{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T07:43:13Z","timestamp":1778226193536,"version":"3.51.4"},"reference-count":161,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2022,1,10]],"date-time":"2022-01-10T00:00:00Z","timestamp":1641772800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Lions Eye Institute (LSC)","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]},{"name":"the Australian Government Research Training Program Stipend and Fees Offset Scholarship","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Inherited retinal diseases (IRDs) are a leading cause of blindness. To date, 260 disease-causing genes have been identified, but there is currently a lack of available and effective treatment options. Cone photoreceptors are responsible for daylight vision but are highly susceptible to disease progression, the loss of cone-mediated vision having the highest impact on the quality of life of IRD patients. Cone degeneration can occur either directly via mutations in cone-specific genes (primary cone death), or indirectly via the primary degeneration of rods followed by subsequent degeneration of cones (secondary cone death). How cones degenerate as a result of pathological mutations remains unclear, hindering the development of effective therapies for IRDs. This review aims to highlight similarities and differences between primary and secondary cone cell death in inherited retinal diseases in order to better define cone death mechanisms and further identify potential treatment options.<\/jats:p>","DOI":"10.3390\/ijms23020726","type":"journal-article","created":{"date-parts":[[2022,1,10]],"date-time":"2022-01-10T17:42:25Z","timestamp":1641836545000},"page":"726","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Primary and Secondary Cone Cell Death Mechanisms in Inherited Retinal Diseases and Potential Treatment Options"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2153-1866","authenticated-orcid":false,"given":"Alicia A.","family":"Brunet","sequence":"first","affiliation":[{"name":"Centre for Ophthalmology and Visual Sciences, The University of Western Australia, 35 Stirling Hwy, Crawley, WA 6009, Australia"},{"name":"Lions Eye Institute Ltd., 2 Verdun St, Nedlands, WA 6009, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2590-831X","authenticated-orcid":false,"given":"Alan R.","family":"Harvey","sequence":"additional","affiliation":[{"name":"School of Human Sciences, The University of Western Australia, 35 Stirling Hwy, Crawley, WA 6009, Australia"},{"name":"Perron Institute for Neurological and Translational Science, 8 Verdun St, Nedlands, WA 6009, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3909-5778","authenticated-orcid":false,"given":"Livia S.","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Centre for Ophthalmology and Visual Sciences, The University of Western Australia, 35 Stirling Hwy, Crawley, WA 6009, Australia"},{"name":"Lions Eye Institute Ltd., 2 Verdun St, Nedlands, WA 6009, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,10]]},"reference":[{"key":"ref_1","unstructured":"The University of Texas Health Science Center (2021, July 01). Retinal Information Network. Available online: https:\/\/sph.uth.edu\/retnet\/."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1136\/bjophthalmol-2013-303993","article-title":"Mortality and hospital morbidity of working-age blind","volume":"97","author":"Crewe","year":"2013","journal-title":"Br. J. Ophthalmol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1080\/17441692.2011.634815","article-title":"An estimation of the worldwide economic and health burden of visual impairment","volume":"7","author":"Gordois","year":"2012","journal-title":"Glob. Public Heal."},{"key":"ref_4","unstructured":"U.S. Food and Drug Administration (2021, July 01). LUXTURNA, Available online: https:\/\/www.fda.gov\/vaccines-blood-biologics\/cellular-gene-therapy-products\/luxturna."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1093\/biostatistics\/kxx069","article-title":"Estimation of clinical trial success rates and related parameters","volume":"20","author":"Wong","year":"2019","journal-title":"Biostatistics"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1126\/science.aaf4770","article-title":"Paying for future success in gene therapy","volume":"352","author":"Orkin","year":"2016","journal-title":"Science"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1111\/j.1442-9071.2010.02466.x","article-title":"Quality of life of the most severely vision-impaired","volume":"39","author":"Crewe","year":"2011","journal-title":"Clin. Exp. Ophthalmol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.cbpa.2008.04.600","article-title":"Rod and cone photoreceptors: Molecular basis of the difference in their physiology","volume":"150","author":"Kawamura","year":"2008","journal-title":"Comp. Biochem. Physiol. Part A Mol. Integr. Physiol."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Carvalho, L.S., and Vandenberghe, L.H. (2016). Understanding Cone Photoreceptor Cell Death in Achromatopsia. Retinal Degenerative Diseases, Springer.","DOI":"10.1007\/978-3-319-17121-0_31"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1167\/tvst.7.4.6","article-title":"Inherited Retinal Degenerations: Current Landscape and Knowledge Gaps","volume":"7","author":"Duncan","year":"2018","journal-title":"Transl. Vis. Sci. Technol."},{"key":"ref_11","unstructured":"Adam, M.P. (2018). Achromatopsia. GeneReviews\u00ae, University of Washington."