{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T14:53:29Z","timestamp":1789052009725,"version":"build-2803163510"},"reference-count":58,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2021,11,24]],"date-time":"2021-11-24T00:00:00Z","timestamp":1637712000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Canadian Institutes for Health Research","award":["MOP-142210"],"award-info":[{"award-number":["MOP-142210"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Lysophosphatidylserine (lysoPS) is known to regulate immune cell functions. Phospholipase A1 member A (PLA1A) can generate this bioactive lipid through hydrolysis of sn-1 fatty acids on phosphatidylserine (PS). PLA1A has been associated with cancer metastasis, asthma, as well as acute coronary syndrome. However, the functions of PLA1A in the development of systemic autoimmune rheumatic diseases remain elusive. To investigate the possible implication of PLA1A during rheumatic diseases, we monitored PLA1A in synovial fluids from patients with rheumatoid arthritis and plasma of early-diagnosed arthritis (EA) patients and clinically stable systemic lupus erythematosus (SLE) patients. We used human primary fibroblast-like synoviocytes (FLSs) to evaluate the PLA1A-induced biological responses. Our results highlighted that the plasma concentrations of PLA1A in EA and SLE patients were elevated compared to healthy donors. High concentrations of PLA1A were also detected in synovial fluids from rheumatoid arthritis patients compared to those from osteoarthritis (OA) and gout patients. The origin of PLA1A in FLSs and the arthritic joints remained unknown, as healthy human primary FLSs does not express the PLA1A transcript. Besides, the addition of recombinant PLA1A stimulated cultured human primary FLSs to secrete IL-8. Preincubation with heparin, autotaxin (ATX) inhibitor HA130 or lysophosphatidic acid (LPA) receptor antagonist Ki16425 reduced PLA1A-induced-secretion of IL-8. Our data suggested that FLS-associated PLA1A cleaves membrane-exposed PS into lysoPS, which is subsequently converted to LPA by ATX. Since primary FLSs do not express any lysoPS receptors, the data suggested PLA1A-mediated pro-inflammatory responses through the ATX-LPA receptor signaling axis.<\/jats:p>","DOI":"10.3390\/ijms222312685","type":"journal-article","created":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T04:48:37Z","timestamp":1638247717000},"page":"12685","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Phospholipase A1 Member A Activates Fibroblast-like Synoviocytes through the Autotaxin-Lysophosphatidic Acid Receptor Axis"],"prefix":"10.3390","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3008-878X","authenticated-orcid":false,"given":"Yang","family":"Zhao","sequence":"first","affiliation":[{"name":"Centre de Recherche du CHU de Qu\u00e9bec, Universit\u00e9 Laval, Qu\u00e9bec, QC G1V 4G2, Canada"},{"name":"Centre ARThrite, Universit\u00e9 Laval, Qu\u00e9bec, QC G1V 4G2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Hasse","sequence":"additional","affiliation":[{"name":"Centre de Recherche du CHU de Qu\u00e9bec, Universit\u00e9 Laval, Qu\u00e9bec, QC G1V 4G2, Canada"},{"name":"Centre ARThrite, Universit\u00e9 Laval, Qu\u00e9bec, QC G1V 4G2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myriam","family":"Vaillancourt","sequence":"additional","affiliation":[{"name":"Centre de Recherche du CHU de Qu\u00e9bec, Universit\u00e9 Laval, Qu\u00e9bec, QC G1V 4G2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenqi","family":"Zhao","sequence":"additional","affiliation":[{"name":"Centre de Recherche du CHU de Qu\u00e9bec, Universit\u00e9 Laval, Qu\u00e9bec, QC G1V 4G2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn","family":"Davis","sequence":"additional","affiliation":[{"name":"Centre de Recherche du CHU de Qu\u00e9bec, Universit\u00e9 Laval, Qu\u00e9bec, QC G1V 4G2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Boilard","sequence":"additional","affiliation":[{"name":"Centre de Recherche du CHU de Qu\u00e9bec, Universit\u00e9 Laval, Qu\u00e9bec, QC G1V 4G2, Canada"},{"name":"Centre ARThrite, Universit\u00e9 Laval, Qu\u00e9bec, QC G1V 4G2, Canada"},{"name":"D\u00e9partement de Microbiologie-Infectiologie et d\u2019Immunologie, Universit\u00e9 Laval, Qu\u00e9bec, QC G1V 