{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T16:23:18Z","timestamp":1782577398798,"version":"3.54.5"},"reference-count":75,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2022,1,16]],"date-time":"2022-01-16T00:00:00Z","timestamp":1642291200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Russian State Budget","award":["0259-2019-0008"],"award-info":[{"award-number":["0259-2019-0008"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by the early onset of communication and behavioral problems. ASD is highly heritable; however, environmental factors also play a considerable role in this disorder. A significant part of both syndromic and idiopathic autism cases could be attributed to disorders caused by mammalian target of rapamycin (mTOR)-dependent translation deregulation. This narrative review analyzes both bioinformatic and experimental evidence that connects mTOR signaling to the maternal autoantibody-related (MAR) autism spectrum and autoimmune neuropsychiatric disorders simultaneously. In addition, we reconstruct a network presenting the interactions between the mTOR signaling and eight MAR ASD genes coding for ASD-specific maternal autoantibody target proteins. The research discussed in this review demonstrates novel perspectives and validates the need for a subtyping of ASD on the grounds of pathogenic mechanisms. The utter necessity of designing ELISA-based test panels to identify all antibodies related to autism-like behavior is also considered.<\/jats:p>","DOI":"10.3390\/ijms23020967","type":"journal-article","created":{"date-parts":[[2022,1,16]],"date-time":"2022-01-16T20:44:00Z","timestamp":1642365840000},"page":"967","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Abnormal mTOR Activity in Pediatric Autoimmune Neuropsychiatric and MIA-Associated Autism Spectrum Disorders"],"prefix":"10.3390","volume":"23","author":[{"given":"Ekaterina A.","family":"Trifonova","sequence":"first","affiliation":[{"name":"Federal Research Center Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zakhar S.","family":"Mustafin","sequence":"additional","affiliation":[{"name":"Federal Research Center Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia"},{"name":"Natural Science Faculty, Novosibirsk National Research State University, 630090 Novosibirsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3138-381X","authenticated-orcid":false,"given":"Sergey A.","family":"Lashin","sequence":"additional","affiliation":[{"name":"Federal Research Center Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia"},{"name":"Natural Science Faculty, Novosibirsk National Research State University, 630090 Novosibirsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex V.","family":"Kochetov","sequence":"additional","affiliation":[{"name":"Federal Research Center Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia"},{"name":"Natural Science Faculty, Novosibirsk National Research State University, 630090 Novosibirsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,16]]},"reference":[{"key":"ref_1","unstructured":"(2020, September 25). Center for Disease Control and Prevention, Available online: https:\/\/www.cdc.gov\/ncbddd\/autism\/data.html."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1001\/jamapsychiatry.2020.0680","article-title":"Etiology of Autism Spectrum Disorders and Autistic Traits Over Time","volume":"77","author":"Taylor","year":"2020","journal-title":"JAMA Psychiatry"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/2040-2392-4-36","article-title":"SFARI Gene 2.0: A community-driven knowledgebase for the autism spectrum disorders (ASDs)","volume":"4","author":"Abrahams","year":"2013","journal-title":"Mol. Autism"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"257","DOI":"10.5607\/en.2015.24.4.257","article-title":"Genetics of autism spectrum disorder: Current status and possible clinical applications","volume":"24","author":"Yoo","year":"2015","journal-title":"Exp. Neurobiol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev-neuro-080317-061747","article-title":"Abnormal mTOR Activation in Autism","volume":"41","author":"Winden","year":"2018","journal-title":"Annu. Rev. Neurosci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1152\/physrev.00038.2014","article-title":"mTOR in Brain Physiology and Pathologies","volume":"95","author":"Bockaert","year":"2015","journal-title":"Physiol. Rev."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"a009886","DOI":"10.1101\/cshperspect.a009886","article-title":"Synaptic dysfunction in neurodevelopmental disorders associated with autism and intellectual disabilities","volume":"4","author":"Zoghbi","year":"2012","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3389\/fped.2017.00043","article-title":"Dynamic Akt\/mTOR Signaling in Children with Autism Spectrum Disorder","volume":"5","author":"Onore","year":"2017","journal-title":"Front. Pediatr."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1002\/ajmg.b.32511","article-title":"Blood transcriptomic comparison of individuals with and without autism spectrum disorder: A combined-samples mega-analysis","volume":"174","author":"Tylee","year":"2017","journal-title":"Am. J. Med. Genet. Part B Neuropsychiatr. Genet."