{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T22:38:52Z","timestamp":1788043132915,"version":"build-2784847793"},"reference-count":204,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2021,12,28]],"date-time":"2021-12-28T00:00:00Z","timestamp":1640649600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Viral infections have afflicted human health and despite great advancements in scientific knowledge and technologies, continue to affect our society today. The current coronavirus (COVID-19) pandemic has put a spotlight on the need to review the evidence on the impact of nutritional strategies to maintain a healthy immune system, particularly in instances where there are limited therapeutic treatments. Selenium, an essential trace element in humans, has a long history of lowering the occurrence and severity of viral infections. Much of the benefits derived from selenium are due to its incorporation into selenocysteine, an important component of proteins known as selenoproteins. Viral infections are associated with an increase in reactive oxygen species and may result in oxidative stress. Studies suggest that selenium deficiency alters immune response and viral infection by increasing oxidative stress and the rate of mutations in the viral genome, leading to an increase in pathogenicity and damage to the host. This review examines viral infections, including the novel SARS-CoV-2, in the context of selenium, in order to inform potential nutritional strategies to maintain a healthy immune system.<\/jats:p>","DOI":"10.3390\/ijms23010280","type":"journal-article","created":{"date-parts":[[2021,12,28]],"date-time":"2021-12-28T06:55:03Z","timestamp":1640674503000},"page":"280","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Role of Selenium in Viral Infections with a Major Focus on SARS-CoV-2"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0158-8104","authenticated-orcid":false,"given":"Sabrina Sales","family":"Martinez","sequence":"first","affiliation":[{"name":"Robert Stempel College of Public Health and Social Work, Florida International University, Miami, FL 33199, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongjun","family":"Huang","sequence":"additional","affiliation":[{"name":"Robert Stempel College of Public Health and Social Work, Florida International University, Miami, FL 33199, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Acuna","sequence":"additional","affiliation":[{"name":"College of Arts, Sciences & Education, Florida International University, Miami, FL 33199, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Laverde","sequence":"additional","affiliation":[{"name":"College of Arts, Sciences & Education, Florida International University, Miami, FL 33199, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Trujillo","sequence":"additional","affiliation":[{"name":"College of Arts, Sciences & Education, Florida International University, Miami, FL 33199, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel A.","family":"Barbieri","sequence":"additional","affiliation":[{"name":"College of Arts, Sciences & Education, Florida International University, Miami, FL 33199, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9385-9049","authenticated-orcid":false,"given":"Javier","family":"Tamargo","sequence":"additional","affiliation":[{"name":"Robert Stempel College of Public Health and Social Work, Florida International University, Miami, FL 33199, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8448-6033","authenticated-orcid":false,"given":"Adriana","family":"Campa","sequence":"additional","affiliation":[{"name":"Robert Stempel College of Public Health and Social Work, Florida International University, Miami, FL 33199, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6577-685X","authenticated-orcid":false,"given":"Marianna K.","family":"Baum","sequence":"additional","affiliation":[{"name":"Robert Stempel College of Public Health and Social Work, Florida International University, Miami, FL 33199, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1126\/science.257.5073.1073","article-title":"The Origin of Plagues: Old and New","volume":"257","author":"Krause","year":"1992","journal-title":"Science"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"3594","DOI":"10.3389\/fmicb.2020.631736","article-title":"Pandemics Throughout History","volume":"11","author":"Piret","year":"2021","journal-title":"Front. Microbiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000478729","article-title":"Evolution and Emergence of Pathogenic Viruses: Past, Present, and Future","volume":"60","author":"Parvez","year":"2017","journal-title":"Intervirology"},{"key":"ref_4","unstructured":"WHO Coronavirus (COVID-19) Dashboard (2021, August 18). WHO Coronavirus (COVID-19) Dashboard with Vaccination Data. Available online: https:\/\/covid19.who.int\/."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Avery, J.C., and Hoffmann, P.R. (2018). Selenium, Selenoproteins, and Immunity. Nutrients, 10.","DOI":"10.3390\/nu10091203"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Guillin, O.M., Vindry, C., Ohlmann, T., and Chavatte, L. (2019). Selenium, Selenoproteins and Viral Infection. Nutrients, 11.","DOI":"10.3390\/nu11092101"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10787-020-00690-x","article-title":"Selenium and Selenoproteins: It\u2019s Role in Regulation of Inflammation","volume":"28","author":"Hariharan","year":"2020","journal-title":"Inflammopharmacology"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1016\/S0140-6736(11)61452-9","article-title":"Selenium and Human Health","volume":"379","author":"Rayman","year":"2012","journal-title":"Lancet"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1089\/ars.2010.3275","article-title":"Selenium in Human Health and Disease","volume":"14","author":"Bao","year":"2011","journal-title":"Antioxid. Redox Signal."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1463S","DOI":"10.1093\/jn\/133.5.1463S","article-title":"Selenium Deficiency and Viral Infection","volume":"133","author":"Beck","year":"2003","journal-title":"J. Nutr."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1093\/jn\/137.6.1466","article-title":"Decreased Selenoprotein Expression Alters the Immune Response during Influenza Virus Infection in Mice","volume":"137","author":"Sheridan","year":"2007","journal-title":"J. Nutr."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.jtemb.2006.11.001","article-title":"Activation of Superoxide Dismutase in Selenium-Deficient Mice Infected with Influenza Virus","volume":"21","author":"Walton","year":"2007","journal-title":"J. Trace Elem. Med. Biol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.tim.2004.07.007","article-title":"Host Nutritional Status: The Neglected Virulence Factor","volume":"12","author":"Beck","year":"2004","journal-title":"Trends Microbiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1152\/physrev.00039.2013","article-title":"Selenoproteins: Molecular Pathways and Physiological Roles","volume":"94","author":"Labunskyy","year":"2014","journal-title":"Physiol. Rev."