{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T12:33:07Z","timestamp":1790944387313,"version":"4.1.0"},"reference-count":60,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2021,11,9]],"date-time":"2021-11-09T00:00:00Z","timestamp":1636416000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31670255"],"award-info":[{"award-number":["31670255"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Natural Science Foundation of China of Jiangsu Province","award":["BK20200561"],"award-info":[{"award-number":["BK20200561"]}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2019M661860"],"award-info":[{"award-number":["2019M661860"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Hydrogen sulfide (H2S) is an important signaling molecule that regulates diverse cellular signaling pathways through persulfidation. Our previous study revealed that H2S is involved in the improvement of rice drought tolerance. However, the corresponding enzymatic sources of H2S and its regulatory mechanism in response to drought stress are not clear. Here, we cloned and characterized a putative l-cysteine desulfhydrase (LCD) gene in rice, which encodes a protein possessing H2S-producing activity and was named OsLCD1. Overexpression of OsLCD1 results in enhanced H2S production, persulfidation of total soluble protein, and confers rice drought tolerance. Further, we found that nitrate reductase (NR) activity was decreased under drought stress, and the inhibition of NR activity was controlled by endogenous H2S production. Persulfidation of NIA2, an NR isoform responsible for the main NR activity, led to a decrease in total NR activity in rice. Furthermore, drought stress-triggered inhibition of NR activity and persulfidation of NIA2 was intensified in the OsLCD1 overexpression line. Phenotypical and molecular analysis revealed that mutation of NIA2 enhanced rice drought tolerance by activating the expression of genes encoding antioxidant enzymes and ABA-responsive genes. Taken together, our results showed the role of OsLCD1 in modulating H2S production and provided insight into H2S-regulated persulfidation of NIA2 in the control of rice drought stress.<\/jats:p>","DOI":"10.3390\/ijms222212119","type":"journal-article","created":{"date-parts":[[2021,11,9]],"date-time":"2021-11-09T12:46:23Z","timestamp":1636461983000},"page":"12119","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Persulfidation of Nitrate Reductase 2 Is Involved in l-Cysteine Desulfhydrase-Regulated Rice Drought Tolerance"],"prefix":"10.3390","volume":"22","author":[{"given":"Heng","family":"Zhou","sequence":"first","affiliation":[{"name":"Laboratory Center of Life Sciences, College of Life Sciences, Nanjing Agricultural University, Nanjing 210095, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhou","sequence":"additional","affiliation":[{"name":"Laboratory Center of Life Sciences, College of Life Sciences, Nanjing Agricultural University, Nanjing 210095, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Laboratory Center of Life Sciences, College of Life Sciences, Nanjing Agricultural University, Nanjing 210095, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxue","family":"Guan","sequence":"additional","affiliation":[{"name":"Laboratory Center of Life Sciences, College of Life Sciences, Nanjing Agricultural University, Nanjing 210095, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Su","sequence":"additional","affiliation":[{"name":"Laboratory Center of Life Sciences, College of Life Sciences, Nanjing Agricultural University, Nanjing 210095, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingxing","family":"Yuan","sequence":"additional","affiliation":[{"name":"Institute of Industrial Crops, Jiangsu Academy of Agricultural Sciences, Nanjing 210014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3503-1267","authenticated-orcid":false,"given":"Yanjie","family":"Xie","sequence":"additional","affiliation":[{"name":"Laboratory Center of Life Sciences, College of Life Sciences, Nanjing Agricultural University, Nanjing 210095, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,11,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/S0958-1669(03)00030-2","article-title":"Molecular responses to drought, salinity and frost: Common and different paths for plant protection","volume":"14","author":"Seki","year":"2003","journal-title":"Curr. Opin. Biotechnol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1111\/j.1365-3040.2009.02041.x","article-title":"Reactive oxygen species homeostasis and signalling during drought and salinity stresses","volume":"33","author":"Miller","year":"2010","journal-title":"Plant Cell Environ."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.cell.2016.08.029","article-title":"Abiotic stress signaling and responses in plants","volume":"167","author":"Zhu","year":"2016","journal-title":"Cell"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1152\/physrev.00017.2011","article-title":"Physiological implications of hydrogen sulfide: A whiff exploration that blossomed","volume":"92","author":"Wang","year":"2012","journal-title":"Physiol. Rev."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"4391","DOI":"10.1093\/jxb\/erz031","article-title":"Nitric oxide and hydrogen sulfide in plants: Which comes first?","volume":"70","author":"Corpas","year":"2019","journal-title":"J. Exp. Bot."