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1097\/IIO.0000000000000256","article-title":"Retinitis Pigmentosa: Review of Current Treatment","volume":"59","author":"Wang","year":"2019","journal-title":"Int. Ophthalmol. Clin."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1080\/13816810.2018.1495745","article-title":"Gene therapy in inherited retinal degenerative diseases, a review","volume":"39","author":"Takahashi","year":"2018","journal-title":"Ophthalmic Genet."},{"key":"ref_14","first-page":"27","article-title":"Mouse Models for Studies of Retinal Degeneration and Diseases","volume":"935","author":"Chang","year":"2012","journal-title":"Springer Protoc. Handb."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1073\/pnas.10.7.329","article-title":"The Inheritance of a Retinal Abnormality in White Mice","volume":"10","author":"Keeler","year":"1924","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Collin, G.B., Gogna, N., Chang, B., Damkham, N., Pinkney, J., Hyde, L.F., Stone, L., Naggert, J.K., Nishina, P.M., and Krebs, M.P. (2020). Mouse Models of Inherited Retinal Degeneration with Photoreceptor Cell Loss. Cells, 9.","DOI":"10.3390\/cells9040931"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Winkler, P.A., Occelli, L.M., and Petersen-Jones, S.M. (2020). Large Animal Models of Inherited Retinal Degenerations: A Review. Cells, 9.","DOI":"10.3390\/cells9040882"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.ceb.2004.09.011","article-title":"Death by design: Apoptosis, necrosis and autophagy","volume":"16","author":"Edinger","year":"2004","journal-title":"Curr. Opin. Cell Biol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"a006080","DOI":"10.1101\/cshperspect.a006080","article-title":"Cell death signaling","volume":"7","author":"Green","year":"2015","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/bjc.1972.33","article-title":"Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics","volume":"26","author":"Kerr","year":"1972","journal-title":"Br. J. Cancer"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2529","DOI":"10.1097\/00001756-199412000-00031","article-title":"Immunohistochemical evidence for apoptosis in Alzheimer\u2019s disease","volume":"5","author":"Su","year":"1994","journal-title":"Neuroreport"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/0022-510X(95)00336-Z","article-title":"Histochemical detection of apoptosis in Parkinson\u2019s disease","volume":"137","author":"Mochizuki","year":"1996","journal-title":"J. Neurol. Sci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2602","DOI":"10.1073\/pnas.0409402102","article-title":"Disturbed Ca2+ signaling and apoptosis of medium spiny neurons in Huntington\u2019s disease","volume":"102","author":"Tang","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1002\/hep.1840210534","article-title":"In situ detection of fragmented dna (tunel assay) fails to discriminate among apoptosis, necrosis, and autolytic cell death: A cautionary note","volume":"21","author":"Kraupp","year":"1995","journal-title":"Hepatology"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"24572","DOI":"10.18632\/oncotarget.8249","article-title":"Fas-associated protein with death domain (FADD) regulates autophagy through promoting the expression of Ras homolog enriched in brain (Rheb) in human breast adenocarcinoma cells","volume":"7","author":"He","year":"2016","journal-title":"Oncotarget"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"16677","DOI":"10.1073\/pnas.0808597105","article-title":"FADD and caspase-8 control the outcome of autophagic signaling in proliferating T cells","volume":"105","author":"Bell","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1167\/iovs.04-1503","article-title":"Impaired opsin targeting and cone photoreceptor migration in the retina of mice lacking the cyclic nucle-otide-gated channel CNGA3","volume":"46","author":"Michalakis","year":"2005","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"18018","DOI":"10.1074\/jbc.M112.342220","article-title":"Endoplasmic Reticulum Stress-associated Cone Photoreceptor Degeneration in Cyclic Nucleotide-gated Channel Deficiency","volume":"287","author":"Thapa","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"20880","DOI":"10.1074\/jbc.M115.641159","article-title":"cGMP\/Protein Kinase G Signaling Suppresses Inositol 1,4,5-Trisphosphate Receptor Phosphorylation and Promotes Endoplasmic Reticulum Stress in Photoreceptors of Cyclic Nucleotide-gated Channel-deficient Mice","volume":"290","author":"Ma","year":"2015","journal-title":"J. Biol. Chem."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1002\/cne.24807","article-title":"Systematic spatiotemporal mapping reveals divergent cell death pathways in three mouse models of hered-itary retinal degeneration","volume":"528","author":"Power","year":"2020","journal-title":"J. Comp. Neurol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1006\/mcne.2001.1036","article-title":"Characterization of Cell Death Pathways in Murine Retinal Neurodegeneration Implicates Cytochrome c Release, Caspase Activation, and Bid Cleavage","volume":"18","author":"Jomary","year":"2001","journal-title":"Mol. Cell. Neurosci."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Sharma, A.K., and Rohrer, B. (2004). Calcium-Induced Calpain Mediates Apoptosis via Caspase-3 in a Mouse Photoreceptor Cell Line, Elsevier.","DOI":"10.1074\/jbc.M401037200"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"17366","DOI":"10.1073\/pnas.0606276103","article-title":"Apoptosis in retinal degeneration involves cross-talk between apoptosis-inducing factor (AIF) and caspase-12 and is blocked by calpain inhibitors","volume":"103","author":"Sanges","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1007\/978-1-4419-1399-9_56","article-title":"Do calcium channel blockers rescue dying photoreceptors in the Pde6b rd1 mouse?","volume":"664","author":"Barabas","year":"2010","journal-title":"Retin. Degener. Dis."