0A6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Fortin","sequence":"additional","affiliation":[{"name":"Centre de Recherche du CHU de Qu\u00e9bec, Universit\u00e9 Laval, Qu\u00e9bec, QC G1V 4G2, Canada"},{"name":"Centre ARThrite, Universit\u00e9 Laval, Qu\u00e9bec, QC G1V 4G2, Canada"},{"name":"D\u00e9partement de M\u00e9decine, Universit\u00e9 Laval, Qu\u00e9bec, QC G1V 0A6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Di Battista","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine and Health Sciences, McGill University, Montr\u00e9al, QC H3G 2M1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrice E.","family":"Poubelle","sequence":"additional","affiliation":[{"name":"Centre de Recherche du CHU de Qu\u00e9bec, Universit\u00e9 Laval, Qu\u00e9bec, QC G1V 4G2, Canada"},{"name":"D\u00e9partement de M\u00e9decine, Universit\u00e9 Laval, Qu\u00e9bec, QC G1V 0A6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvain G.","family":"Bourgoin","sequence":"additional","affiliation":[{"name":"Centre de Recherche du CHU de Qu\u00e9bec, Universit\u00e9 Laval, Qu\u00e9bec, QC G1V 4G2, Canada"},{"name":"Centre ARThrite, Universit\u00e9 Laval, Qu\u00e9bec, QC G1V 4G2, Canada"},{"name":"D\u00e9partement de Microbiologie-Infectiologie et d\u2019Immunologie, Universit\u00e9 Laval, Qu\u00e9bec, QC G1V 0A6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,11,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2192","DOI":"10.1074\/jbc.272.4.2192","article-title":"Serine Phospholipid-specific Phospholipase A That Is Secreted from Activated Platelets","volume":"272","author":"Sato","year":"1997","journal-title":"J. Biol. Chem."},{"key":"ref_2","first-page":"26","article-title":"Structure and function of phosphatidylserine-specific phospholipase A1","volume":"1582","author":"Aoki","year":"2002","journal-title":"Biochim. Biophys. Acta (BBA)-Bioenerg."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"101112","DOI":"10.1016\/j.plipres.2021.101112","article-title":"Phosphatidylserine-specific phospholipase A1: A friend or the devil in disguise","volume":"83","author":"Zhao","year":"2021","journal-title":"Prog. Lipid Res."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"123","DOI":"10.2217\/bmm.15.93","article-title":"Polyunsaturated lysophosphatidic acid as a potential asthma biomarker","volume":"10","author":"Ackerman","year":"2016","journal-title":"Biomark. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1161\/CIRCULATIONAHA.116.022907","article-title":"Gene Expression Profiling for the Identification and Classification of Antibody-Mediated Heart Rejection","volume":"135","author":"Loupy","year":"2017","journal-title":"Circulation"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/S0014-5793(97)00098-7","article-title":"nmd, a novel gene differentially expressed in human melanoma cell lines, encodes a new atypical member of the enzyme family of lipases","volume":"404","author":"Egmond","year":"1997","journal-title":"FEBS Lett."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1038\/ng.3930","article-title":"TMPRSS2\u2013ERG fusion co-opts master transcription factors and activates NOTCH signaling in primary prostate cancer","volume":"49","author":"Kron","year":"2017","journal-title":"Nat. Genet."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1111\/1756-185X.13689","article-title":"Serum phosphatidylserine-specific phospholipase A 1 as a novel biomarker for monitoring systemic lupus erythematosus disease activity","volume":"22","author":"Sawada","year":"2019","journal-title":"Int. J. Rheum. Dis."},{"key":"ref_9","first-page":"1459","article-title":"Phosphatidylserine-specific phospholipase A1 (PS-PLA1) expression in colorectal cancer correlates with tumor invasion and hematogenous metastasis","volume":"35","author":"Iida","year":"2015","journal-title":"Anticancer Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1111\/1346-8138.14278","article-title":"Association between serum autotaxin or phosphatidylserine-specific phospholipase A1 levels and melanoma","volume":"45","author":"Kurano","year":"2018","journal-title":"J. Dermatol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.cca.2020.01.011","article-title":"Elevated phosphatidylserine-specific phospholipase A1 level in hyperthyroidism","volume":"503","author":"Nakawatari","year":"2020","journal-title":"Clin. Chim. Acta"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.bbacli.2015.08.003","article-title":"Blood levels of serotonin are specifically correlated with plasma lysophosphatidylserine among the glycero-lysophospholipids","volume":"4","author":"Kurano","year":"2015","journal-title":"BBA Clin."