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.jplph.2013.09.018","article-title":"Hydrogen sulfide delays GA-triggered programmed cell death in wheat aleurone layers by the modulation of glutathione homeostasis and heme oxygenase-1 expression","volume":"171","author":"Xie","year":"2014","journal-title":"J. Plant Physiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11738-015-2038-x","article-title":"Hydrogen sulfide, a versatile regulator of environmental stress in plants","volume":"38","author":"Guo","year":"2016","journal-title":"Acta Physiol. Plant"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s11105-019-01181-2","article-title":"Cloning and characterization of a gene encoding true D-cysteine desulfhydrase from Oryza Sativa","volume":"38","author":"Zhou","year":"2020","journal-title":"Plant Mol. Biol. Rep."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1111\/jipb.13022","article-title":"Hydrogen sulfide, a signaling molecule in plant stress responses","volume":"63","author":"Zhang","year":"2021","journal-title":"J. Integr. Plant Biol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.plaphy.2012.10.017","article-title":"Hydrogen sulfide interacting with abscisic acid in stomatal regulation responses to drought stress in Arabidopsis","volume":"62","author":"Jin","year":"2013","journal-title":"Plant Physiol. Biochem."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s11104-017-3335-5","article-title":"Hydrogen sulfide mediates ion fluxes inducing stomatal closure in response to drought stress in Arabidopsis thaliana","volume":"419","author":"Jin","year":"2017","journal-title":"Plant Soil"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0163082","article-title":"Alleviation of drought stress by hydrogen sulfde is partially related to the abscisic acid signaling pathway in wheat","volume":"11","author":"Ma","year":"2016","journal-title":"PLoS ONE"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.plaphy.2020.07.038","article-title":"Hydrogen sulfide promotes rice drought tolerance via reestablishing redox homeostasis and activation of ABA biosynthesis and signaling","volume":"155","author":"Zhou","year":"2020","journal-title":"Plant Physiol. Biochem."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1111\/pce.12982","article-title":"l-cysteine desulfhydrase-related H2S production is involved in OsSE5-promoted ammonium tolerance in roots of Oryza sativa","volume":"40","author":"Guo","year":"2017","journal-title":"Plant Cell Environ."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.tplants.2005.08.006","article-title":"Sulfur metabolism: A versatile platform for launching defence operations","volume":"10","author":"Rausch","year":"2005","journal-title":"Trends Plant Sci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1055\/s-2007-965424","article-title":"Characterization of cysteine-degrading and H2S-releasing enzymes of higher plants-from the field to the test tube and tack","volume":"9","author":"Papenbrock","year":"2007","journal-title":"Plant Biol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/S0981-9428(01)01305-5","article-title":"Cysteine synthesis and cysteine desulfuration in Arabidopsis plants at different developmental stages and light conditions","volume":"9","author":"Burandt","year":"2001","journal-title":"Plant Physiol. Biochem."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1104\/pp.109.147975","article-title":"An O-acetylserine(thiol)lyase homolog with l-cysteine desulfhydrase activity regulates cysteine homeostasis in Arabidopsis","volume":"152","author":"Calo","year":"2010","journal-title":"Plant Physiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1111\/pce.13685","article-title":"Abscisic acid-triggered guard cell l-cysteine desulfhydrase function and in situ hydrogen sulfide production contributes to heme oxygenase-modulated stomatal closure","volume":"43","author":"Zhang","year":"2020","journal-title":"Plant Cell Environ."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.jare.2020.07.013","article-title":"The coordination of guard-cell autonomous ABA synthesis and DES1 function in situ regulates plant water deficit responses","volume":"27","author":"Zhang","year":"2020","journal-title":"J. Adv. Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s10725-019-00528-9","article-title":"A putative rice l-cysteine desulfhydrase encodes a true l-cysteine synthase that regulates plant cadmium tolerance","volume":"89","author":"Shen","year":"2019","journal-title":"Plant Growth Regul."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/978-3-319-18144-8_2","article-title":"Persulfidation (S-sulfhydration) and H2S","volume":"230","author":"Filipovic","year":"2015","journal-title":"Handb. Exp. Pharmacol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"4915","DOI":"10.1093\/jxb\/erx294","article-title":"Persulfidation proteome reveals the regulation of protein function by hydrogen sulfide in diverse biological processes in Arabidopsis","volume":"68","author":"Aroca","year":"2017","journal-title":"J. Exp. Bot."