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.bbi.2016.06.005","article-title":"Maternal infection during pregnancy and risk of autism spectrum disorders: A systematic review and meta-analysis","volume":"58","author":"Jiang","year":"2016","journal-title":"Brain Behav. Immun."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.bbi.2014.09.001","article-title":"Maternal hospitalization with infection during pregnancy and risk of autism spectrum disorders","volume":"44","author":"Lee","year":"2015","journal-title":"Brain Behav. Immun."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.biopsych.2013.07.011","article-title":"Prenatal poly(i:C) exposure and other developmental immune activation models in rodent systems","volume":"75","author":"Meyer","year":"2014","journal-title":"Biol. Psychiatry"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.bbi.2012.01.015","article-title":"Maternal immune activation by LPS selectively alters specific gene expression profiles of interneuron migration and oxidative stress in the fetus without triggering a fetal immune response","volume":"26","author":"Oskvig","year":"2012","journal-title":"Brain Behav. Immun."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1126\/science.aad0314","article-title":"The maternal interleukin- 17a pathway in mice promotes autism-like phenotypes in offspring","volume":"351","author":"Choi","year":"2016","journal-title":"Science"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1038\/mp.2016.95","article-title":"Altered proliferation and networks in neural cells derived from idiopathic autistic individuals","volume":"22","author":"Marchetto","year":"2017","journal-title":"Mol. Psychiatry"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1007\/s11481-012-9372-1","article-title":"Maternal immune activation increases neonatal mouse cortex thickness and cell density","volume":"7","author":"Smith","year":"2012","journal-title":"J. Neuroimmune Pharmacol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.stemcr.2014.09.004","article-title":"Maternal inflammation contributes to brain overgrowth and autism-associated behaviors through altered redox signaling in stem and progenitor cells","volume":"3","author":"Sperry","year":"2014","journal-title":"Stem Cell Rep."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1126\/science.1228261","article-title":"Stress in puberty unmasks latent neuropathological consequences of prenatal immune activation in mice","volume":"339","author":"Giovanoli","year":"2013","journal-title":"Science"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1093\/schbul\/sbs195","article-title":"Prenatal immune activation induces maturation-dependent alterations in the prefrontal GABAergic transcriptome","volume":"40","author":"Richetto","year":"2014","journal-title":"Schizophr. Bull."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.bbi.2015.03.009","article-title":"Preliminary evidence of neuropathology in nonhuman primates prenatally exposed to maternal immune activation","volume":"48","author":"Weir","year":"2015","journal-title":"Brain Behav. Immun."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1038\/mp.2017.15","article-title":"Maternal immune activation dysregulation of the fetal brain transcriptome and relevance to the pathophysiology of autism spectrum disorder","volume":"23","author":"Lombardo","year":"2018","journal-title":"Mol. Psychiatry."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/mp.2010.115","article-title":"Gestational immune activation and Tsc2 haploinsufficiency cooperate to disrupt fetal survival and may perturb social behavior in adult mice","volume":"17","author":"Ehninger","year":"2012","journal-title":"Mol. Psychiatry"},{"key":"ref_23","first-page":"226","article-title":"Autism: Maternally derived antibodies specific for fetal brain proteins","volume":"29","author":"Braunschweig","year":"2008","journal-title":"Neurotoxicology"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1007\/s10803-011-1378-7","article-title":"Behavioral correlates of maternal antibody status among children with autism","volume":"42","author":"Braunschweig","year":"2012","journal-title":"J. Autism Dev. Disord."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1002\/ana.10557","article-title":"Maternal neuronal antibodies associated with autism and a language disorder","volume":"53","author":"Dalton","year":"2003","journal-title":"Ann. Neurol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1093\/cercor\/bhu291","article-title":"Prenatal exposure to autism-specific maternal autoantibodies alters proliferation of cortical neural precursor cells, enlarges brain, and increases neuronal size in adult animals","volume":"26","author":"Camacho","year":"2016","journal-title":"Cereb. Cortex"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/s41586-019-1843-6","article-title":"IL-17a promotes sociability in mouse models of neurodevelopmental disorders","volume":"577","author":"Reed","year":"2020","journal-title":"Nature"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1038\/s41380-020-00998-8","article-title":"Risk assessment analysis for maternal autoantibody-related autism (MAR-ASD): A subtype of autism","volume":"26","author":"Becker","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1038\/npp.2016.158","article-title":"The role of the immune system in autism spectrum disorder","volume":"42","author":"Meltzer","year":"2017","journal-title":"Neuropsychopharmacology"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.brainres.2014.09.071","article-title":"Post-infectious autoimmune disorders: Sydenham\u2019s chorea, PANDAS and beyond","volume":"1617","author":"Williams","year":"2015","journal-title":"Brain Res."