{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:49:19Z","timestamp":1790660959108,"version":"4.1.0"},"reference-count":61,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2021,11,8]],"date-time":"2021-11-08T00:00:00Z","timestamp":1636329600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["Vasc-TSP-1"],"award-info":[{"award-number":["Vasc-TSP-1"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>(1) Background: Chronic increases in blood flow, as in cardiovascular diseases, induce outward arterial remodeling. Thrombospondin-1 (TSP-1) is known to interact with matrix proteins and immune cell-surface receptors, but its contribution to flow-mediated remodeling in the microcirculation remains unknown. (2) Methods: Mesenteric arteries were ligated in vivo to generate high- (HF) and normal-flow (NF) arteries in wild-type (WT) and TSP-1-deleted mice (TSP-1\u2212\/\u2212). After 7 days, arteries were isolated and studied ex vivo. (3) Results: Chronic increases in blood flow induced outward remodeling in WT mice (increasing diameter from 221 \u00b1 10 to 280 \u00b1 10 \u00b5m with 75 mmHg intraluminal pressure) without significant effect in TSP-1\u2212\/\u2212 (296 \u00b1 18 to 303 \u00b1 14 \u00b5m), neutropenic or adoptive bone marrow transfer mice. Four days after ligature, pro inflammatory gene expression levels (CD68, Cox2, Gp91phox, p47phox and p22phox) increased in WT HF arteries but not in TSP-1\u2212\/\u2212 mice. Perivascular neutrophil accumulation at day 4 was significantly lower in TSP-1\u2212\/\u2212 than in WT mice. (4) Conclusions: TSP-1 origin is important; indeed, circulating TSP-1 participates in vasodilation, whereas both circulating and tissue TSP-1 are involved in arterial wall thickness and diameter expansion.<\/jats:p>","DOI":"10.3390\/ijms222112086","type":"journal-article","created":{"date-parts":[[2021,11,8]],"date-time":"2021-11-08T22:08:41Z","timestamp":1636409321000},"page":"12086","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Dual Role of Thrombospondin-1 in Flow-Induced Remodeling"],"prefix":"10.3390","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4521-9404","authenticated-orcid":false,"given":"C\u00e9line","family":"Grenier","sequence":"first","affiliation":[{"name":"UMR CNRS 6015, 49100 Angers, France"},{"name":"INSERM U1083, 49100 Angers, France"},{"name":"MITOVASC Institute, University of Angers, 49100 Angers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Caillon","sequence":"additional","affiliation":[{"name":"UMR CNRS 6015, 49100 Angers, France"},{"name":"INSERM U1083, 49100 Angers, France"},{"name":"MITOVASC Institute, University of Angers, 49100 Angers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7194-6846","authenticated-orcid":false,"given":"Mathilde","family":"Munier","sequence":"additional","affiliation":[{"name":"UMR CNRS 6015, 49100 Angers, France"},{"name":"INSERM U1083, 49100 Angers, France"},{"name":"MITOVASC Institute, University of Angers, 49100 Angers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Grimaud","sequence":"additional","affiliation":[{"name":"UMR CNRS 6015, 49100 Angers, France"},{"name":"INSERM U1083, 49100 Angers, France"},{"name":"MITOVASC Institute, University of Angers, 49100 Angers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tristan","family":"Champin","sequence":"additional","affiliation":[{"name":"UMR CNRS 6015, 49100 Angers, France"},{"name":"INSERM U1083, 49100 Angers, France"},{"name":"MITOVASC Institute, University of Angers, 49100 Angers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertrand","family":"Toutain","sequence":"additional","affiliation":[{"name":"UMR CNRS 6015, 49100 Angers, France"},{"name":"INSERM U1083, 49100 Angers, France"},{"name":"MITOVASC Institute, University of Angers, 49100 Angers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9line","family":"Fassot","sequence":"additional","affiliation":[{"name":"UMR CNRS 6015, 49100 Angers, France"},{"name":"INSERM U1083, 49100 Angers, France"},{"name":"MITOVASC Institute, University of Angers, 49100 Angers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Blanc-Brude","sequence":"additional","affiliation":[{"name":"UMR Inserm 970 ParCC-Paris Cardiovascular Center HEGP, 75015 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3397-2335","authenticated-orcid":false,"given":"Laurent","family":"Loufrani","sequence":"additional","affiliation":[{"name":"UMR CNRS 6015, 49100 Angers, France"},{"name":"INSERM U1083, 49100 Angers, France"},{"name":"MITOVASC Institute, University of Angers, 49100 Angers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,11,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1111\/j.1748-1716.2010.02127.x","article-title":"The effects of acute and chronic exercise on the vasculature","volume":"199","author":"Whyte","year":"2010","journal-title":"Acta Physiol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1152\/physiol.00033.2008","article-title":"Maternal uterine vascular remodeling during pregnancy","volume":"24","author":"Osol","year":"2009","journal-title":"Physiology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/micc.12105","article-title":"Mechanisms of the inward remodeling process in resistance vessels: Is the actin cytoskeleton involved?","volume":"21","author":"Staiculescu","year":"2014","journal-title":"Microcirculation"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.pcad.2014.09.005","article-title":"Arterial function in cardio-metabolic diseases: From the micro-circulation to the large conduits","volume":"57","author":"Chantler","year":"2015","journal-title":"Prog. 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