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1080\/02713680601161238","article-title":"Sustained Elevation of Intracellular cGMP Causes Oxidative Stress Triggering Calpain-Mediated Apoptosis in Photoreceptor Degeneration","volume":"32","author":"Sharma","year":"2007","journal-title":"Curr. Eye Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1007\/s00417-002-0427-5","article-title":"Caspase-3 inhibitor transiently delays inherited retinal degeneration in C3H mice carrying the rd gene","volume":"240","author":"Yoshizawa","year":"2002","journal-title":"Graefe\u2019s Arch. Clin. Exp. Ophthalmol."},{"key":"ref_37","first-page":"4188","article-title":"Comparative analysis of neurodegenerative markers in ten different animal models for retinal degeneration reveals prevalence of non-apoptotic cell death mechanisms","volume":"54","author":"Sahaboglu","year":"2013","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_38","first-page":"944","article-title":"Loss of the cone-enriched caspase-7 does not affect secondary cone death in retinitis pigmentosa","volume":"23","author":"Venkatesh","year":"2017","journal-title":"Mol. Vis."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"5723","DOI":"10.1523\/JNEUROSCI.23-13-05723.2003","article-title":"Caspase-Independent Photoreceptor Apoptosis in Mouse Models of Retinal Degeneration","volume":"23","author":"Doonan","year":"2003","journal-title":"J. Neurosci."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1167\/iovs.03-0439","article-title":"Caspase-3 in postnatal retinal development and degeneration","volume":"45","author":"Zeiss","year":"2004","journal-title":"Investig. Opthalmology Vis. Sci."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"3555","DOI":"10.1167\/iovs.14-13917","article-title":"Activation of Bax in Three Models of Retinitis Pigmentosa","volume":"55","author":"Comitato","year":"2014","journal-title":"Investig. Opthalmology Vis. Sci."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Hamann, S., Schorderet, D.F., and Cottet, S. (2009). Bax-induced apoptosis in Leber\u2019s congenital amaurosis: A dual role in rod and cone degeneration. PLoS ONE, 4.","DOI":"10.1371\/journal.pone.0006616"},{"key":"ref_43","first-page":"2434","article-title":"Overexpression of Bcl-2 or Bcl-XL transgenes and photoreceptor degeneration","volume":"37","author":"Joseph","year":"1996","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Kaur, J., Mencl, S., Sahaboglu, A., Farinelli, P., van Veen, T., Zrenner, E., Ekstr\u00f6m, P., Paquet-Durand, F., and Arango-Gonzalez, B. (2011). Calpain and PARP Activation during Photoreceptor Cell Death in P23H and S334ter Rhodopsin Mutant Rats. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0022181"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Akematsu, T., and Endoh, H. (2010). Role of apoptosis-inducing factor (AIF) in programmed nuclear death during conjugation in Tetra-hymena thermophila. BMC Cell Biol., 11.","DOI":"10.1186\/1471-2121-11-13"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1111\/j.1471-4159.2005.03628.x","article-title":"Calpain is activated in degenerating photoreceptors in the rd1 mouse","volume":"96","author":"Azadi","year":"2006","journal-title":"J. Neurochem."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"5191","DOI":"10.1167\/iovs.07-0512","article-title":"Activation of Endoplasmic Reticulum Stress in Degenerating Photoreceptors of the rd1 Mouse","volume":"48","author":"Yang","year":"2007","journal-title":"Investig. Opthalmology Vis. Sci."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"3604","DOI":"10.1002\/cne.22416","article-title":"cGMP-dependent cone photoreceptor degeneration in the cpfl1 mouse retina","volume":"518","author":"Trifunovic","year":"2010","journal-title":"J. Comp. Neurol."},{"key":"ref_49","first-page":"102","article-title":"Topography of the layer of the rods and cones in the human retima","volume":"13","author":"Osterberg","year":"1935","journal-title":"Acta Ophthalmol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1002\/jcp.20346","article-title":"Oxidative damage is a potential cause of cone cell death in retinitis pigmentosa","volume":"203","author":"Shen","year":"2005","journal-title":"J. Cell. Physiol."},{"key":"ref_51","first-page":"3999","article-title":"Intraretinal oxygen levels before and after photoreceptor loss in the RCS rat","volume":"41","author":"Yu","year":"2000","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1111\/j.1471-4159.2009.06195.x","article-title":"NADPH oxidase plays a central role in cone cell death in retinitis pigmentosa","volume":"110","author":"Usui","year":"2009","journal-title":"J. Neurochem."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1038\/ng1386","article-title":"Identification and characterization of rod-derived cone viability factor","volume":"36","author":"Leveillard","year":"2004","journal-title":"Nat. Genet."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nn.2234","article-title":"Stimulation of the insulin\/mTOR pathway delays cone death in a mouse model of retinitis pigmentosa","volume":"12","author":"Punzo","year":"2009","journal-title":"Nat. Neurosci."