{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T10:53:36Z","timestamp":1792407216371,"version":"4.4.0"},"reference-count":232,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2021,12,28]],"date-time":"2021-12-28T00:00:00Z","timestamp":1640649600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.mdpi.com"],"crossmark-restriction":true},"short-container-title":["IJMS"],"abstract":"<jats:p>Depression in older individuals is a common complex mood disorder with high comorbidity of both psychiatric and physical diseases, associated with high disability, cognitive decline, and increased mortality The factors predicting the risk of late-life depression (LLD) are incompletely understood. The reciprocal relationship of depressive disorder and age- and disease-related processes has generated pathogenic hypotheses and provided various treatment options. The heterogeneity of depression complicates research into the underlying pathogenic cascade, and factors involved in LLD considerably differ from those involved in early life depression. Evidence suggests that a variety of vascular mechanisms, in particular cerebral small vessel disease, generalized microvascular, and endothelial dysfunction, as well as metabolic risk factors, including diabetes, and inflammation that may induce subcortical white and gray matter lesions by compromising fronto\u2013limbic and other important neuronal networks, may contribute to the development of LLD. The \u201cvascular depression\u201d hypothesis postulates that cerebrovascular disease or vascular risk factors can predispose, precipitate, and perpetuate geriatric depression syndromes, based on their comorbidity with cerebrovascular lesions and the frequent development of depression after stroke. Vascular burden is associated with cognitive deficits and a specific form of LLD, vascular depression, which is marked by decreased white matter integrity, executive dysfunction, functional disability, and poorer response to antidepressive therapy than major depressive disorder without vascular risk factors. Other pathogenic factors of LLD, such as neurodegeneration or neuroimmune regulatory dysmechanisms, are briefly discussed. Treatment planning should consider a modest response of LLD to antidepressants, while vascular and metabolic factors may provide promising targets for its successful prevention and treatment. However, their effectiveness needs further investigation, and intervention studies are needed to assess which interventions are appropriate and effective in clinical practice.<\/jats:p>","DOI":"10.3390\/ijms23010308","type":"journal-article","created":{"date-parts":[[2021,12,29]],"date-time":"2021-12-29T02:31:27Z","timestamp":1640745087000},"page":"308","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":73,"title":["Pathomechanisms of Vascular Depression in Older Adults"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9641-7649","authenticated-orcid":false,"given":"Kurt A.","family":"Jellinger","sequence":"first","affiliation":[{"name":"Institute of Clinical Neurobiology, Alberichgasse 5\/13, 1150 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1038\/mp.2013.20","article-title":"The vascular depression hypothesis: Mechanisms linking vascular disease with depression","volume":"18","author":"Taylor","year":"2013","journal-title":"Mol. Psychiatry"},{"key":"ref_2","unstructured":"Sekhon, S., Patel, J., and Sapra, A. (2021, November 10). Late-Onset Depression, StatPearls [Internet], Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK551507\/."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1017\/S0033291709990833","article-title":"The pattern and course of cognitive impairment in late-life depression","volume":"40","author":"Thomas","year":"2010","journal-title":"Psychol. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.psc.2013.08.002","article-title":"Cognitive deficits in geriatric depression: Clinical correlates and implications for current and future treatment","volume":"36","author":"Morimoto","year":"2013","journal-title":"Psychiatr. Clin. North. Am."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1093\/geront\/48.5.593","article-title":"Impact of major depression and subsyndromal symptoms on quality of life and attitudes toward aging in an international sample of older adults","volume":"48","author":"Chachamovich","year":"2008","journal-title":"Gerontologist"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1159\/000437299","article-title":"Depression and quality of life in older persons: A review","volume":"40","author":"Sivertsen","year":"2015","journal-title":"Dement. Geriatr. Cogn. Disord."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1080\/13607863.2019.1699900","article-title":"Clinical characteristics of late-life depression predicting mortality","volume":"25","author":"Wiersema","year":"2021","journal-title":"Aging. Ment. Health"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1192\/bjp.bp.112.118307","article-title":"Late-life depression and risk of vascular dementia and Alzheimer\u2019s disease: Systematic review and meta-analysis of community-based cohort studies","volume":"202","author":"Diniz","year":"2013","journal-title":"Br. J. Psychiatry"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1097\/00019442-200105000-00004","article-title":"The association of late-life depression and anxiety with physical disability: A review of the literature and prospectus for future research","volume":"9","author":"Lenze","year":"2001","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"18m12106","DOI":"10.4088\/JCP.18m12106","article-title":"Trajectories in cerebral blood flow following antidepressant treatment in late-life depression: Support for the vascular depression hypothesis","volume":"79","author":"Wei","year":"2018","journal-title":"J. Clin. Psychiatry"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1002\/gps.4204","article-title":"Subsyndromal depression among older adults in the USA: Prevalence, comorbidity, and risk for new-onset psychiatric disorders in late life","volume":"30","author":"Kinley","year":"2015","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"19","DOI":"10.20517\/2574-1209.2021.102","article-title":"Vascular and metabolic risk factors of late-life depression","volume":"6","author":"Geraets","year":"2022","journal-title":"Vessel Plus"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1111\/j.1600-0447.2006.00770.x","article-title":"Prevalence and predictors of depression in populations of elderly: A review","volume":"113","author":"Djernes","year":"2006","journal-title":"Acta Psychiatr. Scand."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1001\/jamapsychiatry.2016.3162","article-title":"Prevalence of depression in patients with mild cognitive impairment: A systematic review and meta-analysis","volume":"74","author":"Ismail","year":"2017","journal-title":"JAMA Psychiatry"},{"key":"ref_15","unstructured":"World Health Organization (2017). Depression and Other Common Mental Disorders. Global Health Estimates, World Health Organization. Available online: https:\/\/www.who.int\/publications\/i\/item\/depression-global-health-estimates."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.jad.2015.04.008","article-title":"Epidemiology of MRI-defined vascular depression: A longitudinal, community-based study in Korean elders","volume":"180","author":"Park","year":"2015","journal-title":"J. Affect. Disord."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/S2215-0366(18)30166-4","article-title":"Associations between age and the course of major depressive disorder: A 2-year longitudinal cohort study","volume":"5","author":"Schaakxs","year":"2018","journal-title":"Lancet Psychiatry"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Comijs, H.C., Nieuwesteeg, J., Kok, R., van Marwijk, H.W., van der Mast, R.C., Naarding, P., Voshaar, R.C., Verhaak, P., de Waal, M.W., and Stek, M.L. (2015). The two-year course of late-life depression; results from the Netherlands study of depression in older persons. BMC Psychiatry, 15.","DOI":"10.1186\/s12888-015-0401-5"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s11920-012-0279-6","article-title":"Biological basis of late life depression","volume":"14","author":"Disabato","year":"2012","journal-title":"Curr. Psychiatry Rep."