{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T11:21:34Z","timestamp":1773832894908,"version":"3.50.1"},"reference-count":28,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2021,12,24]],"date-time":"2021-12-24T00:00:00Z","timestamp":1640304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Th17 cells play an important role in psoriasis. The differentiation of na\u00efve CD4+ T cells into Th17 cells depends on glycolysis as the energy source. CD147\/basigin, an integral transmembrane protein belonging to the immunoglobulin superfamily, regulates glycolysis in association with monocarboxylate transporters (MCTs)-1 and -4 in cancer cells and T cells. We examined whether CD147\/basigin is involved in the pathogenesis of psoriasis in humans and psoriasis-model mice. The serum level of CD147 was increased in patients with psoriasis, and the expression of CD147 and MCT-1 was elevated in their dermal CD4+ ROR\u03b3t+ T cells. In vitro, the potential of na\u00efve CD4+ T cells to differentiate into Th17 cells was abrogated in CD147\u2212\/\u2212 T cells. Imiquimod (IMQ)-induced psoriatic dermatitis was significantly milder in CD147\u2212\/\u2212 mice and bone marrow chimeric mice lacking CD147 in the hematopoietic cells of myeloid lineage. These findings demonstrate that CD147 is essential for the development of psoriasis via the induction of Th17 cell differentiation.<\/jats:p>","DOI":"10.3390\/ijms23010177","type":"journal-article","created":{"date-parts":[[2021,12,24]],"date-time":"2021-12-24T08:38:46Z","timestamp":1640335126000},"page":"177","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["CD147 Is Essential for the Development of Psoriasis via the Induction of Th17 Cell Differentiation"],"prefix":"10.3390","volume":"23","author":[{"given":"Aoi","family":"Okubo","sequence":"first","affiliation":[{"name":"Department of Dermatology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-0075, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youhei","family":"Uchida","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-0075, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3867-0555","authenticated-orcid":false,"given":"Yuko","family":"Higashi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-0075, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuya","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine, University of Yamanashi, Yamanashi 409-3898, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2635-888X","authenticated-orcid":false,"given":"Youichi","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine, University of Yamanashi, Yamanashi 409-3898, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiro","family":"Ryuge","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Nagoya University Graduate School of Medicine, Aichi 466-8560, Japan"},{"name":"Department of Biochemistry, Nagoya University Graduate School of Medicine, Aichi 466-8560, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Kadomatsu","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Nagoya University Graduate School of Medicine, Aichi 466-8560, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3904-5954","authenticated-orcid":false,"given":"Takuro","family":"Kanekura","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-0075, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1146\/annurev-pathol-011811-132448","article-title":"Psoriasis","volume":"7","author":"Perera","year":"2012","journal-title":"Annu. Rev. Pathol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.jaad.2013.12.036","article-title":"Interleukin 17A: Toward a new understanding of psoriasis pathogenesis","volume":"71","author":"Lynde","year":"2014","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/jid.2012.194","article-title":"The emerging role of IL-17 in the pathogenesis of psoriasis: Preclinical and clinical findings","volume":"133","author":"Martin","year":"2013","journal-title":"J. Invest. Dermatol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/j.cell.2006.07.035","article-title":"The orphan nuclear receptor ROR\u03b3t directs the differentiation program of proinflammatory IL-17+ T helper cells","volume":"126","author":"Ivanov","year":"2006","journal-title":"Cell"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.molimm.2015.07.034","article-title":"Glucose, glycolysis and lymphocyte responses","volume":"68","author":"Donnelly","year":"2015","journal-title":"Mol. Immunol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1126\/science.124.3215.269","article-title":"On respiratory impairment in cancer cells","volume":"124","author":"Warburg","year":"1956","journal-title":"Science"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1093\/oxfordjournals.jbchem.a123045","article-title":"Basigin, a new, broadly distributed member of the immunoglobulin superfamily, has strong homology with both the immunoglobulin V domain and the \u03b2-chain of major histocompatibility complex class II antigen","volume":"107","author":"Miyauchi","year":"1990","journal-title":"J. Biochem."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1247\/csf.16.23","article-title":"Basigin, a new member of the immunoglobulin super family: Genes in different mammalian species, glycosylation changes in the molecule from adult organs and possible variation in the N-terminal sequences","volume":"16","author":"Kanekura","year":"1991","journal-title":"Cell Struct. Funct."