{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T23:20:48Z","timestamp":1792192848576,"version":"4.4.0"},"reference-count":257,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2022,1,16]],"date-time":"2022-01-16T00:00:00Z","timestamp":1642291200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Adipose tissue plays an important role in systemic metabolism via the secretion of adipocytokines and storing and releasing energy. In obesity, adipose tissue becomes dysfunctional and characterized by hypertrophied adipocytes, increased inflammation, hypoxia, and decreased angiogenesis. Although adipose tissue is one of the major stores of vitamin D, its deficiency is detective in obese subjects. In the presented review, we show how vitamin D regulates numerous processes in adipose tissue and how their dysregulation leads to metabolic disorders. The molecular response to vitamin D in adipose tissue affects not only energy metabolism and adipokine and anti-inflammatory cytokine production via the regulation of gene expression but also genes participating in antioxidant defense, adipocytes differentiation, and apoptosis. Thus, its deficiency disturbs adipocytokines secretion, metabolism, lipid storage, adipogenesis, thermogenesis, the regulation of inflammation, and oxidative stress balance. Restoring the proper functionality of adipose tissue in overweight or obese subjects is of particular importance in order to reduce the risk of developing obesity-related complications, such as cardiovascular diseases and diabetes. Taking into account the results of experimental studies, it seemed that vitamin D may be a remedy for adipose tissue dysfunction, but the results of the clinical trials are not consistent, as some of them show improvement and others no effect of this vitamin on metabolic and insulin resistance parameters. Therefore, further studies are required to evaluate the beneficial effects of vitamin D, especially in overweight and obese subjects, due to the presence of a volumetric dilution of this vitamin among them.<\/jats:p>","DOI":"10.3390\/ijms23020956","type":"journal-article","created":{"date-parts":[[2022,1,16]],"date-time":"2022-01-16T20:44:00Z","timestamp":1642365840000},"page":"956","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":125,"title":["The Action of Vitamin D in Adipose Tissue: Is There the Link between Vitamin D Deficiency and Adipose Tissue-Related Metabolic Disorders?"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6545-579X","authenticated-orcid":false,"given":"Izabela","family":"Szymczak-Pajor","sequence":"first","affiliation":[{"name":"Department of Nucleic Acid Biochemistry, Medical University of Lodz, 251 Pomorska Str., 92-213 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krystian","family":"Miazek","sequence":"additional","affiliation":[{"name":"Institute of Applied Radiation Chemistry, Faculty of Chemistry, Lodz University of Technology, 15 Wroblewskiego, 93-590 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Selmi","sequence":"additional","affiliation":[{"name":"Department of Molecular Biophysics, University of Lodz, 141\/143 Pomorska, 90-236 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8544-5778","authenticated-orcid":false,"given":"Aneta","family":"Balcerczyk","sequence":"additional","affiliation":[{"name":"Department of Molecular Biophysics, University of Lodz, 141\/143 Pomorska, 90-236 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6864-0704","authenticated-orcid":false,"given":"Agnieszka","family":"\u015aliwi\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Nucleic Acid Biochemistry, Medical University of Lodz, 251 Pomorska Str., 92-213 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Schmidt, F.M., Weschenfelder, J., Sander, C., Minkwitz, J., Thormann, J., Chittka, T., Mergl, R., Kirkby, K.C., Fa\u00dfhauer, M., and Stumvoll, M. (2015). Inflammatory Cytokines in General and Central Obesity and Modulating Effects of Physical Activity. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0121971"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"47","DOI":"10.2147\/ITT.S73223","article-title":"The role of adipokines in chronic inflammation","volume":"5","author":"Mancuso","year":"2016","journal-title":"ImmunoTargets Ther."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Ambele, M.A., Dhanraj, P., Giles, R., and Pepper, M.S. (2020). Adipogenesis: A Complex Interplay of Multiple Molecular Determinants and Pathways. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21124283"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.numecd.2017.10.015","article-title":"The clinical potential of adipogenesis and obesity-related microRNAs","volume":"28","author":"Zaiou","year":"2018","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.tcb.2016.01.004","article-title":"Emerging Complexities in Adipocyte Origins and Identity","volume":"26","author":"Gurmaches","year":"2016","journal-title":"Trends Cell Biol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.cell.2012.09.010","article-title":"Mechanism of Fatty-Acid-Dependent UCP1 Uncoupling in Brown Fat Mitochondria","volume":"151","author":"Fedorenko","year":"2012","journal-title":"Cell"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2853","DOI":"10.7150\/ijbs.60354","article-title":"Non-shivering Thermogenesis Signalling Regulation and Potential Therapeutic Applications of Brown Adipose Tissue","volume":"17","author":"Zhang","year":"2021","journal-title":"Int. J. Biol. Sci."},{"key":"ref_8","first-page":"E567","article-title":"An endocrine role for brown adipose tissue?","volume":"305","author":"Villarroya","year":"2013","journal-title":"Am. J. Physiol. Metab."},{"key":"ref_9","first-page":"1691","article-title":"Contrasting effects of cold acclimation versus obesogenic diets on chemerin gene expression in brown and brite adipose tissues","volume":"1841","author":"Hansen","year":"2014","journal-title":"Biochim. Biophys. Acta (BBA)-Mol. Cell Biol. Lipids"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"6184","DOI":"10.3390\/ijms15046184","article-title":"Obesity and Its Metabolic Complications: The Role of Adipokines and the Relationship between Obesity, Inflammation, Insulin Resistance, Dyslipidemia and Nonalcoholic Fatty Liver Disease","volume":"15","author":"Jung","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1016\/j.celrep.2013.10.044","article-title":"UCP1 in Brite\/Beige Adipose Tissue Mitochondria Is Functionally Thermogenic","volume":"5","author":"Shabalina","year":"2013","journal-title":"Cell Rep."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"R97","DOI":"10.1530\/JOE-18-0598","article-title":"Adipose tissue browning in mice and humans","volume":"241","author":"Herz","year":"2019","journal-title":"J. Endocrinol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.mpmed.2014.11.003","article-title":"Medical consequences of obesity","volume":"43","author":"Finer","year":"2015","journal-title":"Medicine"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Moseti, D., Regassa, A., and Kim, W.-K. (2016). Molecular Regulation of Adipogenesis and Potential Anti-Adipogenic Bioactive Molecules. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17010124"},{"key":"ref_15","first-page":"1","article-title":"Adipose Tissue and Adipokines: The Association with and Application of Adipokines in Obesity","volume":"2014","author":"Khan","year":"2014","journal-title":"Sci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"103","DOI":"10.3389\/fendo.2019.00103","article-title":"Vitamin D Insufficiency in Overweight and Obese Children and Adolescents","volume":"10","author":"Zakharova","year":"2019","journal-title":"Front. Endocrinol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2194","DOI":"10.1111\/bcp.13652","article-title":"Vitamin D assays and the definition of hypovitaminosis D: Results from the First International Conference on Controversies in Vitamin D","volume":"84","author":"Sempos","year":"2018","journal-title":"Br. J. Clin. Pharmacol."},{"key":"ref_18","first-page":"841","article-title":"Recognition and management of vitamin D deficiency","volume":"80","author":"Bordelon","year":"2009","journal-title":"Am. Fam. Physician"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2630","DOI":"10.1210\/jc.2010-0918","article-title":"Vitamin D Insufficiency, Deficiency, and Bone Health","volume":"95","author":"Gallagher","year":"2010","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1038\/s41430-020-0558-y","article-title":"Vitamin D deficiency 2.0: An update on the current status worldwide","volume":"74","author":"Amrein","year":"2020","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"228","DOI":"10.3389\/fphys.2014.00228","article-title":"Vitamin D and adipose tissue\u2014More than storage","volume":"5","author":"Mutt","year":"2014","journal-title":"Front. Physiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1136\/gut.19.4.267","article-title":"Vitamin D-3 intestinal absorption in vivo: Influence of fatty acids, bile salts, and perfusate pH on absorption","volume":"19","author":"Hollander","year":"1978","journal-title":"Gut"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.jsbmb.2016.08.004","article-title":"Physiological functions of Vitamin D in adipose tissue","volume":"165","author":"Abbas","year":"2017","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2552","DOI":"10.1172\/JCI116492","article-title":"Human plasma transport of vitamin D after its endogenous synthesis","volume":"91","author":"Haddad","year":"1993","journal-title":"J. Clin. Investig."