{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:26:31Z","timestamp":1790774791583,"version":"4.1.0"},"reference-count":87,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2021,12,8]],"date-time":"2021-12-08T00:00:00Z","timestamp":1638921600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Myotonic dystrophy is the most common muscular dystrophy in adults. It consists of two forms: type 1 (DM1) and type 2 (DM2). DM1 is associated with a trinucleotide repeat expansion mutation, which is transcribed but not translated into protein. The mutant RNA remains in the nucleus, which leads to a series of downstream abnormalities. DM1 is widely considered to be an RNA-based disorder. Thus, we consider three areas of the RNA pathway that may offer targeting opportunities to disrupt the production, stability, and degradation of the mutant RNA.<\/jats:p>","DOI":"10.3390\/ijms222413225","type":"journal-article","created":{"date-parts":[[2021,12,10]],"date-time":"2021-12-10T02:07:18Z","timestamp":1639102038000},"page":"13225","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Disrupting the Molecular Pathway in Myotonic Dystrophy"],"prefix":"10.3390","volume":"22","author":[{"given":"Xiaomeng","family":"Xing","sequence":"first","affiliation":[{"name":"School of Life Sciences, University of Nottingham, Nottingham NG7 2UH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjani","family":"Kumari","sequence":"additional","affiliation":[{"name":"School of Life Sciences, University of Nottingham, Nottingham NG7 2UH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jake","family":"Brown","sequence":"additional","affiliation":[{"name":"School of Life Sciences, University of Nottingham, Nottingham NG7 2UH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John David","family":"Brook","sequence":"additional","affiliation":[{"name":"School of Life Sciences, University of Nottingham, Nottingham NG7 2UH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1002\/mus.1238","article-title":"Myotonic dystrophy, 3rd edition, by P. Harper, 436 pp., ill., London, W.B. Saunders, 2001, $85","volume":"25","author":"Tapscott","year":"2002","journal-title":"Muscle Nerve"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/0092-8674(92)90154-5","article-title":"Molecular basis of myotonic dystrophy: Expansion of a trinucleotide (CTG) repeat at the 3\u2032 end of a transcript encoding a protein kinase family member","volume":"68","author":"Brook","year":"1992","journal-title":"Cell"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1126\/science.1546325","article-title":"Myotonic dystrophy mutation: An unstable ctg repeat in the 3\u2032 untranslated region of the gene","volume":"255","author":"Mahadevan","year":"1992","journal-title":"Science"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1126\/science.1546326","article-title":"An unstable triplet repeat in a gene related to myotonic muscular dystrophy","volume":"255","author":"Fu","year":"1992","journal-title":"Science"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1126\/science.1062125","article-title":"Myotonic dystrophy type 2 caused by a CCTG expansion in intron 1 of ZNF9","volume":"293","author":"Liquori","year":"2001","journal-title":"Science"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1158\/2159-8290.CD-19-0528","article-title":"Transcription-Associated Cyclin-Dependent Kinases as Targets and Biomarkers for Cancer Therapy","volume":"10","author":"Chou","year":"2020","journal-title":"Cancer Discov."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1126\/scitranslmed.aaz2415","article-title":"CDK12 inhibition reduces abnormalities in cells from patients with myotonic dystrophy and in a mouse model","volume":"12","author":"Ketley","year":"2020","journal-title":"Sci. Transl. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2591","DOI":"10.1242\/jcs.114.14.2591","article-title":"CrkRS: A novel conserved Cdc2-related protein kinase that colocalises with SC35 speckles","volume":"114","author":"Ko","year":"2001","journal-title":"J. Cell Sci."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2158","DOI":"10.1101\/gad.16962311","article-title":"The Cyclin K\/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes","volume":"25","author":"Blazek","year":"2011","journal-title":"Genes Dev."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1747-1028-7-12","article-title":"Cyclin K goes with Cdk12 and Cdk13","volume":"7","author":"Kohoutek","year":"2012","journal-title":"Cell Div."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"3505","DOI":"10.1038\/ncomms4505","article-title":"The structure and substrate specificity of human Cdk12\/Cyclin K","volume":"5","author":"Farnung","year":"2014","journal-title":"Nat. Commun."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2303","DOI":"10.1101\/gad.1968210","article-title":"CDK12 is a transcription elongation-associated CTD kinase, the metazoan ortholog of yeast Ctk1","volume":"24","author":"Bartkowiak","year":"2010","journal-title":"Genes Dev."