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1194\/jlr.P071803","article-title":"Different origins of lysophospholipid mediators between coronary and peripheral arteries in acute coronary syndrome","volume":"58","author":"Kurano","year":"2017","journal-title":"J. Lipid Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1194\/jlr.P072090","article-title":"Analysis of glycero-lysophospholipids in gastric cancerous ascites","volume":"58","author":"Emoto","year":"2017","journal-title":"J. Lipid Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.1194\/jlr.R046920","article-title":"Novel lysophosphoplipid receptors: Their structure and function","volume":"55","author":"Makide","year":"2014","journal-title":"J. Lipid Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1016\/j.bbrc.2006.01.069","article-title":"Identification of a lysophosphatidylserine receptor on mast cells","volume":"341","author":"Sugo","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1111\/cea.13162","article-title":"Lysophosphatidylserine receptor P2Y10: A G protein-coupled receptor that mediates eosinophil degranulation","volume":"48","author":"Hwang","year":"2018","journal-title":"Clin. Exp. Allergy"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"4583","DOI":"10.1074\/jbc.M112.438507","article-title":"Neutrophils Regulate Tissue Neutrophilia in Inflammation via the Oxidant-modified Lipid Lysophosphatidylserine","volume":"288","author":"Frasch","year":"2013","journal-title":"J. Biol. Chem."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1084\/jem.20141827","article-title":"The lysophosphatidylserine receptor GPR174 constrains regulatory T cell development and function","volume":"212","author":"Barnes","year":"2015","journal-title":"J. Exp. Med."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"518","DOI":"10.5551\/jat.25650","article-title":"Lysophosphatidylserine has Bilateral Effects on Macrophages in the Pathogenesis of Atherosclerosis","volume":"22","author":"Nishikawa","year":"2015","journal-title":"J. Atheroscler. Thromb."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.plipres.2012.03.001","article-title":"Emerging roles for lysophosphatidylserine in resolution of inflammation","volume":"51","author":"Frasch","year":"2012","journal-title":"Prog. Lipid Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2524","DOI":"10.1016\/S0021-9258(18)45911-X","article-title":"Identification, purification, and partial sequence analysis of autotaxin, a novel motility-stimulating protein","volume":"267","author":"Stracke","year":"1992","journal-title":"J. Biol. Chem."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"7385","DOI":"10.1074\/jbc.M807820200","article-title":"Autotaxin\/lysopholipase D and lysophosphatidic acid regulate murine hemostasis and thrombosis","volume":"284","author":"Pamuklar","year":"2009","journal-title":"J. Biol. Chem."},{"key":"ref_24","first-page":"513","article-title":"Two pathways for lysophosphatidic acid production","volume":"1781","author":"Aoki","year":"2008","journal-title":"Biochim. Biophys. Acta (BBA)-Mol. Cell Biol. Lipids"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"48737","DOI":"10.1074\/jbc.M206812200","article-title":"Serum Lysophosphatidic Acid Is Produced through Diverse Phospholipase Pathways","volume":"277","author":"Aoki","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.plipres.2007.02.001","article-title":"Regulation and biological activities of the autotaxin-LPA axis","volume":"46","author":"Moolenaar","year":"2007","journal-title":"Prog. Lipid Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"851","DOI":"10.4049\/jimmunol.1302831","article-title":"The Autotaxin\u2013LPA Axis Emerges as a Novel Regulator of Lymphocyte Homing and Inflammation","volume":"192","author":"Knowlden","year":"2014","journal-title":"J. Immunol."},{"key":"ref_28","first-page":"9173090","article-title":"Autotaxin-Lysophosphatidic Acid: From Inflammation to Cancer Development","volume":"2017","year":"2017","journal-title":"Mediat. Inflamm."