{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T20:44:31Z","timestamp":1780087471969,"version":"3.54.0"},"reference-count":90,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2021,11,7]],"date-time":"2021-11-07T00:00:00Z","timestamp":1636243200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31601622"],"award-info":[{"award-number":["31601622"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Key Area Research and Development Program of Guangdong province in China","award":["2020B0202010005"],"award-info":[{"award-number":["2020B0202010005"]}]},{"name":"Science and Technology Poverty Alleviation Project of The Chinese Academy of Sciences","award":["KFJ-FP-201905, KFJ-FP-202001"],"award-info":[{"award-number":["KFJ-FP-201905, KFJ-FP-202001"]}]},{"name":"Priority Research Program of The Chinese Academy of Science","award":["XDA24020104"],"award-info":[{"award-number":["XDA24020104"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Thaxtomin A (TA) is a phytotoxin secreted by Streptomyces scabies that causes common scab in potatoes. However, the mechanism of potato proteomic changes in response to TA is barely known. In this study, the proteomic changes in potato leaves treated with TA were determined using the Isobaric Tags for Relative and Absolute Quantitation (iTRAQ) technique. A total of 693 proteins were considered as differentially expressed proteins (DEPs) following a comparison of leaves treated with TA and sterile water (as a control). Among the identified DEPs, 460 and 233 were upregulated and downregulated, respectively. Based on Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses, many DEPs were found to be involved in defense and stress responses. Most DEPs were grouped in carbohydrate metabolism, amino acid metabolism, energy metabolism, and secondary metabolism including oxidation\u2013reduction process, response to stress, plant\u2013pathogen interaction, and plant hormone signal transduction. In this study, we analyzed the changes in proteins to elucidate the mechanism of potato response to TA, and we provided a molecular basis to further study the interaction between plant and TA. These results also offer the option for potato breeding through analysis of the resistant common scab.<\/jats:p>","DOI":"10.3390\/ijms222112036","type":"journal-article","created":{"date-parts":[[2021,11,7]],"date-time":"2021-11-07T20:41:14Z","timestamp":1636317674000},"page":"12036","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["iTRAQ-Based Proteomics Analysis of Response to Solanum tuberosum Leaves Treated with the Plant Phytotoxin Thaxtomin A"],"prefix":"10.3390","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8949-9105","authenticated-orcid":false,"given":"Lu","family":"Liu","sequence":"first","affiliation":[{"name":"College of Life Science, University of Chinese Academy of Sciences, Beijing 100049, China"},{"name":"State Key Laboratory of Plant Genomics, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liaoyang","family":"Hao","sequence":"additional","affiliation":[{"name":"School of Agriculture, Ningxia University, Yinchuan 750021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Liu","sequence":"additional","affiliation":[{"name":"National Engineering Research Center for Vegetables (Beijing Vegetable Research Center), Beijing Academy of Agricultural and Forestry Sciences, Beijing 100097, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonglong","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Agriculture, Ningxia University, Yinchuan 750021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naiqin","family":"Zhong","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Plant Genomics, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China"},{"name":"Engineering Laboratory for Advanced Microbial Technology of Agriculture, Chinese Academy of Sciences, Beijing 100101, China"},{"name":"The Enterprise Key Laboratory of Advanced Technology for Potato Fertilizer and Pesticide, Hulunbuir 021000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7579-9783","authenticated-orcid":false,"given":"Pan","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Plant Genomics, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China"},{"name":"Engineering Laboratory for Advanced Microbial Technology of Agriculture, Chinese Academy of Sciences, Beijing 100101, China"},{"name":"The Enterprise Key Laboratory of Advanced Technology for Potato Fertilizer and Pesticide, Hulunbuir 021000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,11,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3897\/phytokeys.127.34326","article-title":"Dichotomous keys to the species of Solanum L. (Solanaceae) in continental Africa, Madagascar (incl. the Indian Ocean islands), Macaronesia and the Cape Verde Islands","volume":"127","author":"Knapp","year":"2019","journal-title":"PhytoKeys"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.plaphy.2019.11.019","article-title":"Carbon partitioning mechanisms in potato under drought stress","volume":"146","author":"Aliche","year":"2020","journal-title":"Plant Physiol. Biochem."