Anti-Oxidative, pro-Angiogenic, and Anti-Inflammatory Effects and Promotes Anti-Aging MiRNA Expression Profile in Cerebromicrovascular Endothelial Cells of Aged Rats","volume":"307","author":"Csiszar","year":"2014","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"101336","DOI":"10.1016\/j.redox.2019.101336","article-title":"Inhibiting MicroRNA-144 Potentiates Nrf2-Dependent Antioxidant Signaling in RPE and Protects against Oxidative Stress-Induced Outer Retinal Degeneration","volume":"28","author":"Jadeja","year":"2020","journal-title":"Redox Biol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1016\/j.ajpath.2020.05.008","article-title":"Long Noncoding RNA MEG3 Inhibits Apoptosis of Retinal Pigment Epithelium Cells Induced by High Glucose via the MiR-93\/Nrf2 Axis","volume":"190","author":"Luo","year":"2020","journal-title":"Am. J. Pathol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"7416","DOI":"10.1093\/nar\/gks409","article-title":"Identification of Novel NRF2-Regulated Genes by ChIP-Seq: Influence on Retinoid X Receptor Alpha","volume":"40","author":"Chorley","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"5099","DOI":"10.1038\/ncomms6099","article-title":"A Novel Nrf2-MiR-29-Desmocollin-2 Axis Regulates Desmosome Function in Keratinocytes","volume":"5","author":"Kurinna","year":"2014","journal-title":"Nat. Commun."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"e899","DOI":"10.1038\/cddis.2013.427","article-title":"MiR-125b Transcriptionally Increased by Nrf2 Inhibits AhR Repressor, Which Protects Kidney from Cisplatin-Induced Injury","volume":"4","author":"Joo","year":"2013","journal-title":"Cell Death Dis."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/cdd.2014.152","article-title":"NRF2-Driven MiR-125B1 and MiR-29B1 Transcriptional Regulation Controls a Novel Anti-Apoptotic MiRNA Regulatory Network for AML Survival","volume":"22","author":"Shah","year":"2015","journal-title":"Cell Death Differ."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1172\/JCI62874","article-title":"Myocardial Ischemia-Reperfusion Injury: A Neglected Therapeutic Target","volume":"123","author":"Hausenloy","year":"2013","journal-title":"J. Clin. Investig."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"H566","DOI":"10.1152\/ajpheart.00711.2002","article-title":"Ischemic Preconditioning Alters Real-Time Measure of O2 Radicals in Intact Hearts with Ischemia and Reperfusion","volume":"284","author":"Kevin","year":"2003","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"97","DOI":"10.2174\/138920112798868782","article-title":"Reactive Oxygen Species in Myocardial Reperfusion Injury: From Physiopathology to Therapeutic Approaches","volume":"13","author":"Braunersreuther","year":"2012","journal-title":"Curr. Pharm. Biotechnol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"18890","DOI":"10.1016\/S0021-9258(19)47240-2","article-title":"Measurement and Characterization of Postischemic Free Radical Generation in the Isolated Perfused Heart","volume":"264","author":"Zweier","year":"1989","journal-title":"J. Biol. Chem."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1161\/01.RES.67.6.1453","article-title":"Enhanced Chemiluminescence as a Measure of Oxygen-Derived Free Radical Generation during Ischemia and Reperfusion","volume":"67","author":"Henry","year":"1990","journal-title":"Circ. Res."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.cardiores.2006.02.025","article-title":"The Role of Oxidants and Free Radicals in Reperfusion Injury","volume":"70","author":"Zweier","year":"2006","journal-title":"Cardiovasc. Res."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.redox.2015.08.020","article-title":"Reperfusion Injury and Reactive Oxygen Species: The Evolution of a Concept","volume":"6","author":"Granger","year":"2015","journal-title":"Redox Biol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1159\/000489241","article-title":"Current Mechanistic Concepts in Ischemia and Reperfusion Injury","volume":"46","author":"Wu","year":"2018","journal-title":"Cell Physiol. Biochem."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"2480","DOI":"10.2174\/0929867322666150530210005","article-title":"Modulation of Mitochondrial Permeability Transition in Ischemia-Reperfusion Injury of the Heart. Advantages and Limitations","volume":"22","author":"Bernardi","year":"2015","journal-title":"Curr. Med. Chem."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.cardiores.2006.02.011","article-title":"The End-Effectors of Preconditioning Protection against Myocardial Cell Death Secondary to Ischemia-Reperfusion","volume":"70","author":"Inserte","year":"2006","journal-title":"Cardiovasc. Res."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/S0008-6363(03)00533-9","article-title":"Mitochondrial Permeability Transition Pore Opening during Myocardial Reperfusion\u2014A Target for Cardioprotection","volume":"61","author":"Halestrap","year":"2004","journal-title":"Cardiovasc. Res."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"H1281","DOI":"10.1152\/ajpheart.00435.2009","article-title":"Role of Sarcoplasmic Reticulum in Mitochondrial Permeability Transition and Cardiomyocyte Death during Reperfusion","volume":"297","year":"2009","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1042\/BJ20042006","article-title":"Biochemical Dysfunction in Heart Mitochondria Exposed to Ischaemia and Reperfusion","volume":"390","author":"Solaini","year":"2005","journal-title":"Biochem. J."