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Lin, Y.H., Lin, Y.C., and Chen, C.C. (2021). Lysophosphatidic Acid Receptor Antagonists and Cancer: The Current Trends, Clinical Implications, and Trials. Cells, 10.","DOI":"10.3390\/cells10071629"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Wu, P.-Y., Lin, Y.-C., Huang, Y.-L., Chen, W.-M., Chen, C.-C., and Lee, H. (2018). Mechanisms of Lysophosphatidic Acid-Mediated Lymphangiogenesis in Prostate Cancer. Cancers, 10.","DOI":"10.3390\/cancers10110413"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.bcp.2019.03.035","article-title":"Targeting the autotaxin\u2014Lysophosphatidic acid receptor axis in cardiovascular diseases","volume":"164","author":"Zhao","year":"2019","journal-title":"Biochem. Pharmacol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1194\/jlr.M013326","article-title":"The phospholipase A1 activity of lysophospholipase A-I links platelet activation to LPA production during blood coagulation","volume":"52","author":"Bolen","year":"2011","journal-title":"J. Lipid Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0014-5793(00)01827-5","article-title":"Lysophosphatidic acid (LPA) receptors of the EDG family are differentially activated by LPA species","volume":"478","author":"Bandoh","year":"2000","journal-title":"FEBS Lett."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1056\/NEJMra1004965","article-title":"The pathogenesis of rheumatoid arthritis","volume":"365","author":"McInnes","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"29664","DOI":"10.1074\/jbc.M104597200","article-title":"Phosphatidylserine-specific Phospholipase A1Stimulates Histamine Release from Rat Peritoneal Mast Cells through Production of 2-Acyl-1-lysophosphatidylserine","volume":"276","author":"Hosono","year":"2001","journal-title":"J. Biol. Chem."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1124\/mol.107.038216","article-title":"Regulation of Lysophosphatidic Acid Receptor Expression and Function in Human Synoviocytes: Implications for Rheumatoid Arthritis?","volume":"73","author":"Zhao","year":"2008","journal-title":"Mol. Pharmacol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1016\/j.cca.2010.04.006","article-title":"A novel enzyme immunoassay for the determination of phosphatidylserine-specific phospholipase A1 in human serum samples","volume":"411","author":"Nakamura","year":"2010","journal-title":"Clin. Chim. Acta"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"11053","DOI":"10.1074\/jbc.274.16.11053","article-title":"An Alternative Splicing Form of Phosphatidylserine-specific Phospholipase A1 That Exhibits Lysophosphatidylserine-specific Lysophospholipase Activity in Humans","volume":"274","author":"Nagai","year":"1999","journal-title":"J. Biol. Chem."},{"key":"ref_39","first-page":"3141","article-title":"Interaction of platelet-derived autotaxin with tumor integrin alphaVbeta3 controls metastasis of breast cancer cells to bone","volume":"124","author":"Leblanc","year":"2014","journal-title":"Blood J. Am. Soc. Hematol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.biochi.2006.09.021","article-title":"Structure and function of extracellular phospholipase A1 belonging to the pancreatic lipase gene family","volume":"89","author":"Aoki","year":"2007","journal-title":"Biochimie"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2659","DOI":"10.1038\/s41598-020-59590-3","article-title":"Possible involvement of PS-PLA1 and lysophosphatidylserine receptor (LPS1) in hepatocellular carcinoma","volume":"10","author":"Uranbileg","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.semcdb.2004.05.001","article-title":"Mechanisms of lysophosphatidic acid production","volume":"15","author":"Aoki","year":"2004","journal-title":"Semin. Cell Dev. Biol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1002\/art.20932","article-title":"Chemokines and their receptors in rheumatoid arthritis: Future targets?","volume":"52","author":"Koch","year":"2005","journal-title":"Arthritis Rheum."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1111\/cei.13218","article-title":"Blocking of YY1 reduce neutrophil infiltration by inhibiting IL-8 production via the PI3K-Akt-mTOR signaling pathway in rheumatoid arthritis","volume":"195","author":"Lin","year":"2019","journal-title":"Clin. Exp. Immunol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/ar14","article-title":"Protection against cartilage and bone destruction by systemic interleukin-4 treatment in established murine type II collagen-induced arthritis","volume":"1","author":"Joosten","year":"1999","journal-title":"Arthritis Res."