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1017\/S0029665199000920","article-title":"Selenium and Host Defence towards Viruses","volume":"58","author":"Beck","year":"1999","journal-title":"Proc. Nutr. Soc."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2480","DOI":"10.1016\/j.bbagen.2018.05.010","article-title":"Translation Regulation of Mammalian Selenoproteins","volume":"1862","author":"Vindry","year":"2018","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.1016\/j.bbagen.2018.05.023","article-title":"Delivery of Selenium to Selenophosphate Synthetase for Selenoprotein Biosynthesis","volume":"1862","author":"Tobe","year":"2018","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1039\/C3MT00185G","article-title":"Selenium Biochemistry and Its Role for Human Health","volume":"6","author":"Roman","year":"2013","journal-title":"Metallomics"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1126\/science.1083516","article-title":"Characterization of Mammalian Selenoproteomes","volume":"300","author":"Kryukov","year":"2003","journal-title":"Science"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1007\/s12011-019-01771-x","article-title":"From Selenium Absorption to Selenoprotein Degradation","volume":"192","author":"Ha","year":"2019","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/j.cell.2018.08.046","article-title":"Protein AMPylation by an Evolutionarily Conserved Pseudokinase","volume":"175","author":"Sreelatha","year":"2018","journal-title":"Cell"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.ceca.2017.05.001","article-title":"Endoplasmic Reticulum-Resident Selenoproteins as Regulators of Calcium Signaling and Homeostasis","volume":"70","author":"Pitts","year":"2018","journal-title":"Cell Calcium"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1517S","DOI":"10.1093\/jn\/133.5.1517S","article-title":"Selenoprotein Metabolism and Function: Evidence for More than One Function for Selenoprotein P","volume":"133","author":"Burk","year":"2003","journal-title":"J. Nutr."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1042\/BJ20041973","article-title":"Hepatically Derived Selenoprotein P Is a Key Factor for Kidney but Not for Brain Selenium Supply","volume":"386","author":"Schweizer","year":"2005","journal-title":"Biochem. J."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"32591","DOI":"10.1074\/jbc.M707036200","article-title":"Selective Restoration of the Selenoprotein Population in a Mouse Hepatocyte Selenoproteinless Background with Different Mutant Selenocysteine TRNAs Lacking Um34","volume":"282","author":"Carlson","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1016\/j.bbagen.2009.03.026","article-title":"Selenoprotein P-Expression, Functions, and Roles in Mammals","volume":"1790","author":"Burk","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"35407","DOI":"10.1074\/jbc.M110.205708","article-title":"Glutathione Peroxidase-1 Deficiency Augments Proinflammatory Cytokine-Induced Redox Signaling and Human Endothelial Cell Activation","volume":"286","author":"Lubos","year":"2011","journal-title":"J. Biol. Chem."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1002\/jmv.1890430213","article-title":"Benign Human Enterovirus Becomes Virulent in Selenium-Deficient Mice","volume":"43","author":"Beck","year":"1994","journal-title":"J. Med. Virol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj3460001","article-title":"Thioredoxin Reductase","volume":"346","author":"Mustacich","year":"2000","journal-title":"Biochem. J."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.bbrc.2010.03.083","article-title":"Thioredoxin and Thioredoxin Reductase: Current Research with Special Reference to Human Disease","volume":"396","author":"Holmgren","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"24448","DOI":"10.1074\/jbc.M112.374520","article-title":"Methionine Sulfoxide Reductases Preferentially Reduce Unfolded Oxidized Proteins and Protect Cells from Oxidative Protein Unfolding","volume":"287","author":"Tarrago","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"5119","DOI":"10.1038\/s41598-017-05230-2","article-title":"Selenoprotein MsrB1 Promotes Anti-Inflammatory Cytokine Gene Expression in Macrophages and Controls Immune Response in Vivo","volume":"7","author":"Lee","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Colombo, G., Meli, M., Morra, G., Gabizon, R., and Gasset, M. (2009). Methionine Sulfoxides on Prion Protein Helix-3 Switch on the \u03b1-Fold Destabilization Required for Conversion. PLoS ONE, 4.","DOI":"10.1371\/journal.pone.0004296"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1007\/s12011-019-01774-8","article-title":"Molecular Mechanisms by Which Selenoprotein K Regulates Immunity and Cancer","volume":"192","author":"Marciel","year":"2019","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Khomich, O.A., Kochetkov, S.N., Bartosch, B., and Ivanov, A.V. (2018). Redox Biology of Respiratory Viral Infections. Viruses, 10.","DOI":"10.3390\/v10080392"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.3109\/10715762.2014.945443","article-title":"Reactive Oxygen and Nitrogen Species during Viral Infections","volume":"48","author":"Molteni","year":"2014","journal-title":"Free Radic. Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/s41580-020-0230-3","article-title":"Reactive Oxygen Species (ROS) as Pleiotropic Physiological Signalling Agents","volume":"21","author":"Sies","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.cellsig.2012.01.008","article-title":"Reactive Oxygen Species (ROS) Homeostasis and Redox Regulation in Cellular Signaling","volume":"24","author":"Ray","year":"2012","journal-title":"Cell Signal."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"8416763","DOI":"10.1155\/2017\/8416763","article-title":"Oxidative Stress: Harms and Benefits for Human Health","volume":"2017","author":"Pizzino","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1089\/ars.2011.4377","article-title":"Thioredoxin Reductase Inhibition Elicits Nrf2-Mediated Responses in Clara Cells: Implications for Oxidant-Induced Lung Injury","volume":"17","author":"Locy","year":"2012","journal-title":"Antioxid. Redox Signal."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Ammendolia, D.A., Bement, W.M., and Brumell, J.H. (2021). Plasma Membrane Integrity: Implications for Health and Disease. BMC Biol., 19.","DOI":"10.1186\/s12915-021-00972-y"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1177\/0884533611434116","article-title":"Selenium Supplementation in the Critically Ill","volume":"27","author":"Hardy","year":"2012","journal-title":"Nutr. Clin. Pract."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1016\/j.bbagen.2009.02.014","article-title":"Protection against Reactive Oxygen Species by Selenoproteins","volume":"1790","author":"Steinbrenner","year":"2009","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s00134-004-2522-z","article-title":"Antioxidant Nutrients: A Systematic Review of Trace Elements and Vitamins in the Critically Ill Patient","volume":"31","author":"Heyland","year":"2004","journal-title":"Intensive Care Med."