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Kiourtzidis, M., K\u00fchn, J., Brandsch, C., and Stangl, G.I. (2020). Vitamin D Status of Mice Deficient in Scavenger Receptor Class B Type 1, Cluster Determinant 36 and ATP-Binding Cassette Proteins G5\/G8. Nutrients, 12.","DOI":"10.3390\/nu12082169"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.plipres.2011.07.001","article-title":"Proteins involved in uptake, intracellular transport and basolateral secretion of fat-soluble vitamins and carotenoids by mammalian enterocytes","volume":"50","author":"Reboul","year":"2011","journal-title":"Prog. Lipid Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1002\/mnfr.201000553","article-title":"Vitamin D intestinal absorption is not a simple passive diffusion: Evidences for involvement of cholesterol transporters","volume":"55","author":"Reboul","year":"2011","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1042\/cs0600241","article-title":"Comparison of the Appearance of Radiolabelled Vitamin D3 and 25-Hydroxy-Vitamin D3 in the Chylomicron Fraction of Plasma after Oral Administration in Man","volume":"60","author":"Compston","year":"1981","journal-title":"Clin. Sci."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.3891\/acta.chem.scand.21-1662","article-title":"Intestinal Absorption and Esterification of Vitamin D3-1,2-3H in Man","volume":"21","author":"Blomstrand","year":"1967","journal-title":"Acta Chem. Scand."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Komba, S., Kotake-Nara, E., and Tsuzuki, W. (2019). Simultaneous Synthesis of Vitamins D2, D4, D5, D6, and D7 from Commercially Available Phytosterol, \u03b2-Sitosterol, and Identification of Each Vitamin D by HSQC NMR. Metab., 9.","DOI":"10.3390\/metabo9060107"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.chembiol.2013.12.016","article-title":"Vitamin D Metabolism, Mechanism of Action, and Clinical Applications","volume":"21","author":"Bikle","year":"2014","journal-title":"Chem. Biol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1093\/ajcn\/84.4.694","article-title":"The case against ergocalciferol (vitamin D2) as a vitamin supplement","volume":"84","author":"Vieth","year":"2006","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/0022-4731(84)90063-3","article-title":"Comparison of equilibrium and disequilibrium assay conditions for ergocalciferol, cholecalciferol and their major metabolites","volume":"21","author":"Hollis","year":"1984","journal-title":"J. Steroid Biochem."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"9250","DOI":"10.1016\/S0021-9258(18)67647-1","article-title":"24-Hydroxylation of 1,25-dihydroxyergocalciferol. An unambiguous deactivation process","volume":"261","author":"Horst","year":"1986","journal-title":"J. Biol. Chem."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Kotake-Nara, E., Komba, S., and Hase, M. (2021). Uptake of Vitamins D2, D3, D4, D5, D6, and D7 Solubilized in Mixed Micelles by Human Intestinal Cells, Caco-2, an Enhancing Effect of Lysophosphatidylcholine on the Cellular Uptake, and Estimation of Vitamins D\u2019 Biological Activities. Nutrients, 13.","DOI":"10.3390\/nu13041126"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Phillips, K.M., Horst, R.L., Koszewski, N.J., and Simon, R.R. (2012). Vitamin D4 in Mushrooms. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0040702"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Caccamo, D., Ricca, S., Curr\u00f2, M., and Ientile, R. (2018). Health Risks of Hypovitaminosis D: A Review of New Molecular Insights. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19030892"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2564","DOI":"10.1210\/jc.2016-3591","article-title":"Impaired Release of Vitamin D in Dysfunctional Adipose Tissue: New Cues on Vitamin D Supplementation in Obesity","volume":"102","author":"Sabovic","year":"2017","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.jsbmb.2008.09.006","article-title":"1\u03b1,25-Dihydroxyvitamin D hydroxylase in adipocytes","volume":"112","author":"Li","year":"2008","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1038\/ijo.2012.112","article-title":"Expression of vitamin D-metabolizing enzymes in human adipose tissue\u2014the effect of obesity and diet-induced weight loss","volume":"37","author":"Wamberg","year":"2013","journal-title":"Int. J. Obes."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1056\/NEJMra070553","article-title":"Vitamin D Deficiency","volume":"357","author":"Holick","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1159\/000486536","article-title":"Vitamin D: Classic and Novel Actions","volume":"72","author":"Gil","year":"2018","journal-title":"Ann. Nutr. Metab."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/sji.12403","article-title":"The Active Metabolite of Vitamin D3as a Potential Immunomodulator","volume":"83","author":"Szymczak","year":"2016","journal-title":"Scand. J. Immunol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1006\/bbrc.1993.1717","article-title":"Vitamin D Receptor Gene Expression Is Up-Regulated by 1, 25-Dihydroxyvitamin D3 in 3T3-L1 Preadipocytes","volume":"193","author":"Kamei","year":"1993","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1017\/S0007114512003285","article-title":"Hepatocyte production of modulators of extracellular liver matrix in normal and cirrhotic rat liver","volume":"108","author":"Ding","year":"2012","journal-title":"Br. J. Nutr."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.beem.2011.05.010","article-title":"Vitamin D receptor (VDR)-mediated actions of 1\u03b1,25(OH)2vitamin D3: Genomic and non-genomic mechanisms","volume":"25","author":"Haussler","year":"2011","journal-title":"Best Pr. Res. Clin. Endocrinol. Metab."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s00223-012-9619-0","article-title":"Molecular Mechanisms of Vitamin D Action","volume":"92","author":"Haussler","year":"2013","journal-title":"Calcif. Tissue Int."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.jsbmb.2004.03.031","article-title":"Identification and characterization of 1,25D3-membrane-associated rapid response, steroid (1,25D3-MARRS) binding protein","volume":"89-90","author":"Nemere","year":"2004","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Hii, C.S., and Ferrante, A. (2016). The Non-Genomic Actions of Vitamin D. Nutrients, 8.","DOI":"10.3390\/nu8030135"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1002\/jcp.24371","article-title":"Induction of STEAP4 correlates with 1,25-dihydroxyvitamin D3stimulation of adipogenesis in mesenchymal progenitor cells derived from human adipose tissue","volume":"228","author":"Narvaez","year":"2013","journal-title":"J. Cell. Physiol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.jnutbio.2008.05.010","article-title":"Dihydroxy-cholecalciferol stimulates adipocytic differentiation of porcine mesenchymal stem cells","volume":"20","author":"Mahajan","year":"2009","journal-title":"J. Nutr. Biochem."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.abb.2017.01.002","article-title":"Vitamin D supplementation inhibits oxidative stress and upregulate SIRT1\/AMPK\/GLUT4 cascade in high glucose-treated 3T3L1 adipocytes and in adipose tissue of high fat diet-fed diabetic mice","volume":"615","author":"Manna","year":"2017","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1515\/hmbci-2013-0027","article-title":"Vitamin D, adipose tissue, and obesity","volume":"15","author":"Marcotorchino","year":"2013","journal-title":"Horm. Mol. Biol. Clin. Investig."},{"key":"ref_54","unstructured":"De Groot, L.J., Chrousos, G., Dungan, K., Feingold, K.R., Grossman, A., Hershman, J.M., Koch, C., Korbonits, M., McLachlan, R., and New, M. (2000). Vitamin D: Production, Metabolism, and Mechanisms of Action. Endotext, MDText.com, Inc."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1172\/JCI106538","article-title":"Deposition in and release of vitamin D3 from body fat: Evidence for a storage site in the rat","volume":"50","author":"Rosenstreich","year":"1971","journal-title":"J. Clin. Investig."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1002\/oby.21131","article-title":"Vitamin D, inflammation, and relations to insulin resistance in premenopausal women with morbid obesity","volume":"23","author":"Nguyen","year":"2015","journal-title":"Obes."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"E591","DOI":"10.1210\/jc.2014-3016","article-title":"Serum 25-Hydroxyvitamin D and Adipose Tissue Vitamin D Receptor Gene Expression: Relationship With Obesity and Type 2 Diabetes","volume":"100","author":"Serrano","year":"2015","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Nimitphong, H., Holick, M., Fried, S.K., and Lee, M.