{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T05:06:14Z","timestamp":1789880774515,"version":"4.0.1"},"reference-count":115,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2022,1,16]],"date-time":"2022-01-16T00:00:00Z","timestamp":1642291200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Temporal lobe epilepsy (TLE) is one of the most common forms of focal epilepsy in children and adults. TLE is characterized by variable onset and seizures. Moreover, this form of epilepsy is often resistant to pharmacotherapy. The search for new mechanisms for the development of TLE may provide us with a key to the development of new diagnostic methods and a personalized approach to the treatment. In recent years, the role of non-coding ribonucleic acids (RNA) has been actively studied, among which microRNA (miR) is of the greatest interest. (1) Background: The purpose of the systematic review is to analyze the studies carried out on the role of miRs in the development of mesial TLE (mTLE) and update the existing knowledge about the biomarkers of this disease. (2) Methods: The search for publications was carried out in the databases PubMed, Springer, Web of Science, Clinicalkeys, Scopus, OxfordPress, Cochrane. The search was carried out using keywords and combinations. We analyzed publications for 2016\u20132021, including original studies in an animal model of TLE and with the participation of patients with TLE, thematic and systemic reviews, and Cochrane reviews. (3) Results: this thematic review showed that miR\u2012155, miR\u2012153, miR\u2012361\u20125p, miR\u20124668\u20125p, miR\u20128071, miR\u2012197\u20125p, miR\u2012145, miR\u2012181, miR\u2012199a, miR\u20121183, miR\u2012129\u20122\u20123p, miR\u2012143\u20123p (upregulation), miR\u2013134, miR\u20120067835, and miR\u2012153 (downregulation) can be considered as biomarkers of mTLE. However, the roles of miR\u2012146a, miR\u2012142, miR\u2012106b, and miR\u2012223 are questionable and need further study. (4) Conclusion: In the future, it will be possible to consider previously studied miRs, which have high specificity and sensitivity in mTLE, as prognostic biomarkers (predictors) of the risk of developing this disease in patients with potentially epileptogenic structural damage to the mesial regions of the temporal lobe of the brain (congenital disorders of the neuronal migration and neurogenesis, brain injury, neuro-inflammation, tumor, impaired blood supply, neurodegeneration, etc.).<\/jats:p>","DOI":"10.3390\/ijms23020951","type":"journal-article","created":{"date-parts":[[2022,1,16]],"date-time":"2022-01-16T20:44:00Z","timestamp":1642365840000},"page":"951","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Expression Profile of miRs in Mesial Temporal Lobe Epilepsy: Systematic Review"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2728-5830","authenticated-orcid":false,"given":"Kristina D.","family":"Yakovleva","sequence":"first","affiliation":[{"name":"Department of Medical Genetics and Clinical Neurophysiology, Institute of Postgraduate Education, V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, 660022 Krasnoyarsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana V.","family":"Dmitrenko","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics and Clinical Neurophysiology, Institute of Postgraduate Education, V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, 660022 Krasnoyarsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iulia S.","family":"Panina","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics and Clinical Neurophysiology, Institute of Postgraduate Education, V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, 660022 Krasnoyarsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9678-6719","authenticated-orcid":false,"given":"Anna A.","family":"Usoltseva","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics and Clinical Neurophysiology, Institute of Postgraduate Education, V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, 660022 Krasnoyarsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirill A.","family":"Gazenkampf","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics and Clinical Neurophysiology, Institute of Postgraduate Education, V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, 660022 Krasnoyarsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga V.","family":"Konovalenko","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics and Clinical Neurophysiology, Institute of Postgraduate Education, V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, 660022 Krasnoyarsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena A.","family":"Kantimirova","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics and Clinical Neurophysiology, Institute of Postgraduate Education, V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, 660022 Krasnoyarsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2001-6432","authenticated-orcid":false,"given":"Maxim A.","family":"Novitsky","sequence":"additional","affiliation":[{"name":"Institute of Personalized Psychiatry and Neurology, Shared Core Facilities, V.M. Bekhterev National Medical Research Center for Psychiatry and Neurology, 192019 Saint Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regina F.","family":"Nasyrova","sequence":"additional","affiliation":[{"name":"Institute of Personalized Psychiatry and Neurology, Shared Core Facilities, V.M. Bekhterev National Medical Research Center for Psychiatry and Neurology, 192019 Saint Petersburg, Russia"},{"name":"International Centre for Education and Research in Neuropsychiatry, Samara State Medical University, 443099 Samara, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia A.","family":"Shnayder","sequence":"additional","affiliation":[{"name":"Institute of Personalized Psychiatry and Neurology, Shared Core Facilities, V.M. Bekhterev National Medical Research Center for Psychiatry and Neurology, 192019 Saint Petersburg, Russia"},{"name":"Shared Core Facilities \u201cMolecular and Cell Technologies\u201d, V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, 660022 Krasnoyarsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,16]]},"reference":[{"key":"ref_1","first-page":"849540","article-title":"Temporal lobe epilepsy in children","volume":"2012","author":"Nickels","year":"2012","journal-title":"Epilepsy Res. Treat."},{"key":"ref_2","unstructured":"Nayak, C.S., and Bandyopadhyay, S. (2021). Mesial Temporal Lobe Epilepsy. StatPearls, StatPearls Publishing."},{"key":"ref_3","unstructured":"Karlov, V.A. (2019). Epilepsy in Children and Adult\u2019s Females and Males: Manual for the Physician, Binom. [2nd ed.]."},{"key":"ref_4","first-page":"751510","article-title":"Temporal lobe epilepsy semiology","volume":"2012","author":"Blair","year":"2012","journal-title":"Epilepsy Res. 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