{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T14:39:17Z","timestamp":1792075157055,"version":"4.4.0"},"reference-count":173,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T00:00:00Z","timestamp":1638230400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Differentiated thyroid cancers are more frequent in women than in men. These different frequencies may depend on differences in patient\u2019s behavior and in thyroid investigations. However, an impact on sexual hormones is likely, although this has been insufficiently elucidated. Estrogens may increase the production of mutagenic molecules in the thyroid cell and favor the proliferation and invasion of tumoral cells by regulating both the thyrocyte enzymatic machinery and the inflammatory process associated with tumor growth. On the other hand, the worse prognosis of thyroid cancer associated with the male gender is poorly explained.<\/jats:p>","DOI":"10.3390\/ijms222312992","type":"journal-article","created":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T22:01:11Z","timestamp":1638309671000},"page":"12992","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":90,"title":["Sex Bias in Differentiated Thyroid Cancer"],"prefix":"10.3390","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1316-8190","authenticated-orcid":false,"given":"Valentine","family":"Suteau","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Diabetology and Nutrition, University Hospital Angers, 49000 Angers, France"},{"name":"MITOVASC Institute, University of Angers, 49100 Angers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7194-6846","authenticated-orcid":false,"given":"Mathilde","family":"Munier","sequence":"additional","affiliation":[{"name":"MITOVASC Institute, University of Angers, 49100 Angers, France"},{"name":"Centre de R\u00e9f\u00e9rence des Maladies Rares de la Thyro\u00efde et des R\u00e9cepteurs Hormonaux, CHU Angers, 4 Rue Larrey, CEDEX 9, 49000 Angers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Briet","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetology and Nutrition, University Hospital Angers, 49000 Angers, France"},{"name":"MITOVASC Institute, University of Angers, 49100 Angers, France"},{"name":"Centre de R\u00e9f\u00e9rence des Maladies Rares de la Thyro\u00efde et des R\u00e9cepteurs Hormonaux, CHU Angers, 4 Rue Larrey, CEDEX 9, 49000 Angers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7785-5627","authenticated-orcid":false,"given":"Patrice","family":"Rodien","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetology and Nutrition, University Hospital Angers, 49000 Angers, France"},{"name":"MITOVASC Institute, University of Angers, 49100 Angers, France"},{"name":"Centre de R\u00e9f\u00e9rence des Maladies Rares de la Thyro\u00efde et des R\u00e9cepteurs Hormonaux, CHU Angers, 4 Rue Larrey, CEDEX 9, 49000 Angers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,11,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1111\/j.1365-2265.1977.tb01340.x","article-title":"THE SPECTRUM OF THYROID DISEASE IN A COMMUNITY: THE WHICKHAM SURVEY","volume":"7","author":"Tunbridge","year":"1977","journal-title":"Clin. 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