-J. (2012). 25-Hydroxyvitamin D3 and 1,25-Dihydroxyvitamin D3 Promote the Differentiation of Human Subcutaneous Preadipocytes. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0052171"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1080\/07315724.2009.10719779","article-title":"Vitamin D3 distribution and status in the body","volume":"28","author":"Heaney","year":"2009","journal-title":"J. Am. Coll. Nutr."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"3352","DOI":"10.3390\/nu5093352","article-title":"Association between Subcutaneous White Adipose Tissue and Serum 25-Hydroxyvitamin D in Overweight and Obese Adults","volume":"5","author":"Piccolo","year":"2013","journal-title":"Nutrients"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1530\/EJE-14-0870","article-title":"Vitamin D3 increases in abdominal subcutaneous fat tissue after supplementation with vitamin D3","volume":"172","author":"Didriksen","year":"2015","journal-title":"Eur. J. Endocrinol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.jphotobiol.2014.06.008","article-title":"A new approach to measuring vitamin D in human adipose tissue using time-of-flight secondary ion mass spectrometry: A pilot study","volume":"138","author":"Malmberg","year":"2014","journal-title":"J. Photochem. Photobiol. B Biol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1042\/cs0430413","article-title":"The Distribution and Storage of Vitamin D and its Metabolites in Human Tissues","volume":"43","author":"Mawer","year":"1972","journal-title":"Clin. Sci."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.3390\/nu4111622","article-title":"Lipophilic Micronutrients and Adipose Tissue Biology","volume":"4","author":"Landrier","year":"2012","journal-title":"Nutrients"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1080\/07315724.2008.10719700","article-title":"Body Size and Serum 25 Hydroxy Vitamin D Response to Oral Supplements in Healthy Older Adults","volume":"27","author":"Blum","year":"2008","journal-title":"J. Am. Coll. Nutr."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1038\/oby.2011.404","article-title":"Volumetric Dilution, Rather Than Sequestration Best Explains the Low Vitamin D Status of Obesity","volume":"20","author":"Drincic","year":"2012","journal-title":"Obesity"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1093\/aje\/kwr456","article-title":"Cross-Sectional and Prospective Cohort Study of Serum 25-Hydroxyvitamin D Level and Obesity in Adults: The HUNT Study","volume":"175","author":"Mai","year":"2012","journal-title":"Am. J. Epidemiology"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/ejcn.2013.48","article-title":"Hypovitaminosis D and incidence of obesity: A prospective study","volume":"67","author":"Morcillo","year":"2013","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1111\/obr.12239","article-title":"Obesity and vitamin D deficiency: A systematic review and meta-analysis","volume":"16","author":"Costa","year":"2015","journal-title":"Obes. Rev."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1093\/ajcn\/72.3.690","article-title":"Decreased bioavailability of vitamin D in obesity","volume":"72","author":"Wortsman","year":"2000","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1002\/jbmr.2979","article-title":"Vitamin D Storage in Adipose Tissue of Obese and Normal Weight Women","volume":"32","author":"Carrelli","year":"2016","journal-title":"J. Bone Miner. Res."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1002\/jcb.22936","article-title":"JAK2\/STAT3 pathway is involved in the early stage of adipogenesis through regulatingC\/EBP\u03b2transcription","volume":"112","author":"Zhang","year":"2011","journal-title":"J. Cell. Biochem."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.devcel.2010.02.018","article-title":"S6K1 Plays a Critical Role in Early Adipocyte Differentiation","volume":"18","author":"Carnevalli","year":"2010","journal-title":"Dev. Cell"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.devcel.2006.02.016","article-title":"Schnurri-2 Controls BMP-Dependent Adipogenesis via Interaction with Smad Proteins","volume":"10","author":"Jin","year":"2006","journal-title":"Dev. Cell"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"2681","DOI":"10.1242\/jcs.079699","article-title":"Adipogenesis at a glance","volume":"124","author":"Lowe","year":"2011","journal-title":"J. Cell Sci."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/0092-8674(93)90252-L","article-title":"Pref-1, a protein containing EGF-like repeats, inhibits adipocyte differentiation","volume":"73","author":"Smas","year":"1993","journal-title":"Cell"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1126\/science.289.5481.950","article-title":"Inhibition of Adipogenesis by Wnt Signaling","volume":"289","author":"Ross","year":"2000","journal-title":"Sci."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Fujiwara, K., Hasegawa, K., Ohkumo, T., Miyoshi, H., Tseng, Y.-H., and Yoshikawa, K. (2012). Necdin Controls Proliferation of White Adipocyte Progenitor Cells. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0030948"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.cmet.2005.10.002","article-title":"Rb and p107 regulate preadipocyte differentiation into white versus brown fat through repression of PGC-1\u03b1","volume":"2","author":"Grenier","year":"2005","journal-title":"Cell Metab."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1152\/physrev.1998.78.3.783","article-title":"Understanding Adipocyte Differentiation","volume":"78","author":"Gregoire","year":"1998","journal-title":"Physiol. Rev."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1038\/s41580-018-0093-z","article-title":"Adipogenesis and metabolic health","volume":"20","author":"Ghaben","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1042\/BJ20091112","article-title":"C\/EBP transcription factors regulate SREBP1c gene expression during adipogenesis","volume":"425","author":"Payne","year":"2009","journal-title":"Biochem. J."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.mce.2009.08.023","article-title":"Transcriptional factors that promote formation of white adipose tissue","volume":"318","author":"White","year":"2010","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1146\/annurev.cellbio.16.1.145","article-title":"Molecular Regulation of Adipogenesis","volume":"16","author":"Rosen","year":"2000","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1016\/j.jmb.2007.07.040","article-title":"Structural Basis for Activation of Fatty Acid-binding Protein 4","volume":"372","author":"Gillilan","year":"2007","journal-title":"J. Mol. Biol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"2941","DOI":"10.1101\/gad.1709008","article-title":"PPAR and C\/EBP factors orchestrate adipocyte biology via adjacent binding on a genome-wide scale","volume":"22","author":"Lefterova","year":"2008","journal-title":"Genes Dev."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"2953","DOI":"10.1101\/gad.501108","article-title":"Genome-wide profiling of PPAR\u03b3:RXR and RNA polymerase II occupancy reveals temporal activation of distinct metabolic pathways and changes in RXR dimer composition during adipogenesis","volume":"22","author":"Nielsen","year":"2008","journal-title":"Genes Dev."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1128\/MCB.01344-13","article-title":"Peroxisome Proliferator-Activated Receptor \u03b3 and C\/EBP\u03b1 Synergistically Activate Key Metabolic Adipocyte Genes by Assisted Loading","volume":"34","author":"Madsen","year":"2014","journal-title":"Mol. Cell. Biol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1159\/000491770","article-title":"Role of 1\u03b1,25-Dihydroxyvitamin D3 in Adipogenesis of SGBS Cells: New Insights into Human Preadipocyte Proliferation","volume":"48","author":"Felicidade","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1002\/jcb.10507","article-title":"Proliferation and differentiation of osteoblasts and adipocytes in rat bone marrow stromal cell cultures: Effects of dexamethasone and calcitriol","volume":"89","author":"Atmani","year":"2003","journal-title":"J. Cell. Biochem."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"2221","DOI":"10.1210\/endo.134.5.8156925","article-title":"1,25-dihydroxyvitamin D3 stimulates adipocyte differentiation in cultures of fetal rat calvaria cells: Comparison with the effects of dexamethasone","volume":"134","author":"Bellows","year":"1994","journal-title":"Endocrinology"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1002\/jcb.21151","article-title":"VDR-mediated inhibition of DKK1 and SFRP2 suppresses adipogenic differentiation of murine bone marrow stromal cells","volume":"101","author":"Cianferotti","year":"2007","journal-title":"J. Cell. Biochem."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"2627","DOI":"10.1242\/jcs.00623","article-title":"Secreted antagonists of the Wnt signalling pathway","volume":"116","author":"Kawano","year":"2003","journal-title":"J. Cell Sci."