{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T21:38:59Z","timestamp":1784842739800,"version":"3.55.0"},"reference-count":169,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2022,1,13]],"date-time":"2022-01-13T00:00:00Z","timestamp":1642032000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004488","name":"Croatian Science Foundation","doi-asserted-by":"publisher","award":["IP-16-6-9451"],"award-info":[{"award-number":["IP-16-6-9451"]}],"id":[{"id":"10.13039\/501100004488","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["KK.01.1.1.01.0007"],"award-info":[{"award-number":["KK.01.1.1.01.0007"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/R025002\/1"],"award-info":[{"award-number":["MR\/R025002\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013342","name":"NIHR Imperial Biomedical Research Centre","doi-asserted-by":"publisher","award":["2020-1.1.6-J\u00d6V\u0150-2021-00013"],"award-info":[{"award-number":["2020-1.1.6-J\u00d6V\u0150-2021-00013"]}],"id":[{"id":"10.13039\/501100013342","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000921","name":"European Cooperation in Science and Technology","doi-asserted-by":"publisher","award":["CA1622"],"award-info":[{"award-number":["CA1622"]}],"id":[{"id":"10.13039\/501100000921","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>From the first success in cultivation of cells in vitro, it became clear that developing cell and\/or tissue specific cultures would open a myriad of new opportunities for medical research. Expertise in various in vitro models has been developing over decades, so nowadays we benefit from highly specific in vitro systems imitating every organ of the human body. Moreover, obtaining sufficient number of standardized cells allows for cell transplantation approach with the goal of improving the regeneration of injured\/disease affected tissue. However, different cell types bring different needs and place various types of hurdles on the path of regenerative neurology and regenerative cardiology. In this review, written by European experts gathered in Cost European action dedicated to neurology and cardiology-Bioneca, we present the experience acquired by working on two rather different organs: the brain and the heart. When taken into account that diseases of these two organs, mostly ischemic in their nature (stroke and heart infarction), bring by far the largest burden of the medical systems around Europe, it is not surprising that in vitro models of nervous and heart muscle tissue were in the focus of biomedical research in the last decades. In this review we describe and discuss hurdles which still impair further progress of regenerative neurology and cardiology and we detect those ones which are common to both fields and some, which are field-specific. With the goal to elucidate strategies which might be shared between regenerative neurology and cardiology we discuss methodological solutions which can help each of the fields to accelerate their development.<\/jats:p>","DOI":"10.3390\/ijms23020855","type":"journal-article","created":{"date-parts":[[2022,1,13]],"date-time":"2022-01-13T10:57:37Z","timestamp":1642071457000},"page":"855","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Regenerative Neurology and Regenerative Cardiology: Shared Hurdles and Achievements"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4836-1721","authenticated-orcid":false,"given":"Dinko","family":"Mitre\u010di\u0107","sequence":"first","affiliation":[{"name":"Laboratory for Stem Cells, Croatian Institute for Brain Research, University of Zagreb School of Medicine, 10000 Zagreb, Croatia"},{"name":"Department of Histology and Embryology, University of Zagreb School of Medicine, 10000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Hribljan","sequence":"additional","affiliation":[{"name":"Laboratory for Stem Cells, Croatian Institute for Brain Research, University of Zagreb School of Medicine, 10000 Zagreb, Croatia"},{"name":"Department of Histology and Embryology, University of Zagreb School of Medicine, 10000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Jage\u010di\u0107","sequence":"additional","affiliation":[{"name":"Laboratory for Stem Cells, Croatian Institute for Brain Research, University of Zagreb School of Medicine, 10000 Zagreb, Croatia"},{"name":"Department of Histology and Embryology, University of Zagreb School of Medicine, 10000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5971-3142","authenticated-orcid":false,"given":"Jasmina","family":"Isakovi\u0107","sequence":"additional","affiliation":[{"name":"Omnion Research International Ltd., 10000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9974-1594","authenticated-orcid":false,"given":"Federica","family":"Lamberto","sequence":"additional","affiliation":[{"name":"BioTalentum Ltd., Aulich Lajos Str. 26, 2100 Gordillo, Hungary"},{"name":"Department of Physiology and Animal Health, Institute of Physiology and Animal Health, Hungarian University of Agriculture and Life Sciences, P\u00e1ter K\u00e1roly Str. 1, 2100 Godollo, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8456-9787","authenticated-orcid":false,"given":"Alex","family":"Hor\u00e1nszky","sequence":"additional","affiliation":[{"name":"BioTalentum Ltd., Aulich Lajos Str. 26, 2100 Gordillo, Hungary"},{"name":"Department of Physiology and Animal Health, Institute of Physiology and Animal Health, Hungarian University of Agriculture and Life Sciences, P\u00e1ter K\u00e1roly Str. 1, 2100 Godollo, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5725-1300","authenticated-orcid":false,"given":"Melinda","family":"Zana","sequence":"additional","affiliation":[{"name":"BioTalentum Ltd., Aulich Lajos Str. 26, 2100 Gordillo, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabor","family":"Foldes","sequence":"additional","affiliation":[{"name":"Heart and Vascular Center, Semmelweis University, 1122 Budapest, Hungary"},{"name":"National Heart and Lung Institute, Imperial College London, London W12 0NN, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4779-4456","authenticated-orcid":false,"given":"Barbara","family":"Zavan","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine, University of Ferrara, 44121 Ferrara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7009-2535","authenticated-orcid":false,"given":"Augustas","family":"Pivori\u016bnas","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Biology, State Research Institute Centre for Innovative Medicine, LT-01102 Vilnius, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvador","family":"Martinez","sequence":"additional","affiliation":[{"name":"Instituto de Neurociencias UMH-CSIC, 03550 San Juan de Alicante, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Letizia","family":"Mazzini","sequence":"additional","affiliation":[{"name":"ALS Center, Department of Neurology, Maggiore della Carit\u00e0 Hospital, University of Piemonte Orientale, 28100 Novara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6632-0483","authenticated-orcid":false,"given":"Lidija","family":"Radenovic","sequence":"additional","affiliation":[{"name":"Center for Laser Microscopy, Faculty of Biology, University of Belgrade, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6225-7210","authenticated-orcid":false,"given":"Jelena","family":"Milasin","sequence":"additional","affiliation":[{"name":"Laboratory for Stem Cell Research, School of Dental Medicine, University of Belgrade, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan 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Gordillo, Hungary"},{"name":"Department of Physiology and Animal Health, Institute of Physiology and Animal Health, Hungarian University of Agriculture and Life Sciences, P\u00e1ter K\u00e1roly Str. 1, 2100 Godollo, Hungary"},{"name":"HCEMM-USZ Stem Cell Research Group, Department of Cell Biology and Molecular Medicine, University of Szeged, 6720 Szeged, Hungary"},{"name":"College of Life Sciences, Sichuan University, Chengdu 610064, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.reth.2021.09.001","article-title":"A Review and Update for Registered Clinical Studies of Stem Cells for Non-Tumorous and Non-Hematological Diseases","volume":"18","author":"Chen","year":"2021","journal-title":"Regen. 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