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/nm0595-433","article-title":"Rapid Genomic Evolution of a Non-Virulent Coxsackievirus B3 in Selenium-Deficient Mice Results in Selection of Identical Virulent Isolates","volume":"1","author":"Beck","year":"1995","journal-title":"Nat. Med."},{"key":"ref_46","first-page":"203","article-title":"The Role of Selenium in Keshan Disease","volume":"6","author":"GQ","year":"1984","journal-title":"Adv. Nutr. Res."},{"key":"ref_47","first-page":"316","article-title":"Further Investigation on the Role of Selenium Deficiency in the Aetiology and Pathogenesis of Keshan Disease","volume":"10","author":"Xu","year":"1997","journal-title":"Biomed. Environ. Sci."},{"key":"ref_48","first-page":"422","article-title":"The Effect of Selenium-Fortified Table Salt in the Prevention of Keshan Disease on a Population of 1.05 Million","volume":"3","author":"Cheng","year":"1990","journal-title":"Biomed. Environ. Sci."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1253\/jcj.46.1201","article-title":"A Study of Nutritional and Bio-Geochemical Factors in the Occurrence and Development of Keshan Disease : The 6th Conference on Prevention for Rheumatic Fever and Rheumatic Heart Disease","volume":"46","year":"1982","journal-title":"JPN Circ. J."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/S0891-5849(03)00101-1","article-title":"Coxsackievirus B3-Resistant Mice Become Susceptible in Se\/Vitamin E Deficiency","volume":"34","author":"Beck","year":"2003","journal-title":"Free Radic. Biol. Med."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1093\/infdis\/170.2.351","article-title":"Increased Virulence of a Human Enterovirus (Coxsackievirus B3) in SeleniumDeficient Mice","volume":"170","author":"Beck","year":"1994","journal-title":"J. Infect. Dis."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1096\/fasebj.12.12.1143","article-title":"Glutathione Peroxidase Protects Mice from Viral-Induced Myocarditis","volume":"12","author":"Beck","year":"1998","journal-title":"FASEB J."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1016\/j.freeradbiomed.2007.03.017","article-title":"Selenium Deficiency Alters Epithelial Cell Morphology and Responses to Influenza","volume":"42","author":"Jaspers","year":"2007","journal-title":"Free Radic. Biol. Med."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1096\/fj.00-0721fje","article-title":"Selenium Deficiency Increases the Pathology of an Influenza Virus Infection","volume":"15","author":"Beck","year":"2001","journal-title":"FASEB J."},{"key":"ref_55","first-page":"412","article-title":"Selenium Deficiency Induced an Altered Immune Response and Increased Survival Following Influenza A\/Puerto Rico\/8\/34 Infection","volume":"232","author":"Li","year":"2017","journal-title":"Exp. Biol. Med."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.clnu.2015.12.003","article-title":"Selenium Supplementation Has Beneficial and Detrimental Effects on Immunity to Influenza Vaccine in Older Adults","volume":"36","author":"Ivory","year":"2017","journal-title":"Clin. Nutr."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.2147\/IJN.S155994","article-title":"Inhibition of H1N1 Influenza Virus-Induced Apoptosis by Functionalized Selenium Nanoparticles with Amantadine through ROS-Mediated AKT Signaling Pathways","volume":"13","author":"Li","year":"2018","journal-title":"Int. J. Nanomed."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"5733","DOI":"10.2147\/IJN.S140939","article-title":"Inhibitory Activity of Selenium Nanoparticles Functionalized with Oseltamivir on H1N1 Influenza Virus","volume":"12","author":"Li","year":"2017","journal-title":"Int. Nanomed."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"30633","DOI":"10.1021\/acsomega.0c04624","article-title":"The Inhibition of H1N1 Influenza Virus-Induced Apoptosis by Surface Decoration of Selenium Nanoparticles with \u03b2-Thujaplicin through Reactive Oxygen Species-Mediated AKT and P53 Signaling Pathways","volume":"5","author":"Wang","year":"2020","journal-title":"ACS Omega"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"5787","DOI":"10.2147\/IJN.S177658","article-title":"Restriction of H1N1 Influenza Virus Infection by Selenium Nanoparticles Loaded with Ribavirin via Resisting Caspase-3 Apoptotic Pathway","volume":"13","author":"Lin","year":"2018","journal-title":"Int. J. Nanomed."},{"key":"ref_61","unstructured":"(2021, August 25). Available online: https:\/\/www.who.int\/data\/gho\/data\/themes\/hiv-aids."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"S49","DOI":"10.1097\/00126334-200010001-00008","article-title":"Role of Micronutrients in HIV-Infected Intravenous Drug Users","volume":"25","author":"Baum","year":"2000","journal-title":"J. Acquir. Immune Defic. Syndr."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1097\/00042560-199904150-00015","article-title":"Mortality Risk in Selenium-Deficient HIV-Positive Children","volume":"20","author":"Campa","year":"1999","journal-title":"J. Acquir. Immune Defic. Syndr. Hum. Retrovirol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"110585","DOI":"10.1016\/j.nut.2019.110585","article-title":"Zinc and Selenium Indicators and Their Relation to Immunologic and Metabolic Parameters in Male Patients with Human Immunodeficiency Virus","volume":"70","year":"2020","journal-title":"Nutrition"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Shivakoti, R., Gupte, N., Yang, W.T., Mwelase, N., Kanyama, C., Tang, A.M., Pillay, S., Samaneka, W., Riviere, C., and Berendes, S. (2014). Pre-Antiretroviral Therapy Serum Selenium Concentrations Predict WHO Stages 3, 4 or Death but Not Virologic Failure Post-Antiretroviral Therapy. Nutrients, 6.","DOI":"10.3390\/nu6115061"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/hiv.12952","article-title":"Managing HIV-Associated Inflammation and Ageing in the Era of Modern ART","volume":"21","author":"Bloch","year":"2020","journal-title":"HIV Med."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1038\/srep01425","article-title":"Soil-Type Influences Human Selenium Status and Underlies Widespread Selenium Deficiency Risks in Malawi","volume":"3","author":"Hurst","year":"2013","journal-title":"Sci. Rep."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1111\/j.1753-4887.2010.00337.x","article-title":"Role of Selenium in HIV Infection","volume":"68","author":"Stone","year":"2010","journal-title":"Nutr. Rev."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1038\/sj.ejcn.1602236","article-title":"Selenium Levels in Relation to Morbidity and Mortality among Children Born to HIV-Infected Mothers","volume":"59","author":"Kupka","year":"2005","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1097\/00042560-199708150-00007","article-title":"High Risk of HIV-Related Mortality Is Associated with Selenium Deficiency","volume":"15","author":"Baum","year":"1997","journal-title":"J. Acquir. Immune Defic. Syndr. Hum. Retrovirol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1097\/00042560-199511000-00015","article-title":"Serum Selenium Predicts Outcome in HIV Infection","volume":"10","author":"Constans","year":"1995","journal-title":"J. Acquir. Immune Defic. Syndr. Hum. Retrovirol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1097\/00126334-200212150-00001","article-title":"Rhesus Monkey Simian Immunodeficiency Virus Infection as a Model for Assessing the Role of Selenium in AIDS","volume":"31","author":"Xu","year":"2002","journal-title":"J. Acquir. Immune Defic. Syndr."