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1210\/jc.2011-0385","article-title":"Evaluation, Treatment, and Prevention of Vitamin D Deficiency: An Endocrine Society Clinical Practice Guideline","volume":"96","author":"Holick","year":"2011","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"2622","DOI":"10.1210\/endo.139.5.5970","article-title":"1,25-Dihydroxy Vitamin D3 Inhibits Adipocyte Differentiation and Gene Expression in Murine Bone Marrow Stromal Cell Clones and Primary Cultures*","volume":"139","author":"Kelly","year":"1998","journal-title":"Endocrinology"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1271\/bbb.67.314","article-title":"Insulin-Dependent Adipogenesis in Stromal ST2 Cells Derived from Murine Bone Marrow","volume":"67","author":"Ding","year":"2003","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1002\/jcb.240480411","article-title":"1\u03b1,25-Dihydroxyvitamin D3 modulation in lipid metabolism in established bone marrow-derived stromal cells, MC3T3-G2\/PA6","volume":"48","author":"Shionome","year":"1992","journal-title":"J. Cell. Biochem."},{"key":"ref_98","first-page":"E916","article-title":"Molecular mechanism of 1,25-dihydroxyvitamin D3inhibition of adipogenesis in 3T3-L1 cells","volume":"290","author":"Kong","year":"2006","journal-title":"Am. J. Physiol. Metab."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"11205","DOI":"10.1074\/jbc.M510343200","article-title":"Complex Role of the Vitamin D Receptor and Its Ligand in Adipogenesis in 3T3-L1 Cells","volume":"281","author":"Blumberg","year":"2006","journal-title":"J. Biol. Chem."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/oby.2007.90","article-title":"Enhanced Effects of 1,25(OH)2 D3 Plus Genistein on Adipogenesis and Apoptosis in 3T3-L1 Adipocytes","volume":"16","author":"Rayalam","year":"2008","journal-title":"Obesity"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3177\/jnsv.58.1","article-title":"The Involvement of Mitogen-Activated Protein Kinases in the 1^|^alpha;,25-Dihydroxy-Cholecalciferol-Induced Inhibition of Adipocyte Differentiation In Vitro","volume":"58","author":"Sakuma","year":"2012","journal-title":"J. Nutr. Sci. Vitaminol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/0300-9629(90)90699-S","article-title":"Comparative investigation of vitamins and their analogues on terminal differentiation, from preadipocytes to adipocytes, of 3T3-L1 cells","volume":"96","author":"Kawada","year":"1990","journal-title":"Comp. Biochem. Physiol. Part A Physiol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.3892\/ijmm.2012.1101","article-title":"Anti-adipogenic effects of 1,25-dihydroxyvitamin D3 are mediated by the maintenance of the wingless-type MMTV integration site\/\u03b2-catenin pathway","volume":"30","author":"Lee","year":"2012","journal-title":"Int. J. Mol. Med."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"PL205","DOI":"10.1016\/S0024-3205(98)00059-9","article-title":"Counteraction of retinoic acid and 1,25-dihydroxyvitamin D3 on up-regulation of adipocyte differentiation with PPAR\u03b3 ligand, an antidiabetic thiazolidinedione, in 3T3-L1 cells","volume":"62","author":"Hida","year":"1998","journal-title":"Life Sci."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1016\/S0006-291X(88)80482-0","article-title":"Possible involvement of 1\u03b1,25-dihydroxyvitamine D3 in proliferation and differentiation of 3T3-L1 cells","volume":"151","author":"Ishida","year":"1988","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1002\/jcp.1041350326","article-title":"Demonstration of 1?,25-dihydroxyvitamin D3 receptor-like molecule in ST 13 and 3T3 L1 preadipocytes and its inhibitory effects on preadipocyte differentiation","volume":"135","author":"Sato","year":"1988","journal-title":"J. Cell. Physiol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.abb.2006.12.020","article-title":"2-Methylene-19-nor-1\u03b1-hydroxyvitamin D3 analogs inhibit adipocyte differentiation and PPAR\u03b32 gene transcription","volume":"460","author":"Thomson","year":"2007","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Ji, S., Doumit, M.E., and Hill, R.A. (2015). Regulation of Adipogenesis and Key Adipogenic Gene Expression by 1, 25-Dihydroxyvitamin D in 3T3-L1 Cells. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0134199"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"2437","DOI":"10.1210\/me.2004-0539","article-title":"A Nuclear Receptor Atlas: 3T3-L1 Adipogenesis","volume":"19","author":"Fu","year":"2005","journal-title":"Mol. Endocrinol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"9863","DOI":"10.1128\/MCB.24.22.9863-9872.2004","article-title":"ETO\/MTG8 Is an Inhibitor of C\/EBP\u03b2 Activity and a Regulator of Early Adipogenesis","volume":"24","author":"Rochford","year":"2004","journal-title":"Mol. Cell. Biol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.tem.2008.09.002","article-title":"Adipogenesis and WNT signalling","volume":"20","author":"Christodoulides","year":"2009","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"2613","DOI":"10.1073\/pnas.052707099","article-title":"The peroxisome proliferator-activated receptor, an integrator of transcriptional repression and nuclear receptor signaling","volume":"99","author":"Shi","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1038\/oby.2011.212","article-title":"Regulation of Wnt\/\u03b2-Catenin Signaling by CCAAT\/Enhancer Binding Protein \u03b2 During Adipogenesis","volume":"20","author":"Chung","year":"2012","journal-title":"Obesity"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"3393","DOI":"10.1002\/jcb.23273","article-title":"Mammary adipocytes bioactivate 25-hydroxyvitamin D3 and signal via vitamin D3 receptor, modulating mammary epithelial cell growth","volume":"112","author":"Ching","year":"2011","journal-title":"J. Cell. Biochem."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.cbi.2007.07.012","article-title":"Effects of 1,25-dihydroxyvitamin D3 on proliferation and differentiation of porcine preadipocyte in vitro","volume":"170","author":"Zhuang","year":"2007","journal-title":"Chem. Interactions"},{"key":"ref_116","first-page":"8","article-title":"Insulin resistance and adipogenesis: Role of transcription and secreted factors","volume":"78","author":"Penkov","year":"2013","journal-title":"Biochemistry"},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Galicia-Garcia, U., Benito-Vicente, A., Jebari, S., Larrea-Sebal, A., Siddiqi, H., Uribe, K.B., Ostolaza, H., and Mart\u00edn, C. (2020). Pathophysiology of Type 2 Diabetes Mellitus. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21176275"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.bbrc.2007.10.051","article-title":"Enhanced effects of guggulsterone plus 1,25(OH)2D3 on 3T3-L1 adipocytes","volume":"364","author":"Rayalam","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"3760","DOI":"10.1128\/MCB.19.5.3760","article-title":"ADD1\/SREBP-1c Is Required in the Activation of Hepatic Lipogenic Gene Expression by Glucose","volume":"19","author":"Foretz","year":"1999","journal-title":"Mol. Cell. Biol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1101\/gad.10.9.1096","article-title":"ADD1\/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism","volume":"10","author":"Kim","year":"1996","journal-title":"Genes Dev."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1210\/me.2004-0324","article-title":"Identification of a Functional Vitamin D Response Element in the Murine Insig-2 Promoter and Its Potential Role in the Differentiation of 3T3-L1 Preadipocytes","volume":"19","author":"Lee","year":"2005","journal-title":"Mol. Endocrinol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"E271","DOI":"10.1152\/ajpendo.90920.2008","article-title":"Lipoprotein lipase: From gene to obesity","volume":"297","author":"Wang","year":"2009","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_123","first-page":"30","article-title":"Role of Calcitriol and Cortisol on Human Adipocyte Proliferation and Oxidative and Inflammatory Stress: A Microarray Study","volume":"1","author":"Sun","year":"2007","journal-title":"J. Nutr. Nutr."},{"key":"ref_124","first-page":"8","article-title":"Increase of adipose differentiation by hypolipidemic fibrate drugs in Ob 17 preadipocytes: Requirement for thyroid hormones","volume":"1177","author":"Teboul","year":"1993","journal-title":"Biochim. Biophys. Acta (BBA)-Bioenerg."