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Hippert, C., Graca, A.B., Barber, A.C., West, E., Smith, A.J., Ali, R., and Pearson, R.A. (2015). M\u00fcller Glia Activation in Response to Inherited Retinal Degeneration Is Highly Varied and Disease-Specific. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0120415"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"2992","DOI":"10.1167\/iovs.05-0118","article-title":"Identification of Sequential Events and Factors Associated with Microglial Activation, Migration, and Cytotoxicity in Retinal Degeneration inrdMice","volume":"46","author":"Zeng","year":"2005","journal-title":"Investig. Opthalmol. Vis. Sci."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.15252\/emmm.201505298","article-title":"Microglial phagocytosis of living photoreceptors contributes to inherited retinal degeneration","volume":"7","author":"Zhao","year":"2015","journal-title":"EMBO Mol. Med."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1006\/exer.2002.1155","article-title":"Cell death in retinitis pigmentosa: Gap junctions and the \u2018bystander\u2019effect","volume":"74","author":"Ripps","year":"2002","journal-title":"Exp. Eye Res."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s12868-019-0528-2","article-title":"Spatio-temporal characterization of S- and M\/L-cone degeneration in the Rd1 mouse model of retinitis pigmentosa","volume":"20","author":"Narayan","year":"2019","journal-title":"BMC Neurosci."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1002\/cne.903250302","article-title":"Unique topographic separation of two spectral classes of cones in the mouse retina","volume":"325","author":"Juliusson","year":"1992","journal-title":"J. Comp. Neurol."},{"key":"ref_61","first-page":"31","article-title":"Development of the cone photoreceptor mosaic in the mouse retina revealed by fluorescent cones in transgenic mice","volume":"9","author":"Fei","year":"2003","journal-title":"Mol. Vis."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1056\/NEJMra1310050","article-title":"Necroptosis","volume":"370","author":"Linkermann","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.ajpath.2019.10.012","article-title":"Necroptosis in the Pathophysiology of Disease","volume":"190","author":"Khoury","year":"2020","journal-title":"Am. J. Pathol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1186\/s12974-018-1235-0","article-title":"Necroptosis: A regulated inflammatory mode of cell death","volume":"15","author":"Dhuriya","year":"2018","journal-title":"J. Neuroinflammation"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.cell.2012.06.019","article-title":"The RIP1\/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis","volume":"150","author":"Li","year":"2012","journal-title":"Cell"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1016\/j.cell.2018.03.032","article-title":"The Structure of the Necrosome RIPK1-RIPK3 Core, a Human Hetero-Amyloid Signaling Complex","volume":"173","author":"Li","year":"2018","journal-title":"Cell"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"14329","DOI":"10.1038\/ncomms14329","article-title":"RIP1 autophosphorylation is promoted by mitochondrial ROS and is essential for RIP3 recruitment into necrosome","volume":"8","author":"Zhang","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1007\/s10495-018-1475-6","article-title":"MLKL mediates apoptosis via a mutual regulation with PERK\/eIF2\u03b1 pathway in response to reactive oxygen species generation","volume":"23","author":"Cao","year":"2018","journal-title":"Apoptosis"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/nature09852","article-title":"Catalytic activity of the caspase-8\u2013FLIP L complex inhibits RIPK3-dependent necrosis","volume":"471","author":"Oberst","year":"2011","journal-title":"Nature"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"2056","DOI":"10.1016\/j.cellsig.2007.05.016","article-title":"Cleavage of RIP3 inactivates its caspase-independent apoptosis pathway by removal of kinase domain","volume":"19","author":"Feng","year":"2007","journal-title":"Cell. Signal."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/cdd.2013.191","article-title":"Rip3 knockdown rescues photoreceptor cell death in blind pde6c zebrafish","volume":"21","author":"Viringipurampeer","year":"2014","journal-title":"Cell Death Differ."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"14598","DOI":"10.1073\/pnas.1206937109","article-title":"Receptor interacting protein kinase mediates necrotic cone but not rod cell death in a mouse model of inherited degeneration","volume":"109","author":"Murakami","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1007\/s12035-018-1192-8","article-title":"Cell death pathways in mutant rhodopsin rat models identifies genotype-specific targets con-trolling retinal degeneration","volume":"56","author":"Viringipurampeer","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/s12035-008-8045-9","article-title":"Photoreceptor Cell Death Mechanisms in Inherited Retinal Degeneration","volume":"38","author":"Kustermann","year":"2008","journal-title":"Mol. Neurobiol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"6561","DOI":"10.1073\/pnas.1204429109","article-title":"Role of autophagy in histone deacetylase inhibitor-induced apoptotic and nonapoptotic cell death","volume":"109","author":"Gammoh","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"3966","DOI":"10.1158\/0008-5472.CAN-03-3740","article-title":"Activation of protein kinase G is sufficient to induce apoptosis and inhibit cell migration in colon cancer cells","volume":"64","author":"Deguchi","year":"2004","journal-title":"Cancer Res."