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Kuo, C.Y., Lin, C.H., and Lane, H.Y. (2021). Molecular basis of late-life depression. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22147421"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Geraets, A.F.J., Schram, M.T., Jansen, J.F.A., Koster, A., Dagnelie, P.C., van Greevenbroek, M.M.J., Stehouwer, C.D.A., Verhey, F.R.J., and K\u00f6hler, S. (2021). The relation of depression with structural brain abnormalities and cognitive functioning: The Maastricht study. Psychol. Med., 1\u201310.","DOI":"10.1017\/S0033291721000222"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.jad.2021.05.096","article-title":"The association of markers of cerebral small vessel disease and brain atrophy with incidence and course of depressive symptoms\u2013the maastricht study","volume":"292","author":"Geraets","year":"2021","journal-title":"J. Affect. Disord."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Aizenstein, H.J., Baskys, A., Boldrini, M., Butters, M.A., Diniz, B.S., Jaiswal, M.K., Jellinger, K.A., Kruglov, L.S., Meshandin, I.A., and Mijajlovic, M.D. (2016). Vascular depression consensus report\u2013a critical update. BMC Med., 14.","DOI":"10.1186\/s12916-016-0720-5"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1016\/S0140-6736(05)66665-2","article-title":"Depression in the elderly","volume":"365","author":"Alexopoulos","year":"2005","journal-title":"Lancet"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1176\/appi.ajp.2018.18050568","article-title":"Perspectives on the management of vascular depression","volume":"175","author":"Taylor","year":"2018","journal-title":"Am. J. Psychiatry"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1586\/ern.10.92","article-title":"NICHT 2014\u2013Vascular depression: Where do we go from here?","volume":"11","author":"Naarding","year":"2011","journal-title":"Expert Rev. Neurother."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.jpsychires.2012.01.011","article-title":"Vascular depression prevalence and epidemiology in the United States","volume":"46","author":"Gonzalez","year":"2012","journal-title":"J. Psychiatr. Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1001\/archpsyc.1997.01830220033006","article-title":"\u2018Vascular depression\u2019 hypothesis","volume":"54","author":"Alexopoulos","year":"1997","journal-title":"Arch. Gen. Psychiatry"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"68","DOI":"10.31887\/DCNS.1999.1.2\/galexopoulos","article-title":"Vascular depression: A new view of late-onset depression","volume":"1","author":"Alexopoulos","year":"1999","journal-title":"Dialogues Clin. Neurosci."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.jns.2014.09.038","article-title":"Poststroke depression and its multifactorial nature: Results from a prospective longitudinal study","volume":"347","author":"Fransen","year":"2014","journal-title":"J. Neurol. Sci."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"e02158","DOI":"10.1002\/brb3.2158","article-title":"Association between neurological outcome and poststroke comorbid mood and anxiety disorders: A real-life experience","volume":"11","author":"Rabat","year":"2021","journal-title":"Brain Behav."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1007\/s00702-021-02334-y","article-title":"A sudden and severe depressive episode after a left cingulate gyrus stroke: A case report of post-stroke depression and review of literature","volume":"128","author":"Ribeiro","year":"2021","journal-title":"J. Neural. Transm."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1002\/gps.4674","article-title":"Cerebrovascular burden and depressive symptomatology interrelate over 18 years: Support for the vascular depression hypothesis","volume":"33","author":"Scott","year":"2018","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1038\/s41398-019-0514-6","article-title":"Mechanisms and treatment of late-life depression","volume":"9","author":"Alexopoulos","year":"2019","journal-title":"Transl. Psychiatry"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1007\/s12035-016-9711-y","article-title":"Klotho gene and selective serotonin reuptake inhibitors: Response to treatment in late-life major depressive disorder","volume":"54","author":"Paroni","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"ref_36","first-page":"16","article-title":"Treatment-resistant depression","volume":"67","author":"Souery","year":"2006","journal-title":"J. Clin. Psychiatry"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1176\/appi.ajp.163.1.28","article-title":"Evaluation of outcomes with citalopram for depression using measurement-based care in STAR*D: Implications for clinical practice","volume":"163","author":"Trivedi","year":"2006","journal-title":"Am. J. Psychiatry"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1176\/ajp.154.4.497","article-title":"MRI-defined vascular depression","volume":"154","author":"Krishnan","year":"1997","journal-title":"Am. J. Psychiatry"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1002\/gps.3943","article-title":"The external validity of MRI-defined vascular depression","volume":"28","author":"Pimontel","year":"2013","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"151","DOI":"10.31887\/DCNS.2015.17.2\/cagudelo","article-title":"Applications of magnetic resonance imaging for treatment-resistant late-life depression","volume":"17","author":"Agudelo","year":"2015","journal-title":"Dialogues Clin. Neurosci."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1097\/WCO.0000000000000028","article-title":"Depression in the elderly: Brain correlates, neuropsychological findings, and role of vascular lesion load","volume":"26","author":"Vu","year":"2013","journal-title":"Curr. Opin. Neurol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"179","DOI":"10.2147\/JIR.S141033","article-title":"The role of neuroinflammation and neurovascular dysfunction in major depressive disorder","volume":"11","author":"Jeon","year":"2018","journal-title":"J. Inflamm. Res."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1007\/s00702-012-0945-1","article-title":"Organic bases of late-life depression: A critical update","volume":"120","author":"Jellinger","year":"2013","journal-title":"J. Neural. Transm."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1097\/01.JGP.0000218326.91287.66","article-title":"Data from the VITA study do not support the concept of vascular depression","volume":"14","author":"Rainer","year":"2006","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1177\/0891988720901783","article-title":"Are apathy and depressive symptoms related to vascular white matter hyperintensities in severe late life depression?","volume":"34","author":"Oudega","year":"2021","journal-title":"J. Geriatr. Psychiatry Neurol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0013-7006(07)91557-2","article-title":"Validity of vascular depression as a specific diagnostic: A review","volume":"33","author":"Thuile","year":"2007","journal-title":"Encephale"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1136\/jnnp.70.1.83","article-title":"A neuropathological study of vascular factors in late-life depression","volume":"70","author":"Thomas","year":"2001","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_48","first-page":"22","article-title":"\u201cThe depression-executive dysfunction syndrome of late life\u201d: A specific target for D3 agonists?","volume":"9","author":"Alexopoulos","year":"2001","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.biopsych.2003.08.014","article-title":"Clinical characteristics of magnetic resonance imaging-defined subcortical ischemic depression","volume":"55","author":"Krishnan","year":"2004","journal-title":"Biol. Psychiatry"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.jagp.2014.06.010","article-title":"Vascular burden and cognitive function in late-life depression","volume":"23","author":"Zuidersma","year":"2015","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"e743","DOI":"10.1097\/MD.0000000000000743","article-title":"Can we clinically recognize a vascular depression? The role of personality in an expanded threshold model","volume":"94","author":"Turk","year":"2015","journal-title":"Medicine"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.jad.2004.06.007","article-title":"Depression in older persons with versus without vascular disease in the open population: Similar depressive symptom patterns, more disability","volume":"83","author":"Bremmer","year":"2004","journal-title":"J. Affect. Disord."