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"4268","DOI":"10.1210\/endo.137.10.8828486","article-title":"Calcitriol down-modulates the 3,5,3\u2019 triiodothyronine (T3) receptors and affects, in a biphasic manner, the T3-dependent adipose differentiation of Ob 17 preadipocytes","volume":"137","author":"Lenoir","year":"1996","journal-title":"Endocrinology"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.jsbmb.2015.09.035","article-title":"Adipose-specific Vdr deletion alters body fat and enhances mammary epithelial density","volume":"164","author":"Matthews","year":"2016","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1210\/en.2008-1118","article-title":"Lean Phenotype and Resistance to Diet-Induced Obesity in Vitamin D Receptor Knockout Mice Correlates with Induction of Uncoupling Protein-1 in White Adipose Tissue","volume":"150","author":"Narvaez","year":"2009","journal-title":"Endocrinology"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1111\/j.1439-0396.2012.01308.x","article-title":"Differences in triglyceride and cholesterol metabolism and resistance to obesity in male and female vitamin D receptor knockout mice","volume":"97","author":"Weber","year":"2012","journal-title":"J. Anim. Physiol. Anim. Nutr."},{"key":"ref_129","first-page":"E820","article-title":"Involvement of the vitamin D receptor in energy metabolism: Regulation of uncoupling proteins","volume":"296","author":"Wong","year":"2009","journal-title":"Am. J. Physiol. Metab."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1530\/JOE-12-0344","article-title":"1,25-Dihydroxyvitamin D3 upregulates leptin expression in mouse adipose tissue","volume":"216","author":"Kong","year":"2012","journal-title":"J. Endocrinol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"33804","DOI":"10.1074\/jbc.M111.257568","article-title":"Targeted Expression of Human Vitamin D Receptor in Adipocytes Decreases Energy Expenditure and Induces Obesity in Mice","volume":"286","author":"Wong","year":"2011","journal-title":"J. Biol. Chem."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"1700726","DOI":"10.1002\/mnfr.201700726","article-title":"Vitamin D Does Not Play a Functional Role in Adipose Tissue Development in Rodent Models","volume":"62","author":"Schutkowski","year":"2018","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1007\/s00394-016-1359-x","article-title":"Maternal vitamin D deficiency during pregnancy affects expression of adipogenic-regulating genes peroxisome proliferator-activated receptor gamma (PPAR\u03b3) and vitamin D receptor (VDR) in lean male mice offspring","volume":"57","author":"Belenchia","year":"2018","journal-title":"Eur. J. Nutr."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.mce.2017.04.013","article-title":"Spotlight on vitamin D receptor, lipid metabolism and mitochondria: Some preliminary emerging issues","volume":"450","author":"Silvagno","year":"2017","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1002\/jsfa.4622","article-title":"Vitamin D3 regulation of body fat, cytokines, and calpain gene expression","volume":"92","author":"Choi","year":"2011","journal-title":"J. Sci. Food Agric."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.exger.2003.11.008","article-title":"1,25(OH)2D3 inhibits bone marrow adipogenesis in senescence accelerated mice (SAM-P\/6) by decreasing the expression of peroxisome proliferator-activated receptor gamma 2 (PPAR\u03b32)","volume":"39","author":"Duque","year":"2004","journal-title":"Exp. Gerontol."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1002\/mnfr.201300503","article-title":"High vitamin D and calcium intakes reduce diet-induced obesity in mice by increasing adipose tissue apoptosis","volume":"58","author":"Sergeev","year":"2014","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_138","doi-asserted-by":"crossref","unstructured":"Sergeev, I.N. (2020). Vitamin D Status and Vitamin D-Dependent Apoptosis in Obesity. Nutrients, 12.","DOI":"10.3390\/nu12051392"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"S139","DOI":"10.1111\/j.1753-4887.2008.00099.x","article-title":"Calcitriol and energy metabolism","volume":"66","author":"Zemel","year":"2008","journal-title":"Nutr. Rev."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1096\/fj.04-1971fje","article-title":"Role of uncoupling protein 2 (UCP2) expression and 1\u03b1, 25-dihydroxyvitamin D 3 in modulating adipocyte apoptosis","volume":"18","author":"Sun","year":"2004","journal-title":"FASEB J."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.bbrc.2009.04.078","article-title":"1,25-Dihydroxyvitamin D3 induces Ca2+-mediated apoptosis in adipocytes via activation of calpain and caspase-12","volume":"384","author":"Sergeev","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1515\/hmbci-2015-0069","article-title":"1,25-Dihydroxyvitamin D3 and type 2 diabetes: Ca2+-dependent molecular mechanisms and the role of vitamin D status","volume":"26","author":"Sergeev","year":"2016","journal-title":"Horm. Mol. Biol. Clin. Investig."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.jsbmb.2004.03.010","article-title":"Calcium as a mediator of 1,25-dihydroxyvitamin D3-induced apoptosis","volume":"89\u201390","author":"Sergeev","year":"2004","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1096\/fj.01-0584fje","article-title":"1\u03b1,25-Dihydroxyvitamin D3modulates human adipocyte metabolism via nongenomic action","volume":"15","author":"Shi","year":"2001","journal-title":"FASEB J."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.3892\/ijmm.2015.2300","article-title":"The effects of vitamin D3 on lipogenesis in the liver and adipose tissue of pregnant rats","volume":"36","author":"Kang","year":"2015","journal-title":"Int. J. Mol. Med."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"2527","DOI":"10.1096\/fj.01-0278fje","article-title":"Mechanism of intracellular calcium ([Ca2+]i) inhibition of lipolysis in human adipocytes","volume":"15","author":"Xue","year":"2001","journal-title":"FASEB J."},{"key":"ref_147","first-page":"702","article-title":"Vitamin D decreases adipocyte lipid storage and increases NAD-SIRT1 pathway in 3T3-L1 adipocytes","volume":"32","author":"Chang","year":"2016","journal-title":"Nutrients"},{"key":"ref_148","doi-asserted-by":"crossref","unstructured":"1Larrick, B.M., Kim, K.-H., Donkin, S.S., and Teegarden, D. (2018). 1,25-Dihydroxyvitamin D regulates lipid metabolism and glucose utilization in differentiated 3T3-L1 adipocytes. Nutr. Res., 58, 72\u201383.","DOI":"10.1016\/j.nutres.2018.07.004"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1016\/j.jnutbio.2014.05.010","article-title":"Vitamin D protects against diet-induced obesity by enhancing fatty acid oxidation","volume":"25","author":"Marcotorchino","year":"2014","journal-title":"J. Nutr. Biochem."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"4171","DOI":"10.1073\/pnas.94.8.4171","article-title":"Insulin receptor substrate (IRS) 1 is reduced and IRS-2 is the main docking protein for phosphatidylinositol 3-kinase in adipocytes from subjects with non-insulin-dependent diabetes mellitus","volume":"94","author":"Rondinone","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1056\/NEJM199907223410406","article-title":"Glucose Transporters and Insulin Action \u2014 Implications for Insulin Resistance and Diabetes Mellitus","volume":"341","author":"Shepherd","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.mce.2009.08.018","article-title":"Adipose tissue as an endocrine organ","volume":"316","author":"Galic","year":"2010","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.steroids.2015.08.014","article-title":"Vitamin D reduces LPS-induced cytokine release in omental adipose tissue of women but not men","volume":"104","author":"Roy","year":"2015","journal-title":"Steroids"},{"key":"ref_154","doi-asserted-by":"crossref","unstructured":"Walker, G.E., Ricotti, R., Roccio, M., Moia, S., Bellone, S., Prodam, F., and Bona, G. (2014). Pediatric Obesity and Vitamin D Deficiency: A Proteomic Approach Identifies Multimeric Adiponectin as a Key Link between These Conditions. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0083685"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"2442","DOI":"10.2337\/diacare.26.8.2442","article-title":"Adiponectin: More Than Just Another Fat Cell Hormone?","volume":"26","author":"Chandran","year":"2003","journal-title":"Diabetes Care"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"26746","DOI":"10.1074\/jbc.270.45.26746","article-title":"A Novel Serum Protein Similar to C1q, Produced Exclusively in Adipocytes","volume":"270","author":"Scherer","year":"1995","journal-title":"J. Biol. Chem."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1006\/bbrc.1996.0587","article-title":"cDNA Cloning and Expression of a Novel Adipose Specific Collagen-like Factor, apM1 (AdiposeMost Abundant Gene Transcript 1)","volume":"221","author":"Maeda","year":"1996","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_158","first-page":"293","article-title":"The role of the novel adipocyte-derived hormone adiponectin in human disease","volume":"148","author":"Iglesias","year":"2003","journal-title":"Eur. J. Endocrinol."},{"key":"ref_159","first-page":"95","article-title":"The Role of Adiponectin in Maintaining Metabolic Homeostasis","volume":"16","author":"Adiyaman","year":"2020","journal-title":"Curr. Diabetes Rev."