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/0009-8981(96)06394-2","article-title":"Oxidative Stress in Blood of HIV Infected Patients","volume":"255","author":"Repetto","year":"1996","journal-title":"Clin. Chim. Acta"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/1423-0127-16-61","article-title":"Total Antioxidant Capacity a Novel Early Bio-Chemical Marker of Oxidative Stress in HIV Infected Individuals","volume":"16","author":"Suresh","year":"2009","journal-title":"J. Biomed. Sci."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4103\/1117-1936.177149","article-title":"Plasma Selenium Concentration and Glutathione Peroxidase Activity in HIV-1\/AIDS Infected Patients: A Correlation with the Disease Progression","volume":"13","author":"Ogunro","year":"2006","journal-title":"Niger. Postgrad. Med. J."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/0891-5849(95)00047-2","article-title":"The Role of Oxidative Stress in HIV Disease","volume":"19","author":"Pace","year":"1995","journal-title":"Free Radic. Biol. Med."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1002\/jcp.1041650110","article-title":"An Increase of Acidic Isoform of Catalase in Red Blood Cells from HIV(+) Population","volume":"165","author":"Yano","year":"1996","journal-title":"Mol. Cell. Biochem."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S1043-6618(02)00320-1","article-title":"Contribution to Characterization of Oxidative Stress in HIV\/AIDS Patients","volume":"47","author":"Gil","year":"2003","journal-title":"Pharmacol. Res."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/0306-9877(88)90053-9","article-title":"Reappraisal of Aids\u2014Is the Oxidation Induced by the Risk Factors the Primary Cause?","volume":"25","year":"1988","journal-title":"Med. Hypotheses"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/0360-3016(89)90128-4","article-title":"An Alternative Explanation for the Radiosensitization of AIDS Patients","volume":"17","author":"Causer","year":"1989","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1016\/S0140-6736(89)91909-0","article-title":"Systemic Glutathione Deficiency In Symptom-Free Hiv-Seropositive Individuals","volume":"334","author":"Buhl","year":"1989","journal-title":"Lancet"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1097\/00042560-199605010-00011","article-title":"Micronutrient Profiles in HIV-1-Infected Heterosexual Adults","volume":"12","author":"Skurnick","year":"1996","journal-title":"J. Acquir. Immune Defic. Syndr. Hum. Retrovirol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1093\/ajcn\/64.1.101","article-title":"The Enzymatic Antioxidant System in Blood and Glutathione Status in Human Immunodeficiency Virus (HIV)-Infected Patients: Effects of Supplementation with Selenium or Beta-Carotene","volume":"64","author":"Peuchant","year":"1996","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1097\/00042560-200202010-00008","article-title":"Associations between Dietary Antioxidant Intake and Oxidative Stress in HIV-Seropositive and HIV-Seronegative Men and Women","volume":"29","author":"McDermid","year":"2002","journal-title":"J. Acquir. Immune Defic. Syndr."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1097\/MPG.0000000000001577","article-title":"Dietary Inadequacies in HIV-Infected and Uninfected School-Aged Children in Johannesburg, South Africa HHS Public Access","volume":"65","author":"Shiau","year":"2017","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_86","first-page":"351043","article-title":"Serum Micronutrient Status of Haart-Na\u00efve, HIV Infected Children in South Western Nigeria: A Case Controlled Study","volume":"2014","author":"Anyabolu","year":"2014","journal-title":"AIDS Res. Treat"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"21","DOI":"10.7196\/SAJCH.2017.v11i1.1134","article-title":"Serum Selenium Status of HIV-Infected Children on Care and Treatment in Enugu, Nigeria","volume":"11","author":"Ubesie","year":"2017","journal-title":"SAJCH"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1300\/J053v03n01_05","article-title":"Selenium and Immunity in HIV-1 Infected Pediatric Patients","volume":"3","author":"Bologna","year":"1994","journal-title":"J. Nutr. Immunol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/BF02790110","article-title":"Relationship of Trace Element, Immunological Markers, and HIV1 Infection Progression","volume":"47","author":"Allavena","year":"1995","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/sj.ejcn.1600401","article-title":"Serum Selenium, Plasma Glutathione (GSH) and Erythrocyte Glutathione Peroxidase (GSH-Px)-Levels in Asymptomatic versus Symptomatic Human Immunodeficiency Virus-1 (HIV-1)-Infection","volume":"51","author":"Look","year":"1997","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1310\/A7LC-7C9V-EWKF-2Y0H","article-title":"Impact of a Selenium Chemoprevention Clinical Trial on Hospital Admissions of HIV-Infected Participants","volume":"3","author":"Burbano","year":"2002","journal-title":"HIV Clin. Trials"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1001\/archinte.167.2.148","article-title":"Suppression of Human Immunodeficiency Virus Type 1 Viral Load with Selenium Supplementation: A Randomized Controlled Trial","volume":"167","author":"Hurwitz","year":"2007","journal-title":"Arch. Intern. Med."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1086\/598334","article-title":"Effect of Selenium Supplements on Hemoglobin Concentration and Morbidity among HIV-1-Infected Tanzanian Women","volume":"48","author":"Kupka","year":"2009","journal-title":"Clin. Infect. Dis."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1093\/ajcn\/87.6.1802","article-title":"Randomized, Double-Blind, Placebo-Controlled Trial of Selenium Supplements among HIV-Infected Pregnant Women in Tanzania: Effects on Maternal and Child Outcomes","volume":"87","author":"Kupka","year":"2008","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"2154","DOI":"10.1001\/jama.2013.280923","article-title":"Effect of Micronutrient Supplementation on Disease Progression in Asymptomatic, Antiretroviral-Naive, HIV-Infected Adults in Botswana: A Randomized Clinical Trial","volume":"310","author":"Baum","year":"2013","journal-title":"JAMA"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1097\/QAD.0000000000000673","article-title":"Effect of Selenium Supplementation on CD4R T-Cell Recovery, Viral Suppression and Morbidity of HIV-Infected Patients in Rwanda: A Randomized Controlled Trial","volume":"29","author":"Kamwesiga","year":"2015","journal-title":"AIDS"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.clnesp.2019.09.005","article-title":"Selenium Supplementation in HIV-Infected Individuals: A Systematic Review of Randomized Controlled Trials","volume":"34","author":"Muzembo","year":"2019","journal-title":"Clin. Nutr. ESPEN"},{"key":"ref_98","first-page":"CD003650","article-title":"Micronutrient Supplementation in Adults with HIV Infection","volume":"2017","author":"Visser","year":"2017","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_99","unstructured":"(2021, August 16). Global Hepatitis Report. Available online: https:\/\/www.who.int\/publications\/i\/item\/global-hepatitis-report-2017."