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1002\/gps.2203","article-title":"The symptom profile of vascular depression","volume":"24","author":"Naarding","year":"2009","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1017\/S0033291706009196","article-title":"Clinically defined vascular depression in the general population","volume":"37","author":"Naarding","year":"2007","journal-title":"Psychol. Med."},{"key":"ref_55","first-page":"307","article-title":"Vascular risk factors and cognitive impairment of patients with magnetic resonance imaging-defined subcortical ischemic depression","volume":"92","author":"Long","year":"2012","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"211","DOI":"10.2174\/1874609810666170404105634","article-title":"Late versus early onset depression in elderly patients: Vascular risk and cognitive impairment","volume":"10","author":"Hashem","year":"2017","journal-title":"Curr. Aging Sci."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1002\/gps.4400","article-title":"Factors related to prevalence, persistence, and incidence of depressive symptoms in mild cognitive impairment: Vascular depression construct","volume":"31","author":"Kim","year":"2015","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1136\/jnnp-2016-313914","article-title":"Cognitive reserve moderates long-term cognitive and functional outcome in cerebral small vessel disease","volume":"87","author":"Jokinen","year":"2016","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/S1474-4422(19)30079-1","article-title":"Small vessel disease: Mechanisms and clinical implications","volume":"18","author":"Wardlaw","year":"2019","journal-title":"Lancet Neurol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"316","DOI":"10.3389\/fpsyt.2018.00316","article-title":"Impaired cerebral haemodynamics in vascular depression: Insights from transcranial doppler ultrasonography","volume":"9","author":"Puglisi","year":"2018","journal-title":"Front. Psychiatry"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"3326","DOI":"10.1073\/pnas.1914655117","article-title":"Molecular adaptations of the blood-brain barrier promote stress resilience vs. depression","volume":"117","author":"Dudek","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1016\/j.jagp.2019.07.016","article-title":"Disruption of neural homeostasis as a model of relapse and recurrence in late-life depression","volume":"27","author":"Andreescu","year":"2019","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1038\/mp.2014.76","article-title":"Plasma biosignature and brain pathology related to persistent cognitive impairment in late-life depression","volume":"20","author":"Diniz","year":"2015","journal-title":"Mol. Psychiatry"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1093\/brain\/awaa405","article-title":"Depression, dementia and immune dysregulation","volume":"144","author":"Hayley","year":"2021","journal-title":"Brain"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1038\/nrn.2016.69","article-title":"Integrating neuroimmune systems in the neurobiology of depression","volume":"17","author":"Wohleb","year":"2016","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Tonhajzerova, I., Sekaninova, N., Bona Olexova, L., and Visnovcova, Z. (2020). Novel insight into neuroimmune regulatory mechanisms and biomarkers linking major depression and vascular diseases: The dilemma continues. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21072317"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/ejn.14720","article-title":"Neuroinflammation and depression: A review","volume":"53","author":"Troubat","year":"2021","journal-title":"Eur. J. Neurosci."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1176\/appi.focus.20160036","article-title":"Overlay of late-life depression and cognitive impairment","volume":"15","author":"Aziz","year":"2017","journal-title":"Focus"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1002\/gps.2093","article-title":"Neuropsychological correlates of magnetic resonance imaging-defined subcortical ischemic depression","volume":"24","author":"Potter","year":"2009","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"ref_70","first-page":"160","article-title":"Intrinsic functional network connectivity is associated with clinical symptoms and cognition in late-life depression","volume":"4","author":"Gandelman","year":"2019","journal-title":"Biol. Psychiatry Cogn. Neurosci. Neuroimaging"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.jad.2021.07.106","article-title":"Brain controllability distinctiveness between depression and cognitive impairment","volume":"294","author":"Fang","year":"2021","journal-title":"J. Affect. Disord."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.3389\/fpsyg.2019.01241","article-title":"Confining the concept of vascular depression to late-onset depression: A meta-analysis of mri-defined hyperintensity burden in major depressive disorder and bipolar disorder","volume":"10","author":"Salo","year":"2019","journal-title":"Front. Psychol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1038\/s41386-021-00973-z","article-title":"Late-life depression accentuates cognitive weaknesses in older adults with small vessel disease","volume":"47","author":"Oberlin","year":"2022","journal-title":"Neuropsychopharmacology"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"597","DOI":"10.3233\/JAD-180394","article-title":"Vascular effects on depressive symptoms in cognitive impairment","volume":"65","author":"Kim","year":"2018","journal-title":"J. Alzheimers Dis."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.jad.2019.03.042","article-title":"Depression related cerebral pathology and its relationship with cognitive functioning: A systematic review","volume":"250","author":"Jamieson","year":"2019","journal-title":"J. Affect. Disord."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"673","DOI":"10.3233\/JAD-200156","article-title":"Cortical alterations are associated with depression in subcortical vascular mild cognitive impairment revealed by surface-based morphometry","volume":"78","author":"Wang","year":"2020","journal-title":"J. Alzheimers Dis."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"48","DOI":"10.4329\/wjr.v12.i5.48","article-title":"Vascular depression for radiology: A review of the construct, methodology, and diagnosis","volume":"12","author":"Rushia","year":"2020","journal-title":"World J. Radiol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1002\/gps.5465","article-title":"Cognitive variability, brain aging, and cognitive decline in late-life major depression","volume":"36","author":"Manning","year":"2021","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"ref_79","first-page":"202","article-title":"Cognitive functions in late life depression","volume":"19","author":"Masse","year":"2021","journal-title":"Geriatr. Psychol. Neuropsychiatr. Vieil"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/S1474-4422(13)70060-7","article-title":"Mechanisms of sporadic cerebral small vessel disease: Insights from neuroimaging","volume":"12","author":"Wardlaw","year":"2013","journal-title":"Lancet Neurol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.neubiorev.2018.04.003","article-title":"Cerebral small vessel disease and risk of incident stroke, dementia and depression, and all-cause mortality: A systematic review and meta-analysis","volume":"90","author":"Rensma","year":"2018","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1176\/appi.ajp.2014.14050578","article-title":"Cerebral small vessel disease and association with higher incidence of depressive symptoms in a general elderly population: The AGES-Reykjavik study","volume":"172","author":"Sigurdsson","year":"2015","journal-title":"Am. J. Psychiatry"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.jagp.2017.03.013","article-title":"CADASIL as a useful medical model and genetic form of vascular depression","volume":"25","author":"Park","year":"2017","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1001\/jamapsychiatry.2017.0984","article-title":"Association of microvascular dysfunction with late-life depression: A systematic review and meta-analysis","volume":"74","author":"Houben","year":"2017","journal-title":"JAMA Psychiatry"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/gps.5217","article-title":"Empirical support for the vascular apathy hypothesis: A structured review","volume":"35","author":"Wouts","year":"2020","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.jad.2017.05.039","article-title":"Structural network connectivity impairment and depressive symptoms in cerebral small vessel disease","volume":"220","author":"Xie","year":"2017","journal-title":"J. Affect. Disord."