{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:38:26Z","timestamp":1790786306438,"version":"4.1.0"},"reference-count":69,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T00:00:00Z","timestamp":1640217600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003827","name":"National Research, Development and Innovation Office","doi-asserted-by":"publisher","award":["128832"],"award-info":[{"award-number":["128832"]}],"id":[{"id":"10.13039\/501100003827","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Psoriasis is a systemic inflammatory skin disorder that can be associated with sleep disturbance and negatively influence the daily rhythm. The link between the pathomechanism of psoriasis and the circadian rhythm has been suggested by several previous studies. However, there are insufficient data on altered clock mechanisms in psoriasis to prove these theories. Therefore, we investigated the expression of the core clock genes in human psoriatic lesional and non-lesional skin and in human adult low calcium temperature (HaCaT) keratinocytes after stimulation with pro-inflammatory cytokines. Furthermore, we examined the clock proteins in skin biopsies from psoriatic patients by immunohistochemistry. We found that the clock gene transcripts were elevated in psoriatic lesions, especially in non-lesional psoriatic areas, except for rev-erb\u03b1, which was consistently downregulated in the psoriatic samples. In addition, the REV-ERB\u03b1 protein showed a different epidermal distribution in non-lesional skin than in healthy skin. In cytokine-treated HaCaT cells, changes in the amplitude of the bmal1, cry1, rev-erb\u03b1 and per1 mRNA oscillation were observed, especially after TNF\u03b1 stimulation. In conclusion, in our study a perturbation of clock gene transcripts was observed in uninvolved and lesional psoriatic areas compared to healthy skin. These alterations may serve as therapeutic targets and facilitate the development of chronotherapeutic strategies in the future.<\/jats:p>","DOI":"10.3390\/ijms23010121","type":"journal-article","created":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T10:16:18Z","timestamp":1640254578000},"page":"121","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Expression Patterns of Clock Gene mRNAs and Clock Proteins in Human Psoriatic Skin Samples"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6452-9817","authenticated-orcid":false,"given":"Vikt\u00f3ria","family":"N\u00e9meth","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology and Oncodermatology, Medical School, University of P\u00e9cs, H-7632 Pecs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5168-1622","authenticated-orcid":false,"given":"Szabina","family":"Horv\u00e1th","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Oncodermatology, Medical School, University of P\u00e9cs, H-7632 Pecs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1gnes","family":"Kiny\u00f3","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Oncodermatology, Medical School, University of P\u00e9cs, H-7632 Pecs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3286-8846","authenticated-orcid":false,"given":"Rolland","family":"Gyulai","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Oncodermatology, Medical School, University of P\u00e9cs, H-7632 Pecs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zsuzsanna","family":"Lengyel","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Oncodermatology, Medical School, University of P\u00e9cs, H-7632 Pecs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1677\/JOE-07-0378","article-title":"Circadian clocks: Regulators of endocrine and metabolic rhythms","volume":"195","author":"Hastings","year":"2007","journal-title":"J. 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