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s12230-017-9575-3","article-title":"Potato common scab: A review of the causal pathogens, management practices, varietal resistance screening methods, and host resistance","volume":"94","author":"Braun","year":"2017","journal-title":"Am. J. Potato Res."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/aab.12106","article-title":"Global gene expression in the common scab pathogen, Streptomyces scabies, exposed to potato microtubers","volume":"165","author":"Dees","year":"2014","journal-title":"Ann. Appl. Biol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1111\/j.1744-7348.2005.040083.x","article-title":"Responses of potato cultivars to the common scab pathogens, Streptomyces scabies and S. turgidiscabies","volume":"146","author":"Hiltunen","year":"2005","journal-title":"Ann. Appl. Biol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1146\/annurev.phyto.44.032905.091147","article-title":"Evolution of plant pathogenicity in Streptomyces","volume":"44","author":"Loria","year":"2006","journal-title":"Annu. Rev. Phytopathol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1094\/PHYTO.1998.88.5.442","article-title":"Pathogenicity of Streptomyces scabies mutants altered in thaxtomin A production","volume":"88","author":"Goyer","year":"1998","journal-title":"Phytopathology"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1039\/c39890000849","article-title":"Isolation and characterization of phytotoxins associated with Streptomyces scabies","volume":"13","author":"King","year":"1989","journal-title":"J. Chem. Soc. Chem. Commun."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1094\/Phyto-80-606","article-title":"Induction of common scab symptoms in aseptically cultured potato tubers by the vivotoxin, thaxtomin","volume":"80","author":"Lawrence","year":"1990","journal-title":"Phytopathology"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1094\/PDIS.1997.81.8.836","article-title":"Plant pathogenicity in the genus Streptomyces","volume":"81","author":"Loria","year":"1997","journal-title":"Plant Dis."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1046\/j.1365-2958.2000.02170.x","article-title":"The txtAB genes of the plant pathogen Streptomyces acidiscabies encode a peptide synthetase required for phytotoxin thaxtomin A production and pathogenicity","volume":"38","author":"Healy","year":"2000","journal-title":"Mol. Microbiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1128\/JB.184.7.2019-2029.2002","article-title":"Involvement of a cytochrome P450 monooxygenase in thaxtomin A biosynthesis by Streptomyces acidiscabies","volume":"184","author":"Healy","year":"2002","journal-title":"J. Bacteriol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/nature02504","article-title":"Nitration of a peptide phytotoxin by bacterial nitric oxide synthase","volume":"429","author":"Kers","year":"2004","journal-title":"Nature"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1038\/nchembio.1048","article-title":"Cytochrome P450-catalyzed L-tryptophan nitration in thaxtomin phytotoxin biosynthesis","volume":"8","author":"Barry","year":"2012","journal-title":"Nat. Chem. Biol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1111\/mpp.12843","article-title":"TxtH is a key component of the thaxtomin biosynthetic machinery in the potato common scab pathogen Streptomyces scabies","volume":"20","author":"Li","year":"2019","journal-title":"Mol. Plant Pathol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1094\/MPMI-03-11-0073","article-title":"Evidence that thaxtomin C is an apathogenicity determinant of Streptomyces ipomoeae, the causative agent of Streptomyces soil rot disease of sweet potato","volume":"25","author":"Guan","year":"2012","journal-title":"Mol. Plant-Microbe Interact."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1111\/j.1365-2958.2004.04461.x","article-title":"A large, mobile pathogenicity island confers plant pathogenicity on Streptomyces species","volume":"55","author":"Kers","year":"2005","journal-title":"Mol. Microbiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s10482-008-9240-4","article-title":"Thaxtomin biosynthesis: The path to plant pathogenicity in the genus Streptomyces","volume":"94","author":"Loria","year":"2008","journal-title":"Antonie van Leeuwenhoek"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1111\/j.1365-2958.2007.05942.x","article-title":"The AraC\/XylS regulator TxtR modulates thaxtomin biosynthesis and virulence in Streptomyces scabies","volume":"66","author":"Joshi","year":"2007","journal-title":"Mol. Microbiol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1039\/c1np00003a","article-title":"The regulation of the secondary metabolism of Streptomyces: New links and experimental advances","volume":"28","author":"McDowall","year":"2011","journal-title":"Nat. Prod. Rep."