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"9369","DOI":"10.1128\/JVI.79.15.9369-9380.2005","article-title":"Stealth and Cunning: Hepatitis B and Hepatitis C Viruses","volume":"79","author":"Wieland","year":"2005","journal-title":"J. Virol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"104925","DOI":"10.1016\/j.antiviral.2020.104925","article-title":"Hepatitis B Virus Biology and Life Cycle","volume":"182","author":"Tsukuda","year":"2020","journal-title":"Antiviral Res."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/nrmicro3003","article-title":"The Role of Mutational Robustness in RNA Virus","volume":"11","author":"Lauring","year":"2013","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"106","DOI":"10.4103\/1319-3767.93811","article-title":"The Possible Role of Selenium Concentration in Hepatitis B and C Patients","volume":"18","author":"Khan","year":"2012","journal-title":"Saudi J. Gastroenterol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1007\/s12011-011-9182-y","article-title":"Serum Selenium Concentration in Liver Cirrhotic Patients Suffering from Hepatitis B and C in Pakistan","volume":"145","author":"Rauf","year":"2011","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/j.nutres.2011.09.021","article-title":"Selenium Deficiency Is Associated with Insulin Resistance in Patients with Hepatitis C Virus\u2013Related Chronic Liver Disease","volume":"31","author":"Himoto","year":"2011","journal-title":"Nutr. Res."},{"key":"ref_106","first-page":"667","article-title":"Determination of Trace Elements in Patients with Chronic Hepatitis B","volume":"49","author":"Abediankenari","year":"2011","journal-title":"Acta Med. Iran."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"4697","DOI":"10.3748\/wjg.v11.i30.4697","article-title":"Blood Micronutrient, Oxidative Stress, and Viral Load in Patients with Chronic Hepatitis C","volume":"11","author":"Ko","year":"2005","journal-title":"World J. Gastroenterol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.1002\/hep.26142","article-title":"Selenium Levels in Patients with Hepatitis C Virus-Related Chronic Hepatitis, Liver Cirrhosis, and Hepatocellular Carcinoma: A Pilot Study","volume":"57","author":"Bettinger","year":"2013","journal-title":"Hepatology"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"467452","DOI":"10.1155\/2014\/467452","article-title":"RNA Viruses: ROS-Mediated Cell Death","volume":"2014","author":"Reshi","year":"2014","journal-title":"Int. J. Cell Biol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s42826-020-00037-1","article-title":"Relevance of Reactive Oxygen Species in Liver Disease Observed in Transgenic Mice Expressing the Hepatitis B Virus X Protein","volume":"36","author":"Yu","year":"2020","journal-title":"Lab. Anim. Res."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1038\/cdd.2015.129","article-title":"HBV-Induced ROS Accumulation Promotes Hepatocarcinogenesis through Snail-Mediated Epigenetic Silencing of SOCS3","volume":"23","author":"Yuan","year":"2016","journal-title":"Cell Death Differ."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/S0168-8278(02)00060-0","article-title":"Oxidative Stress in Chronic Hepatitis C: Not Just a Feature of Late Stage Disease","volume":"36","author":"Jain","year":"2002","journal-title":"J. Hepatol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"5080843","DOI":"10.1155\/2019\/5080843","article-title":"Reactive Oxygen Species-Induced Lipid Peroxidation in Apoptosis, Autophagy, and Ferroptosis","volume":"2019","author":"Su","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"4350965","DOI":"10.1155\/2016\/4350965","article-title":"ROS and ROS-Mediated Cellular Signaling","volume":"2016","author":"Zhang","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.3389\/fimmu.2018.02499","article-title":"Reactive Oxygen Species as Regulators of MDSC-Mediated Immune Suppression","volume":"9","author":"Ohl","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Yahfoufi, N., Alsadi, N., Jambi, M., and Matar, C. (2018). The Immunomodulatory and Anti-Inflammatory Role of Polyphenols. Nutrients, 10.","DOI":"10.3390\/nu10111618"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.bbacli.2014.09.006","article-title":"Viral Load Is Associated with Abnormal Serum Levels of Micronutrients and Glutathione and Glutathione-Dependent Enzymes in Genotype 3 HCV Patients","volume":"2","author":"Razzaq","year":"2014","journal-title":"BBA Clin."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"412","DOI":"10.4103\/1947-2714.100993","article-title":"Oxidative Stress in Alcoholic and Viral Hepatitis","volume":"4","author":"Kundu","year":"2012","journal-title":"N. Am. J. Med. Sci."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"8831","DOI":"10.1074\/jbc.M413730200","article-title":"Expression of Gastrointestinal Glutathione Peroxidase Is Inversely Correlated to the Presence of Hepatitis C Virus Subgenomic RNA in Human Liver Cells","volume":"280","author":"Morbitzer","year":"2005","journal-title":"J. Biol. Chem."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1016\/j.jhep.2008.12.026","article-title":"Hepatitis C Virus NS5A and Core Proteins Induce Oxidative Stress-Mediated Calcium Signalling Alterations in Hepatocytes","volume":"50","author":"Dionisio","year":"2009","journal-title":"J. Hepatol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1136\/gutjnl-2014-307904","article-title":"Glutathione Peroxidase 4 Is Reversibly Induced by HCV to Control Lipid Peroxidation and to Increase Virion Infectivity","volume":"65","author":"Brault","year":"2016","journal-title":"Gut"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1007\/BF03042181","article-title":"Hepatitis C Virus Encodes a Selenium-Dependent Glutathione Peroxidase Gene","volume":"94","author":"Zhang","year":"1999","journal-title":"Med. Klin"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"245","DOI":"10.17219\/acem\/67222","article-title":"Selenium\u2014A Fascinating Antioxidant of Protective Properties","volume":"27","author":"Kocot","year":"2018","journal-title":"Adv. Clin. Exp. Med."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"2350","DOI":"10.1002\/mnfr.201400438","article-title":"Consumption of Selenium-Enriched Broccoli Increases Cytokine Production in Human Peripheral Blood Mononuclear Cells Stimulated Ex Vivo, a Preliminary Human Intervention Study","volume":"58","author":"Chen","year":"2014","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/BF02778987","article-title":"Protective Role of Selenium against Hepatitis B Virus and Primary Liver Cancer in Qidong","volume":"56","author":"Zhu","year":"1997","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_126","first-page":"603","article-title":"Effect of Selenium on Immune Response against Hepatitis B Vaccine with Accelerated Method in Insulin-Dependent Diabetes Mellitus Patients","volume":"4","author":"Janbakhsh","year":"2013","journal-title":"Caspian J. Intern. Med."