{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:07:55Z","timestamp":1790726875525,"version":"4.1.0"},"reference-count":79,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2022,1,6]],"date-time":"2022-01-06T00:00:00Z","timestamp":1641427200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of Liverpool (MRes studentships L.B, E.T., A.B.)","award":["NO"],"award-info":[{"award-number":["NO"]}]},{"name":"Liverpool Women\u2019s Hospital NHS Trust (Research and development J.D.)","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]},{"name":"Higher Committee for Education Development in Iraq (R.A.)","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]},{"name":"Wellbeing of Women\u2019s","award":["grants RG1487 and RG2137"],"award-info":[{"award-number":["grants RG1487 and RG2137"]}]},{"name":"Northwest Cancer Research","award":["RDG2021.18"],"award-info":[{"award-number":["RDG2021.18"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Risk of relapse of endometrial cancer (EC) after surgical treatment is 13% and recurrent disease carries a poor prognosis. Research into prognostic indicators is essential to improve EC management and outcome. \u201cImmortality\u201d of most cancer cells is dependent on telomerase, but the role of associated proteins in the endometrium is poorly understood. The Cancer Genome Atlas data highlighted telomere\/telomerase associated genes (TTAGs) with prognostic relevance in the endometrium, and a recent in silico study identified a group of TTAGs and proteins as key regulators within a network of dysregulated genes in EC. We characterise relevant telomere\/telomerase associated proteins (TTAPs) NOP10, NHP2, NOP56, TERF1, TERF2 and TERF2IP in the endometrium using quantitative polymerase chain reaction (qPCR) and immunohistochemistry (IHC). qPCR data demonstrated altered expression of multiple TTAPs; specifically, increased NOP10 (p = 0.03) and reduced NHP2 (p = 0.01), TERF2 (p = 0.01) and TERF2IP (p &lt; 0.003) in EC relative to post-menopausal endometrium. Notably, we report reduced NHP2 in EC compared to post-menopausal endometrium in qPCR and IHC (p = 0.0001) data; with survival analysis indicating high immunoscore is favourable in EC (p = 0.0006). Our findings indicate a potential prognostic role for TTAPs in EC, particularly NHP2. Further evaluation of the prognostic and functional role of the examined TTAPs is warranted to develop novel treatment strategies.<\/jats:p>","DOI":"10.3390\/ijms23020626","type":"journal-article","created":{"date-parts":[[2022,1,7]],"date-time":"2022-01-07T01:15:26Z","timestamp":1641518126000},"page":"626","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Telomere and Telomerase-Associated Proteins in Endometrial Carcinogenesis and Cancer-Associated Survival"],"prefix":"10.3390","volume":"23","author":[{"given":"Lucy","family":"Button","sequence":"first","affiliation":[{"name":"Centre for Women\u2019s Health Research, Department of Women\u2019s and Children\u2019s Health, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool L8 7SS, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryony","family":"Rogers","sequence":"additional","affiliation":[{"name":"Centre for Women\u2019s Health Research, Department of Women\u2019s and Children\u2019s Health, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool L8 7SS, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Thomas","sequence":"additional","affiliation":[{"name":"Centre for Women\u2019s Health Research, Department of Women\u2019s and Children\u2019s Health, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool L8 7SS, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Bradfield","sequence":"additional","affiliation":[{"name":"Liverpool Women\u2019s NHS Foundation Trust, Liverpool L8 7SS, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafah","family":"Alnafakh","sequence":"additional","affiliation":[{"name":"Centre for Women\u2019s Health Research, Department of Women\u2019s and Children\u2019s Health, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool L8 7SS, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2275-6664","authenticated-orcid":false,"given":"Josephine","family":"Drury","sequence":"additional","affiliation":[{"name":"Centre for Women\u2019s Health Research, Department of Women\u2019s and Children\u2019s Health, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool L8 7SS, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0270-0150","authenticated-orcid":false,"given":"Dharani K.","family":"Hapangama","sequence":"additional","affiliation":[{"name":"Centre for Women\u2019s Health Research, Department of Women\u2019s and Children\u2019s Health, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool L8 7SS, UK"},{"name":"Liverpool Women\u2019s NHS Foundation Trust, Liverpool L8 7SS, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/S0140-6736(05)67063-8","article-title":"Endometrial cancer","volume":"366","author":"Amant","year":"2005","journal-title":"Lancet"},{"key":"ref_2","unstructured":"(2021, October 10). 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