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s11540-012-9206-9","article-title":"In search of better management of potato common scab","volume":"55","author":"Dees","year":"2012","journal-title":"Potato Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1007\/s00299-009-0670-x","article-title":"Transcriptional profiling in response to inhibition of cellulose synthesis by thaxtomin A and isoxaben in Arabidopsis thaliana suspension cells","volume":"28","author":"Duval","year":"2009","journal-title":"Plant Cell Rep."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"4259","DOI":"10.1093\/jxb\/ern267","article-title":"An early Ca2+ influx is a prerequisite to thaxtomin A-induced cell death in Arabidopsis thaliana cells","volume":"59","author":"Errakhi","year":"2008","journal-title":"J. Exp. Bot."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s00299-015-1888-4","article-title":"Mechanisms of thaxtomin A-induced root toxicity revealed by a thaxtomin A sensitive Arabidopsis mutant (ucu2-2\/gi-2)","volume":"35","author":"Tegg","year":"2016","journal-title":"Plant Cell Rep."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"e02018","DOI":"10.1128\/mBio.02018-14","article-title":"The cellobiose sensor CebR is the gatekeeper of Streptomyces scabies pathogenicity","volume":"6","author":"Francis","year":"2015","journal-title":"mBio"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"27144","DOI":"10.1038\/srep27144","article-title":"The CebE\/MsiK transporter is a doorway to the cello-oligosaccharide-mediated induction of Streptomyces scabies pathogenicity","volume":"6","author":"Jourdan","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1111\/mpp.12631","article-title":"Contribution of the beta-glucosidase BglC to the onset of the pathogenic lifestyle of Streptomyces scabies","volume":"19","author":"Jourdan","year":"2018","journal-title":"Mol. Plant Pathol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1111\/j.1364-3703.2008.00493.x","article-title":"Effect of potato suberin on Streptomyces scabies proteome","volume":"9","author":"Lauzier","year":"2008","journal-title":"Mol. Plant Pathol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1111\/j.1365-2958.2010.07206.x","article-title":"The twin arginine protein transport pathway exports multiple virulence proteins in the plant pathogen Streptomyces scabies","volume":"77","author":"Joshi","year":"2010","journal-title":"Mol. Microbiol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/1477-5956-12-35","article-title":"Comparative secretome analysis of Streptomyces scabiei during growth in the presence or absence of potato suberin","volume":"12","author":"Komeil","year":"2014","journal-title":"Proteome Sci."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"3837","DOI":"10.1021\/acs.jproteome.8b00528","article-title":"Proteomic response to thaxtomin phytotoxin elicitor cellobiose and to deletion of cellulose utilization regulator CebR in Streptomyces scabies","volume":"17","author":"Planckaert","year":"2018","journal-title":"J. Proteome Res."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Li, X., Bi, X., An, M., Xia, Z., and Wu, Y. (2020). iTRAQ-based proteomic analysis of watermelon fruits in response to Cucumber green mottle mosaic virus infection. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21072541"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2952","DOI":"10.1021\/pr800072x","article-title":"iTRAQ experimental design for plasma biomarker discovery","volume":"7","author":"Song","year":"2008","journal-title":"J. Proteome Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1021\/pr050405o","article-title":"Comparative study of three proteomic quantitative methods, DIGE, cICAT, and iTRAQ, using 2D gel or LC-MALDITOF\/TOF","volume":"5","author":"Wu","year":"2006","journal-title":"J. Proteome Res."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Guo, Y., Wang, Z., Guan, X., Hu, Z., Zhang, Z., Zheng, J., and Lu, Y. (2017). Proteomic analysis of Potentilla fruticosa L. leaves by iTRAQ reveals responses to heat stress. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0182917"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"109190","DOI":"10.1016\/j.scienta.2020.109190","article-title":"iTRAQ-based quantitative proteomic analysis of the response of Hylotelephium erythrostictum leaves to salt stress","volume":"264","author":"Zhao","year":"2020","journal-title":"Sci. Hortic."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1021\/pr401165b","article-title":"Comparative quantitative proteomics analysis of the ABA response of roots of drought-sensitive and drought-tolerant wheat varieties identifies proteomic signatures of drought adaptability","volume":"13","author":"Alvarez","year":"2014","journal-title":"J. Proteome Res."