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1007\/BF03042201","article-title":"A Conservative Triple Antioxidant Approach to the Treatment of Hepatitis C","volume":"94","author":"Berkson","year":"1999","journal-title":"Med. Klin."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1097\/01.meg.0000231746.76136.4a","article-title":"The Effect of Antioxidant Supplementation on Hepatitis C Viral Load, Transaminases and Oxidative Status: A Randomized Trial among Chronic Hepatitis C Virus-Infected Patients","volume":"18","author":"Groenbaek","year":"2006","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"101519","DOI":"10.1016\/j.redox.2020.101519","article-title":"Selenium Deficiency-Induced Redox Imbalance Leads to Metabolic Reprogramming and Inflammation in the Liver","volume":"36","author":"Tang","year":"2020","journal-title":"Redox Biol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1039\/c9mt00295b","article-title":"The Role of Necroptosis and Apoptosis through the Oxidative Stress Pathway in the Liver of Selenium-Deficient Swine","volume":"12","author":"Zhang","year":"2020","journal-title":"Metallomics"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1016\/j.freeradbiomed.2008.01.016","article-title":"Selenium Deficiency Activates Mouse Liver Nrf2-ARE but Vitamin E Deficiency Does Not","volume":"44","author":"Burk","year":"2008","journal-title":"Free Radic. Biol. Med."},{"key":"ref_132","first-page":"6707","article-title":"Acquired Tolerance of Hepatocellular Carcinoma Cells to Selenium Deficiency: A Selective Survival Mechanism?","volume":"63","author":"Irmak","year":"2003","journal-title":"Cancer Res."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"11670","DOI":"10.1128\/JVI.01560-13","article-title":"Global RNA Structure Analysis of Poliovirus Identifies a Conserved RNA Structure Involved in Viral Replication and Infectivity","volume":"87","author":"Burrill","year":"2013","journal-title":"J. Virol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"73","DOI":"10.3945\/an.114.007575","article-title":"Dietary Selenium in Adjuvant Therapy of Viral and Bacterial Infections","volume":"6","author":"Steinbrenner","year":"2015","journal-title":"Adv. Nutr."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1093\/ajcn\/80.1.154","article-title":"An Increase in Selenium Intake Improves Immune Function and Poliovirus Handling in Adults with Marginal Selenium Status","volume":"80","author":"Broome","year":"2004","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1002\/mnfr.200700330","article-title":"The Influence of Selenium on Immune Responses","volume":"52","author":"Hoffmann","year":"2008","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/S0140-6736(20)30566-3","article-title":"Clinical Course and Risk Factors for Mortality of Adult Inpatients with COVID-19 in Wuhan, China: A Retrospective Cohort Study","volume":"395","author":"Zhou","year":"2020","journal-title":"Lancet"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1158\/2159-8290.CD-20-0422","article-title":"Patients with Cancer Appear More Vulnerable to SARS-CoV-2: A Multicenter Study during the COVID-19 Outbreak","volume":"10","author":"Dai","year":"2020","journal-title":"Cancer Discov."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1001\/jama.2020.12839","article-title":"Pathophysiology, Transmission, Diagnosis, and Treatment of Coronavirus Disease 2019 (COVID-19): A Review","volume":"324","author":"Wiersinga","year":"2020","journal-title":"JAMA"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.cca.2020.06.017","article-title":"Cytokine Storm Induced by SARS-CoV-2","volume":"509","author":"Song","year":"2020","journal-title":"Clin. Chim. Acta"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/S0140-6736(20)30628-0","article-title":"UK COVID-19: Consider Cytokine Storm Syndromes and Immunosuppression","volume":"395","author":"Mehta","year":"2020","journal-title":"Lancet"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"e24","DOI":"10.1111\/bjh.16797","article-title":"Dynamic Relationship between D-dimer and COVID-19 Severity","volume":"190","author":"Li","year":"2020","journal-title":"Br. J. Haematol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"748136","DOI":"10.3389\/fncel.2021.748136","article-title":"Systemic Inflammation and Astrocyte Reactivity in the Neuropsychiatric Sequelae of COVID-19: Focus on Autism Spectrum Disorders","volume":"15","author":"Valenza","year":"2021","journal-title":"Front. Cell. Neurosci."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00415-020-09929-7","article-title":"Understanding the Neurotropic Characteristics of SARS-CoV-2: From Neurological Manifestations of COVID-19 to Potential Neurotropic Mechanisms","volume":"267","author":"Zhou","year":"2020","journal-title":"J. Neurol."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"172950","DOI":"10.1016\/j.ejphar.2020.172950","article-title":"Effect of Spinal Angiotensin-Converting Enzyme 2 Activation on the Formalin-Induced Nociceptive Response in Mice","volume":"872","author":"Nemoto","year":"2020","journal-title":"Eur. J. Pharmacol."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"118568","DOI":"10.1016\/j.lfs.2020.118568","article-title":"Involvement of the Nervous System in COVID-19: The Bell Should Toll in the Brain","volume":"262","author":"Satarker","year":"2020","journal-title":"Life Sci."},{"key":"ref_147","first-page":"1","article-title":"Pathological Inflammation in Patients with COVID-19: A Key Role for Monocytes and Macrophages","volume":"20","author":"Merad","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"ref_148","doi-asserted-by":"crossref","unstructured":"Erickson, M.A., Rhea, E.M., Knopp, R.C., and Banks, W.A. (2021). Interactions of SARS-CoV-2 with the Blood\u2013Brain Barrier. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22052681"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"164","DOI":"10.3389\/fnut.2020.00164","article-title":"Selenium and RNA Virus Interactions: Potential Implications for SARS-CoV-2 Infection (COVID-19)","volume":"7","author":"Hiffler","year":"2020","journal-title":"Front. Nutr."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"110984","DOI":"10.1016\/j.envres.2021.110984","article-title":"Selenium (Se) Plays a Key Role in the Biological Effects of Some Viruses: Implications for COVID-19","volume":"196","author":"Liu","year":"2021","journal-title":"Environ. Res."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"121","DOI":"10.23937\/2474-3658\/1510121","article-title":"Oxidative Stress Associated with SARS-CoV-2 (COVID-19) Increases the Severity of the Lung Disease\u2014A Systematic Review","volume":"6","author":"Samir","year":"2020","journal-title":"J. Infect. Dis. Epidemiol."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1080\/08820139.2018.1496098","article-title":"The Effect of Intravenous Selenium on Oxidative Stress in Critically Ill Patients with Acute Respiratory Distress Syndrome","volume":"48","author":"Mahmoodpoor","year":"2019","journal-title":"Immunol. Investig."