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0005-2728(88)90119-3","article-title":"An Assessment of Anaerobic Metabolism during Ischemia and Reperfusion in Isolated Guinea Pig Heart","volume":"934","author":"Pisarenko","year":"1988","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_102","first-page":"H281","article-title":"Tricarboxylic Acid Cycle Metabolites during Ischemia in Isolated Perfused Rat Heart","volume":"244","author":"Peuhkurinen","year":"1983","journal-title":"Am. J. Physiol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/nature13909","article-title":"Ischaemic Accumulation of Succinate Controls Reperfusion Injury through Mitochondrial ROS","volume":"515","author":"Chouchani","year":"2014","journal-title":"Nature"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.cmet.2015.12.009","article-title":"A Unifying Mechanism for Mitochondrial Superoxide Production during Ischemia-Reperfusion Injury","volume":"23","author":"Chouchani","year":"2016","journal-title":"Cell Metab."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1093\/cvr\/cvw100","article-title":"Succinate Metabolism: A New Therapeutic Target for Myocardial Reperfusion Injury","volume":"111","author":"Pell","year":"2016","journal-title":"Cardiovasc. Res."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1111\/j.1749-6632.2010.05627.x","article-title":"Animal and Human Studies with the Mitochondria-Targeted Antioxidant MitoQ","volume":"1201","author":"Smith","year":"2010","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1096\/fj.05-3718com","article-title":"Targeting an Antioxidant to Mitochondria Decreases Cardiac Ischemia-Reperfusion Injury","volume":"19","author":"Adlam","year":"2005","journal-title":"FASEB J."},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Andrienko, T., Pasdois, P., Rossbach, A., and Halestrap, A.P. (2016). Real-Time Fluorescence Measurements of ROS and [Ca2+] in Ischemic\/Reperfused Rat Hearts: Detectable Increases Occur Only after Mitochondrial Pore Opening and Are Attenuated by Ischemic Preconditioning. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0167300"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.yjmcc.2017.06.016","article-title":"The Role of Succinate and ROS in Reperfusion Injury\u2014A Critical Appraisal","volume":"110","author":"Andrienko","year":"2017","journal-title":"J. Mol. Cell Cardiol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.ejphar.2015.04.009","article-title":"Differences in the Profile of Protection Afforded by TRO40303 and Mild Hypothermia in Models of Cardiac Ischemia\/Reperfusion Injury","volume":"760","author":"Hansson","year":"2015","journal-title":"Eur. J. Pharmacol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1093\/cvr\/cvv279","article-title":"Succinate Dehydrogenase Inhibition with Malonate during Reperfusion Reduces Infarct Size by Preventing Mitochondrial Permeability Transition","volume":"109","author":"Barba","year":"2016","journal-title":"Cardiovasc. Res."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1016\/j.bbadis.2014.06.002","article-title":"Myocardial Ischemic Reperfusion Induces de Novo Nrf2 Protein Translation","volume":"1842","author":"Xu","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"2624","DOI":"10.1096\/fj.06-5097fje","article-title":"Reoxygenation-Specific Activation of the Antioxidant Transcription Factor Nrf2 Mediates Cytoprotective Gene Expression in Ischemia-Reperfusion Injury","volume":"20","author":"Leonard","year":"2006","journal-title":"FASEB J."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"7042105","DOI":"10.1155\/2018\/7042105","article-title":"MicroRNA MiR-24-3p Reduces Apoptosis and Regulates Keap1-Nrf2 Pathway in Mouse Cardiomyocytes Responding to Ischemia\/Reperfusion Injury","volume":"2018","author":"Xiao","year":"2018","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s10577-019-09608-y","article-title":"MiR-153 Regulates Cardiomyocyte Apoptosis by Targeting Nrf2\/HO-1 Signaling","volume":"27","author":"Zhu","year":"2019","journal-title":"Chromosome Res."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s12938-020-0759-6","article-title":"Inhibition of MiR-153 Ameliorates Ischemia\/Reperfusion-Induced Cardiomyocytes Apoptosis by Regulating Nrf2\/HO-1 Signaling in Rats","volume":"19","author":"Hou","year":"2020","journal-title":"Biomed. Eng. Online"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.freeradbiomed.2013.04.007","article-title":"The Transcription Factor Nrf2 Promotes Survival by Enhancing the Expression of Uncoupling Protein 3 under Conditions of Oxidative Stress","volume":"61","author":"Anedda","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.yjmcc.2010.05.011","article-title":"4-Hydroxy-2-Nonenal Protects against Cardiac Ischemia-Reperfusion Injury via the Nrf2-Dependent Pathway","volume":"49","author":"Zhang","year":"2010","journal-title":"J. Mol. Cell Cardiol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.freeradbiomed.2015.03.032","article-title":"4-Hydroxynonenal Induces Nrf2-Mediated UCP3 Upregulation in Mouse Cardiomyocytes","volume":"88","author":"Anedda","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1161\/ATVBAHA.109.189480","article-title":"Nrf2 Protects against Maladaptive Cardiac Responses to Hemodynamic Stress","volume":"29","author":"Li","year":"2009","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1111\/ajt.15724","article-title":"Protective Role of Nrf2 against Ischemia Reperfusion Injury and Cardiac Allograft Vasculopathy","volume":"20","author":"Fukunaga","year":"2020","journal-title":"Am. J. Transpl."