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"3360","DOI":"10.1111\/j.1742-4658.2011.08260.x","article-title":"Cyclic GMP induced apoptosis via protein kinase G in oestrogen receptor-positive and-negative breast cancer cell lines","volume":"278","author":"Fallahian","year":"2011","journal-title":"FEBS J."},{"key":"ref_78","unstructured":"AB, N.M. (2021, July 01). All Nobel Prizes. Available online: https:\/\/www.nobelprize.org\/prizes\/lists\/all-nobel-prizes\/."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.biopha.2018.05.007","article-title":"Autophagy in health and disease: A comprehensive review","volume":"104","author":"Saha","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1038\/cr.2010.82","article-title":"Overview of macroautophagy regulation in mammalian cells","volume":"20","author":"Mehrpour","year":"2010","journal-title":"Cell Res."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1080\/15548627.2015.1084456","article-title":"Autophagy supports color vision","volume":"11","author":"Zhou","year":"2015","journal-title":"Autophagy"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1038\/cdd.2008.101","article-title":"Does autophagy have a license to kill mammalian cells?","volume":"16","author":"Scarlatti","year":"2008","journal-title":"Cell Death Differ."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"433","DOI":"10.4161\/auto.4294","article-title":"Apoptosis and Autophagy in Photoreceptors Exposed to Oxidative Stress","volume":"3","author":"Kunchithapautham","year":"2007","journal-title":"Autophagy"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1111\/aos.13141","article-title":"A review of the mechanisms of cone degeneration in retinitis pigmentosa","volume":"94","author":"Narayan","year":"2016","journal-title":"Acta Ophthalmol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.cell.2015.03.023","article-title":"Rod-Derived Cone Viability Factor Promotes Cone Survival by Stimulating Aerobic Glycolysis","volume":"161","author":"Fridlich","year":"2015","journal-title":"Cell"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/mt.2009.28","article-title":"Functional Cone Rescue by RdCVF Protein in a Dominant Model of Retinitis Pigmentosa","volume":"17","author":"Yang","year":"2009","journal-title":"Mol. Ther."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1172\/JCI65654","article-title":"Viral-mediated RdCVF and RdCVFL expression protects cone and rod photoreceptors in retinal degeneration","volume":"125","author":"Byrne","year":"2015","journal-title":"J. Clin. Investig."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1080\/15548627.2018.1463121","article-title":"Inhibiting autophagy reduces retinal degeneration caused by protein misfolding","volume":"14","author":"Yao","year":"2018","journal-title":"Autophagy"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"4304","DOI":"10.1038\/emboj.2012.278","article-title":"Mechanism and functions of membrane binding by the Atg5\u2013Atg12\/Atg16 complex during autophagosome formation","volume":"31","author":"Romanov","year":"2012","journal-title":"EMBO J."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/j.molcel.2011.10.014","article-title":"The autophagy protein Atg12 associates with antiapoptotic Bcl-2 family members to promote mito-chondrial apoptosis","volume":"44","author":"Rubinstein","year":"2011","journal-title":"Mol. Cell"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1111\/j.1742-4658.2010.07965.x","article-title":"Bcl-2 and Bcl-xL play important roles in the crosstalk between autophagy and apoptosis","volume":"278","author":"Zhou","year":"2010","journal-title":"FEBS J."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1038\/cdd.2014.229","article-title":"Autophagy supports survival and phototransduction protein levels in rod photoreceptors","volume":"22","author":"Zhou","year":"2015","journal-title":"Cell Death Differ."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"4193","DOI":"10.1167\/iovs.10-7090","article-title":"Autophagy Activation in the Injured Photoreceptor Inhibits Fas-Mediated Apoptosis","volume":"52","author":"Besirli","year":"2011","journal-title":"Investig. Opthalmology Vis. Sci."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"2651","DOI":"10.1016\/j.jmb.2020.01.037","article-title":"Autophagy in Parkinson\u2019s disease","volume":"432","author":"Hou","year":"2020","journal-title":"J. Mol. Biol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.jnutbio.2006.10.007","article-title":"A review of the interaction among dietary antioxidants and reactive oxygen species","volume":"18","author":"Seifried","year":"2007","journal-title":"J. Nutr. Biochem."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/cdd.2010.138","article-title":"cIAP1 and TAK1 protect cells from TNF-induced necrosis by preventing RIP1\/RIP3-dependent reactive oxygen species production","volume":"18","author":"Vandenabeele","year":"2011","journal-title":"Cell Death Differ."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"5741","DOI":"10.1038\/sj.onc.1209581","article-title":"CD44 ligation induces caspase-independent cell death via a novel calpain\/AIF pathway in human erythroleukemia cells","volume":"25","author":"Artus","year":"2006","journal-title":"Oncogene"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/S0006-8993(99)02148-4","article-title":"Oxidative stress and Ca2+ influx upregulate calpain and induce apoptosis in PC12 cells","volume":"852","author":"Ray","year":"2000","journal-title":"Brain Res."