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.biopsych.2021.04.012","article-title":"Microvascular contribution to late-onset depression: Mechanisms, current evidence, association with other brain diseases, and therapeutic perspectives","volume":"90","author":"Empana","year":"2021","journal-title":"Biol. Psychiatry"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"3461","DOI":"10.1681\/ASN.2017020157","article-title":"Assessing microvascular function in humans from a chronic disease perspective","volume":"28","author":"Houben","year":"2017","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1161\/01.RES.0000255691.76142.4a","article-title":"Phenotypic heterogeneity of the endothelium: I. Structure, function, and mechanisms","volume":"100","author":"Aird","year":"2007","journal-title":"Circ. Res."},{"key":"ref_90","unstructured":"Hall, J.E. (2011). Guyton and Hall Textbook of Medical Physiology, Saunders. [12th ed.]."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.biopsych.2012.01.019","article-title":"Cerebral hemodynamics and incident depression: The Rotterdam Study","volume":"72","author":"Direk","year":"2012","journal-title":"Biol. Psychiatry"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.ultrasmedbio.2019.11.007","article-title":"Seeing the invisible-ultrasound molecular imaging","volume":"46","author":"Kosareva","year":"2020","journal-title":"Ultrasound Med. Biol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1093\/aje\/kwaa023","article-title":"Microvascular phenotyping in the Maastricht Study: Design and main findings, 2010\u20132018","volume":"189","author":"Li","year":"2020","journal-title":"Am. J. Epidemiol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.21037\/qims-19-402","article-title":"Impaired cerebral hemodynamics in late-onset depression: Computed tomography angiography, computed tomography perfusion, and magnetic resonance imaging evaluation","volume":"10","author":"Wang","year":"2020","journal-title":"Quant. Imaging Med. Surg."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"111383","DOI":"10.1016\/j.pscychresns.2021.111383","article-title":"Cerebral hemodynamics and capillary dysfunction in late-onset major depressive disorder","volume":"317","author":"Dalby","year":"2021","journal-title":"Psychiatry Res. Neuroimaging"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.4088\/JCP.15m10399","article-title":"Metabolic syndrome and symptom resolution in depression: A 5-year follow-up of older adults","volume":"78","author":"Virtanen","year":"2017","journal-title":"J. Clin. Psychiatry"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1002\/gps.2020","article-title":"Vascular factors and depression","volume":"23","author":"Teper","year":"2008","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1017\/S0033291713002043","article-title":"Endothelial dysfunction is associated with a greater depressive symptom score in a general elderly population: The Hoorn Study","volume":"44","author":"Schram","year":"2014","journal-title":"Psychol. Med."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.bbi.2016.03.004","article-title":"Associations of low grade inflammation and endothelial dysfunction with depression\u2013The Maastricht Study","volume":"56","author":"Schram","year":"2016","journal-title":"Brain Behav. Immun."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1161\/HYPERTENSIONAHA.120.15260","article-title":"Association of markers of microvascular dysfunction with prevalent and incident depressive symptoms: The Maastricht Study","volume":"76","author":"Geraets","year":"2020","journal-title":"Hypertension"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1177\/0003319720903586","article-title":"Novel biomarkers for evaluation of endothelial dysfunction","volume":"71","author":"Leite","year":"2020","journal-title":"Angiology"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1159\/000508110","article-title":"Regional brain perfusion is associated with endothelial dysfunction markers in major depressive disorder","volume":"80","author":"Massardo","year":"2021","journal-title":"Neuropsychobiology"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"e1055","DOI":"10.1038\/tp.2017.36","article-title":"VEGF-related polymorphisms identified by GWAS and risk for major depression","volume":"7","author":"Xie","year":"2017","journal-title":"Transl. Psychiatry"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.psyneuen.2015.07.002","article-title":"Peripheral vascular endothelial growth factor as a novel depression biomarker: A meta-analysis","volume":"62","author":"Carvalho","year":"2015","journal-title":"Psychoneuroendocrinology"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.bbi.2021.06.013","article-title":"Low-grade inflammation and endothelial dysfunction predict four-year risk and course of depressive symptoms: The Maastricht study","volume":"97","author":"Janssen","year":"2021","journal-title":"Brain Behav. Immun."},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Kalkman, H.O. (2020). The association between vascular inflammation and depressive disorder. causality, biomarkers and targeted treatment. Pharmaceuticals, 13.","DOI":"10.3390\/ph13050092"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1161\/CIRCULATIONAHA.109.192644","article-title":"Harmonizing the metabolic syndrome: A joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity","volume":"120","author":"Alberti","year":"2009","journal-title":"Circulation"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1007\/s11906-018-0812-z","article-title":"The global epidemic of the metabolic syndrome","volume":"20","author":"Saklayen","year":"2018","journal-title":"Curr. Hypertens. Rep."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1136\/svn-2020-000813","article-title":"Metabolic syndrome, intracranial arterial stenosis and cerebral small vessel disease in community-dwelling populations","volume":"6","author":"Shu","year":"2021","journal-title":"Stroke Vasc. Neurol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"S8","DOI":"10.1016\/S0165-0327(12)70004-6","article-title":"Epidemiology of depression and diabetes: A systematic review","volume":"142","author":"Roy","year":"2012","journal-title":"J. Affect. Disord."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.maturitas.2016.01.003","article-title":"Duration of diabetes and its association with depression in later life: The Health In Men Study (HIMS)","volume":"86","author":"Almeida","year":"2016","journal-title":"Maturitas"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.12688\/f1000research.13898.1","article-title":"Understanding depression in type 2 diabetes: A biological approach in observational studies [version 1; peer review: 2 approved]","volume":"7","author":"Schram","year":"2018","journal-title":"F1000Research"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/S1474-4422(20)30139-3","article-title":"Understanding multifactorial brain changes in type 2 diabetes: A biomarker perspective","volume":"19","author":"Biessels","year":"2020","journal-title":"Lancet Neurol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"166","DOI":"10.2337\/dc12-0702","article-title":"Inflammatory markers and risk of type 2 diabetes: A systematic review and meta-analysis","volume":"36","author":"Wang","year":"2013","journal-title":"Diabetes Care"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1007\/s11064-007-9385-y","article-title":"Inflammation, depression and dementia: Are they connected?","volume":"32","author":"Leonard","year":"2007","journal-title":"Neurochem. Res."