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1210\/jc.2011-3465","article-title":"Improvement of Vitamin D Status via Daily Intake of Fortified Yogurt Drink Either with or without Extra Calcium Ameliorates Systemic Inflammatory Biomarkers, including Adipokines, in the Subjects with Type 2 Diabetes","volume":"97","author":"Neyestani","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1002\/mnfr.201200383","article-title":"Vitamin D reduces the inflammatory response and restores glucose uptake in adipocytes","volume":"56","author":"Marcotorchino","year":"2012","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/1476-511X-10-37","article-title":"Supplementing Alpha-Tocopherol (Vitamin E) and Vitamin D3 in High Fat Diet Decrease IL-6 Production in Murine Epididymal Adipose Tissue and 3T3-L1 Adipocytes Following LPS Stimulation","volume":"10","author":"Lira","year":"2011","journal-title":"Lipids Health Dis."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1038\/oby.2007.540","article-title":"Calcium and 1,25-Dihydroxyvitamin D3 Regulation of Adipokine Expression*","volume":"15","author":"Sun","year":"2007","journal-title":"Obesity"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.phrs.2016.03.035","article-title":"Does vitamin D supplementation alter plasma adipokines concentrations? A systematic review and meta-analysis of randomized controlled trials","volume":"107","author":"Dinca","year":"2016","journal-title":"Pharmacol. Res."},{"key":"ref_165","first-page":"335","article-title":"Differential effects of 1\u03b1,25-dihydroxycholecalciferol on MCP-1 and adiponectin production in human white adipocytes","volume":"51","author":"Eriksson","year":"2011","journal-title":"Eur. J. Nutr."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/35007534","article-title":"Central nervous system control of food intake","volume":"404","author":"Schwartz","year":"2000","journal-title":"Nature"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1006\/bbrc.1998.9277","article-title":"Lipolytic Effect ofin VivoLeptin Administration on Adipocytes of Lean andob\/obMice, but Notdb\/dbMice","volume":"250","author":"Aguado","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1006\/bbrc.1997.7716","article-title":"In VitroLipolytic Effect of Leptin on Mouse Adipocytes: Evidence for a Possible Autocrine\/Paracrine Role of Leptin","volume":"240","author":"Aguado","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"260","DOI":"10.5114\/ceji.2014.43732","article-title":"Obesity, adipose tissue function and the role of vitamin D","volume":"2","author":"Koszowska","year":"2014","journal-title":"Central Eur. J. Immunol."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"348","DOI":"10.5114\/pdia.2012.31487","article-title":"Nutritive value of daily food rations of patients with psoriasis vulgaris: A preliminary report","volume":"5","author":"Wasiluk","year":"2012","journal-title":"Adv. Dermatol. Allergol."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"4023","DOI":"10.1096\/fj.14-269811","article-title":"1,25-Dihydroxyvitamin D regulates expression of the tryptophan hydroxylase 2 and leptin genes: Implication for behavioral influences of vitamin D","volume":"29","author":"Kaneko","year":"2015","journal-title":"FASEB J."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1002\/jbmr.65","article-title":"Leptin stimulates fibroblast growth factor 23 expression in bone and suppresses renal 1\u03b1,25-dihydroxyvitamin D3 synthesis in leptin-deficient ob\/ob Mice","volume":"25","author":"Tsuji","year":"2010","journal-title":"J. Bone Miner. Res."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/nrendo.2013.226","article-title":"Vitamin D and energy homeostasis\u2014of mice and men","volume":"10","author":"Bouillon","year":"2013","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s00394-019-01899-5","article-title":"Vitamin D supplementation increases adipokine concentrations in overweight or obese adults","volume":"59","author":"Mousa","year":"2019","journal-title":"Eur. J. Nutr."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1038\/ejcn.2016.245","article-title":"Vitamin D and serum leptin: A systematic review and meta-analysis of observational studies and randomized controlled trials","volume":"71","author":"Hajimohammadi","year":"2016","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/dom.12154","article-title":"The immune cells in adipose tissue","volume":"15","author":"Ferrante","year":"2013","journal-title":"Diabetes Obes. Metab."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1096\/fj.05-5678fje","article-title":"Separation of human adipocytes by size: Hypertrophic fat cells display distinct gene expression","volume":"20","author":"Palming","year":"2006","journal-title":"FASEB J."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.physbeh.2007.10.010","article-title":"The role of adipose tissue dysfunction in the pathogenesis of obesity-related insulin resistance","volume":"94","author":"Goossens","year":"2008","journal-title":"Physiol. Behav."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1152\/physrev.00017.2012","article-title":"Hypoxia and Adipose Tissue Function and Dysfunction in Obesity","volume":"93","author":"Trayhurn","year":"2013","journal-title":"Physiol. Rev."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1172\/JCI20514","article-title":"Obesity-induced inflammatory changes in adipose tissue","volume":"112","author":"Wellen","year":"2003","journal-title":"J. Clin. Investig."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mce.2009.07.031","article-title":"Adipokine dysregulation, adipose tissue inflammation and metabolic syndrome","volume":"314","author":"Maury","year":"2010","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/j.1748-1716.2010.02171.x","article-title":"Role of adipokines in obesity-associated hypertension","volume":"200","author":"Vlasova","year":"2010","journal-title":"Acta Physiol."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.cmet.2010.12.008","article-title":"NF-\u03baB, Inflammation, and Metabolic Disease","volume":"13","author":"Baker","year":"2011","journal-title":"Cell Metab."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1172\/JCI200319451","article-title":"Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance","volume":"112","author":"Xu","year":"2003","journal-title":"J. Clin. Investig."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"3757","DOI":"10.3390\/nu5093757","article-title":"Activation and Regulation of the Pattern Recognition Receptors in Obesity-Induced Adipose Tissue Inflammation and Insulin Resistance","volume":"5","author":"Watanabe","year":"2013","journal-title":"Nutrients"},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1172\/JCI200319246","article-title":"Obesity is associated with macrophage accumulation in adipose tissue","volume":"112","author":"Weisberg","year":"2003","journal-title":"J. Clin. Investig."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1007\/s00424-009-0693-8","article-title":"Microarray analysis identifies matrix metalloproteinases (MMPs) as key genes whose expression is up-regulated in human adipocytes by macrophage-conditioned medium","volume":"458","author":"Lim","year":"2009","journal-title":"Pfl\u00fcger\u2019s Archiv f\u00fcr die Gesammte Physiologie des Menschen und der Tiere"},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1210\/me.2008-0183","article-title":"Macrophage-Secreted Factors Promote a Profibrotic Phenotype in Human Preadipocytes","volume":"23","author":"Keophiphath","year":"2009","journal-title":"Mol. Endocrinol."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.mce.2010.05.020","article-title":"Macrophage-secreted factors inhibit ZAG expression and secretion by human adipocytes","volume":"325","author":"Gao","year":"2010","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"2869","DOI":"10.1002\/jcp.22630","article-title":"Macrophage-induced expression and release of matrix metalloproteinase 1 and 3 by human preadipocytes is mediated by IL-1\u03b2 via activation of MAPK signaling","volume":"226","author":"Gao","year":"2011","journal-title":"J. Cell. Physiol."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1038\/nri2873","article-title":"Sterile inflammation: Sensing and reacting to damage","volume":"10","author":"Chen","year":"2010","journal-title":"Nat. Rev. Immunol."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.jnutbio.2007.05.013","article-title":"Calcitriol and calcium regulate cytokine production and adipocyte\u2013macrophage cross-talk","volume":"19","author":"Sun","year":"2008","journal-title":"J. Nutr. Biochem."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.abb.2010.12.020","article-title":"1,25-Dihydroxyvitamin D3 suppresses inflammation-induced expression of plasminogen activator inhibitor-1 by blocking nuclear factor-\u03baB activation","volume":"507","author":"Chen","year":"2011","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1093\/ndt\/gfi254","article-title":"Vitamin D decreases NF\u03baB activity by increasing I\u03baB\u03b1 levels","volume":"21","author":"Shany","year":"2006","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.4049\/jimmunol.1102412","article-title":"Vitamin D Inhibits Monocyte\/Macrophage Proinflammatory Cytokine Production by Targeting MAPK Phosphatase-1","volume":"188","author":"Zhang","year":"2012","journal-title":"J. Immunol."