},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Kura, B., Szeiffova Bacova, B., Kalocayova, B., Sykora, M., and Slezak, J. (2020). Oxidative Stress-Responsive MicroRNAs in Heart Injury. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21010358"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.freeradbiomed.2021.04.034","article-title":"Systematic Review and Network Analysis of MicroRNAs Involved in Cardioprotection against Myocardial Ischemia\/Reperfusion Injury and Infarction: Involvement of Redox Signalling","volume":"172","author":"Makkos","year":"2021","journal-title":"Free Radic. Biol. Med."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"101607","DOI":"10.1016\/j.redox.2020.101607","article-title":"MicroRNAs in the Regulation of Cellular Redox Status and Its Implications in Myocardial Ischemia-Reperfusion Injury","volume":"36","author":"Carbonell","year":"2020","journal-title":"Redox Biol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"H1519","DOI":"10.1152\/ajpheart.01080.2010","article-title":"MicroRNA-210 Is Upregulated in Hypoxic Cardiomyocytes through Akt- and P53-Dependent Pathways and Exerts Cytoprotective Effects","volume":"301","author":"Mutharasan","year":"2011","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1097\/TP.0000000000003215","article-title":"Dual MicroRNA Blockade Increases Expression of Antioxidant Protective Proteins: Implications for Ischemia-Reperfusion Injury","volume":"104","author":"Tingle","year":"2020","journal-title":"Transplantation"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.3892\/ijmm.2016.2719","article-title":"Overexpression of MiR-200a Protects Cardiomyocytes against Hypoxia-Induced Apoptosis by Modulating the Kelch-like ECH-Associated Protein 1-Nuclear Factor Erythroid 2-Related Factor 2 Signaling Axis","volume":"38","author":"Sun","year":"2016","journal-title":"Int. J. Mol. Med."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.neuroscience.2007.02.066","article-title":"Role of Reactive Oxygen Species in Modulation of Nrf2 Following Ischemic Reperfusion Injury","volume":"147","author":"Shah","year":"2007","journal-title":"Neuroscience"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"10321","DOI":"10.1523\/JNEUROSCI.4014-05.2005","article-title":"A Small-Molecule-Inducible Nrf2-Mediated Antioxidant Response Provides Effective Prophylaxis against Cerebral Ischemia in Vivo","volume":"25","author":"Shih","year":"2005","journal-title":"J. Neurosci."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.neuroscience.2019.08.027","article-title":"Nuclear Factor (Erythroid-Derived 2)-Like 2 (Nrf2) Contributes to the Neuroprotective Effects of Histone Deacetylase Inhibitors In Retinal Ischemia-Reperfusion Injury","volume":"418","author":"Zhou","year":"2019","journal-title":"Neuroscience"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"3625","DOI":"10.1038\/srep03625","article-title":"Nrf2 Protects against TWEAK-Mediated Skeletal Muscle Wasting","volume":"4","author":"Fragoulis","year":"2014","journal-title":"Sci. Rep."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1097\/SLA.0000000000000287","article-title":"Nrf2 Activation Protects the Liver from Ischemia\/Reperfusion Injury in Mice","volume":"260","author":"Kudoh","year":"2014","journal-title":"Ann. Surg."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1002\/lt.24303","article-title":"Overactivation of the Nuclear Factor (Erythroid-Derived 2)-like 2-Antioxidant Response Element Pathway in Hepatocytes Decreases Hepatic Ischemia\/Reperfusion Injury in Mice","volume":"22","author":"Lee","year":"2016","journal-title":"Liver Transpl."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1097\/TP.0000000000000316","article-title":"Nuclear Factor Erythroid 2-Related Factor 2 Regulates Toll-like Receptor 4 Innate Responses in Mouse Liver Ischemia-Reperfusion Injury through Akt-Forkhead Box Protein O1 Signaling Network","volume":"98","author":"Huang","year":"2014","journal-title":"Transplantation"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1016\/j.jhep.2013.07.016","article-title":"KEAP1-NRF2 Complex in Ischemia-Induced Hepatocellular Damage of Mouse Liver Transplants","volume":"59","author":"Ke","year":"2013","journal-title":"J. Hepatol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/ki.2009.157","article-title":"Transcription Factor Nrf2 Is Protective during Ischemic and Nephrotoxic Acute Kidney Injury in Mice","volume":"76","author":"Liu","year":"2009","journal-title":"Kidney Int."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.kint.2016.08.023","article-title":"Transcription Factor Nrf2 Hyperactivation in Early-Phase Renal Ischemia-Reperfusion Injury Prevents Tubular Damage Progression","volume":"91","author":"Nezu","year":"2017","journal-title":"Kidney Int."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/nrcardio.2016.5","article-title":"Ischaemic Conditioning and Reperfusion Injury","volume":"13","author":"Hausenloy","year":"2016","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1161\/01.CIR.74.5.1124","article-title":"Preconditioning with Ischemia: A Delay of Lethal Cell Injury in Ischemic Myocardium","volume":"74","author":"Murry","year":"1986","journal-title":"Circulation"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s11010-013-1812-6","article-title":"Nrf2-Dependent Upregulation of Antioxidative Enzymes: A Novel Pathway for Hypoxic Preconditioning-Mediated Delayed Cardioprotection","volume":"385","author":"Huang","year":"2014","journal-title":"Mol. Cell Biochem."