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1093\/infdis\/jiaa150","article-title":"Characteristics of Peripheral Lymphocyte Subset Alteration in COVID-19 Pneumonia","volume":"221","author":"Wang","year":"2020","journal-title":"J. Infect. Dis."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1089\/ars.2011.4145","article-title":"The Role of Selenium in Inflammation and Immunity: From Molecular Mechanisms to Therapeutic Opportunities","volume":"16","author":"Huang","year":"2012","journal-title":"Antioxid. Redox Signal."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.3945\/jn.109.120725","article-title":"Dietary Selenium Modulates Activation and Differentiation of CD4+ T Cells in Mice through a Mechanism Involving Cellular Free Thiols","volume":"140","author":"Hoffmann","year":"2010","journal-title":"J. Nutr."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1093\/ajcn\/nqaa095","article-title":"Association between Regional Selenium Status and Reported Outcome of COVID-19 Cases in China","volume":"111","author":"Zhang","year":"2020","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_157","doi-asserted-by":"crossref","unstructured":"Zhang, H.Y., Zhang, A.R., Lu, Q.B., Zhang, X.A., Zhang, Z.J., Guan, X.G., Che, T.L., Yang, Y., Li, H., and Liu, W. (2021). Association between Fatality Rate of COVID-19 and Selenium Deficiency in China. BMC Infect. Dis., 21.","DOI":"10.1186\/s12879-021-06167-8"},{"key":"ref_158","first-page":"1601","article-title":"Preliminary Analysis on COVID-19 Case Spectrum and Spread Intensity in Different Provinces in China except Hubei Province","volume":"41","author":"Cheng","year":"2020","journal-title":"Zhonghua Liu Xing Bing Xue Za Zhi"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"110670","DOI":"10.1016\/j.envres.2020.110670","article-title":"Urinary Trace Elements in Association with Disease Severity and Outcome in Patients with COVID-19","volume":"194","author":"Zeng","year":"2021","journal-title":"Environ. Res."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.ijid.2020.08.018","article-title":"Nutritional Status of Patients with COVID-19","volume":"100","author":"Im","year":"2020","journal-title":"Int. J. Infect. Dis."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"111053","DOI":"10.1016\/j.nut.2020.111053","article-title":"An Exploratory Study of Selenium Status in Healthy Individuals and in Patients with COVID-19 in a South Indian Population: The Case for Adequate Selenium Status","volume":"82","author":"Majeed","year":"2021","journal-title":"Nutrition"},{"key":"ref_162","doi-asserted-by":"crossref","unstructured":"Younesian, O., Khodabakhshi, B., Abdolahi, N., Norouzi, A., Behnampour, N., Hosseinzadeh, S., Alarzi, S.S.H., and Joshaghani, H. (2021). Decreased Serum Selenium Levels of COVID-19 Patients in Comparison with Healthy Individuals. Biol. Trace Elem. Res., 1\u20136.","DOI":"10.1007\/s12011-021-02797-w"},{"key":"ref_163","doi-asserted-by":"crossref","unstructured":"Skalny, A., Timashev, P.S., Aschner, M., Aaseth, J., Chernova, L.N., Belyaev, V.E., Grabeklis, A.R., Notova, S.V., Lobinski, R., and Tsatsakis, A. (2021). Serum Zinc, Copper, and Other Biometals Are Associated with COVID-19 Severity Markers. Metabolites, 11.","DOI":"10.3390\/metabo11040244"},{"key":"ref_164","doi-asserted-by":"crossref","unstructured":"Moghaddam, A., Heller, R.A., Sun, Q., Seelig, J., Cherkezov, A., Seibert, L., Hackler, J., Seemann, P., Diegmann, J., and Pilz, M. (2020). Selenium Deficiency Is Associated with Mortality Risk from COVID-19. Nutrients, 12.","DOI":"10.20944\/preprints202007.0113.v1"},{"key":"ref_165","doi-asserted-by":"crossref","unstructured":"Pincemail, J., Cavalier, E., Charlier, C., Cheramy\u2013Bien, J.-P., Brevers, E., Courtois, A., Fadeur, M., Meziane, S., Goff, C.L., and Misset, B. (2021). Oxidative Stress Status in COVID-19 Patients Hospitalized in Intensive Care Unit for Severe Pneumonia. A Pilot Study. Antioxidants, 10.","DOI":"10.3390\/antiox10020257"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1021\/acsinfecdis.0c00288","article-title":"Endogenous Deficiency of Glutathione as the Most Likely Cause of Serious and Death in COVID-19 Patients","volume":"6","author":"Polonikov","year":"2020","journal-title":"ACS Infect. Dis."},{"key":"ref_167","first-page":"101063","article-title":"Efficacy of Glutathione Therapy in Relieving Dyspnea Associated with COVID-19 Pneumonia: A Report of 2 Cases","volume":"30","author":"Horowitz","year":"2020","journal-title":"Respir. Med. Case Rep."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"109878","DOI":"10.1016\/j.mehy.2020.109878","article-title":"Selenium Supplementation in the Prevention of Coronavirus Infections (COVID-19)","volume":"143","author":"Kieliszek","year":"2020","journal-title":"Med. Hypotheses"},{"key":"ref_169","first-page":"3377","article-title":"Cellular Thioredoxin Reductase Activity Is Regulated by Selenium","volume":"17","author":"Berggren","year":"1997","journal-title":"Anticancer Res."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1111\/aas.13573","article-title":"Serum Selenium in Critically Ill Patients: Profile and Supplementation in a Depleted Region","volume":"64","author":"Broman","year":"2020","journal-title":"Acta Anaesthesiol. Scand."},{"key":"ref_171","first-page":"387","article-title":"Selenium Deficiency in Tissue Culture: Implications for Oxidative Metabolism","volume":"27","author":"Baker","year":"1998","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1182\/blood.2020007214","article-title":"Platelet Gene Expression and Function in Patients with COVID-19","volume":"136","author":"Denorme","year":"2020","journal-title":"Blood"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/S0049-3848(03)00338-4","article-title":"Effect of Sodium Selenite Treatment on Platelet Aggregation of Streptozotocin-Induced Diabetic Rats","volume":"111","author":"Yakaryilmaz","year":"2003","journal-title":"Thromb Res."},{"key":"ref_174","doi-asserted-by":"crossref","unstructured":"Varlamova, E.G., Turovsky, E.A., and Blinova, E.V. (2021). Therapeutic Potential and Main Methods of Obtaining Selenium Nanoparticles. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms221910808"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/S0891-5849(03)00428-3","article-title":"Free Radical Scavenging Efficiency of Nano-Se in Vitro","volume":"35","author":"Huang","year":"2003","journal-title":"Free Radic. Biol. Med."