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1192\/bjp.bp.109.076430","article-title":"Association of high-sensitivity C-reactive protein with de novo major depression","volume":"197","author":"Pasco","year":"2010","journal-title":"Br. J. Psychiatry"},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Beran, M., Muzambi, R., Geraets, A., Albertorio-Diaz, J.R., Adriaanse, M.C., Iversen, M.M., Kokoszka, A., Nefs, G., Nouwen, A., and Pouwer, F. (2021). The bidirectional longitudinal association between depressive symptoms and HbA(1c): A systematic review and meta-analysis. Diabet. Med., e14671.","DOI":"10.1111\/dme.14671"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1097\/PSY.0000000000000255","article-title":"Association of depressive and anxiety disorders with diagnosed versus undiagnosed diabetes: An epidemiological study of 90,686 participants","volume":"78","author":"Meurs","year":"2016","journal-title":"Psychosom. Med."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1007\/s00213-015-3919-9","article-title":"Low-grade inflammation predicts persistence of depressive symptoms","volume":"233","author":"Zalli","year":"2016","journal-title":"Psychopharmacology"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.jad.2013.06.004","article-title":"CRP, IL-6 and depression: A systematic review and meta-analysis of longitudinal studies","volume":"150","author":"Valkanova","year":"2013","journal-title":"J. Affect. Disord."},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Wu, S., Yin, Y., and Du, L. (2021). Blood-brain barrier dysfunction in the pathogenesis of major depressive disorder. Cell Mol. Neurobiol.","DOI":"10.1007\/s10571-021-01153-9"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1038\/nn.4113","article-title":"Neuroimmune mechanisms of depression","volume":"18","author":"Hodes","year":"2015","journal-title":"Nat. Neurosci."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/nrn2297","article-title":"From inflammation to sickness and depression: When the immune system subjugates the brain","volume":"9","author":"Dantzer","year":"2008","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0165-5728(01)00270-3","article-title":"The glossopharyngeal nerve as a novel pathway in immune-to-brain communication: Relevance to neuroimmune surveillance of the oral cavity","volume":"115","author":"Romeo","year":"2001","journal-title":"J. Neuroimmunol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1038\/sj.mp.4000813","article-title":"Cytokine signals propagate through the brain","volume":"5","author":"Vitkovic","year":"2000","journal-title":"Mol. Psychiatry"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.ncl.2006.03.009","article-title":"The blood-brain barrier in psychoneuroimmunology","volume":"24","author":"Banks","year":"2006","journal-title":"Neurol. Clin."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"5606","DOI":"10.1523\/JNEUROSCI.22-13-05606.2002","article-title":"Distinct brain vascular cell types manifest inducible cyclooxygenase expression as a function of the strength and nature of immune insults","volume":"22","author":"Schiltz","year":"2002","journal-title":"J. Neurosci."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.pnpbp.2010.04.011","article-title":"Glucocorticoids, cytokines and brain abnormalities in depression","volume":"35","author":"Zunszain","year":"2011","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1038\/sj.mp.4001879","article-title":"The etiology of poststroke depression: A review of the literature and a new hypothesis involving inflammatory cytokines","volume":"11","author":"Spalletta","year":"2006","journal-title":"Mol. Psychiatry"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"100336","DOI":"10.1016\/j.bbih.2021.100336","article-title":"A pilot [(11)C]PBR28 PET\/MRI study of neuroinflammation and neurodegeneration in chronic stroke patients","volume":"17","author":"Schaechter","year":"2021","journal-title":"Brain Behav. Immun. Health"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.jad.2020.12.109","article-title":"Reconsidering the reasons for heightened inflammation in major depressive disorder","volume":"282","author":"Palmos","year":"2021","journal-title":"J. Affect. Disord."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.2174\/0929867326666190712091515","article-title":"Inflammation as the common biological link between depression and cardiovascular diseases: Can carnosine exert a protective role?","volume":"27","author":"Caruso","year":"2020","journal-title":"Curr. Med. Chem."},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Kadoya, M., and Koyama, H. (2019). Sleep, autonomic nervous function and atherosclerosis. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20040794"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"682","DOI":"10.12998\/wjcc.v3.i8.682","article-title":"Depressive symptoms in neurodegenerative diseases","volume":"3","author":"Baquero","year":"2015","journal-title":"World J. Clin. Cases"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1586\/14737175.6.1.65","article-title":"Late-life depression: A neuropsychiatric approach","volume":"6","author":"Burgut","year":"2006","journal-title":"Expert Rev. Neurother."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/ima.22089","article-title":"Structural brain changes in early-onset and late-onset depression: An update of volumetric MRI findings","volume":"24","author":"Tittmann","year":"2014","journal-title":"Int. J. Imaging Syst. Technol."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.jad.2014.04.040","article-title":"Corpus callosum size may predict late-life depression in women: A 10-year follow-up study","volume":"165","author":"Cyprien","year":"2014","journal-title":"J. Affect. Disord."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"781-e50","DOI":"10.1111\/ene.12651","article-title":"White matter lesions and temporal lobe atrophy related to incidence of both dementia and major depression in 70-year-olds followed over 10 years","volume":"22","author":"Gudmundsson","year":"2015","journal-title":"Eur. J. Neurol."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1017\/S003329170300758X","article-title":"Depression with late onset is associated with right frontal lobe atrophy","volume":"33","author":"Almeida","year":"2003","journal-title":"Psychol. Med."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1002\/gps.4649","article-title":"Factors associated with brain volume in major depression in older adults without dementia: Results from a large autopsy study","volume":"33","author":"Nunes","year":"2018","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1136\/jnnp-2013-307110","article-title":"Structural brain changes associated with depressive symptoms in the elderly with Alzheimer\u2019s disease","volume":"85","author":"Lebedeva","year":"2014","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.pneurobio.2012.05.009","article-title":"The neurobiology of depression in later-life: Clinical, neuropsychological, neuroimaging and pathophysiological features","volume":"98","author":"Naismith","year":"2012","journal-title":"Prog. Neurobiol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1002\/gps.4409","article-title":"High amyloid-beta deposition related to depressive symptoms in older individuals with normal cognition: A pilot study","volume":"31","author":"Yasuno","year":"2016","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.jagp.2015.12.003","article-title":"Amyloid hypothesis: Is there a role for antiamyloid treatment in late-life depression?","volume":"24","author":"Mahgoub","year":"2016","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1007\/s00259-013-2627-0","article-title":"Increased brain amyloid deposition in patients with a lifetime history of major depression: Evidenced on 18F-florbetapir (AV-45\/Amyvid) positron emission tomography","volume":"41","author":"Wu","year":"2014","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1007\/s00259-015-3291-3","article-title":"Beta-amyloid deposition and cognitive function in patients with major depressive disorder with different subtypes of mild cognitive impairment: (18)F-florbetapir (AV-45\/Amyvid) PET study","volume":"43","author":"Wu","year":"2016","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.neurobiolaging.2021.01.002","article-title":"Molecular imaging of beta-amyloid deposition in late-life depression","volume":"101","author":"Smith","year":"2021","journal-title":"Neurobiol. Aging"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.jad.2020.12.049","article-title":"Cerebral amyloid accumulation is associated with distinct structural and functional alterations in the brain of depressed elders with mild cognitive impairment","volume":"281","author":"Hyung","year":"2021","journal-title":"J. Affect. Disord."