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"49438","DOI":"10.1074\/jbc.M213018200","article-title":"Biochemical and Molecular Characterization of Two Phosphatidic Acid-selective Phospholipase A1s, mPA-PLA1\u03b1 and mPA-PLA1\u03b2","volume":"278","author":"Hiramatsu","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2450","DOI":"10.1002\/art.20367","article-title":"Induction of RANKL expression and osteoclast maturation by the binding of fibroblast growth factor 2 to heparan sulfate proteoglycan on rheumatoid synovial fibroblasts","volume":"50","author":"Nakano","year":"2004","journal-title":"Arthritis Rheum."},{"key":"ref_48","first-page":"515","article-title":"Autotaxin and lysophospholipids in rheumatoid arthritis","volume":"11","author":"Bourgoin","year":"2010","journal-title":"Curr. Opin. Investig. Drugs"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1083\/jcb.200204026","article-title":"Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production","volume":"158","author":"Kishi","year":"2002","journal-title":"J. Cell Biol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"3948","DOI":"10.1242\/jcs.184424","article-title":"Exosomes bind autotaxin and act as a physiological delivery mechanism to stimulate LPA receptor signalling in cells","volume":"129","author":"Jethwa","year":"2016","journal-title":"J. Cell Sci."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1038\/nrm3188","article-title":"Insights into autotaxin: How to produce and present a lipid mediator","volume":"12","author":"Moolenaar","year":"2011","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"14312","DOI":"10.1074\/jbc.RA118.004450","article-title":"Lysophosphatidic acid produced by autotaxin acts as an allosteric modulator of its catalytic efficiency","volume":"293","author":"Fish","year":"2018","journal-title":"J. Biol. Chem."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"34654","DOI":"10.1074\/jbc.M111.276725","article-title":"Binding of Autotaxin to Integrins Localizes Lysophosphatidic Acid Production to Platelets and Mammalian Cells","volume":"286","author":"Fulkerson","year":"2011","journal-title":"J. Biol. Chem."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"21155","DOI":"10.1074\/jbc.M413183200","article-title":"Inhibition of autotaxin by lysophosphatidic acid and sphingosine 1-phosphate","volume":"280","author":"Ruurs","year":"2005","journal-title":"J. Biol. Chem."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1194\/jlr.M057661","article-title":"Regulation of autotaxin expression and secretion by lysophosphatidate and sphingosine 1-phosphate","volume":"56","author":"Benesch","year":"2015","journal-title":"J. Lipid Res."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"C204","DOI":"10.1152\/ajpcell.1994.267.1.C204","article-title":"Lysophosphatidic acids induce proliferation of cultured vascular smooth muscle cells from rat aorta","volume":"267","author":"Tokumura","year":"1994","journal-title":"Am. J. Physiol. Physiol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1161\/hh1501.094265","article-title":"Phenotypic Modulation of Vascular Smooth Muscle Cells Induced by Unsaturated Lysophosphatidic Acids","volume":"89","author":"Hayashi","year":"2001","journal-title":"Circ. Res."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/nsmb.1998","article-title":"Crystal structure of autotaxin and insight into GPCR activation by lipid mediators","volume":"18","author":"Nishimasu","year":"2011","journal-title":"Nat. Struct. Mol. Biol."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/22\/23\/12685\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:35:03Z","timestamp":1760168103000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/22\/23\/12685"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,24]]},"references-count":58,"journal-issue":{"issue":"23","published-online":{"date-parts":[[2021,12]]}},"alternative-id":["ijms222312685"],"URL":"https:\/\/doi.org\/10.3390\/ijms222312685","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,24]]}}}