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1038\/cdd.2015.157","article-title":"Cdk12 is essential for embryonic development and the maintenance of genomic stability","volume":"23","author":"Juan","year":"2016","journal-title":"Cell Death Differ."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1038\/nchembio.2166","article-title":"Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors","volume":"12","author":"Zhang","year":"2016","journal-title":"Nat. Chem. Biol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"7934","DOI":"10.1073\/pnas.82.23.7934","article-title":"A unique structure at the carboxyl terminus of the largest subunit of eukaryotic RNA polymerase II","volume":"82","author":"Corden","year":"1985","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.tig.2008.03.010","article-title":"Molecular evolution of the RNA polymerase II CTD","volume":"24","author":"Chapman","year":"2008","journal-title":"Trends Genet."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/nsb0903-679","article-title":"The CTD code","volume":"10","author":"Buratowski","year":"2003","journal-title":"Nat. Struct. Mol. Biol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1038\/nsmb.2399","article-title":"Cyclin-dependent kinase control of the initiation-to-elongation switch of RNA polymerase II","volume":"19","author":"Larochelle","year":"2012","journal-title":"Nat. Struct. Mol. Biol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e47592","DOI":"10.15252\/embr.201847592","article-title":"CDK12 controls G1\/S progression by regulating RNAPII processivity at core DNA replication genes","volume":"20","author":"Pilarova","year":"2019","journal-title":"EMBO Rep."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-019-09703-y","article-title":"CDK12 loss in cancer cells affects DNA damage response genes through premature cleavage and polyadenylation","volume":"10","author":"Krajewska","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/s41586-018-0758-y","article-title":"CDK12 regulates DNA repair genes by suppressing intronic polyadenylation","volume":"564","author":"Dubbury","year":"2018","journal-title":"Nature"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1128\/MCB.01426-14","article-title":"Characterization of human cyclin-dependent kinase 12 (CDK12) and CDK13 complexes in C-terminal domain phosphorylation, gene transcription, and RNA processing","volume":"35","author":"Liang","year":"2015","journal-title":"Mol. Cell. Biol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1074\/jbc.M114.612226","article-title":"Expression, purification, and identification of associated proteins of the full-length hCDK12\/CyclinK complex","volume":"290","author":"Bartkowiak","year":"2015","journal-title":"J. Biol. Chem."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1093\/nar\/gks1327","article-title":"CTD serine-2 plays a critical role in splicing and termination factor recruitment to RNA polymerase II in vivo","volume":"41","author":"Gu","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1101\/gad.2038011","article-title":"The RNA polymerase II C-terminal domain promotes splicing activation through recruitment of a U2AF65\u2013Prp19 complex","volume":"25","author":"David","year":"2011","journal-title":"Genes Dev."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"6698","DOI":"10.1093\/nar\/gkx187","article-title":"CDK12 regulates alternative last exon mRNA splicing and promotes breast cancer cell invasion","volume":"45","author":"Tien","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1101\/gad.231274.113","article-title":"3\u2032 end formation of pre-mRNA and phosphorylation of Ser2 on the RNA polymerase II CTD are reciprocally coupled in human cells","volume":"28","author":"Davidson","year":"2014","journal-title":"Genes Dev."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1093\/hmg\/ddt542","article-title":"High-content screening identifies small molecules that remove nuclear foci, affect MBNL distribution and CELF1 protein levels via a PKC-independent pathway in myotonic dystrophy cell lines","volume":"23","author":"Ketley","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"742","DOI":"10.4161\/rna.28799","article-title":"Small molecule kinase inhibitors alleviate different molecular features of myotonic dystrophy type 1","volume":"11","author":"Wojciechowska","year":"2014","journal-title":"RNA Biol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1016\/j.bbadis.2016.05.015","article-title":"Nuclear speckles are detention centers for transcripts containing expanded CAG repeats","volume":"1862","author":"Urbanek","year":"2016","journal-title":"Biochim. Biophys. Acta (BBA)\u2014Mol. Basis Dis."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1111\/j.1365-2443.2007.01112.x","article-title":"Defective mRNA in myotonic dystrophy accumulates at the periphery of nuclear splicing speckles","volume":"12","author":"Holt","year":"2007","journal-title":"Genes Cells"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2386","DOI":"10.1016\/j.celrep.2015.11.028","article-title":"Actinomycin D specifically reduces expanded CUG repeat RNA in myotonic dystrophy models","volume":"13","author":"Siboni","year":"2015","journal-title":"Cell Rep."