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Ma, Z., Wang, L., Zhao, M., Gu, S., Wang, C., Zhao, J., Tang, Z., Gao, H., Zhang, L., and Fu, L. (2020). iTRAQ proteomics reveals the regulatory response to Magnaporthe oryzae in durable resistant vs. susceptible rice genotypes. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0227470"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.jprot.2016.11.011","article-title":"iTRAQ-based proteomic analysis of defence responses triggered by the necrotrophic pathogen Rhizoctonia solani in cotton","volume":"152","author":"Zhang","year":"2017","journal-title":"J. Proteom."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1080\/15548627.2017.1423438","article-title":"iTRAQ-based proteomics analysis of autophagy-mediated immune responses against the vascular fungal pathogen Verticillium dahliae in Arabidopsis","volume":"14","author":"Wang","year":"2018","journal-title":"Autophagy"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.21775\/cimb.023.001","article-title":"Plant immune system: Crosstalk between responses to biotic and abiotic stresses the missing link in understanding plant defence","volume":"23","author":"Nejat","year":"2017","journal-title":"Curr. Issues Mol. Biol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/nrg2812","article-title":"Plant immunity: Towards an integrated view of plant-pathogen interactions","volume":"11","author":"Dodds","year":"2010","journal-title":"Nat. Rev. Genet."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.pbi.2010.04.006","article-title":"Comparing signaling mechanisms engaged in pattern-triggered and effector-triggered immunity","volume":"13","author":"Tsuda","year":"2010","journal-title":"Curr. Opin. Plant Biol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1146\/annurev-phyto-073009-114447","article-title":"Hormone crosstalk in plant disease and defense: More than just jasmonate-salicylate antagonism","volume":"49","author":"Grant","year":"2011","journal-title":"Annu. Rev. Phytopathol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1111\/nph.13325","article-title":"Secondary metabolites in plant innate immunity: Conserved function of divergent chemicals","volume":"206","author":"Piasecka","year":"2015","journal-title":"New Phytol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1093\/mp\/ssq035","article-title":"Plant immunity triggered by microbial molecular signatures","volume":"3","author":"Zhang","year":"2010","journal-title":"Mol. Plant"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.molp.2014.12.022","article-title":"Signaling mechanisms in pattern-triggered immunity (PTI)","volume":"8","author":"Bigeard","year":"2015","journal-title":"Mol. Plant"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/j.tplants.2018.06.004","article-title":"Plant immunity: From signaling to epigenetic control of defense","volume":"23","author":"Abulfaraj","year":"2018","journal-title":"Trends Plant Sci."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1104\/pp.106.078295","article-title":"Reactive oxygen species in plant cell death","volume":"141","author":"Dat","year":"2006","journal-title":"Plant Physiol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"2827","DOI":"10.1093\/jxb\/erv099","article-title":"ROS and RNS in plant physiology: An overview","volume":"66","year":"2015","journal-title":"J. Exp. Bot."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.plaphy.2016.02.035","article-title":"Reactive oxygen species, essential molecules, during plant-pathogen interactions","volume":"103","author":"Camejo","year":"2016","journal-title":"Plant Physiol. Biochem."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1111\/j.1365-313X.2010.04371.x","article-title":"Recruitment of glutathione into the nucleus during cell proliferation adjusts whole-cell redox homeostasis in Arabidopsis thaliana and lowers the oxidative defence shield","volume":"64","author":"Vivancos","year":"2010","journal-title":"Plant J."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.jplph.2010.09.012","article-title":"Effect of oligogalacturonides on root length, extracellular alkalinization and O2\u2212-accumulation in alfalfa","volume":"168","author":"Camejo","year":"2011","journal-title":"J. Plant Physiol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1146\/annurev-arplant-042817-040322","article-title":"Reactive oxygen species in plant signaling","volume":"69","author":"Waszczak","year":"2018","journal-title":"Annu. Rev. Plant Biol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/j.plaphy.2010.08.016","article-title":"Reactive oxygen species and antioxidant machinery in abiotic stress tolerance in crop plants","volume":"48","author":"Gill","year":"2010","journal-title":"Plant Physiol. Biochem."