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1021\/acs.chemrev.7b00205","article-title":"Chemical biology of H2S signaling through persulfidation","volume":"118","author":"Filipovic","year":"2018","journal-title":"Chem. Rev."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Jurado-Flores, A., Romero, L.C., and Gotor, C. (2021). Label-free quantitative proteomic analysis of nitrogen starvation in Arabidopsis root reveals new aspects of H2S signaling by protein persulfidation. Antioxidants, 10.","DOI":"10.3390\/antiox10040508"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1105\/tpc.19.00826","article-title":"Persulfdation-based modifcation of cysteine desulfhydrase and the NADPH oxidase RBOHD controls guard cell abscisic acid signaling","volume":"32","author":"Shen","year":"2020","journal-title":"Plant Cell"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.molp.2021.03.007","article-title":"Hydrogen sulfide-linked persulfidation of ABI4 controls ABA responses through the transactivation of MAPKKK18 in Arabidopsis","volume":"14","author":"Zhou","year":"2021","journal-title":"Mol. Plant"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.tplants.2016.12.001","article-title":"Nitrate reductase regulates plant nitric oxide homeostasis","volume":"22","author":"Llamas","year":"2017","journal-title":"Trends Plant Sci."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"474","DOI":"10.3389\/fpls.2018.00474","article-title":"Putative connections between nitrate reductase S-nitrosylation and NO synthesis under pathogen attacks and abiotic stresses","volume":"9","author":"Fu","year":"2018","journal-title":"Front Plant Sci."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1104\/pp.109.148023","article-title":"Enhanced abscisic acid-mediated responses in nia1nia2noa1-2 triple mutant impaired in NIA\/NR- and AtNOA1-dependent nitric oxide biosynthesis in Arabidopsis","volume":"152","year":"2010","journal-title":"Plant Physiol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1111\/pce.12707","article-title":"Nitric oxide function in plant abiotic stress","volume":"40","author":"Fancy","year":"2017","journal-title":"Plant Cell Environ."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"3816","DOI":"10.1242\/jeb.021303","article-title":"Hypotaurine and sulfhydryl containing antioxidants reduce H2S toxicity in erythrocytes from a marine invertebrate","volume":"211","author":"Ortega","year":"2008","journal-title":"J. Exp. Biol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1111\/pce.12073","article-title":"Hydrogen sulfide: Environmental factor or signalling molecule","volume":"36","author":"Lisjak","year":"2013","journal-title":"Plant Cell Environ."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/S1002-0160(08)60061-2","article-title":"Effect of nitrate on activities and transcript levels of nitrate reductase and glutamine synthetase in rice","volume":"18","author":"Cao","year":"2008","journal-title":"Pedosphere"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1111\/pce.12709","article-title":"Strigolactones are required for nitric oxide to induce root elongation in response to nitrogen and phosphate deficiencies in rice","volume":"39","author":"Sun","year":"2016","journal-title":"Plant Cell Environ."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.plaphy.2012.03.016","article-title":"The biology of reactive sulfur species (RSS)","volume":"59","author":"Gruhlke","year":"2012","journal-title":"Plant Physiol. Biochem."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1093\/mp\/sst168","article-title":"Cysteine and cysteine-related signaling pathways in Arabidopsis thaliana","volume":"7","author":"Romero","year":"2014","journal-title":"Mol. Plant"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1093\/aob\/mcl006","article-title":"Regulation of sulfate assimilation in Arabidopsis and beyond","volume":"97","author":"Kopriva","year":"2006","journal-title":"Ann. Bot."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1111\/j.1365-2672.2012.05408.x","article-title":"Cadmium toxicity is alleviated by AtLCD and AtDCD in Escherichia coli","volume":"113","author":"Shen","year":"2012","journal-title":"J. Appl. Microbiol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1111\/j.1742-4658.2005.04567.x","article-title":"Isolation and characterization of a D-cysteine desulfhydrase protein from Arabidopsis thaliana","volume":"272","author":"Riemenschneider","year":"2005","journal-title":"FEBS J."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1111\/j.1399-3054.2009.01208.x","article-title":"Ethylene levels are regulated by plant encoded 1-inocyclopropane-1-arboxylic acid deaminase","volume":"136","author":"McDonnell","year":"2009","journal-title":"Physiol. Plant"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s11103-018-00817-3","article-title":"L-Cysteine desulfhydrase-dependent hydrogen sulfide is required for methane-induced lateral root formation","volume":"99","author":"Mei","year":"2019","journal-title":"Plant Mol. Biol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"4251","DOI":"10.1093\/jxb\/erz225","article-title":"Signaling by hydrogen sulfide and cyanide through post-translational modification","volume":"70","author":"Gotor","year":"2019","journal-title":"J. Exp. Bot."