},{"key":"ref_33","first-page":"4461","article-title":"GSK3\u03b2 is a new therapeutic target for myotonic dystrophy type 1","volume":"1","author":"Wei","year":"2013","journal-title":"Rare Dis."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Wang, M., Weng, W.C., Stock, L., Lindquist, D., Martines, A., Gourdon, G., Timchenko, N., Snape, M., and Timchenko, L. (2019). Correction of Glycogen Synthase Kinase 3beta in Myotonic Dystrophy 1 Reduces the Mutant RNA and Improves Postnatal Survival of DMSXL Mice. Mol. Cell. Biol., 39.","DOI":"10.1128\/MCB.00155-19"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"4461","DOI":"10.1172\/JCI64081","article-title":"GSK3beta mediates muscle pathology in myotonic dystrophy","volume":"122","author":"Jones","year":"2012","journal-title":"J. Clin. Investig."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.pediatrneurol.2020.08.001","article-title":"A Phase 2 Study of AMO-02 (Tideglusib) in Congenital and Childhood-Onset Myotonic Dystrophy Type 1 (DM1)","volume":"112","author":"Horrigan","year":"2020","journal-title":"Pediatr. Neurol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2016.02.050","article-title":"Roles for RNA-binding proteins in development and disease","volume":"1647","author":"Brinegar","year":"2016","journal-title":"Brain Res."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/978-1-4939-1221-6_10","article-title":"RNA-binding protein misregulation in microsatellite expansion disorders","volume":"825","author":"Goodwin","year":"2014","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_39","first-page":"509","article-title":"Myotonic dystrophy and developmental regulation of RNA processing","volume":"8","author":"Thomas","year":"2011","journal-title":"Compr. Physiol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.molcel.2014.08.027","article-title":"Loss of MBNL leads to disruption of developmentally regulated alternative polyadenylation in RNA-mediated disease","volume":"56","author":"Batra","year":"2014","journal-title":"Mol. Cell"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1093\/hmg\/ddy432","article-title":"Transcriptome alterations in myotonic dystrophy skeletal muscle and heart","volume":"28","author":"Wang","year":"2019","journal-title":"Hum. Mol. Genet."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1101\/gr.184390.114","article-title":"Antagonistic regulation of mRNA expression and splicing by CELF and MBNL proteins","volume":"25","author":"Wang","year":"2015","journal-title":"Genome Res."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/gtc.12201","article-title":"ABLIM1 splicing is abnormal in skeletal muscle of patients with DM1 and regulated by MBNL, CELF and PTBP1","volume":"20","author":"Ohsawa","year":"2015","journal-title":"Genes Cells"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.tig.2010.12.001","article-title":"Understanding splicing regulation through RNA splicing maps","volume":"27","author":"Witten","year":"2011","journal-title":"Trends Genet."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"5472","DOI":"10.1073\/pnas.1907297117","article-title":"HNRNPA1-induced spliceopathy in a transgenic mouse model of myotonic dystrophy","volume":"117","author":"Li","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1101\/gad.328492.119","article-title":"The RNA hairpin binder TRIM71 modulates alternative splicing by repressing MBNL1","volume":"33","author":"Welte","year":"2019","journal-title":"Genes Dev."},{"key":"ref_47","first-page":"11861","article-title":"The mRNA repressor TRIM71 cooperates with Nonsense-Mediated Decay factors to destabilize the mRNA of CDKN1A\/p21","volume":"47","author":"Jux","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Lavysh, D., and Neu-Yilik, G. (2020). UPF1-Mediated RNA Decay\u2014Danse Macabre in a Cloud. Biomolecules, 10.","DOI":"10.3390\/biom10070999"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1038\/nsmb.2858","article-title":"Identification of genes in toxicity pathways of trinucleotide-repeat RNA in C. elegans","volume":"21","author":"Garcia","year":"2014","journal-title":"Nat. Struct. Mol. Biol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1038\/nsmb.1519","article-title":"Structural insights into RNA recognition by the alternative-splicing regulator muscleblind-like MBNL1","volume":"15","author":"Teplova","year":"2008","journal-title":"Nat. Struct. Mol. Biol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"3152","DOI":"10.1093\/nar\/gkx1304","article-title":"An engineered RNA binding protein with improved splicing regulation","volume":"46","author":"Hale","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1002\/cbic.201100487","article-title":"MBNL1-RNA recognition: Contributions of MBNL1 sequence and RNA