{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:19:21Z","timestamp":1791893961075,"version":"4.3.4"},"reference-count":184,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2021,12,10]],"date-time":"2021-12-10T00:00:00Z","timestamp":1639094400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Nicotine, the main psychoactive component in tobacco smoke, plays a major role in tobacco addiction, producing a high morbidity and mortality in the world. A great amount of research has been developed to elucidate the neural pathways and neurotransmitter systems involved in such a complex addictive behavior. The endocannabinoid system, which has been reported to participate in the addictive properties of most of the prototypical drugs of abuse, is also implicated in nicotine dependence. This review summarizes and updates the main behavioral and biochemical data involving the endocannabinoid system in the rewarding properties of nicotine as well as in nicotine withdrawal and relapse to nicotine-seeking behavior. Promising results from preclinical studies suggest that manipulation of the endocannabinoid system could be a potential therapeutic strategy for treating nicotine addiction.<\/jats:p>","DOI":"10.3390\/ijms222413316","type":"journal-article","created":{"date-parts":[[2021,12,13]],"date-time":"2021-12-13T01:28:11Z","timestamp":1639358891000},"page":"13316","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["New Insights in the Involvement of the Endocannabinoid System and Natural Cannabinoids in Nicotine Dependence"],"prefix":"10.3390","volume":"22","author":[{"given":"Rocio","family":"Saravia","sequence":"first","affiliation":[{"name":"Laboratory of Neuropharmacology, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, PRBB, 08003 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Ten-Blanco","sequence":"additional","affiliation":[{"name":"Faculty of Experimental Sciences, Universidad Francisco de Vitoria, UFV, Pozuelo de Alarc\u00f3n, 28223 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inmaculada","family":"Pereda-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Faculty of Experimental Sciences, Universidad Francisco de Vitoria, UFV, Pozuelo de Alarc\u00f3n, 28223 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Berrendero","sequence":"additional","affiliation":[{"name":"Faculty of Experimental Sciences, Universidad Francisco de Vitoria, UFV, Pozuelo de Alarc\u00f3n, 28223 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,10]]},"reference":[{"key":"ref_1","unstructured":"National Institute on Drug Abuse (NIDA) (2021, November 12). 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