{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:42:32Z","timestamp":1790700152004,"version":"4.1.0"},"reference-count":157,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2021,12,21]],"date-time":"2021-12-21T00:00:00Z","timestamp":1640044800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Selenium is a fascinating element that has a long history, most of which documents it as a deleterious element to health. In more recent years, selenium has been found to be an essential element in the diet of humans, all other mammals, and many other life forms. It has many health benefits that include, for example, roles in preventing heart disease and certain forms of cancer, slowing AIDS progression in HIV patients, supporting male reproduction, inhibiting viral expression, and boosting the immune system, and it also plays essential roles in mammalian development. Elucidating the molecular biology of selenium over the past 40 years generated an entirely new field of science which encompassed the many novel features of selenium. These features were (1) how this element makes its way into protein as the 21st amino acid in the genetic code, selenocysteine (Sec); (2) the vast amount of machinery dedicated to synthesizing Sec uniquely on its tRNA; (3) the incorporation of Sec into protein; and (4) the roles of the resulting Sec-containing proteins (selenoproteins) in health and development. One of the research areas receiving the most attention regarding selenium in health has been its role in cancer prevention, but further research has also exposed the role of this element as a facilitator of various maladies, including cancer.<\/jats:p>","DOI":"10.3390\/ijms23010005","type":"journal-article","created":{"date-parts":[[2021,12,21]],"date-time":"2021-12-21T04:35:57Z","timestamp":1640061357000},"page":"5","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Historical Roles of Selenium and Selenoproteins in Health and Development: The Good, the Bad and the Ugly"],"prefix":"10.3390","volume":"23","author":[{"given":"Petra A.","family":"Tsuji","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, Towson University, 8000 York Rd., Towson, MD 21252, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3398-8943","authenticated-orcid":false,"given":"Didac","family":"Santesmasses","sequence":"additional","affiliation":[{"name":"Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA 02215, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byeong J.","family":"Lee","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul 08826, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vadim N.","family":"Gladyshev","sequence":"additional","affiliation":[{"name":"Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA 02215, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dolph L.","family":"Hatfield","sequence":"additional","affiliation":[{"name":"Scientist Emeritus, Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,21]]},"reference":[{"key":"ref_1","first-page":"42","article-title":"Unders\u00f6kning af en ny Mineral-kropp, funnen i de orenare sorterna af det I Falun tillverkade svafl et","volume":"6","author":"Berzelius","year":"1818","journal-title":"Afhandlingar Fysik Kemi Och Mineral."},{"key":"ref_2","unstructured":"Wright, T. 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