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s11010-012-1458-9","article-title":"Participation of Protein Kinase C in the Activation of Nrf2 Signaling by Ischemic Preconditioning in the Isolated Rabbit Heart","volume":"372","author":"Zhang","year":"2013","journal-title":"Mol. Cell Biochem."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.freeradbiomed.2014.06.021","article-title":"Nrf2-Regulated Antioxidant Response Is Activated by Protein Kinase C in Postconditioned Rat Hearts","volume":"74","author":"Zazueta","year":"2014","journal-title":"Free Radic. Biol. Med."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"H2196","DOI":"10.1152\/ajpheart.00934.2010","article-title":"H2O2 Preconditioning Modulates Phase II Enzymes through P38 MAPK and PI3K\/Akt Activation","volume":"300","author":"Angeloni","year":"2011","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.yjmcc.2011.11.005","article-title":"Carbon Monoxide Induces a Late Preconditioning-Mimetic Cardioprotective and Antiapoptotic Milieu in the Myocardium","volume":"52","author":"Stein","year":"2012","journal-title":"J. Mol. Cell Cardiol."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1089\/ars.2018.7541","article-title":"Nuclear Factor (Erythroid-Derived 2)-Like 2 Regulates the Hepatoprotective Effects of Remote Ischemic Conditioning in Hemorrhagic Shock","volume":"30","author":"Leung","year":"2019","journal-title":"Antioxid. Redox Signal."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"313","DOI":"10.33549\/physiolres.932834","article-title":"Activation of Nrf2 by Ischemic Preconditioning and Sulforaphane in Renal Ischemia\/Reperfusion Injury: A Comparative Experimental Study","volume":"64","author":"Shokeir","year":"2015","journal-title":"Physiol. Res."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1124\/mol.106.029033","article-title":"Hepatic Ischemia-Reperfusion Induces Renal Heme Oxygenase-1 via NF-E2-Related Factor 2 in Rats and Mice","volume":"71","author":"Tanaka","year":"2007","journal-title":"Mol. Pharmacol."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/j.freeradbiomed.2013.08.190","article-title":"Sulforaphane Preconditioning of the Nrf2\/HO-1 Defense Pathway Protects the Cerebral Vasculature against Blood-Brain Barrier Disruption and Neurological Deficits in Stroke","volume":"65","author":"Alfieri","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s12975-017-0574-y","article-title":"Ischemic Preconditioning Protects Astrocytes against Oxygen Glucose Deprivation Via the Nuclear Erythroid 2-Related Factor 2 Pathway","volume":"9","author":"Narayanan","year":"2018","journal-title":"Transl. Stroke Res."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"E1","DOI":"10.1073\/pnas.1015229108","article-title":"Mild Oxidative Stress Activates Nrf2 in Astrocytes, Which Contributes to Neuroprotective Ischemic Preconditioning","volume":"108","author":"Bell","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.redox.2018.05.001","article-title":"Brain Ischemic Preconditioning Protects against Ischemic Injury and Preserves the Blood-Brain Barrier via Oxidative Signaling and Nrf2 Activation","volume":"17","author":"Yang","year":"2018","journal-title":"Redox Biol."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"113142","DOI":"10.1016\/j.expneurol.2019.113142","article-title":"Ischemic Preconditioning Provides Long-Lasting Neuroprotection against Ischemic Stroke: The Role of Nrf2","volume":"325","author":"Yang","year":"2020","journal-title":"Exp. Neurol."},{"key":"ref_153","first-page":"9372182","article-title":"Activators and Inhibitors of NRF2: A Review of Their Potential for Clinical Development","volume":"2019","author":"Manda","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_154","doi-asserted-by":"crossref","unstructured":"Yagishita, Y., Gatbonton-Schwager, T.N., McCallum, M.L., and Kensler, T.W. (2020). Current Landscape of NRF2 Biomarkers in Clinical Trials. Antioxidants, 9.","DOI":"10.3390\/antiox9080716"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/s41573-018-0008-x","article-title":"Therapeutic Targeting of the NRF2 and KEAP1 Partnership in Chronic Diseases","volume":"18","author":"Cuadrado","year":"2019","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1161\/CIRCULATIONAHA.109.920991","article-title":"Genetic and Pharmacologic Hydrogen Sulfide Therapy Attenuates Ischemia-Induced Heart Failure in Mice","volume":"122","author":"Calvert","year":"2010","journal-title":"Circulation"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1161\/CIRCRESAHA.109.199919","article-title":"Hydrogen Sulfide Mediates Cardioprotection Through Nrf2 Signaling","volume":"105","author":"Calvert","year":"2009","journal-title":"Circ. Res."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.brainresbull.2015.12.007","article-title":"Preconditioning of H2S Inhalation Protects against Cerebral Ischemia\/Reperfusion Injury by Induction of HSP70 through PI3K\/Akt\/Nrf2 Pathway","volume":"121","author":"Ji","year":"2016","journal-title":"Brain Res. Bull."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3892\/mmr.2021.12157","article-title":"Hydrogen Sulfide Attenuates Renal I\/R-induced Activation of the Inflammatory Response and Apoptosis via Regulating Nrf2-mediated NLRP3 Signaling Pathway Inhibition","volume":"24","author":"Su","year":"2021","journal-title":"Mol. Med. Rep."