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.1038\/s41386-021-01072-9","article-title":"Default mode network dissociation linking cerebral beta amyloid retention and depression in cognitively normal older adults","volume":"46","author":"Wang","year":"2021","journal-title":"Neuropsychopharmacology"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/j.biopsych.2020.06.017","article-title":"Late-life depression is associated with reduced cortical amyloid burden: Findings from the Alzheimer\u2019s Disease Neuroimaging Initiative Depression Project","volume":"89","author":"Mackin","year":"2021","journal-title":"Biol. Psychiatry"},{"key":"ref_151","doi-asserted-by":"crossref","unstructured":"Pagni, G., Tagliarini, C., Carbone, M.G., Imbimbo, B.P., Marazziti, D., and Pomara, N. (2021). Different sides of depression in the elderly: An in-depth view on the role of Abeta peptides. Curr. Med. Chem.","DOI":"10.2174\/0929867328666210921164816"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1097\/JGP.0b013e3181df48be","article-title":"Plasma amyloid beta-42 independently predicts both late-onset depression and Alzheimer disease","volume":"18","author":"Blasko","year":"2010","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"e198964","DOI":"10.1001\/jamanetworkopen.2019.8964","article-title":"Longitudinal association of depression symptoms with cognition and cortical amyloid among community-dwelling older adults","volume":"2","author":"Gatchel","year":"2019","journal-title":"JAMA Netw. Open"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.archger.2012.10.008","article-title":"History of depression prior to Alzheimer\u2019s disease and vascular dementia verified post-mortem","volume":"56","author":"Passant","year":"2013","journal-title":"Arch. Gerontol. Geriatr."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"63","DOI":"10.3233\/JAD-142940","article-title":"Depressive symptoms and biomarkers of Alzheimer\u2019s disease in cognitively normal older adults","volume":"46","author":"Donovan","year":"2015","journal-title":"J. Alzheimers Dis."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"15981","DOI":"10.1038\/s41598-021-95206-0","article-title":"Lower regional gray matter volume in the absence of higher cortical amyloid burden in late-life depression","volume":"11","author":"Takamiya","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.jad.2020.09.062","article-title":"Beta-amyloid pathology is not associated with depression in a large community sample autopsy study","volume":"278","author":"Saldanha","year":"2021","journal-title":"J. Affect. Disord."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"279","DOI":"10.3389\/fphar.2020.00279","article-title":"Pathways connecting late-life depression and dementia","volume":"11","author":"Linnemann","year":"2020","journal-title":"Front. Pharmacol."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.jagp.2012.10.019","article-title":"A systematic review and meta-analysis of magnetic resonance imaging studies in late-life depression","volume":"21","author":"Sexton","year":"2013","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1016\/j.biopsych.2006.05.028","article-title":"Psychiatric disease in the twenty-first century: The case for subcortical ischemic depression","volume":"60","author":"Taylor","year":"2006","journal-title":"Biol. Psychiatry"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1002\/hbm.21445","article-title":"Fiber tract-specific white matter lesion severity Findings in late-life depression and by AGTR1 A1166C genotype","volume":"34","author":"Taylor","year":"2013","journal-title":"Hum. Brain Mapp."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1002\/gps.4129","article-title":"Diffusion tensor imaging studies in late-life depression: Systematic review and meta-analysis","volume":"29","author":"Wen","year":"2014","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1017\/S0033291714002517","article-title":"Corticostriatothalamic reward prediction error signals and executive control in late-life depression","volume":"45","author":"Dombrovski","year":"2015","journal-title":"Psychol. Med."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"101852","DOI":"10.1016\/j.nicl.2019.101852","article-title":"The impact of white matter hyperintensities on the structural connectome in late-life depression: Relationship to executive functions","volume":"23","author":"Respino","year":"2019","journal-title":"Neuroimage Clin."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"697489","DOI":"10.3389\/fpsyt.2021.697489","article-title":"Cortical thickness and hippocampal volume in vascular and non-vascular depressed patients","volume":"12","author":"Egglefield","year":"2021","journal-title":"Front. Psychiatry"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.jad.2016.06.031","article-title":"Disrupted orbitomedial prefrontal limbic network in individuals with later-life depression","volume":"204","author":"Harada","year":"2016","journal-title":"J. Affect. Disord."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jad.2017.06.063","article-title":"Corpus callosum macro and microstructure in late-life depression","volume":"222","author":"Emsell","year":"2017","journal-title":"J. Affect. Disord."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"110010","DOI":"10.1016\/j.pnpbp.2020.110010","article-title":"Neural substrates for late-life depression: A selective review of structural neuroimaging studies","volume":"104","author":"Kim","year":"2021","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1002\/gps.1596","article-title":"Relationship between periventricular and deep white matter lesions and depressive symptoms in older people. The LADIS Study","volume":"21","author":"Krishnan","year":"2006","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1002\/gps.4469","article-title":"Effects of white matter integrity and brain volumes on late life depression in the Framingham Heart Study","volume":"32","author":"Qiu","year":"2017","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.biopsych.2007.09.006","article-title":"White matter lesions as a predictor of depression in the elderly: The 3C-Dijon study","volume":"63","author":"Godin","year":"2008","journal-title":"Biol. Psychiatry"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/j.jad.2020.12.171","article-title":"Disentangling the pathologies linking white matter hyperintensity and geriatric depressive symptoms in subjects with different degrees of vascular impairment","volume":"282","author":"Zhang","year":"2021","journal-title":"J. Affect. Disord."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1002\/gps.5005","article-title":"Associations of white matter hyperintensities with poststroke depression: A 1-year longitudinal study","volume":"34","author":"Bae","year":"2019","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"102360","DOI":"10.1016\/j.nicl.2020.102360","article-title":"Microstructural changes in the reward system are associated with post-stroke depression","volume":"28","author":"Oestreich","year":"2020","journal-title":"Neuroimage Clin."},{"key":"ref_175","doi-asserted-by":"crossref","unstructured":"Weaver, N.A., Lim, J.S., Schilderinck, J., Biessels, G.J., Kang, Y., Kim, B.J., Kuijf, H.J., Lee, B.C., Lee, K.J., and Yu, K.H. (2021). Strategic infarct locations for post-stroke depressive symptoms: A lesion- and disconnection-symptom mapping study. Biol. Psychiatry Cogn. Neurosci. Neuroimaging.","DOI":"10.1101\/2021.05.05.442398"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1177\/2396987319883445","article-title":"Imaging markers associated with the development of post-stroke depression and apathy: Results of the Cognition and Affect after Stroke\u2013a Prospective Evaluation of Risks study","volume":"5","author":"Douven","year":"2020","journal-title":"Eur. Stroke J."