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.indcrop.2015.12.032","article-title":"Profiling of polyphenolics, nutrients and antioxidant potential of germplasm\u2019s leaves from seven cultivars of Moringa oleifera Lam","volume":"83","author":"Nouman","year":"2016","journal-title":"Ind. Crops Prod."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1104\/pp.16.00434","article-title":"ROS, calcium, and electric signals: Key mediators of rapid systemic signaling in plants","volume":"171","author":"Gilroy","year":"2016","journal-title":"Plant Physiol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1111\/jipb.12654","article-title":"Reactive oxygen species signaling and stomatal movement in plant responses to drought stress and pathogen attack","volume":"60","author":"Qi","year":"2018","journal-title":"J. Integr. Plant Biol."},{"key":"ref_59","first-page":"87","article-title":"Mechanisms of salt tolerance in rice plants: Cell wall-related genes and expansins","volume":"66","author":"Kao","year":"2017","journal-title":"J. Taiwan Agric. Res."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"8577","DOI":"10.1073\/pnas.1431173100","article-title":"A Pseudomonas syringae type III effector suppresses cell wall-based extracellular defense in susceptible Arabidopsis plants","volume":"100","author":"Hauck","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1104\/pp.110.161273","article-title":"Emerging complexity in reactive oxygen species production and signaling during the response of plants to pathogens","volume":"154","author":"Vellosillo","year":"2010","journal-title":"Plant Physiol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/mpp.12370","article-title":"Absence of Cu-Zn superoxide dismutase BCSOD1 reduces Botrytis cinerea virulence in Arabidopsis and in tomato plants, which reveals interplay among ROS, callose and signaling pathways","volume":"18","year":"2017","journal-title":"Mol. Plant Pathol."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Awwad, F., Bertrand, G., Grandbois, M., and Beaudoin, N. (2019). Reactive oxygen species alleviate cell death induced by thaxtomin A in Arabidopsis thaliana cell cultures. Plants, 8.","DOI":"10.3390\/plants8090332"},{"key":"ref_64","first-page":"374","article-title":"Ultrastructural effects of thaxtomin A produced by Streptomyces scabies on mature potato tuber tissues","volume":"78","author":"Goyer","year":"2000","journal-title":"Can. J. Bot."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/j.phytochem.2009.04.013","article-title":"The thaxtomin phytotoxins: Sources, synthesis, biosynthesis, biotransformation and biological activity","volume":"70","author":"King","year":"2009","journal-title":"Phytochemistry"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1105\/tpc.013342","article-title":"An Arabidopsis mutant resistant to thaxtomin A, a cellulose synthesis inhibitor from Streptomyces species","volume":"15","author":"Scheible","year":"2003","journal-title":"Plant Cell"},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Tegg, R.S., Shabala, S.N., Cuin, T.A., Davies, N.W., and Wilson, C.R. (2013). Enhanced resistance to the cellulose biosynthetic inhibitors, thaxtomin A and isoxaben in Arabidopsis thaliana mutants, also provides specific co-resistance to the auxin transport inhibitor, 1-NPA. BMC Plant Biol., 13.","DOI":"10.1186\/1471-2229-13-76"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1093\/jxb\/ern344","article-title":"Thaxtomin A affects CESA-complex density, expression of cell wall genes, cell wall composition, and causes ectopic lignification in Arabidopsis thaliana seedlings","volume":"60","author":"Bischoff","year":"2009","journal-title":"J. Exp. Bot."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"26378","DOI":"10.3390\/ijms161125967","article-title":"Carbon fluxes between primary metabolism and phenolic pathway in plant tissues under stress","volume":"16","author":"Caretto","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s00203-007-0225-x","article-title":"Effect of carbohydrates on the production of thaxtomin A by Streptomyces acidiscabies","volume":"188","author":"Wach","year":"2007","journal-title":"Arch. Microbiol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"5535","DOI":"10.1093\/jxb\/eru320","article-title":"Regulation of amino acid metabolic enzymes and transporters in plants","volume":"65","author":"Pratelli","year":"2014","journal-title":"J. Exp. Bot."