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.freeradbiomed.2019.08.012","article-title":"Sulforaphane Protects from Myocardial Ischemia-Reperfusion Damage through the Balanced Activation of Nrf2\/AhR","volume":"143","author":"Zazueta","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.brainres.2010.04.036","article-title":"Sulforaphane Protects Brains against Hypoxic\u2013Ischemic Injury through Induction of Nrf2-Dependent Phase 2 Enzyme","volume":"1343","author":"Ping","year":"2010","journal-title":"Brain Res."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.neulet.2005.09.065","article-title":"Sulforaphane Reduces Infarct Volume Following Focal Cerebral Ischemia in Rodents","volume":"393","author":"Zhao","year":"2006","journal-title":"Neurosci. Lett."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"3525","DOI":"10.1113\/jphysiol.2013.257964","article-title":"Temporal and Spatial Distribution of Nrf2 in Rat Brain Following Stroke: Quantification of Nuclear to Cytoplasmic Nrf2 Content Using a Novel Immunohistochemical Technique","volume":"591","author":"Srivastava","year":"2013","journal-title":"J. Physiol."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"101708","DOI":"10.1016\/j.redox.2020.101708","article-title":"Nrf2-Regulated Redox Signaling in Brain Endothelial Cells Adapted to Physiological Oxygen Levels: Consequences for Sulforaphane Mediated Protection against Hypoxia-Reoxygenation","volume":"37","author":"Warpsinski","year":"2020","journal-title":"Redox Biol."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"2214","DOI":"10.1016\/j.bcp.2008.02.029","article-title":"Sulforaphane Protects Kidneys against Ischemia-Reperfusion Injury through Induction of the Nrf2-Dependent Phase 2 Enzyme","volume":"75","author":"Yoon","year":"2008","journal-title":"Biochem. Pharmacol."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.lfs.2016.01.038","article-title":"Molecular and Biochemical Evidence on the Protective Effects of Embelin and Carnosic Acid in Isoproterenol-Induced Acute Myocardial Injury in Rats","volume":"147","author":"Kocak","year":"2016","journal-title":"Life Sci."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s11010-014-2092-5","article-title":"Carnosic Acid Promotes Myocardial Antioxidant Response and Prevents Isoproterenol-Induced Myocardial Oxidative Stress and Apoptosis in Mice","volume":"394","author":"Sahu","year":"2014","journal-title":"Mol. Cell Biochem."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1111\/j.1471-4159.2007.05039.x","article-title":"Carnosic Acid, a Catechol-Type Electrophilic Compound, Protects Neurons Both in Vitro and in Vivo through Activation of the Keap1\/Nrf2 Pathway via S-Alkylation of Targeted Cysteines on Keap1","volume":"104","author":"Satoh","year":"2008","journal-title":"J. Neurochem."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"481","DOI":"10.4103\/1673-5374.153700","article-title":"Curcumin Pretreatment and Post-Treatment Both Improve the Antioxidative Ability of Neurons with Oxygen-Glucose Deprivation","volume":"10","author":"Wu","year":"2015","journal-title":"Neural Regen. Res."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.mvr.2015.12.008","article-title":"Curcumin by Down-Regulating NF-KB and Elevating Nrf2, Reduces Brain Edema and Neurological Dysfunction after Cerebral I\/R","volume":"106","author":"Li","year":"2016","journal-title":"Microvasc. Res."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.brainres.2009.05.009","article-title":"Curcumin Upregulates Transcription Factor Nrf2, HO-1 Expression and Protects Rat Brains against Focal Ischemia","volume":"1282","author":"Yang","year":"2009","journal-title":"Brain Res."},{"key":"ref_172","doi-asserted-by":"crossref","unstructured":"Wu, J., Li, Q., Wang, X., Yu, S., Li, L., Wu, X., Chen, Y., Zhao, J., and Zhao, Y. (2013). Neuroprotection by Curcumin in Ischemic Brain Injury Involves the Akt\/Nrf2 Pathway. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0059843"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"106131","DOI":"10.1016\/j.intimp.2019.106131","article-title":"Dimethyl Fumarate and Curcumin Attenuate Hepatic Ischemia\/Reperfusion Injury via Nrf2\/HO-1 Activation and Anti-Inflammatory Properties","volume":"80","author":"Ibrahim","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"e2719252","DOI":"10.1155\/2019\/2719252","article-title":"Luteolin Attenuates Cardiac Ischemia\/Reperfusion Injury in Diabetic Rats by Modulating Nrf2 Antioxidative Function","volume":"2019","author":"Xiao","year":"2019","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"3562","DOI":"10.1039\/D0FO02942D","article-title":"Sestrin2 Is Involved in the Nrf2-Regulated Antioxidative Signaling Pathway in Luteolin-Induced Prevention of the Diabetic Rat Heart from Ischemia\/Reperfusion Injury","volume":"12","author":"Zhou","year":"2021","journal-title":"Food Funct."},{"key":"ref_176","first-page":"10420","article-title":"Resveratrol Attenuates Inflammation and Oxidative Stress Induced by Myocardial Ischemia-Reperfusion Injury: Role of Nrf2\/ARE Pathway","volume":"8","author":"Cheng","year":"2015","journal-title":"Int. J. Clin. Exp. Med."