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1192\/bjp.bp.111.098897","article-title":"Relationship between progression of brain white matter changes and late-life depression: 3-year results from the LADIS study","volume":"201","author":"Firbank","year":"2012","journal-title":"Br. J. Psychiatry"},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1136\/jnnp.2010.232413","article-title":"Location of cerebrovascular and degenerative changes, depressive symptoms and cognitive functioning in later life: The SMART-Medea study","volume":"82","author":"Grool","year":"2011","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/nrneurol.2015.10","article-title":"White matter hyperintensities, cognitive impairment and dementia: An update","volume":"11","author":"Prins","year":"2015","journal-title":"Nat. Rev. Neurol."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1212\/WNL.0000000000000882","article-title":"Depression in small-vessel disease relates to white matter ultrastructural damage, not disability","volume":"83","author":"Brookes","year":"2014","journal-title":"Neurology"},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"200","DOI":"10.4103\/2347-8659.167301","article-title":"Microstructural brain abnormalities, affective temperaments, and suicidal behavior in patients with major depression","volume":"2","author":"Serafini","year":"2015","journal-title":"Neuroimmunol. Neuroinflammation"},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.3233\/JAD-190890","article-title":"Alterations of white matter microstructure in subcortical vascular mild cognitive impairment with and without depressive symptoms","volume":"73","author":"Xu","year":"2020","journal-title":"J. Alzheimers Dis."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"249","DOI":"10.3389\/fpsyt.2020.00249","article-title":"Cognitive reserve moderates effects of white matter hyperintensity on depressive symptoms and cognitive function in late-life depression","volume":"11","author":"Lin","year":"2020","journal-title":"Front. Psychiatry"},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1038\/npp.2013.345","article-title":"Reconciling variable findings of white matter integrity in major depressive disorder","volume":"39","author":"Choi","year":"2014","journal-title":"Neuropsychopharmacology"},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1016\/j.jpsychires.2012.09.001","article-title":"DTI voxelwise analysis did not differentiate older depressed patients from older subjects without depression","volume":"46","author":"Bezerra","year":"2012","journal-title":"J. Psychiatr. Res."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s11682-018-9969-y","article-title":"Medial temporal lobe volumes in late-life depression: Effects of age and vascular risk factors","volume":"14","author":"Taylor","year":"2020","journal-title":"Brain Imaging Behav."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.jad.2016.08.070","article-title":"Cerebral vascular burden on hippocampal subfields in first-onset drug-na\u00c3\u00afve subjects with late-onset depression","volume":"208","author":"Choi","year":"2017","journal-title":"J. Affect. Disord."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jpsychires.2017.11.005","article-title":"Anterior-posterior gradient differences in lobar and cingulate cortex cerebral blood flow in late-life depression","volume":"97","author":"Boyd","year":"2018","journal-title":"J. Psychiatr. Res."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.brainresrev.2009.08.003","article-title":"The impact of vascular burden on late-life depression","volume":"62","author":"Santos","year":"2009","journal-title":"Brain Res. Rev."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/s00401-012-1021-5","article-title":"Neuropathological substrates and structural changes in late-life depression: The impact of vascular burden","volume":"124","author":"Xekardaki","year":"2012","journal-title":"Acta Neuropathol."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1192\/bjp.bp.110.078816","article-title":"Neuropathological correlates of late-life depression in older people","volume":"198","author":"Tsopelas","year":"2011","journal-title":"Br. J. Psychiatry"},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1586\/ern.11.88","article-title":"Neuropathological correlates of late-life depression","volume":"11","author":"Beekman","year":"2011","journal-title":"Expert Rev. Neurother."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1212\/01.WNL.0000092914.04345.97","article-title":"Depressive symptoms, clinical AD, and cortical plaques and tangles in older persons","volume":"61","author":"Wilson","year":"2003","journal-title":"Neurology"},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jpsychires.2015.10.010","article-title":"Evidence for alterations of the glial syncytial function in major depressive disorder","volume":"72","author":"Medina","year":"2016","journal-title":"J. Psychiatr. Res."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.1017\/S1041610212000828","article-title":"The role of glia in late-life depression","volume":"24","author":"Paradise","year":"2012","journal-title":"Int. Psychogeriatr."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1002\/gps.2672","article-title":"The inflammation hypothesis in geriatric depression","volume":"26","author":"Alexopoulos","year":"2011","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.jagp.2012.10.026","article-title":"Involvement of brain-derived neurotrophic factor in late-life depression","volume":"21","author":"Dwivedi","year":"2013","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/978-981-33-6044-0_14","article-title":"The role of neurotrophic factors in pathophysiology of major depressive disorder","volume":"1305","author":"Amidfar","year":"2021","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/s41398-021-01248-3","article-title":"Genome-wide analysis suggests the importance of vascular processes and neuroinflammation in late-life antidepressant response","volume":"11","author":"Marshe","year":"2021","journal-title":"Transl. Psychiatry"},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1001\/jamapsychiatry.2020.3436","article-title":"Dissecting the association between inflammation, metabolic dysregulation, and specific depressive symptoms: A genetic correlation and 2-sample mendelian randomization study","volume":"78","author":"Kappelmann","year":"2021","journal-title":"JAMA Psychiatry"},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.bbi.2021.03.024","article-title":"Polygenic risk for immuno-metabolic markers and specific depressive symptoms: A multi-sample network analysis study","volume":"95","author":"Kappelmann","year":"2021","journal-title":"Brain Behav. Immun."},{"key":"ref_202","unstructured":"Steffens, D.C., Garrett, M.E., Soldano, K.L., McQuoid, D.R., Ashley-Koch, A.E., and Potter, G.G. (2020). Genome-wide screen to identify genetic loci associated with cognitive decline in late-life depression. Int. Psychogeriatr."},{"key":"ref_203","doi-asserted-by":"crossref","unstructured":"Westermair, A.L., Munz, M., Schaich, A., Nitsche, S., Willenborg, B., Mu\u00f1oz Venegas, L.M., Willenborg, C., Schunkert, H., Schweiger, U., and Erdmann, J. (2018). Association of genetic variation at aqp4 locus with vascular depression. Biomolecules, 8.","DOI":"10.3390\/biom8040164"},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1161\/STROKEAHA.118.020811","article-title":"Genetic study of white matter integrity in UK biobank (n = 8448) and the overlap with stroke, depression, and dementia","volume":"49","author":"Tozer","year":"2018","journal-title":"Stroke"},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.pscychresns.2011.04.008","article-title":"Cellular pathology within the anterior cingulate cortex of patients with late-life depression: A morphometric study","volume":"194","author":"Khundakar","year":"2011","journal-title":"Psychiatry Res."