{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T23:11:32Z","timestamp":1775171492792,"version":"3.50.1"},"reference-count":93,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2021,12,28]],"date-time":"2021-12-28T00:00:00Z","timestamp":1640649600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010665","name":"H2020 Marie Sk\u0142odowska-Curie Actions","doi-asserted-by":"publisher","award":["765274"],"award-info":[{"award-number":["765274"]}],"id":[{"id":"10.13039\/100010665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>In a prospective study, 48 fetuses were evaluated with Doppler ultrasound after 34 weeks and classified, according to the cerebroplacental ratio (CPR) and estimated fetal weight (EFW), into fetuses with normal growth and fetuses with late-onset fetal growth restriction (LO-FGR). Overexpression of miRNAs from neonatal cord blood belonging to LO-FGR fetuses, was validated by real-time PCR. In addition, functional characterization of overexpressed miRNAs was performed by analyzing overrepresented pathways, gene ontologies, and prioritization of synergistically working miRNAs. Three miRNAs: miR-25-3p, miR-185-5p and miR-132-3p, were significantly overexpressed in cord blood of LO-FGR fetuses. Pathway and gene ontology analysis revealed over-representation of certain molecular pathways associated with cardiac development and neuron death. In addition, prioritization of synergistically working miRNAs highlighted the importance of miR-185-5p and miR-25-3p in cholesterol efflux and starvation responses associated with LO-FGR phenotypes. Evaluation of miR-25-3p; miR-132-3p and miR-185-5p might serve as molecular biomarkers for the diagnosis and management of LO-FGR; improving the understanding of its influence on adult disease.<\/jats:p>","DOI":"10.3390\/ijms23010293","type":"journal-article","created":{"date-parts":[[2021,12,28]],"date-time":"2021-12-28T06:55:03Z","timestamp":1640674503000},"page":"293","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Overexpression of microRNAs miR-25-3p, miR-185-5p and miR-132-3p in Late Onset Fetal Growth Restriction, Validation of Results and Study of the Biochemical Pathways Involved"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1410-1702","authenticated-orcid":false,"given":"Gabriela","family":"Loscalzo","sequence":"first","affiliation":[{"name":"Instituto de Investigaci\u00f3n Sanitaria La Fe, 46026 Valencia, Spain"},{"name":"Department of Obstetrics and Gynecology, Hospital Universitario y Polit\u00e9cnico La Fe, 46026 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0034-7755","authenticated-orcid":false,"given":"Julia","family":"Scheel","sequence":"additional","affiliation":[{"name":"Department of Systems Biology and Bioinformatics, University Rostock, 18055 Rostock, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Santiago","family":"Iba\u00f1ez-Cabellos","sequence":"additional","affiliation":[{"name":"EpiDisease S.L, Parc Cient\u00edfic, University of Valencia, 46980 Paterna, Spain"},{"name":"Consortium Center for Biomedical Network Research on Rare Diseases (CIBERER), Carrer d\u2019Alvaro de Bazan, 10, 46010 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Garc\u00eda-Lopez","sequence":"additional","affiliation":[{"name":"EpiDisease S.L, Parc Cient\u00edfic, University of Valencia, 46980 Paterna, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3470-3260","authenticated-orcid":false,"given":"Shailendra","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Systems Biology and Bioinformatics, University Rostock, 18055 Rostock, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7547-7872","authenticated-orcid":false,"given":"Jos\u00e9 Luis","family":"Garc\u00eda-Gimenez","sequence":"additional","affiliation":[{"name":"EpiDisease S.L, Parc Cient\u00edfic, University of Valencia, 46980 Paterna, Spain"},{"name":"Consortium Center for Biomedical Network Research on Rare Diseases (CIBERER), Carrer d\u2019Alvaro de Bazan, 10, 46010 Valencia, Spain"},{"name":"Institute of Health Carlos III, Biomedical Research Institute INCLIVA, 46010 Valencia, Spain"},{"name":"Department of Physiology, School of Medicine and Dentistry, University of Valencia, 46010 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvador","family":"Mena-Moll\u00e1","sequence":"additional","affiliation":[{"name":"EpiDisease S.L, Parc Cient\u00edfic, University of Valencia, 46980 Paterna, Spain"},{"name":"Institute of Health Carlos III, Biomedical Research Institute INCLIVA, 46010 Valencia, Spain"},{"name":"Department of Physiology, School of Medicine and Dentistry, University of Valencia, 46010 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2221-2560","authenticated-orcid":false,"given":"Alfredo","family":"Perales-Mar\u00edn","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Sanitaria La Fe, 46026 Valencia, Spain"},{"name":"Department of Obstetrics and Gynecology, Hospital Universitario y Polit\u00e9cnico La Fe, 46026 Valencia, Spain"},{"name":"Department of Pediatrics, Obstetrics and Gynecology, School of Medicine and Dentistry, University of Valencia, 46010 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8783-6710","authenticated-orcid":false,"given":"Jos\u00e9","family":"Morales-Rosell\u00f3","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Sanitaria La Fe, 46026 Valencia, Spain"},{"name":"Department of Obstetrics and Gynecology, Hospital Universitario y Polit\u00e9cnico La Fe, 46026 Valencia, Spain"},{"name":"Department of Pediatrics, Obstetrics and Gynecology, School of Medicine and Dentistry, University of Valencia, 46010 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1002\/uog.15884","article-title":"Consensus definition of fetal growth restriction: A Delphi procedure","volume":"48","author":"Gordijn","year":"2016","journal-title":"Ultrasound Obstet. 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