},{"key":"ref_177","first-page":"1677","article-title":"Resveratrol Alleviates Inflammatory Responses and Oxidative Stress in Rat Kidney Ischemia-Reperfusion Injury and H2O2-Induced NRK-52E Cells via the Nrf2\/TLR4\/NF-\u039aB Pathway","volume":"45","author":"Li","year":"2018","journal-title":"CPB"},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.taap.2014.12.001","article-title":"Novel Curcumin Analogue 14p Protects against Myocardial Ischemia Reperfusion Injury through Nrf2-Activating Anti-Oxidative Activity","volume":"282","author":"Li","year":"2015","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.cmet.2012.01.017","article-title":"Fumarate Is Cardioprotective via Activation of the Nrf2 Antioxidant Pathway","volume":"15","author":"Ashrafian","year":"2012","journal-title":"Cell Metab."},{"key":"ref_180","first-page":"2783","article-title":"Protective Effect of Dimethyl Fumarate on Oxidative Damage and Signaling in Cardiomyocytes","volume":"22","author":"Kuang","year":"2020","journal-title":"Mol. Med. Rep."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1007\/s12975-016-0496-0","article-title":"Dimethyl Fumarate and Monomethyl Fumarate Promote Post-Ischemic Recovery in Mice","volume":"7","author":"Yao","year":"2016","journal-title":"Transl. Stroke Res."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s12035-019-01760-0","article-title":"Reactive Gliosis Contributes to Nrf2-Dependent Neuroprotection by Pretreatment with Dimethyl Fumarate or Korean Red Ginseng Against Hypoxic-Ischemia: Focus on Hippocampal Injury","volume":"57","author":"Liu","year":"2020","journal-title":"Mol. Neurobiol."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"111130","DOI":"10.1016\/j.biopha.2020.111130","article-title":"Dimethyl Fumarate Protects against Intestinal Ischemia\/Reperfusion Lesion: Participation of Nrf2\/HO-1, GSK-3\u03b2 and Wnt\/\u03b2-Catenin Pathway","volume":"134","author":"Gendy","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1186\/s12974-015-0452-z","article-title":"Monomethyl Fumarate Promotes Nrf2-Dependent Neuroprotection in Retinal Ischemia-Reperfusion","volume":"12","author":"Cho","year":"2015","journal-title":"J. Neuroinflammation"},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1089\/ars.2012.4645","article-title":"Hydrogen Sulfide Protects against Cellular Senescence via S-Sulfhydration of Keap1 and Activation of Nrf2","volume":"18","author":"Yang","year":"2013","journal-title":"Antioxid. Redox Signal."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.taap.2011.09.026","article-title":"Hydrogen Sulfide Mediates the Anti-Survival Effect of Sulforaphane on Human Prostate Cancer Cells","volume":"257","author":"Pei","year":"2011","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"15560","DOI":"10.1073\/pnas.0705891104","article-title":"Hydrogen Sulfide Attenuates Myocardial Ischemia-Reperfusion Injury by Preservation of Mitochondrial Function","volume":"104","author":"Elrod","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/j.ejcts.2008.01.047","article-title":"The Effects of Therapeutic Sulfide on Myocardial Apoptosis in Response to Ischemia\u2014Reperfusion Injury","volume":"33","author":"Sodha","year":"2008","journal-title":"Eur. J. Cardiothorac. Surg."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.phrs.2010.06.002","article-title":"Hydrogen Sulfide and Ischemia-Reperfusion Injury","volume":"62","author":"Nicholson","year":"2010","journal-title":"Pharmacol. Res."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1007\/s00018-007-6484-5","article-title":"Molecular Basis for Chemoprevention by Sulforaphane: A Comprehensive Review","volume":"64","author":"Juge","year":"2007","journal-title":"Cell Mol. Life Sci."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1073\/pnas.89.6.2399","article-title":"A Major Inducer of Anticarcinogenic Protective Enzymes from Broccoli: Isolation and Elucidation of Structure","volume":"89","author":"Zhang","year":"1992","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"3147","DOI":"10.1073\/pnas.91.8.3147","article-title":"Anticarcinogenic Activities of Sulforaphane and Structurally Related Synthetic Norbornyl Isothiocyanates","volume":"91","author":"Zhang","year":"1994","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.etp.2010.11.005","article-title":"Protective Effect of Sulforaphane against Oxidative Stress: Recent Advances","volume":"64","author":"Chirino","year":"2012","journal-title":"Exp. Toxicol. Pathol."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1007\/s11357-019-00061-7","article-title":"Sulforaphane\u2014Role in Aging and Neurodegeneration","volume":"41","author":"Chondrogianni","year":"2019","journal-title":"GeroScience"},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"5615","DOI":"10.1021\/jf900549c","article-title":"Modulation of Phase II Enzymes by Sulforaphane: Implications for Its Cardioprotective Potential","volume":"57","author":"Angeloni","year":"2009","journal-title":"J. Agric. Food Chem."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.phrs.2009.11.009","article-title":"Sulforaphane Protects Ischemic Injury of Hearts through Antioxidant Pathway and Mitochondrial KATP Channels","volume":"61","author":"Piao","year":"2010","journal-title":"Pharmacol. Res."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1111\/bph.13025","article-title":"Melatonin-Sulforaphane Hybrid ITH12674 Induces Neuroprotection in Oxidative Stress Conditions by a \u201cdrug-Prodrug\u201d Mechanism of Action","volume":"172","author":"Egea","year":"2015","journal-title":"Br. J. Pharmacol."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"488","DOI":"10.12659\/AOT.884013","article-title":"Sulforaphane Decreases Kidney Injury after Transplantation in Rats: Role of Mitochondrial Damage","volume":"18","author":"Cekauskas","year":"2013","journal-title":"Ann. Transplant."