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.jagp.2013.06.003","article-title":"Cellular morphometry in late-life depression: A review of postmortem studies","volume":"22","author":"Khundakar","year":"2014","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0165-0327(02)00349-X","article-title":"Depression and vascular disease: What is the relationship?","volume":"79","author":"Thomas","year":"2004","journal-title":"J. Affect. Disord."},{"key":"ref_208","doi-asserted-by":"crossref","unstructured":"Van Dooren, F.E., Nefs, G., Schram, M.T., Verhey, F.R., Denollet, J., and Pouwer, F. (2013). Depression and risk of mortality in people with diabetes mellitus: A systematic review and meta-analysis. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0057058"},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.jamda.2014.10.023","article-title":"Depression, frailty, and all-cause mortality: A cohort study of men older than 75 years","volume":"16","author":"Almeida","year":"2015","journal-title":"J. Am. Med. Dir. Assoc."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1001\/archgenpsychiatry.2009.204","article-title":"Support for the vascular depression hypothesis in late-life depression: Results of a 2-site, prospective, antidepressant treatment trial","volume":"67","author":"Sheline","year":"2010","journal-title":"Arch. Gen. Psychiatry"},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1176\/appi.ajp.2014.14070889","article-title":"Citalopram, methylphenidate, or their combination in geriatric depression: A randomized, double-blind, placebo-controlled trial","volume":"172","author":"Lavretsky","year":"2015","journal-title":"Am. J. Psychiatry"},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1002\/gps.5536","article-title":"Methylphenidate use in geriatric depression: A systematic review","volume":"36","author":"Smith","year":"2021","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1176\/appi.ajp.2011.10081165","article-title":"A systematic review of treatments for refractory depression in older people","volume":"168","author":"Cooper","year":"2011","journal-title":"Am. J. Psychiatry"},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"2404","DOI":"10.1016\/S0140-6736(15)00308-6","article-title":"Efficacy, safety, and tolerability of augmentation pharmacotherapy with aripiprazole for treatment-resistant depression in late life: A randomised, double-blind, placebo-controlled trial","volume":"386","author":"Lenze","year":"2015","journal-title":"Lancet"},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1001\/archgenpsychiatry.2010.184","article-title":"Maintenance treatment of depression in old age: A randomized, double-blind, placebo-controlled evaluation of the efficacy and safety of donepezil combined with antidepressant pharmacotherapy","volume":"68","author":"Reynolds","year":"2011","journal-title":"Arch. Gen. Psychiatry"},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1177\/0891988720915515","article-title":"Predictors of cognitive improvement following treatment for late-life depression","volume":"34","author":"Siddarth","year":"2021","journal-title":"J. Geriatr. Psychiatry Neurol."},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1192\/bjp.bp.114.148213","article-title":"Speed of remission in elderly patients with depression: Electroconvulsive therapy v. medication","volume":"206","author":"Spaans","year":"2015","journal-title":"Br. J. Psychiatry"},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1002\/gps.4754","article-title":"Vascular risk factors in older patients with depression: Outcome of electroconvulsive therapy versus medication","volume":"33","author":"Spaans","year":"2018","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.jad.2020.10.025","article-title":"Impact of vascular risk factors on clinical outcome in elderly patients with depression receiving electroconvulsive therapy","volume":"279","author":"Jurek","year":"2021","journal-title":"J. Affect. Disord."},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"e238922","DOI":"10.1136\/bcr-2020-238922","article-title":"Successful electroconvulsive therapy for depression in a man with cerebral amyloid angiopathy","volume":"14","author":"Schurgers","year":"2021","journal-title":"BMJ Case Rep."},{"key":"ref_221","first-page":"403","article-title":"Vascular depression with melancholic symptoms: Response to electroconvulsive therapy","volume":"35","year":"2007","journal-title":"Actas Esp. Psiquiatr."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"2792","DOI":"10.1016\/j.jstrokecerebrovasdis.2016.08.043","article-title":"Repetitive transcranial magnetic stimulation for depression due to cerebrovascular disease: A systematic review","volume":"25","author":"McIntyre","year":"2016","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1007\/s40473-017-0108-7","article-title":"Network-guided transcranial magnetic stimulation for depression","volume":"4","author":"Dubin","year":"2017","journal-title":"Curr. Behav. Neurosci. Rep."},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1038\/s41386-018-0121-x","article-title":"Efficacy, tolerability, and cognitive effects of deep transcranial magnetic stimulation for late-life depression: A prospective randomized controlled trial","volume":"43","author":"Kaster","year":"2018","journal-title":"Neuropsychopharmacology"},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1001\/archgenpsychiatry.2007.45","article-title":"Treatment of vascular depression using repetitive transcranial magnetic stimulation","volume":"65","author":"Jorge","year":"2008","journal-title":"Arch. Gen. Psychiatry"},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1017\/S1041610205001493","article-title":"A double-blind, randomized clinical trial to assess the augmentation with nimodipine of antidepressant therapy in the treatment of \u201cvascular depression\u201d","volume":"17","author":"Taragano","year":"2005","journal-title":"Int. Psychogeriatr."},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/S2213-8587(15)00045-5","article-title":"Depression and diabetes: Treatment and health-care delivery","volume":"3","author":"Petrak","year":"2015","journal-title":"Lancet Diabetes Endocrinol."},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.2337\/dbi17-0044","article-title":"Microvascular dysfunction and hyperglycemia: A vicious cycle with widespread consequences","volume":"67","author":"Stehouwer","year":"2018","journal-title":"Diabetes"},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1176\/appi.focus.20210006","article-title":"Late life depression: The essentials and the essential distinctions","volume":"19","author":"Ellison","year":"2021","journal-title":"Focus"},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/7854_2016_26","article-title":"The promise and limitations of anti-inflammatory agents for the treatment of major depressive disorder","volume":"31","author":"Raison","year":"2017","journal-title":"Curr. Top. Behav. Neurosci."},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/j.jagp.2016.06.010","article-title":"Executive dysfunction predicts treatment response to neuroplasticity-based computerized cognitive remediation (nCCR-GD) in elderly patients with major depression","volume":"24","author":"Morimoto","year":"2016","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"ref_232","doi-asserted-by":"crossref","unstructured":"Dafsari, F.S., Bewernick, B., Biewer, M., Christ, H., Domschke, K., Froelich, L., Hellmich, M., Luppa, M., Peters, O., and Ramirez, A. (2019). Cognitive behavioural therapy for the treatment of late life depression: Study protocol of a multicentre, randomized, observer-blinded, controlled trial (CBTlate). BMC Psychiatry, 19.","DOI":"10.1186\/s12888-019-2412-0"}],"updated-by":[{"DOI":"10.3390\/ijms232112949","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2021,12,28]],"date-time":"2021-12-28T00:00:00Z","timestamp":1640649600000}}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/1\/308\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,3]],"date-time":"2025-08-03T22:15:43Z","timestamp":1754259343000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/1\/308"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,28]]},"references-count":232,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,1]]}},"alternative-id":["ijms23010308"],"URL":"https:\/\/doi.org\/10.3390\/ijms23010308","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,28]]}}}