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1210\/en.2014-1647","article-title":"Vitamin D Limits Chemokine Expression in Adipocytes and Macrophage Migration In Vitro and in Male Mice","volume":"156","author":"Karkeni","year":"2015","journal-title":"Endocrinol."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1093\/rheumatology\/keq124","article-title":"Vitamin D3 down-regulates intracellular Toll-like receptor 9 expression and Toll-like receptor 9-induced IL-6 production in human monocytes","volume":"49","author":"Dickie","year":"2010","journal-title":"Rheumatology"},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1002\/eji.200425995","article-title":"Vitamin D3 down-regulates monocyte TLR expression and triggers hyporesponsiveness to pathogen-associated molecular patterns","volume":"36","author":"Sadeghi","year":"2006","journal-title":"Eur. J. Immunol."},{"key":"ref_199","doi-asserted-by":"crossref","unstructured":"Park, C.Y., Kim, T.Y., Yoo, J.S., Seo, Y., Pae, M., and Han, S.N. (2020). Effects of 1,25-Dihydroxyvitamin D3 on the Inflammatory Responses of Stromal Vascular Cells and Adipocytes from Lean and Obese Mice. Nutrients, 12.","DOI":"10.3390\/nu12020364"},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jsbmb.2006.07.008","article-title":"The Vitamin D analogue TX 527 blocks NF-\u03baB activation in peripheral blood mononuclear cells of patients with Crohn\u2019s disease","volume":"103","author":"Stio","year":"2007","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.it.2004.03.008","article-title":"The two NF-\u03baB activation pathways and their role in innate and adaptive immunity","volume":"25","author":"Bonizzi","year":"2004","journal-title":"Trends Immunol."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/ijo.2012.53","article-title":"1,25-Dihydroxyvitamin D3 inhibits the cytokine-induced secretion of MCP-1 and reduces monocyte recruitment by human preadipocytes","volume":"37","author":"Gao","year":"2013","journal-title":"Int. J. Obes."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"4400","DOI":"10.1096\/fj.12-210880","article-title":"Inhibition of cytokine secretion from adipocytes by 1,25-dihydroxyvitamin D 3 via the NF-\u03baB pathway","volume":"26","author":"Mutt","year":"2012","journal-title":"FASEB J."},{"key":"ref_204","doi-asserted-by":"crossref","unstructured":"Ding, C., Wilding, J., and Bing, C. (2013). 1,25-dihydroxyvitamin D3 Protects against Macrophage-Induced Activation of NF\u03baB and MAPK Signalling and Chemokine Release in Human Adipocytes. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0061707"},{"key":"ref_205","doi-asserted-by":"crossref","unstructured":"Rafique, A., Rejnmark, L., Heickendorff, L., and M\u00f8ller, H.J. (2019). 25(OH)D3 and 1.25(OH)2D3 inhibits TNF-\u03b1 expression in human monocyte derived macrophages. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0215383"},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.diabres.2006.10.007","article-title":"Monocytes from type 2 diabetic patients have a pro-inflammatory profile","volume":"77","author":"Giulietti","year":"2007","journal-title":"Diabetes Res. Clin. Pr."},{"key":"ref_207","doi-asserted-by":"crossref","unstructured":"Marziou, A., Philouze, C., Couturier, C., Astier, J., Obert, P., Landrier, J.-F., and Riva, C. (2020). Vitamin D Supplementation Improves Adipose Tissue Inflammation and Reduces Hepatic Steatosis in Obese C57BL\/6J Mice. Nutrients, 12.","DOI":"10.3390\/nu12020342"},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1007\/s10753-017-0610-9","article-title":"Adipose Tissue Inflammation and Oxidative Stress: The Ameliorative Effects of Vitamin D","volume":"40","author":"Farhangi","year":"2017","journal-title":"Inflammation"},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.nutres.2015.10.006","article-title":"Association between 25-hydroxyvitamin D and inflammatory biomarker levels in a cross-sectional population-based study, S\u00e3o Paulo, Brazil","volume":"36","author":"Norde","year":"2016","journal-title":"Nutr. Res."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1055\/s-0032-1331746","article-title":"Investigations of the Anti-inflammatory Effects of Vitamin D in Adipose Tissue: Results from an In Vitro Study and a Randomized Controlled Trial","volume":"45","author":"Wamberg","year":"2013","journal-title":"Horm. Metab. Res."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1159\/000490358","article-title":"Effect of Vitamin D Supplementation on Some Inflammatory Biomarkers in Type 2 Diabetes Mellitus Subjects: A Systematic Review and Meta-Analysis of Randomized Controlled Trials","volume":"73","author":"Yu","year":"2018","journal-title":"Ann. Nutr. Metab."},{"key":"ref_212","first-page":"2163","article-title":"The effect of vitamin D supplementation on selected inflammatory biomarkers in obese and overweight subjects: A systematic review with meta-analysis","volume":"55","author":"Jamka","year":"2016","journal-title":"Zeitschrift f\u00fcr Ern\u00e4hrungswissenschaft"},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1146\/annurev-physiol-021909-135846","article-title":"Macrophages, Inflammation, and Insulin Resistance","volume":"72","author":"Olefsky","year":"2010","journal-title":"Annu. Rev. Physiol."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/nature16151","article-title":"Depletion of fat-resident Treg cells prevents age-associated insulin resistance","volume":"528","author":"Bapat","year":"2015","journal-title":"Nature"},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1111\/imm.12269","article-title":"Adipose invariant natural killer T cells","volume":"142","author":"Lynch","year":"2014","journal-title":"Immunology"},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1089\/ars.2016.6746","article-title":"Modulation of T Cell Activation in Obesity","volume":"26","author":"Morin","year":"2017","journal-title":"Antioxid. Redox Signal."},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.it.2014.08.003","article-title":"Metabolic control of regulatory T cell development and function","volume":"36","author":"Zeng","year":"2015","journal-title":"Trends Immunol."},{"key":"ref_218","first-page":"965","article-title":"Current status in vitamin D and regulatory T cells--immunological implications","volume":"117","author":"Mocanu","year":"2013","journal-title":"Rev. Med. Chir. Soc. Med. Nat. Iasi."},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"3368","DOI":"10.1210\/jc.2010-0195","article-title":"Vitamin D-Binding Protein Directs Monocyte Responses to 25-Hydroxy- and 1,25-Dihydroxyvitamin D","volume":"95","author":"Chun","year":"2010","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.jsbmb.2010.03.005","article-title":"Mechanisms involved in vitamin D mediated intestinal calcium absorption and in non-classical actions of vitamin D","volume":"121","author":"Christakos","year":"2010","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.3389\/fphys.2019.01638","article-title":"The Impact of Oxidative Stress on Adipose Tissue Energy Balance","volume":"10","author":"Masschelin","year":"2020","journal-title":"Front. Physiol."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1074\/jbc.R118.003214","article-title":"Adipose oxidative stress and protein carbonylation","volume":"294","author":"Hauck","year":"2019","journal-title":"J. Biol. Chem."},{"key":"ref_223","doi-asserted-by":"crossref","unstructured":"Nankam, P.N., Nguelefack, T., Goedecke, J., and Bl\u00fcher, M. (2021). Contribution of Adipose Tissue Oxidative Stress to Obesity-Associated Diabetes Risk and Ethnic Differences: Focus on Women of African Ancestry. Antioxidants, 10.","DOI":"10.3390\/antiox10040622"},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.7150\/ijms.47103","article-title":"Vitamin C: A Review on its Role in the Management of Metabolic Syndrome","volume":"17","author":"Wong","year":"2020","journal-title":"Int. J. Med. Sci."},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"3117","DOI":"10.3390\/ijms12053117","article-title":"Inflammation, Oxidative Stress, and Obesity","volume":"12","author":"Bautista","year":"2011","journal-title":"Int. J. Mol. Sci."},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"R143","DOI":"10.1530\/JOE-18-0163","article-title":"Mitochondrial oxidative stress in obesity: Role of the mineralocorticoid receptor","volume":"238","author":"Lefranc","year":"2018","journal-title":"J. Endocrinol."