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"558","DOI":"10.12659\/AOT.889342","article-title":"Sulforaphane Protects Hearts from Early Injury after Experimental Transplantation","volume":"18","author":"Li","year":"2013","journal-title":"Ann. Transplant."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.phrs.2014.10.004","article-title":"The Emerging Role of Redox-Sensitive Nrf2\u2013Keap1 Pathway in Diabetes","volume":"91","author":"Bhakkiyalakshmi","year":"2015","journal-title":"Pharmacol. Res."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"407580","DOI":"10.1155\/2015\/407580","article-title":"Sulforaphane Protects against Cardiovascular Disease via Nrf2 Activation","volume":"2015","author":"Bai","year":"2015","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"H175","DOI":"10.1111\/j.1750-3841.2011.02311.x","article-title":"Cruciferous Vegetable Phytochemical Sulforaphane Affects Phase II Enzyme Expression and Activity in Rat Cardiomyocytes through Modulation of Akt Signaling Pathway","volume":"76","author":"Leoncini","year":"2011","journal-title":"J. Food Sci."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"eaah4477","DOI":"10.1126\/scitranslmed.aah4477","article-title":"Sulforaphane Reduces Hepatic Glucose Production and Improves Glucose Control in Patients with Type 2 Diabetes","volume":"9","author":"Axelsson","year":"2017","journal-title":"Sci. Transl. Med."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.diabres.2012.01.009","article-title":"Broccoli Sprouts Powder Could Improve Serum Triglyceride and Oxidized LDL\/LDL-Cholesterol Ratio in Type 2 Diabetic Patients: A Randomized Double-Blind Placebo-Controlled Clinical Trial","volume":"96","author":"Bahadoran","year":"2012","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_205","first-page":"5629","article-title":"Protective Effects of Carnosic Acid against Mitochondria-mediated Injury in H9c2 Cardiomyocytes Induced by Hypoxia\/Reoxygenation","volume":"14","author":"Liu","year":"2017","journal-title":"Exp. Ther. Med."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.neures.2010.12.016","article-title":"Edaravone and Carnosic Acid Synergistically Enhance the Expression of Nerve Growth Factor in Human Astrocytes under Hypoxia\/Reoxygenation","volume":"69","author":"Yoshida","year":"2011","journal-title":"Neurosci. Res."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.redox.2013.09.003","article-title":"Renoprotective Effect of the Antioxidant Curcumin: Recent Findings","volume":"1","author":"Trujillo","year":"2013","journal-title":"Redox Biol."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S1043-6618(02)00123-8","article-title":"Protective Effects of Curcumin against Ischaemia\/Reperfusion Insult in Rat Forebrain","volume":"46","author":"Ghoneim","year":"2002","journal-title":"Pharmacol. Res."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/j.lfs.2003.06.042","article-title":"Neuroprotective Effect of Curcumin in Middle Cerebral Artery Occlusion Induced Focal Cerebral Ischemia in Rats","volume":"74","author":"Thiyagarajan","year":"2004","journal-title":"Life Sci."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.brainres.2008.06.117","article-title":"Neuroprotective Effect of Curcumin on Transient Focal Cerebral Ischemia in Rats","volume":"1229","author":"Zhao","year":"2008","journal-title":"Brain Res."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1002\/jnr.20610","article-title":"Neuroprotective Mechanisms of Curcumin against Cerebral Ischemia-Induced Neuronal Apoptosis and Behavioral Deficits","volume":"82","author":"Wang","year":"2005","journal-title":"J. Neurosci. Res."},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1021\/mp700113r","article-title":"Bioavailability of Curcumin: Problems and Promises","volume":"4","author":"Anand","year":"2007","journal-title":"Mol. Pharm."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1080\/13880209.2016.1214741","article-title":"Protective Effect of Curcumin against Myocardium Injury in Ischemia Reperfusion Rats","volume":"55","author":"Liu","year":"2017","journal-title":"Pharm. Biol."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1002\/mnfr.201200131","article-title":"Curcuminoids Exert Glucose-Lowering Effect in Type 2 Diabetes by Decreasing Serum Free Fatty Acids: A Double-Blind, Placebo-Controlled Trial","volume":"57","author":"Na","year":"2013","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ctim.2017.05.006","article-title":"Curcuminoids Modify Lipid Profile in Type 2 Diabetes Mellitus: A Randomized Controlled Trial","volume":"33","author":"Panahi","year":"2017","journal-title":"Complement. Ther. Med."},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.jnutbio.2013.09.013","article-title":"Reduction of Atherogenic Risk in Patients with Type 2 Diabetes by Curcuminoid Extract: A Randomized Controlled Trial","volume":"25","author":"Chuengsamarn","year":"2014","journal-title":"J. Nutr. Biochem."},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.ctim.2019.02.014","article-title":"Nano Curcumin Supplementation Reduced the Severity of Diabetic Sensorimotor Polyneuropathy in Patients with Type 2 Diabetes Mellitus: A Randomized Double-Blind Placebo- Controlled Clinical Trial","volume":"43","author":"Asadi","year":"2019","journal-title":"Complement. Ther. Med."},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s13098-019-0437-7","article-title":"The Effect of Curcumin Supplementation on Anthropometric Indices, Insulin Resistance and Oxidative Stress in Patients with Type 2 Diabetes: A Randomized, Double-Blind Clinical Trial","volume":"11","author":"Hodaei","year":"2019","journal-title":"Diabetol. Metab. Syndr."