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"5893","DOI":"10.1093\/jxb\/erab239","article-title":"Hydrogen sulfide signaling in plant adaptations to adverse conditions: Molecular mechanisms","volume":"72","author":"Aroca","year":"2021","journal-title":"J. Exp. Bot."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Costa-Broseta, \u00c1., Castillo, M., and Le\u00f3n, J. (2020). Nitrite Reductase 1 is a target of nitric oxide-mediated post-translational modifications and controls nitrogen flux and growth in Arabidopsis. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21197270"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1104\/pp.117.1.283","article-title":"Drought-induced effects on nitrate reductase activity and mRNA and on the coordination of nitrogen and carbon metabolism in maize leaves","volume":"117","author":"Foyer","year":"1998","journal-title":"Plant Physiol."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Han, M.L., Lv, Q.Y., Zhang, J., Wang, T., Zhang, C.X., Tan, R.J., Wang, Y.L., Zhong, L.Y., Gao, Y.Q., and Chao, Z.F. (2021). Decreasing nitrogen assimilation under drought stress by suppressing DST-mediated activation of Nitrate Reductase 1.2 in rice. Mol. Plant, in press.","DOI":"10.1016\/j.molp.2021.09.005"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/0031-9422(80)85100-4","article-title":"Regulation of nitrate reductase activity in higher plants","volume":"19","author":"Srivastava","year":"1980","journal-title":"Phytochemistry"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1007\/s004250050682","article-title":"Discrepancy between nitrate reduction rates in intact leaves and nitrate reductase activity in leaf extracts: What limits nitrate reduction in situ?","volume":"210","author":"Kaiser","year":"2000","journal-title":"Planta"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1007\/s00425-017-2726-4","article-title":"Light regulation of nitrate reductase by catalytic subunits of protein phosphatase 2A","volume":"246","author":"Creighton","year":"2017","journal-title":"Planta"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1016\/j.molp.2021.07.002","article-title":"Persulfidation-induced structural change in SnRK2.6 establishes intramolecular interaction between phosphorylation and persulfidation","volume":"14","author":"Chen","year":"2021","journal-title":"Mol. Plant"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1093\/jexbot\/52.363.1981","article-title":"Post-translational regulation of nitrate reductase: Mechanism, physiological relevance and environmental triggers","volume":"52","author":"Kaiser","year":"2001","journal-title":"J. Exp. Bot."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1093\/jxb\/erh132","article-title":"Mechanism and importance of post-translational regulation of nitrate reductase","volume":"55","author":"Lillo","year":"2004","journal-title":"J. Exp. Bot."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.3389\/fpls.2020.01245","article-title":"Co-Overexpression of OsNAR2.1 and OsNRT2.3a increased agronomic nitrogen use efficiency in transgenic rice plants","volume":"11","author":"Chen","year":"2020","journal-title":"Front. Plant Sci."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/0003-2697(65)90051-5","article-title":"A direct microdetermination for sulfide","volume":"11","author":"Siegel","year":"1965","journal-title":"Anal. Biochem."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1007\/s12033-012-9621-9","article-title":"Molecular cloning, characterization, and expression analysis of a novel gene encoding L-cysteine desulfhydrase from Brassica napus","volume":"54","author":"Xie","year":"2013","journal-title":"Mol. Biotechnol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0014-5793(95)00255-8","article-title":"A new member of the cytosolic O-acetylserine(thiol)lyase gene family in Arabidopsis thaliana","volume":"363","author":"Barroso","year":"1995","journal-title":"FEBS Lett."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1046\/j.1365-313X.1994.6020271.x","article-title":"Efficient transformation of rice (Oryza sativa L.) mediated by Agrobacterium and sequence analysis of the boundaries of the T-DNA","volume":"6","author":"Hiei","year":"1994","journal-title":"Plant J."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/1746-4811-7-30","article-title":"A highly efficient rice green tissue protoplast system for transient gene expression and studying light\/chloroplast-related processes","volume":"7","author":"Zhang","year":"2011","journal-title":"Plant Methods"},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Zhou, H., Wu, H.H., Zhang, F., Su, Y., Guan, W.X., Xie, Y.J., Giroldo, J.P., and Shen, W.B. (2021). Molecular basis of cerium oxide nanoparticle enhancement of rice salt tolerance and yield. Environ. Sci. Nano.","DOI":"10.1039\/D1EN00390A"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/22\/22\/12119\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:28:08Z","timestamp":1760167688000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/22\/22\/12119"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,9]]},"references-count":60,"journal-issue":{"issue":"22","published-online":{"date-parts":[[2021,11]]}},"alternative-id":["ijms222212119"],"URL":"https:\/\/doi.org\/10.3390\/ijms222212119","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,9]]}}}