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"11300","DOI":"10.1073\/pnas.0604056103","article-title":"Antioxidants reduce cone cell death in a model of retinitis pigmentosa","volume":"103","author":"Komeima","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1016\/j.neuroscience.2006.12.034","article-title":"Significant photoreceptor rescue by treatment with a combination of antioxidants in an animal model for retinal degeneration","volume":"145","author":"Sanz","year":"2007","journal-title":"Neuroscience"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"S311","DOI":"10.1194\/jlr.R800049-JLR200","article-title":"Membrane phospholipid synthesis and endoplasmic reticulum function","volume":"50","author":"Fagone","year":"2009","journal-title":"J. Lipid Res."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"2656","DOI":"10.1172\/JCI26373","article-title":"Endoplasmic reticulum stress: Cell life and death decisions","volume":"115","author":"Xu","year":"2005","journal-title":"J. Clin. Investig."},{"key":"ref_103","first-page":"409","article-title":"CDK5 and MEKK1 mediate pro-apoptotic signalling following endoplasmic reticulum stress in an autosomal dominant retinitis pigmentosa model","volume":"14","author":"Kang","year":"2012","journal-title":"Nature"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.brainres.2016.04.021","article-title":"Endoplasmic reticulum stress in human photoreceptor diseases","volume":"1648","author":"Chan","year":"2016","journal-title":"Brain Res."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1038\/ng.3319","article-title":"Mutations in the unfolded protein response regulator ATF6 cause the cone dysfunction disorder achromatopsia","volume":"47","author":"Kohl","year":"2015","journal-title":"Nat. Genet."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1038\/ejhg.2017.131","article-title":"Autosomal recessive cone-rod dystrophy can be caused by mutations in the ATF6 gene","volume":"25","author":"Chiang","year":"2017","journal-title":"Eur. J. Hum. Genet."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1038\/nrm1150","article-title":"Regulation of cell death: The calcium\u2013apoptosis link","volume":"4","author":"Orrenius","year":"2003","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1038\/s41419-018-0613-y","article-title":"Pigment epithelium-derived factor hinders photoreceptor cell death by reducing intracellular calcium in the degenerating retina","volume":"9","author":"Comitato","year":"2018","journal-title":"Cell Death Dis."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1007\/s00424-021-02556-9","article-title":"The role of cGMP-signalling and calcium-signalling in photoreceptor cell death: Perspectives for therapy devel-opment","volume":"473","author":"Das","year":"2021","journal-title":"Pfl\u00fcgers Arch. Eur. J. Physiol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"11189","DOI":"10.1074\/jbc.M117.782326","article-title":"Endoplasmic reticulum (ER) Ca2+-channel activity contributes to ER stress and cone death in cyclic nucleo-tide-gated channel deficiency","volume":"292","author":"Butler","year":"2017","journal-title":"J. Biol. Chem."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"3729","DOI":"10.1093\/hmg\/ddw219","article-title":"Calcium dynamics change in degenerating cone photoreceptors","volume":"25","author":"Kulkarni","year":"2016","journal-title":"Hum. Mol. Genet."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1111\/j.1471-4159.2008.05822.x","article-title":"PKG activity causes photoreceptor cell death in two retinitis pigmentosa models","volume":"108","author":"Hauck","year":"2009","journal-title":"J. Neurochem."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.preteyeres.2008.05.003","article-title":"Leber congenital amaurosis: Genes, proteins and disease mechanisms","volume":"27","author":"Roepman","year":"2008","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"8879","DOI":"10.1073\/pnas.1017127108","article-title":"Cone opsin determines the time course of cone photoreceptor degeneration in Leber congenital amaurosis","volume":"108","author":"Zhang","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"3349","DOI":"10.1167\/iovs.12-9851","article-title":"Chemical Chaperone TUDCA Preserves Cone Photoreceptors in a Mouse Model of Leber Congenital Amaurosis","volume":"53","author":"Zhang","year":"2012","journal-title":"Investig. Opthalmology Vis. Sci."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1167\/iovs.11-8544","article-title":"TUDCA Slows Retinal Degeneration in Two Different Mouse Models of Retinitis Pigmentosa and Prevents Obesity in Bardet-Biedl Syndrome Type 1 Mice","volume":"53","author":"Drack","year":"2012","journal-title":"Investig. Opthalmology Vis. Sci."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.tins.2018.05.005","article-title":"Epigenetic Regulation in Neurodegenerative Diseases","volume":"41","author":"Berson","year":"2018","journal-title":"Trends Neurosci."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/nrm1945","article-title":"Chromatin remodelling: The industrial revolution of DNA around histones","volume":"7","author":"Saha","year":"2006","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1146\/annurev.biochem.71.110601.135400","article-title":"ATP-Dependent Nucleosome Remodeling","volume":"71","author":"Becker","year":"2002","journal-title":"Annu. Rev. Biochem."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"e24","DOI":"10.1038\/cddis.2010.4","article-title":"Excessive HDAC activation is critical for neurodegeneration in the rd1 mouse","volume":"1","author":"Alavi","year":"2010","journal-title":"Cell Death Dis."