},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Jia, M., Wu, H., Clay, K.L., Jung, R., Larkins, B.A., and Gibbon, B.C. (2013). Identification and characterization of lysine-rich proteins and starch biosynthesis genes in the opaque2 mutant by transcriptional and proteomic analysis. BMC Plant Biol., 13.","DOI":"10.1186\/1471-2229-13-60"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1104\/pp.109.150045","article-title":"Glycolysis and the tricarboxylic acid cycle are linked by alanine aminotransferase during hypoxia induced by waterlogging of Lotus japonicus","volume":"152","author":"Rocha","year":"2010","journal-title":"Plant Physiol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s12374-018-0288-z","article-title":"FLOURY ENDOSPERM12 encoding alanine aminotransferase 1 regulates carbon and nitrogen metabolism in rice","volume":"62","author":"Zhong","year":"2019","journal-title":"J. Plant Biol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s00497-018-0322-9","article-title":"New insights into the metabolism of aspartate-family amino acids in plant seeds","volume":"31","author":"Wang","year":"2018","journal-title":"Plant Reprod."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1139\/w02-031","article-title":"Effect of amino acids on thaxtomin A biosynthesis by Streptomyces scabies","volume":"48","author":"Lauzier","year":"2002","journal-title":"Can. J. Microbiol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"2450","DOI":"10.1111\/pce.12563","article-title":"The saccharopine pathway in seed development and stress response of maize","volume":"38","author":"Kiyota","year":"2015","journal-title":"Plant Cell Environ."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1105\/tpc.15.00496","article-title":"Pipecolic acid orchestrates plant systemic acquired resistance and defense priming via salicylic acid-dependent and -independent pathways","volume":"28","author":"Bernsdorff","year":"2016","journal-title":"Plant Cell"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"587","DOI":"10.3389\/fpls.2020.00587","article-title":"Lysine catabolism through the saccharopine pathway: Enzymes and intermediates involved in plant responses to abiotic and biotic stress","volume":"11","author":"Arruda","year":"2020","journal-title":"Front. Plant Sci."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1111\/pce.12122","article-title":"New insights into the regulation of plant immunity by amino acid metabolic pathways","volume":"36","author":"Zeier","year":"2013","journal-title":"Plant Cell Environ."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/j.1365-3059.2008.01903.x","article-title":"Enhanced resistance to common scab of potato through somatic cell selection in cv. Iwa with the phytotoxin thaxtomin A","volume":"58","author":"Wilson","year":"2009","journal-title":"Plant Pathol."},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Brochu, V., Girard-Martel, M., Duval, I., Lerat, S., Grondin, G., Domingue, O., Beaulieu, C., and Beaudoin, N. (2010). Habituation to thaxtomin A in hybrid poplar cell suspensions provides enhanced and durable resistance to inhibitors of cellulose synthesis. BMC Plant Biol., 10.","DOI":"10.1186\/1471-2229-10-272"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1111\/j.1365-3059.2010.02386.x","article-title":"Elimination of common scab sensitive progeny from a potato breeding population using thaxtomin A as a selective agent","volume":"60","author":"Hiltunen","year":"2011","journal-title":"Plant Pathol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1111\/j.1399-3054.1962.tb08052.x","article-title":"A revised medium for rapid growth and bioassays with tobacco tissue culture","volume":"15","author":"Murashige","year":"1962","journal-title":"Physiol. Plant"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1111\/mpp.13093","article-title":"Cotton GhSSI2 isoforms from the stearoyl acyl carrier protein fatty acid desaturase family regulate Verticillium wilt resistance","volume":"22","author":"Mo","year":"2021","journal-title":"Mol. Plant Pathol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"3976","DOI":"10.1002\/elps.200600805","article-title":"A protein extraction method compatible with proteomic analysis for the euhalophyte Salicornia europaea","volume":"28","author":"Wang","year":"2007","journal-title":"Electrophoresis"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212\u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"e263","DOI":"10.21769\/BioProtoc.263","article-title":"Detection of hydrogen peroxide by DAB staining in Arabidopsis leaves","volume":"2","author":"Daudi","year":"2012","journal-title":"Bio. Protoc."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.chemosphere.2006.10.007","article-title":"Effect of heavy metal stress on antioxidative enzymes and lipid peroxidation in leaves and roots of two mangrove plant seedlings (Kandelia candel and Bruguiera gymnorrhiza)","volume":"67","author":"Zhang","year":"2007","journal-title":"Chemosphere"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"109367","DOI":"10.1016\/j.scienta.2020.109367","article-title":"Papaya treatment with putrescine maintained the overall quality and promoted the antioxidative enzyme activities of the stored fruit","volume":"268","author":"Hanif","year":"2020","journal-title":"Sci. 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