{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T05:34:46Z","timestamp":1782797686516,"version":"3.54.5"},"reference-count":34,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2021,12,21]],"date-time":"2021-12-21T00:00:00Z","timestamp":1640044800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology","doi-asserted-by":"publisher","award":["BT\/PR14198\/MED\/29\/980\/2015"],"award-info":[{"award-number":["BT\/PR14198\/MED\/29\/980\/2015"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Human Cytomegalovirus (HCMV) is a prototypic beta herpesvirus, causing persistent infections in humans. There are medications that are used to treat the symptoms; however, there is no cure yet. Thus, understanding the molecular mechanisms of HCMV replication and its persistence may reveal new prevention strategies. HCMV evasive strategies on the antiviral responses of the human host largely rely on its significant portion of genome. Numerous studies have highlighted the importance of miRNA-mediated regulation of apoptosis, which is an innate immune mechanism that eradicates virus-infected cells. In this study, we explore the antiapoptotic role of hcmv-miR-UL70-3p in HEK293T cells. We establish that hcmv-miR-UL70-3p targets the proapoptotic gene Modulator of Apoptosis-1 (MOAP1) through interaction with its 3\u2019UTR region of mRNA. The ectopic expression of hcmv-miR-UL70-3p mimic significantly downregulates the H2O2-induced apoptosis through the translational repression of MOAP1. Silencing of MOAP1 through siRNA also inhibits the H2O2-induced apoptosis, which further supports the hcmv-miR-UL70-3p mediated antiapoptotic effect by regulating MOAP1 expression. These results uncover a role for hcmv-miR-UL70-3p and its target MOAP1 in regulating apoptosis.<\/jats:p>","DOI":"10.3390\/ijms23010018","type":"journal-article","created":{"date-parts":[[2021,12,21]],"date-time":"2021-12-21T09:50:43Z","timestamp":1640080243000},"page":"18","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Human Cytomegalovirus miR-UL70-3p Downregulates the H2O2-Induced Apoptosis by Targeting the Modulator of Apoptosis-1 (MOAP1)"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7624-4197","authenticated-orcid":false,"given":"Abhishek","family":"Pandeya","sequence":"first","affiliation":[{"name":"Department of Biotechnology, Babasaheb Bhimrao Ambedkar University, Lucknow 226025, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raj Kumar","family":"Khalko","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Babasaheb Bhimrao Ambedkar University, Lucknow 226025, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anup","family":"Mishra","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Babasaheb Bhimrao Ambedkar University, Lucknow 226025, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nishant","family":"Singh","sequence":"additional","affiliation":[{"name":"Developmental Toxicology Division, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Lucknow 226001, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sukhveer","family":"Singh","sequence":"additional","affiliation":[{"name":"Developmental Toxicology Division, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Lucknow 226001, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudipta","family":"Saha","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University, Lucknow 226025, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay","family":"Yadav","sequence":"additional","affiliation":[{"name":"Developmental Toxicology Division, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Lucknow 226001, India"},{"name":"Department of Biochemistry, All India Institute of Medical Sciences, Rae Bareli 229405, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sangeeta","family":"Saxena","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Babasaheb Bhimrao Ambedkar University, Lucknow 226025, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil Babu","family":"Gosipatala","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Babasaheb Bhimrao Ambedkar University, Lucknow 226025, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Zuhair, M., Smit, G., Wallis, G., Jabbar, F., Smith, C., Devleesschauwer, B., and Griffiths, P. 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