},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Trifunovi\u0107, D., Petridou, E., Comitato, A., Marigo, V., Ueffing, M., and Paquet-Durand, F. (2018). Primary Rod and Cone Degeneration Is Prevented by HDAC Inhibition, Springer.","DOI":"10.1007\/978-3-319-75402-4_45"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1038\/s41418-020-00653-3","article-title":"HDAC inhibition ameliorates cone survival in retinitis pigmentosa mice","volume":"28","author":"Samardzija","year":"2021","journal-title":"Cell Death Differ."},{"key":"ref_123","first-page":"4462","article-title":"HDAC inhibition in the cpfl1 mouse protects degenerating cone photoreceptors in vivo","volume":"25","author":"Comitato","year":"2016","journal-title":"Hum. Mol. Genet."},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Chen, B., and Cepko, C.L. (2007). Requirement of histone deacetylase activity for the expression of critical photoreceptor genes. BMC Dev. Biol., 7.","DOI":"10.1186\/1471-213X-7-78"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4068\/cmj.2016.52.1.1","article-title":"HDAC and HDAC Inhibitor: From Cancer to Cardiovascular Diseases","volume":"52","author":"Yoon","year":"2016","journal-title":"Chonnam. Med. J."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S1672-0229(08)60044-3","article-title":"A Brief Review on the Mechanisms of miRNA Regulation","volume":"7","author":"Cai","year":"2009","journal-title":"Genom. Proteom. Bioinform."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"6689","DOI":"10.1111\/j.1742-4658.2009.07383.x","article-title":"MicroRNA-143 reduces viability and increases sensitivity to 5-fluorouracil in HCT116 human colorectal cancer cells","volume":"276","author":"Borralho","year":"2009","journal-title":"FEBS J."},{"key":"ref_128","doi-asserted-by":"crossref","unstructured":"Borralho, P., Sim\u00f5es, A., Gomes, S., Lima, R.T., Carvalho, T., Ferreira, D.M.S., Vasconcelos, M.H., Castro, R., and Rodrigues, C.M.P. (2011). miR-143 Overexpression Impairs Growth of Human Colon Carcinoma Xenografts in Mice with Induction of Apoptosis and Inhibition of Proliferation. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0023787"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"2653","DOI":"10.1158\/1535-7163.MCT-15-0461","article-title":"MiRNA-203 reduces nasopharyngeal carcinoma radioresistance by targeting IL8\/AKT signaling","volume":"14","author":"Qu","year":"2015","journal-title":"Mol. Cancer Ther."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"3104","DOI":"10.1016\/j.ejca.2009.09.014","article-title":"MiRNA-29a regulates the expression of numerous proteins and reduces the invasiveness and prolifera-tion of human carcinoma cell lines","volume":"45","author":"Muniyappa","year":"2009","journal-title":"Eur. J. Cancer"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1038\/nn.2897","article-title":"miR-124a is required for hippocampal axogenesis and retinal cone survival through Lhx2 suppression","volume":"14","author":"Sanuki","year":"2011","journal-title":"Nat. Neurosci."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.neuron.2014.06.020","article-title":"miRNAs 182 and 183 Are Necessary to Maintain Adult Cone Photoreceptor Outer Segments and Visual Function","volume":"83","author":"Busskamp","year":"2014","journal-title":"Neuron"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"4663","DOI":"10.1093\/emboj\/cdf476","article-title":"MicroRNA maturation: Stepwise processing and subcellular localization","volume":"21","author":"Lee","year":"2002","journal-title":"EMBO J."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"R248","DOI":"10.1186\/gb-2007-8-11-r248","article-title":"Altered retinal microRNA expression profile in a mouse model of retinitis pigmentosa","volume":"8","author":"Loscher","year":"2007","journal-title":"Genome Biol."},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"Genini, S., Guziewicz, K., Beltran, W., and Aguirre, G.D. (2014). Altered miRNA expression in canine retinas during normal development and in models of retinal degeneration. BMC Genom., 15.","DOI":"10.1186\/1471-2164-15-172"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"3780","DOI":"10.1096\/fj.14-254292","article-title":"DICER1 is essential for survival of postmitotic rod photoreceptor cells in mice","volume":"28","author":"Sundermeier","year":"2014","journal-title":"FASEB J."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1016\/S0140-6736(00)04904-7","article-title":"An overview of the immune system","volume":"357","author":"Parkin","year":"2001","journal-title":"Lancet"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.preteyeres.2006.05.003","article-title":"M\u00fcller cells in the healthy and diseased retina","volume":"25","author":"Bringmann","year":"2006","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1146\/annurev-vision-091517-034425","article-title":"Microglia in the Retina: Roles in Development, Maturity, and Disease","volume":"4","author":"Silverman","year":"2018","journal-title":"Annu. Rev. Vis. Sci."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1167\/iovs.03-0301","article-title":"Proliferation of microglia, but not photoreceptors, in the outer nuclear layer of the rd-1 mouse","volume":"45","author":"Zeiss","year":"2004","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1111\/joa.12653","article-title":"M\u00fcller glia and phagocytosis of cell debris in retinal tissue","volume":"231","year":"2017","journal-title":"J. Anat."