{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T14:06:03Z","timestamp":1789049163491,"version":"build-2803163510"},"reference-count":53,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T00:00:00Z","timestamp":1641254400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003549","name":"Hungarian Scientific Research Fund","doi-asserted-by":"publisher","award":["K128736"],"award-info":[{"award-number":["K128736"]}],"id":[{"id":"10.13039\/501100003549","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003549","name":"Hungarian Scientific Research Fund","doi-asserted-by":"publisher","award":["FK134355"],"award-info":[{"award-number":["FK134355"]}],"id":[{"id":"10.13039\/501100003549","id-type":"DOI","asserted-by":"publisher"}]},{"name":"EU Horizon 2020 Research and Innovation Program","award":["739593"],"award-info":[{"award-number":["739593"]}]},{"name":"Hungarian Research Development, Innovation Office grant","award":["EFOP-3.6.1-16-2016-00008"],"award-info":[{"award-number":["EFOP-3.6.1-16-2016-00008"]}]},{"name":"Bolyai J\u00e1nos Research Fellowship.","award":["\u00daNKP-20-5"],"award-info":[{"award-number":["\u00daNKP-20-5"]}]},{"name":"New National Excellence Program of the Hungarian Ministry for Innovation and Technology from the source of the National Research Development and Innovation Fund","award":["\u00daNKP-21-3"],"award-info":[{"award-number":["\u00daNKP-21-3"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Psoriasis is a multifactorial, chronic inflammatory skin disease, the development of which is affected by both genetic and environmental factors. Cytosolic nucleic acid fragments, recognized as pathogen- and danger-associated molecular patterns, are highly abundant in psoriatic skin. It is known that psoriatic skin exhibits increased levels of IL-23 compared to healthy skin. However, the relationship between free nucleic acid levels and IL-23 expression has not been clarified yet. To examine a molecular mechanism by which nucleic acids potentially modulate IL-23 levels, an in vitro system was developed to investigate the IL-23 mRNA expression of normal human epidermal keratinocytes under psoriasis-like circumstances. This system was established using synthetic nucleic acid analogues (poly(dA:dT) and poly(I:C)). Signaling pathways, receptor involvement and the effect of PRINS, a long non-coding RNA previously identified and characterized by our research group, were analyzed to better understand the regulation of IL-23 in keratinocytes. Our results indicate that free nucleic acids regulate epithelial IL-23 mRNA expression through the TLR3 receptor and specific signaling pathways, thereby, contributing to the development of an inflammatory milieu favorable for the appearance of psoriatic symptoms. A moderate negative correlation was confirmed between the nucleic-acid-induced IL-23 mRNA level and the rate of its decrease upon PRINS overexpression.<\/jats:p>","DOI":"10.3390\/ijms23010540","type":"journal-article","created":{"date-parts":[[2022,1,7]],"date-time":"2022-01-07T01:15:26Z","timestamp":1641518126000},"page":"540","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Psoriasis-Associated Inflammatory Conditions Induce IL-23 mRNA Expression in Normal Human Epidermal Keratinocytes"],"prefix":"10.3390","volume":"23","author":[{"given":"Evelyn","family":"Kelemen","sequence":"first","affiliation":[{"name":"Department of Dermatology and Allergology, University of Szeged, 6720 Szeged, Hungary"},{"name":"Department of Medical Genetics, University of Szeged, 6720 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c9va","family":"\u00c1d\u00e1m","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, University of Szeged, 6720 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stella M\u00e1rta","family":"S\u00e1gi","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology, University of Szeged, 6720 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anik\u00f3","family":"G\u00f6bl\u00f6s","sequence":"additional","affiliation":[{"name":"MTA-SZTE Dermatological Research Group, E\u00f6tv\u00f6s Lor\u00e1nd Research Network, 6720 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2119-9501","authenticated-orcid":false,"given":"Lajos","family":"Kem\u00e9ny","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology, University of Szeged, 6720 Szeged, Hungary"},{"name":"MTA-SZTE Dermatological Research Group, E\u00f6tv\u00f6s Lor\u00e1nd Research Network, 6720 Szeged, Hungary"},{"name":"HCEMM-USZ Skin Research Group, 6720 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zsuzsanna","family":"Bata-Cs\u00f6rg\u0151","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology, University of Szeged, 6720 Szeged, Hungary"},{"name":"MTA-SZTE Dermatological Research Group, E\u00f6tv\u00f6s Lor\u00e1nd Research Network, 6720 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rta","family":"Sz\u00e9ll","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, University of Szeged, 6720 Szeged, Hungary"},{"name":"MTA-SZTE Dermatological Research Group, E\u00f6tv\u00f6s Lor\u00e1nd Research Network, 6720 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0270-5309","authenticated-orcid":false,"given":"Judit","family":"Danis","sequence":"additional","affiliation":[{"name":"MTA-SZTE Dermatological Research Group, E\u00f6tv\u00f6s Lor\u00e1nd Research Network, 6720 Szeged, Hungary"},{"name":"HCEMM-USZ Skin Research Group, 6720 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"a015354","DOI":"10.1101\/cshperspect.a015354","article-title":"Psoriasis","volume":"4","author":"Meglio","year":"2014","journal-title":"Cold Springs Harb. 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