},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1139\/cjpp-2019-0340","article-title":"Vitamin D alleviates oxidative stress in adipose tissue and mesenteric vessels from obese patients with subclinical inflammation","volume":"98","author":"Ionica","year":"2020","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.1038\/oby.2007.232","article-title":"1\u03b1,25-Dihydroxyvitamin D3 Modulation of Adipocyte Reactive Oxygen Species Production","volume":"15","author":"Sun","year":"2007","journal-title":"Obesity"},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.mce.2010.01.039","article-title":"Mitochondrial dysfunction is induced by high levels of glucose and free fatty acids in 3T3-L1 adipocytes","volume":"320","author":"Gao","year":"2010","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1111\/pedi.13055","article-title":"Relationship of oxidative stress to visceral adiposity in youth and role played by vitamin D","volume":"21","author":"Samouda","year":"2020","journal-title":"Pediatr. Diabetes"},{"key":"ref_231","doi-asserted-by":"crossref","unstructured":"C\u0103toi, A.F., Iancu, M., P\u00e2rvu, A.E., Cecan, A.D., Bidian, C., Chera, E.I., Pop, I.D., and Macri, A.M. (2021). Relationship between 25 Hydroxyvitamin D, Overweight\/Obesity Status, Pro-Inflammatory and Oxidative Stress Markers in Patients with Type 2 Diabetes: A Simplified Empirical Path Model. Nutrients, 13.","DOI":"10.3390\/nu13082889"},{"key":"ref_232","doi-asserted-by":"crossref","unstructured":"Wenclewska, S., Szymczak-Pajor, I., Drzewoski, J., Bunk, M., and \u015aliwi\u0144ska, A. (2019). Vitamin D Supplementation Reduces Both Oxidative DNA Damage and Insulin Resistance in the Elderly with Metabolic Disorders. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20122891"},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.ebiom.2018.03.004","article-title":"Inflammatory Cytokine Profiles in Visceral and Subcutaneous Adipose Tissues of Obese Patients Undergoing Bariatric Surgery Reveal Lack of Correlation With Obesity or Diabetes","volume":"30","author":"Rakotoarivelo","year":"2018","journal-title":"EBioMedicine"},{"key":"ref_234","first-page":"101","article-title":"Open Surgical and Needle Biopsy to Study Abdominal Subcutaneous Adipose Tissue in Obesity","volume":"14","author":"Mocanu","year":"2018","journal-title":"Jurnalul de Chir."},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.clnu.2010.11.006","article-title":"Diet induced thermogenesis, fat oxidation and food intake following sequential meals: Influence of calcium and vitamin D","volume":"30","author":"Soares","year":"2011","journal-title":"Clin. Nutr."},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1096\/fj.02-0255fje","article-title":"1\u03b1,25-dihydroxyvitamin D3inhibits uncoupling protein 2 expression in human adipocytes","volume":"16","author":"Shi","year":"2002","journal-title":"FASEB J."},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1002\/biof.1610","article-title":"Effects of 1,25(OH) 2 D 3 on lipid droplet growth in adipocytes","volume":"46","author":"Xiang","year":"2020","journal-title":"BioFactors"},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1177\/1535370216629009","article-title":"Women may respond different from men to vitamin D supplementation regarding cardiometabolic biomarkers","volume":"241","author":"Sharifi","year":"2016","journal-title":"Exp. Biol. Med."},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1016\/j.clnu.2016.09.020","article-title":"Effect of daily calcitriol supplementation with and without calcium on disease regression in non-alcoholic fatty liver patients following an energy-restricted diet: Randomized, controlled, double-blind trial","volume":"36","author":"Amiri","year":"2017","journal-title":"Clin. Nutr."},{"key":"ref_240","first-page":"969","article-title":"Effect of Vitamin D Supplementation on C-reactive Protein in Patients with Nonalcoholic Fatty Liver","volume":"5","author":"Foroughi","year":"2014","journal-title":"Int. J. Prev. Med."},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"63","DOI":"10.4103\/ijpvm.IJPVM_329_15","article-title":"Effect of Vitamin D supplementation on weight loss, glycemic indices, and lipid profile in obese and overweight women: A clinical trial study","volume":"9","author":"Entezari","year":"2018","journal-title":"Int. J. Prev. Med."},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/j.ejim.2013.03.005","article-title":"Effects of vitamin D supplementation on body fat accumulation, inflammation, and metabolic risk factors in obese adults with low vitamin D levels\u2014Results from a randomized trial","volume":"24","author":"Wamberg","year":"2013","journal-title":"Eur. J. Intern. Med."},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/1475-2891-11-78","article-title":"A 12-week double-blind randomized clinical trial of vitamin D3supplementation on body fat mass in healthy overweight and obese women","volume":"11","author":"Salehpour","year":"2012","journal-title":"Nutr. J."},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.3945\/ajcn.2008.27004","article-title":"Vitamin D supplementation enhances the beneficial effects of weight loss on cardiovascular disease risk markers","volume":"89","author":"Zittermann","year":"2009","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1530\/EJE-08-0339","article-title":"Supplementation with cholecalciferol does not result in weight reduction in overweight and obese subjects","volume":"159","author":"Sneve","year":"2008","journal-title":"Eur. J. Endocrinol."},{"key":"ref_246","first-page":"54","article-title":"Supplementation with calcium + vitamin D enhances the beneficial effect of weight loss on plasma lipid and lipoprotein concentrations","volume":"85","author":"Major","year":"2007","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_247","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1016\/j.dsx.2019.01.029","article-title":"Effects of vitamin D supplementation along with endurance physical activity on lipid profile in metabolic syndrome patients: A randomized controlled trial","volume":"13","author":"Farag","year":"2019","journal-title":"Diabetes Metab. Syndr. Clin. Res. Rev."},{"key":"ref_248","doi-asserted-by":"crossref","first-page":"e52","DOI":"10.5114\/amsad.2017.70504","article-title":"No effect of vitamin D supplementation on cardiovascular risk factors in subjects with metabolic syndrome: A pilot randomised study","volume":"2","author":"Makariou","year":"2017","journal-title":"Arch. Med Sci.-Atheroscler. Dis."},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"100093","DOI":"10.1016\/j.jnim.2019.100093","article-title":"No effect of vitamin D administration plus dietary intervention on emerging cardiovascular risk factors in patients with metabolic syndrome","volume":"16","author":"Makariou","year":"2019","journal-title":"J. Nutr. Intermed. Metab."},{"key":"ref_250","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1007\/s40618-016-0507-8","article-title":"Effect of high-dose vitamin D supplementation on cardiometabolic risk factors in subjects with metabolic syndrome: A randomized controlled double-blind clinical trial","volume":"39","author":"Salekzamani","year":"2016","journal-title":"J. Endocrinol. Investig."},{"key":"ref_251","first-page":"558","article-title":"Effects of vitamin D2 supplementation on insulin sensitivity and metabolic parameters in metabolic syndrome patients","volume":"36","author":"Wongwiwatthananukit","year":"2013","journal-title":"J. Endocrinol. Investig."},{"key":"ref_252","first-page":"71","article-title":"Correction of hypovitaminosis D does not improve the metabolic syndrome risk profile in a Chinese population: A randomized controlled trial for 1 year","volume":"25","author":"Yin","year":"2016","journal-title":"Asia Pac. J. Clin. Nutr."},{"key":"ref_253","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.dsx.2018.11.008","article-title":"The effects of vitamin D supplementation on lipid profiles and oxidative indices among diabetic nephropathy patients with marginal vitamin D status","volume":"13","author":"Barzegari","year":"2019","journal-title":"Diabetes Metab. Syndr. Clin. Res. Rev."},{"key":"ref_254","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1007\/s12603-018-1083-8","article-title":"Effect of Vitamin D Treatment on Glucose Homeostasis and Metabolism in Lebanese Older Adults: A Randomized Controlled Trial","volume":"22","author":"Chardigny","year":"2018","journal-title":"J. Nutr. Health Aging"},{"key":"ref_255","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1007\/s00125-014-3313-x","article-title":"Effects of calcium\u2013vitamin D co-supplementation on metabolic profiles in vitamin D insufficient people with type 2 diabetes: A randomised controlled clinical trial","volume":"57","author":"Tabesh","year":"2014","journal-title":"Diabetologia"},{"key":"ref_256","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.dsx.2018.03.008","article-title":"Effect of oral vitamin D supplementation on glycemic control in patients with type 2 diabetes mellitus with coexisting hypovitaminosis D: A parellel group placebo controlled randomized controlled pilot study","volume":"12","author":"Upreti","year":"2018","journal-title":"Diabetes Metab. Syndr. Clin. Res. Rev."},{"key":"ref_257","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1111\/dom.12650","article-title":"Differences in homeostatic model assessment (HOMA) values and insulin levels after vitamin D supplementation in healthy men: A double-blind randomized controlled trial","volume":"18","author":"Tepper","year":"2016","journal-title":"Diabetes Obes. 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