conformation","volume":"13","author":"Fu","year":"2012","journal-title":"ChemBioChem"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"2769","DOI":"10.1093\/nar\/gkq1155","article-title":"Identification of MBNL1 and MBNL3 domains required for splicing activation and repression","volume":"39","author":"Grammatikakis","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1093\/hmg\/ddu492","article-title":"Nuclear localization of MBNL1: Splicing-mediated autoregulation and repression of repeat-derived aberrant proteins","volume":"24","author":"Kino","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1002\/emmm.201303275","article-title":"Compound loss of muscleblind-like function in myotonic dystrophy","volume":"5","author":"Lee","year":"2013","journal-title":"EMBO Mol. Med."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"2294","DOI":"10.1016\/j.celrep.2018.02.025","article-title":"Ubiquitination of MBNL1 is required for its cytoplasmic localization and function in promoting neurite outgrowth","volume":"22","author":"Wang","year":"2018","journal-title":"Cell Rep."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"e201800157","DOI":"10.26508\/lsa.201800157","article-title":"MBNL1 alternative splicing isoforms play opposing roles in cancer","volume":"1","author":"Tabaglio","year":"2018","journal-title":"Life Sci. Alliance"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"10873","DOI":"10.1093\/nar\/gku767","article-title":"MBNL proteins and their target RNAs, interaction and splicing regulation","volume":"42","author":"Konieczny","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"18115","DOI":"10.1002\/chem.201804368","article-title":"A Dimeric 2,9-Diamino-1,10-phenanthroline Derivative Improves Alternative Splicing in Myotonic Dystrophy Type 1 Cell and Mouse Models","volume":"24","author":"Li","year":"2018","journal-title":"Chemistry"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.chembiol.2020.10.007","article-title":"A Small Molecule that Binds an RNA Repeat Expansion Stimulates Its Decay via the Exosome Complex","volume":"28","author":"Angelbello","year":"2021","journal-title":"Cell Chem. Biol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"8709","DOI":"10.1073\/pnas.1820827116","article-title":"Intrinsically cell-penetrating multivalent and multitargeting ligands for myotonic dystrophy type 1","volume":"116","author":"Lee","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"14180","DOI":"10.1021\/jacs.5b09266","article-title":"Rationally designed small molecules that target both the DNA and RNA causing myotonic dystrophy type 1","volume":"137","author":"Nguyen","year":"2015","journal-title":"J. Am. Chem. Soc."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"dmm032557","DOI":"10.1242\/dmm.032557","article-title":"Daunorubicin reduces MBNL1 sequestration caused by CUG-repeat expansion and rescues cardiac dysfunctions in a Drosophila model of myotonic dystrophy","volume":"11","author":"Chakraborty","year":"2018","journal-title":"Dis. Models Mech."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1002\/acn3.271","article-title":"Oral administration of erythromycin decreases RNA toxicity in myotonic dystrophy","volume":"3","author":"Nakamori","year":"2016","journal-title":"Ann. Clin. Transl. Neurol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/s41419-020-02756-8","article-title":"MBNL1 reverses the proliferation defect of skeletal muscle satellite cells in myotonic dystrophy type 1 by inhibiting autophagy via the mTOR pathway","volume":"11","author":"Song","year":"2020","journal-title":"Cell Death Dis."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"25203","DOI":"10.1073\/pnas.1820297116","article-title":"Increased Muscleblind levels by chloroquine treatment improve myotonic dystrophy type 1 phenotypes in in vitro and in vivo models","volume":"116","author":"Bargiela","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1038\/s41419-019-1789-5","article-title":"The natural compound neobractatin inhibits tumor metastasis by upregulating the RNA-binding-protein MBNL2","volume":"10","author":"Zhang","year":"2019","journal-title":"Cell Death Dis."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"154815","DOI":"10.1016\/j.cyto.2019.154815","article-title":"TNF-alpha regulates alternative splicing of genes participating in pathways of crucial metabolic syndromes; a transcriptome wide study","volume":"125","author":"Louis","year":"2020","journal-title":"Cytokine"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1002\/1873-3468.14029","article-title":"Global analysis of RNA\u2013protein interactions in TNF-\u03b1 induced alternative splicing in metabolic disorders","volume":"595","author":"Louis","year":"2021","journal-title":"FEBS Lett."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1080\/13813455.2018.1427764","article-title":"High glucose induces inflammatory responses in HepG2 cells via the oxidative stress-mediated activation of NF-kappaB, and MAPK pathways in HepG2 cells","volume":"124","author":"Panahi","year":"2018","journal-title":"Arch. Physiol. Biochem."