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/j.biopha.2018.12.146","article-title":"Therapeutic Applications of Selenium Nanoparticles","volume":"111","author":"Khurana","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.2147\/IJN.S157541","article-title":"Nano-Selenium and Its Nanomedicine Applications: A Critical Review","volume":"13","author":"Hosnedlova","year":"2018","journal-title":"Int. J. Nanomedicine"},{"key":"ref_178","doi-asserted-by":"crossref","unstructured":"Turovsky, E.A., and Varlamova, E.G. (2021). Mechanism of Ca2+-Dependent pro-Apoptotic Action of Selenium Nanoparticles, Mediated by Activation of Cx43 Hemichannels. Biology, 10.","DOI":"10.3390\/biology10080743"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"101037","DOI":"10.1016\/j.nantod.2020.101037","article-title":"Using Nano-Selenium to Combat Coronavirus Disease 2019 (COVID-19)?","volume":"36","author":"He","year":"2021","journal-title":"Nano Today"},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"3060","DOI":"10.1016\/j.apsb.2021.04.023","article-title":"Nanomedicine for Acute Respiratory Distress Syndrome: The Latest Application, Targeting Strategy, and Rational Design","volume":"11","author":"Qiao","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/s41586-020-2223-y","article-title":"Structure of Mpro from SARS-CoV-2 and Discovery of Its Inhibitors","volume":"582","author":"Jin","year":"2020","journal-title":"Nature"},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"4865","DOI":"10.1007\/s11033-014-3417-x","article-title":"Ebselen, a Promising Antioxidant Drug: Mechanisms of Action and Targets of Biological Pathways","volume":"41","author":"Azad","year":"2014","journal-title":"Mol. Biol. Rep."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"264","DOI":"10.2174\/1871530317666170921142055","article-title":"Diet Bioactive Compounds: Implications for Oxidative Stress and Inflammation in the Vascular System","volume":"17","author":"Gabriele","year":"2017","journal-title":"Endocr. Metab. Immune Disord. Drug Targets"},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.pmedr.2018.10.008","article-title":"The Global Burden of Multiple Chronic Conditions: A Narrative Review","volume":"12","author":"Hajat","year":"2018","journal-title":"Prev. Med. Rep."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"e16","DOI":"10.1016\/j.jinf.2020.04.021","article-title":"Risk Factors of Critical & Mortal COVID-19 Cases: A Systematic Literature Review and Meta-Analysis","volume":"81","author":"Zheng","year":"2020","journal-title":"J. Infect."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.nutres.2018.06.002","article-title":"The Importance of Healthy Dietary Patterns in Chronic Disease Prevention","volume":"70","author":"Neuhouser","year":"2019","journal-title":"Nutr. Res."},{"key":"ref_187","doi-asserted-by":"crossref","unstructured":"Zabetakis, I., Lordan, R., Norton, C., and Tsoupras, A. (2020). COVID-19: The Inflammation Link and the Role of Nutrition in Potential Mitigation. Nutrients, 12.","DOI":"10.3390\/nu12051466"},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1017\/S0007114599000379","article-title":"Micronutrients and the Pathogenesis of Human Immunodeficiency Virus Infection","volume":"81","author":"Semba","year":"1999","journal-title":"Br. J. Nutr."},{"key":"ref_189","doi-asserted-by":"crossref","unstructured":"Pecora, F., Persico, F., Argentiero, A., Neglia, C., and Esposito, S. (2020). The Role of Micronutrients in Support of the Immune Response against Viral Infections. Nutrients, 12.","DOI":"10.3390\/nu12103198"},{"key":"ref_190","doi-asserted-by":"crossref","unstructured":"Calder, P.C., Carr, A.C., Gombart, A.F., and Eggersdorfer, M. (2020). Optimal Nutritional Status for a Well-Functioning Immune System Is an Important Factor to Protect against Viral Infections. Nutrients, 12.","DOI":"10.3390\/nu12041181"},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1080\/2574254X.2021.1941706","article-title":"The Potential Role of Zinc, Magnesium and Selenium against COVID-19: A Pragmatic Review","volume":"4","author":"Pecoraro","year":"2021","journal-title":"Child. Adolesc. Obes."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.maturitas.2020.08.003","article-title":"Immune-Boosting Role of Vitamins D, C, E, Zinc, Selenium and Omega-3 Fatty Acids: Could They Help against COVID-19?","volume":"143","author":"Shakoor","year":"2021","journal-title":"Maturitas"},{"key":"ref_193","doi-asserted-by":"crossref","unstructured":"C\u00e1mara, M., S\u00e1nchez-Mata, M.C., Fern\u00e1ndez-Ruiz, V., C\u00e1mara, R.M., Cebadera, E., and Dom\u00ednguez, L. (2021). A Review of the Role of Micronutrients and Bioactive Compounds on Immune System Supporting to Fight against the COVID-19 Disease. Foods, 10.","DOI":"10.3390\/foods10051088"},{"key":"ref_194","unstructured":"FAO\/WHO (2021, December 19). Human Vitamin and Mineral Requirments. In Chapter 15, Selenium. Available online: https:\/\/www.fao.org\/3\/Y2809E\/y2809e0l.htm."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1007\/s12011-011-8977-1","article-title":"Review: Micronutrient Selenium Deficiency Influences Evolution of Some Viral Infectious Diseases","volume":"143","author":"Harthill","year":"2011","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1080\/19440049.2012.746474","article-title":"Predicted Dietary Intake of Selenium by the General Adult Population in Belgium","volume":"30","author":"Waegeneers","year":"2013","journal-title":"Food Addit. Contam. Part A Chem. Anal. Control Expo. Risk Assess"},{"key":"ref_197","unstructured":"Ross, A., Caballero, B., Cousins, R., Tucker, K., and Ziegler, T. (2012). Selenium. Modern Nutrition in Health and Disease, Lippincott Williams & Williams."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"317","DOI":"10.3945\/jn.109.114413","article-title":"Estimation of Antioxidant Intakes from Diet and Supplements in U.S. Adults","volume":"140","author":"Chun","year":"2010","journal-title":"J. Nutr."},{"key":"ref_199","unstructured":"Institute of Medicine (US) Panel on Dietary Antioxidants and Related Compounds (2000). Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids, National Academies Press."},{"key":"ref_200","unstructured":"World Health Organization and Food and Agriculture Organization (2021, December 21). Food as a Source of Nutrients. Vitamin and Mineral Requirements in Human Nutrition, Available online: https:\/\/www.who.int\/publications\/i\/item\/9241546123."},{"key":"ref_201","doi-asserted-by":"crossref","unstructured":"(2014). Scientific Opinion on Dietary Reference Values for Selenium. EFSA J., 12, 3846.","DOI":"10.2903\/j.efsa.2014.3846"},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1001\/archinternmed.2009.495","article-title":"Acute Selenium Toxicity Associated with a Dietary Supplement","volume":"170","author":"MacFarquhar","year":"2010","journal-title":"Arch. Intern. Med."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1385\/BTER:98:2:143","article-title":"Metabolism of Subtoxic Level of Selenite by Double-Perfused Small Intestine in Rats","volume":"98","author":"Park","year":"2004","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1017\/S0007114508939830","article-title":"Food-Chain Selenium and Human Health: Emphasis on Intake","volume":"100","author":"Rayman","year":"2008","journal-title":"Br. J. Nutr."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/1\/280\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:54:32Z","timestamp":1760169272000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/1\/280"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,28]]},"references-count":204,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,1]]}},"alternative-id":["ijms23010280"],"URL":"https:\/\/doi.org\/10.3390\/ijms23010280","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,28]]}}}