},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.freeradbiomed.2014.03.009","article-title":"Luteolin Provides Neuroprotection in Models of Traumatic Brain Injury via the Nrf2-ARE Pathway","volume":"71","author":"Xu","year":"2014","journal-title":"Free Radic. Biol. Med."},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"37157","DOI":"10.1038\/srep37157","article-title":"Regulation of Sirt1\/Nrf2\/TNF-\u03b1 Signaling Pathway by Luteolin Is Critical to Attenuate Acute Mercuric Chloride Exposure Induced Hepatotoxicity","volume":"6","author":"Yang","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"4477","DOI":"10.1021\/jf904061x","article-title":"Neurotrophic and Cytoprotective Action of Luteolin in PC12 Cells through ERK-Dependent Induction of Nrf2-Driven HO-1 Expression","volume":"58","author":"Lin","year":"2010","journal-title":"J. Agric. Food Chem."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.abb.2019.01.012","article-title":"A Physiological Concentration of Luteolin Induces Phase II Drug-Metabolizing Enzymes through the ERK1\/2 Signaling Pathway in HepG2 Cells","volume":"663","author":"Kitakaze","year":"2019","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"e803971","DOI":"10.1155\/2015\/803971","article-title":"An Organ System Approach to Explore the Antioxidative, Anti-Inflammatory, and Cytoprotective Actions of Resveratrol","volume":"2015","author":"Malhotra","year":"2015","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2016.09.016","article-title":"Resveratrol Attenuates Myocardial Ischemia\/Reperfusion Injury through up-Regulation of Vascular Endothelial Growth Factor B","volume":"101","author":"Yang","year":"2016","journal-title":"Free Radic. Biol. Med."},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"9180","DOI":"10.1021\/jf302831d","article-title":"Resveratrol Upregulates Nrf2 Expression to Attenuate Methylglyoxal-Induced Insulin Resistance in Hep G2 Cells","volume":"60","author":"Cheng","year":"2012","journal-title":"J. Agric. Food Chem."},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/j.bbrc.2005.03.237","article-title":"Resveratrol Upregulates Heme Oxygenase-1 Expression via Activation of NF-E2-Related Factor 2 in PC12 Cells","volume":"331","author":"Chen","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"7591840","DOI":"10.1155\/2019\/7591840","article-title":"Resveratrol Attenuates Oxidative Stress-Induced Intestinal Barrier Injury through PI3K\/Akt-Mediated Nrf2 Signaling Pathway","volume":"2019","author":"Zhuang","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.redox.2017.11.007","article-title":"Resveratrol Attenuates Testicular Apoptosis in Type 1 Diabetic Mice: Role of Akt-Mediated Nrf2 Activation and P62-Dependent Keap1 Degradation","volume":"14","author":"Zhao","year":"2018","journal-title":"Redox. Biol."},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/s11064-017-2421-7","article-title":"Resveratrol Attenuates the Cytotoxicity Induced by Amyloid-\u03921-42 in PC12 Cells by Upregulating Heme Oxygenase-1 via the PI3K\/Akt\/Nrf2 Pathway","volume":"43","author":"Hui","year":"2018","journal-title":"Neurochem. Res."},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1053\/j.jrn.2016.06.005","article-title":"Effects of Resveratrol Supplementation in Nrf2 and NF-\u039aB Expressions in Nondialyzed Chronic Kidney Disease Patients: A Randomized, Double-Blind, Placebo-Controlled, Crossover Clinical Trial","volume":"26","author":"Saldanha","year":"2016","journal-title":"J. Ren. Nutr."},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1002\/mnfr.201100673","article-title":"Consumption of a Grape Extract Supplement Containing Resveratrol Decreases Oxidized LDL and ApoB in Patients Undergoing Primary Prevention of Cardiovascular Disease: A Triple-Blind, 6-Month Follow-up, Placebo-Controlled, Randomized Trial","volume":"56","author":"Larrosa","year":"2012","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_232","doi-asserted-by":"crossref","unstructured":"Movahed, A., Raj, P., Nabipour, I., Mahmoodi, M., Ostovar, A., Kalantarhormozi, M., and Netticadan, T. (2020). Efficacy and Safety of Resveratrol in Type 1 Diabetes Patients: A Two-Month Preliminary Exploratory Trial. Nutrients, 12.","DOI":"10.3390\/nu12010161"},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"106733","DOI":"10.1016\/j.intimp.2020.106733","article-title":"Dimethyl Fumarate Protects Cardiomyocytes against Oxygen-Glucose Deprivation\/Reperfusion (OGD\/R)-Induced Inflammatory Response and Damages via Inhibition of Egr-1","volume":"86","author":"Zhao","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1093\/brain\/awq386","article-title":"Fumaric Acid Esters Exert Neuroprotective Effects in Neuroinflammation via Activation of the Nrf2 Antioxidant Pathway","volume":"134","author":"Linker","year":"2011","journal-title":"Brain"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/22\/21\/11939\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:25:28Z","timestamp":1760167528000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/22\/21\/11939"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,3]]},"references-count":234,"journal-issue":{"issue":"21","published-online":{"date-parts":[[2021,11]]}},"alternative-id":["ijms222111939"],"URL":"https:\/\/doi.org\/10.3390\/ijms222111939","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,3]]}}}