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"31222","DOI":"10.1038\/srep31222","article-title":"Insulin receptor alternative splicing is regulated by insulin signaling and modulates beta cell survival","volume":"6","author":"Malakar","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1016\/j.sjbs.2020.02.010","article-title":"Spiroindolone analogues bearing benzofuran moiety as a selective cyclooxygenase COX-1 with TNF-\u03b1 and IL-6 inhibitors","volume":"27","author":"Altowyan","year":"2020","journal-title":"Saudi J. Biol. Sci."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"25317","DOI":"10.1038\/srep25317","article-title":"Phenylbutazone induces expression of MBNL1 and suppresses formation of MBNL1-CUG RNA foci in a mouse model of myotonic dystrophy","volume":"6","author":"Chen","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"2558","DOI":"10.1038\/s41598-020-59517-y","article-title":"Inhibition of cyclooxygenase-1 by nonsteroidal anti-inflammatory drugs demethylates MeR2 enhancer and promotes Mbnl1 transcription in myogenic cells","volume":"10","author":"Huang","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1126\/science.1173110","article-title":"Reversal of RNA dominance by displacement of protein sequestered on triplet repeat RNA","volume":"325","author":"Wheeler","year":"2009","journal-title":"Science"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.omtn.2017.05.007","article-title":"Targeting DMPK with antisense oligonucleotide improves muscle strength in myotonic dystrophy type 1 mice","volume":"7","author":"Jauvin","year":"2017","journal-title":"Mol. Ther.-Nucleic Acids"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"20991","DOI":"10.1073\/pnas.1901893116","article-title":"A CTG repeat-selective chemical screen identifies microtubule inhibitors as selective modulators of toxic CUG RNA levels","volume":"116","author":"Reddy","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.tcb.2021.03.014","article-title":"Interphase microtubules in nuclear organization and genome maintenance","volume":"31","author":"Shokrollahi","year":"2021","journal-title":"Trends Cell Biol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"349","DOI":"10.3389\/fneur.2018.00349","article-title":"and Wojciechowska, M. Small Molecules Which Improve Pathogenesis of Myotonic Dystrophy Type 1","volume":"9","author":"Brook","year":"2018","journal-title":"Front Neurol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1016\/j.drudis.2017.07.011","article-title":"Myotonic dystrophy: Candidate small molecule therapeutics","volume":"22","author":"Konieczny","year":"2017","journal-title":"Drug Discov. Today"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1073\/pnas.1013343108","article-title":"Non-ATG\u2013initiated translation directed by microsatellite expansions","volume":"108","author":"Zu","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.molcel.2005.09.002","article-title":"Antisense transcription and heterochromatin at the DM1 CTG repeats are constrained by CTCF","volume":"20","author":"Cho","year":"2005","journal-title":"Mol. Cell"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"3174","DOI":"10.1093\/hmg\/ddm293","article-title":"An antisense transcript spanning the CGG repeat region of FMR1 is upregulated in premutation carriers but silenced in full mutation individuals","volume":"16","author":"Ladd","year":"2007","journal-title":"Hum. Mol. Genet."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1038\/ng1827","article-title":"Bidirectional expression of CUG and CAG expansion transcripts and intranuclear polyglutamine inclusions in spinocerebellar ataxia type 8","volume":"38","author":"Moseley","year":"2006","journal-title":"Nat. Genet."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/nrm2838","article-title":"The mechanism of eukaryotic translation initiation and principles of its regulation","volume":"11","author":"Jackson","year":"2010","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/sj.cdd.4400819","article-title":"Extended polyglutamine selectively interacts with caspase-8 and -10 in nuclear aggregates","volume":"8","author":"Miyashita","year":"2001","journal-title":"Cell Death Differ."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1016\/j.neuron.2017.08.039","article-title":"RAN translation regulated by muscleblind proteins in myotonic dystrophy type 2","volume":"95","author":"Zu","year":"2017","journal-title":"Neuron"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/22\/24\/13225\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:43:26Z","timestamp":1760168606000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/22\/24\/13225"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,8]]},"references-count":87,"journal-issue":{"issue":"24","published-online":{"date-parts":[[2021,12]]}},"alternative-id":["ijms222413225"],"URL":"https:\/\/doi.org\/10.3390\/ijms222413225","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,8]]}}}