{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T10:57:14Z","timestamp":1788433034929,"version":"build-2803163510"},"reference-count":74,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2021,12,31]],"date-time":"2021-12-31T00:00:00Z","timestamp":1640908800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fond d\u2019Investissement pour la Recherche Scientifique\u201d (FIRS)","award":["2016"],"award-info":[{"award-number":["2016"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>An inflamed synovial membrane plays a major role in joint destruction and is characterized by immune cells infiltration and fibroblast proliferation. This proteomic study considers the inflammatory process at the molecular level by analyzing synovial biopsies presenting a histological inflammatory continuum throughout different arthritis joint diseases. Knee synovial biopsies were obtained from osteoarthritis (OA; n = 9), chronic pyrophosphate arthropathy (CPPA; n = 7) or rheumatoid arthritis (RA; n = 8) patients. The histological inflammatory score was determined using a semi-quantitative scale based on synovial hyperplasia, lymphocytes, plasmocytes, neutrophils and macrophages infiltration. Proteomic analysis was performed by liquid chromatography-mass spectrometry (LC-MS\/MS). Differentially expressed proteins were confirmed by immunohistochemistry. Out of the 1871 proteins identified and quantified by LC-MS\/MS, 10 proteins (LAP3, MANF, LCP1, CTSZ, PTPRC, DNAJB11, EML4, SCARA5, EIF3K, C1orf123) were differentially expressed in the synovial membrane of at least one of the three disease groups (RA, OA and CPPA). Significant increased expression of the seven first proteins was detected in RA and correlated to the histological inflammatory score. Proteomics is therefore a powerful tool that provides a molecular pattern to the classical histology usually applied for synovitis characterization. Except for LCP1, CTSZ and PTPRC, all proteins have never been described in human synovitis.<\/jats:p>","DOI":"10.3390\/ijms23010434","type":"journal-article","created":{"date-parts":[[2022,1,3]],"date-time":"2022-01-03T20:49:38Z","timestamp":1641242978000},"page":"434","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["New Proteins Contributing to Immune Cell Infiltration and Pannus Formation of Synovial Membrane from Arthritis Diseases"],"prefix":"10.3390","volume":"23","author":[{"given":"Dominique","family":"de Seny","sequence":"first","affiliation":[{"name":"Laboratory and Service of Rheumatology, GIGA Research, Centre Hospitalier Universitaire de Li\u00e8ge, University of Li\u00e8ge, 4000 Li\u00e8ge, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1622-0118","authenticated-orcid":false,"given":"Dominique","family":"Baiwir","sequence":"additional","affiliation":[{"name":"GIGA Proteomics Facility, University of Li\u00e8ge, 4000 Li\u00e8ge, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elettra","family":"Bianchi","sequence":"additional","affiliation":[{"name":"Department of Pathology, GIGA Research, Centre Hospitalier Universitaire de Li\u00e8ge, University of Li\u00e8ge, 4000 Li\u00e8ge, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ga\u00ebl","family":"Cobraiville","sequence":"additional","affiliation":[{"name":"Laboratory and Service of Rheumatology, GIGA Research, Centre Hospitalier Universitaire de Li\u00e8ge, University of Li\u00e8ge, 4000 Li\u00e8ge, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9line","family":"Deroyer","sequence":"additional","affiliation":[{"name":"Laboratory and Service of Rheumatology, GIGA Research, Centre Hospitalier Universitaire de Li\u00e8ge, University of Li\u00e8ge, 4000 Li\u00e8ge, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4055-5441","authenticated-orcid":false,"given":"Christophe","family":"Poulet","sequence":"additional","affiliation":[{"name":"Laboratory and Service of Rheumatology, GIGA Research, Centre Hospitalier Universitaire de Li\u00e8ge, University of Li\u00e8ge, 4000 Li\u00e8ge, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2799-2949","authenticated-orcid":false,"given":"Olivier","family":"Malaise","sequence":"additional","affiliation":[{"name":"Laboratory and Service of Rheumatology, GIGA Research, Centre Hospitalier Universitaire de Li\u00e8ge, University of Li\u00e8ge, 4000 Li\u00e8ge, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genevi\u00e8ve","family":"Paulissen","sequence":"additional","affiliation":[{"name":"Laboratory and Service of Rheumatology, GIGA Research, Centre Hospitalier Universitaire de Li\u00e8ge, University of Li\u00e8ge, 4000 Li\u00e8ge, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Jo\u00eblle","family":"Kaiser","sequence":"additional","affiliation":[{"name":"Laboratory and Service of Rheumatology, GIGA Research, Centre Hospitalier Universitaire de Li\u00e8ge, University of Li\u00e8ge, 4000 Li\u00e8ge, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Philippe","family":"Hauzeur","sequence":"additional","affiliation":[{"name":"Laboratory and Service of Rheumatology, GIGA Research, Centre Hospitalier Universitaire de Li\u00e8ge, University of Li\u00e8ge, 4000 Li\u00e8ge, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8757-8133","authenticated-orcid":false,"given":"Gabriel","family":"Mazzucchelli","sequence":"additional","affiliation":[{"name":"Mass Spectrometry Laboratory, MolSys Research Unit, University of Li\u00e8ge, 4000 Li\u00e8ge, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Delvenne","sequence":"additional","affiliation":[{"name":"GIGA Proteomics Facility, University of Li\u00e8ge, 4000 Li\u00e8ge, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Malaise","sequence":"additional","affiliation":[{"name":"Laboratory and Service of Rheumatology, GIGA Research, Centre Hospitalier Universitaire de Li\u00e8ge, University of Li\u00e8ge, 4000 Li\u00e8ge, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"100","DOI":"10.2174\/1874312901105010100","article-title":"The Normal Synovium","volume":"5","author":"Smith","year":"2011","journal-title":"Open Rheumatol. 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