},{"key":"ref_9","first-page":"1","article-title":"Epidermal CD147 expression plays a key role in IL-22-induced psoriatic dermatitis","volume":"7","author":"Peng","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1093\/jb\/mvv127","article-title":"Basigin (CD147), a multifunctional transmembrane glycoprotein with various binding partners","volume":"159","author":"Muramatsu","year":"2016","journal-title":"J. Biochem."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"3896","DOI":"10.1093\/emboj\/19.15.3896","article-title":"CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression","volume":"19","author":"Kirk","year":"2000","journal-title":"EMBO J."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.canlet.2008.07.034","article-title":"A CD147-targeting siRNA inhibits the proliferation, invasiveness, and VEGF production of human malignant melanoma cells by down-regulating glycolysis","volume":"273","author":"Su","year":"2009","journal-title":"Cancer Lett."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"4182","DOI":"10.1158\/0008-5472.CAN-06-3184","article-title":"Monocarboxylate transporter 4 regulates maturation and trafficking of CD147 to the plasma membrane in the metastatic breast cancer cell line MDA-MB-231","volume":"67","author":"Gallagher","year":"2007","journal-title":"Cancer Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.bbrc.2008.06.122","article-title":"CD147 induces cell death in cancer cells through impairment of glycolytic energy metabolism","volume":"374","author":"Baba","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"16663","DOI":"10.1073\/pnas.1106123108","article-title":"CD147 subunit of lactate\/H+ symportes MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors","volume":"108","author":"Chiche","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"3299","DOI":"10.4049\/jimmunol.1003613","article-title":"Cutting edge: Distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets","volume":"186","author":"Michalek","year":"2011","journal-title":"J. Immunol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1002\/iub.572","article-title":"The monocarboxylate transporter family\u2014Role and regulation","volume":"64","author":"Halestrap","year":"2012","journal-title":"IUBMB Life"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/nchembio744","article-title":"Monocarboxylate transporter MCT1 is a target for immunosuppression","volume":"1","author":"Murray","year":"2005","journal-title":"Nat. Chem. Biol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1189\/jlb.3RU0215-045R","article-title":"The role of EMMPRIN in T cell biology and immunological diseases","volume":"98","author":"Hahn","year":"2015","journal-title":"J. Leukocyte Biol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/apm.12629","article-title":"CD147 modulates the differentiation of T-helper 17 cells in patients with rheumatoid arthritis","volume":"125","author":"Yang","year":"2017","journal-title":"APMIS"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/1010428317718192","article-title":"Effects of matrix metalloproteinase inhibitor doxycycline and CD147 antagonist peptide-9 on gallbladder carcinoma cell lines","volume":"39","author":"Wang","year":"2017","journal-title":"Tumour Biol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1007\/s00424-003-1067-2","article-title":"The SLC16 gene family\u2014From monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond","volume":"447","author":"Halestrap","year":"2004","journal-title":"Pflugers Arch."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"e266","DOI":"10.1111\/1346-8138.14305","article-title":"Role of soluble CD147 in psoriatic patients: A preliminary study","volume":"45","author":"Gao","year":"2018","journal-title":"J. Dermatol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1177\/0961203314520840","article-title":"Plasma CD147 reflects histological features in patients with lupus nephritis","volume":"23","author":"Kosugi","year":"2014","journal-title":"Lupus"},{"key":"ref_25","first-page":"7091","article-title":"Cleaved CD147 shed from the surface of malignant melanoma cells activates MMP2 produced by fibroblasts","volume":"34","author":"Hatanaka","year":"2014","journal-title":"Anticancer Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1111\/j.1346-8138.2010.00935.x","article-title":"CD147 is highly expressed on peripheral blood neutrophils from patients with psoriasis and induces neutrophil chemotaxis","volume":"37","author":"Lu","year":"2010","journal-title":"J. Dermatol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1006\/dbio.1997.8819","article-title":"A null mutation in Basigin, an immunoglobulin superfamily member, indicates its important roles in peri-implantation development and spermatogenesis","volume":"194","author":"Igakura","year":"1998","journal-title":"Dev. Biol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.bbrc.2004.08.232","article-title":"Effects of flanking genes on the phenotypes of mice deficient in basigin\/CD147","volume":"324","author":"Chen","year":"2004","journal-title":"Biochem. Biophys. Res. 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