},{"key":"ref_142","first-page":"1361","article-title":"The fate of M\u00fcller\u2019s glia following experimental retinal detachment: Nuclear migration, cell division, and subretinal glial scar formation","volume":"16","author":"Lewis","year":"2010","journal-title":"Mol. Vis."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/s00441-013-1666-y","article-title":"The role of M\u00fcller glia and microglia in glaucoma","volume":"353","author":"Seitz","year":"2013","journal-title":"Cell Tissue Res."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1038\/mt.2010.149","article-title":"Restoration of Cone Vision in the CNGA3\u2212\/\u2212 Mouse Model of Congenital Complete Lack of Cone Photoreceptor Function","volume":"18","author":"Michalakis","year":"2010","journal-title":"Mol. Ther."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/978-3-540-46826-4_11","article-title":"How the neural retina regenerates","volume":"31","author":"Raymond","year":"2000","journal-title":"Results Probl. Cell Differ."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/85090","article-title":"M\u00fcller glia are a potential source of neural regeneration in the postnatal chicken retina","volume":"4","author":"Fischer","year":"2001","journal-title":"Nat. Neurosci."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.exer.2008.07.009","article-title":"Characterization of M\u00fcller glia and neuronal progenitors during adult zebrafish retinal regeneration","volume":"87","author":"Thummel","year":"2008","journal-title":"Exp. Eye Res."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"6303","DOI":"10.1523\/JNEUROSCI.0332-06.2006","article-title":"A role for \u03b11 tubulin-expressing M\u00fcller glia in regeneration of the injured zebrafish retina","volume":"26","author":"Fausett","year":"2006","journal-title":"J. Neu-rosci."},{"key":"ref_149","first-page":"775","article-title":"Gene expression profiles of intact and regenerating zebrafish retina","volume":"11","author":"Cameron","year":"2005","journal-title":"Mol. Vis."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.exer.2013.07.012","article-title":"Regulation of M\u00fcller glial dependent neuronal regeneration in the damaged adult zebrafish retina","volume":"123","author":"Gorsuch","year":"2014","journal-title":"Exp. Eye Res."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"323","DOI":"10.5966\/sctm.2013-0112","article-title":"Transplantation of Photoreceptors Derived From Human M\u00fcller Glia Restore Rod Function in the P23H Rat","volume":"3","author":"Jayaram","year":"2014","journal-title":"STEM CELLS Transl. Med."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"3104","DOI":"10.1172\/JCI85193","article-title":"Reprogramming M\u00fcller glia via in vivo cell fusion regenerates murine photoreceptors","volume":"126","author":"Sanges","year":"2016","journal-title":"J. Clin. Investig."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1167\/iovs.07-0434","article-title":"\u03b1-Aminoadipate induces progenitor cell properties of Muller glia in adult mice","volume":"49","author":"Takeda","year":"2008","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/nature23283","article-title":"Stimulation of functional neuronal regeneration from M\u00fcller glia in adult mice","volume":"548","author":"Jorstad","year":"2017","journal-title":"Nature"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1189\/jlb.0207114","article-title":"Microglia activation in retinal degeneration","volume":"81","author":"Langmann","year":"2007","journal-title":"J. Leukoc. Biol."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"9228","DOI":"10.1523\/JNEUROSCI.22-21-09228.2002","article-title":"Microglia\u2013M\u00fcller Glia Cell Interactions Control Neurotrophic Factor Production during Light-Induced Retinal Degeneration","volume":"22","author":"Harada","year":"2002","journal-title":"J. Neurosci."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"41839","DOI":"10.1074\/jbc.M402872200","article-title":"Microglia-derived Pronerve Growth Factor Promotes Photoreceptor Cell Death via p75 Neurotrophin Receptor","volume":"279","author":"Srinivasan","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.2353\/ajpath.2008.080024","article-title":"Activation of bone marrow-derived microglia promotes photoreceptor survival in inherited retinal de-generation","volume":"172","author":"Sasahara","year":"2008","journal-title":"Am. J. Pathol."},{"key":"ref_159","first-page":"6160","article-title":"Microglia modulation by TGF-\u03b21 protects cones in mouse models of retinal degeneration","volume":"130","author":"Wang","year":"2020","journal-title":"J. Clin. Investig."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"3294","DOI":"10.1523\/JNEUROSCI.2717-16.2017","article-title":"Tamoxifen Provides Structural and Functional Rescue in Murine Models of Photoreceptor Degeneration","volume":"37","author":"Wang","year":"2017","journal-title":"J. Neurosci."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.3389\/fimmu.2020.01463","article-title":"Microglia Inhibition Delays Retinal Degeneration Due to MerTK Phagocytosis Receptor Deficiency","volume":"11","author":"Lew","year":"2020","journal-title":"Front. Immunol."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/2\/726\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T14:14:49Z","timestamp":1760364889000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/2\/726"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,10]]},"references-count":161,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2022,1]]}},"alternative-id":["ijms23020726"],"URL":"https:\/\/doi.org\/10.3390\/ijms23020726","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,10]]}}}