},{"key":"ref_31","unstructured":"(2019, February 19). MCPAP News. Available online: https:\/\/www.mcpap.com\/pdf\/Vol19Feb19MCPAPNews.pdf."},{"key":"ref_32","unstructured":"(2014, April 04). Autism Speaks. Available online: https:\/\/www.autismspeaks.org\/expert-opinion\/what-pandas-how-it-different-autism."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.imlet.2018.09.009","article-title":"Pediatric acute-onset neuropsychiatric syndrome (PANS) misdiagnosed as autism spectrum disorder","volume":"203","author":"Goncalves","year":"2018","journal-title":"Immunol. Lett."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1176\/ajp.154.1.110","article-title":"Identification of children with pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections by a marker associated with rheumatic fever","volume":"154","author":"Swedo","year":"1997","journal-title":"Am. J. Psychiatry."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1097\/BOR.0b013e32835461d3","article-title":"Streptococcus and rheumatic fever","volume":"24","author":"Cunningham","year":"2012","journal-title":"Curr. Opin. Rheumatol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"314","DOI":"10.3109\/08830185.2014.917411","article-title":"Rheumatic fever, autoimmunity, and molecular mimicry: The streptococcal connection","volume":"33","author":"Cunningham","year":"2014","journal-title":"Int. Rev. Immunol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"577138","DOI":"10.1016\/j.jneuroim.2019.577138","article-title":"Evaluation of the Cunningham Panel\u2122 in pediatric autoimmune neuropsychiatric disorder associated with streptococcal infection (PANDAS) and pediatric acute-onset neuropsychiatric syndrome (PANS): Changes in antineuronal antibody titers parallel changes in patient symptoms","volume":"339","author":"Shimasaki","year":"2020","journal-title":"J. Neuroimmunol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1002\/mds.25623","article-title":"Herpes simplex encephalitis relapse with chorea is associated with autoantibodies to N-Methyl-D-aspartate receptor or dopamine-2 receptor","volume":"29","author":"Mohammad","year":"2014","journal-title":"Mov. Disord."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S1474-4422(10)70253-2","article-title":"Clinical experience and laboratory investigations in patients with anti-NMDAR encephalitis","volume":"10","author":"Dalmau","year":"2011","journal-title":"Lancet Neurol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/S0140-6736(11)60548-5","article-title":"Late onset autism and anti-NMDA-receptor encephalitis","volume":"378","author":"Creten","year":"2011","journal-title":"Lancet"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1111\/dmcn.13169","article-title":"N-methyl-d-aspartate (NMDA) receptor antibodies encephalitis mimicking an autistic regression","volume":"58","author":"Hacohen","year":"2016","journal-title":"Dev. Med. Child Neurol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"e130","DOI":"10.1212\/NXI.0000000000000130","article-title":"Earlier treatment of NMDAR antibody encephalitis in children results in a better outcome","volume":"2","author":"Byrne","year":"2015","journal-title":"Neurol. Neuroimmunol. Neuroinflamm."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Martin, S., Saha, B., and Riley, J.L. (2012). The Battle over mTOR: An Emerging Theatre in Host\u2013Pathogen Immunity. PLoS Pathog., 8.","DOI":"10.1371\/journal.ppat.1002894"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2627","DOI":"10.1101\/gad.1978310","article-title":"Constitutive mTORC1 activation by a herpesvirus Akt surrogate stimulates mRNA translation and viral replication","volume":"24","author":"Chuluunbaatar","year":"2010","journal-title":"Genes Dev."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1007\/s10753-019-01035-9","article-title":"Inhibition of the PI3K\/AKT Signaling Pathway or Overexpression of Beclin1 Blocks Reinfection of Streptococcus pneumoniae After Infection of Influenza A Virus in Severe Community-Acquired Pneumonia","volume":"42","author":"Yang","year":"2019","journal-title":"Inflammation"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"e02148-19","DOI":"10.1128\/mBio.02148-19","article-title":"Group A Streptococcus Induces LAPosomes via SLO\/\u03b21 Integrin\/NOX2\/ROS Pathway in Endothelial Cells That Are Ineffective in Bacterial Killing and Suppress Xenophagy","volume":"10","author":"Cheng","year":"2019","journal-title":"mBio"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"e00771-20","DOI":"10.1128\/mBio.00771-20","article-title":"Integrin \u03b15\u03b21, as a Receptor of Fibronectin, Binds the FbaA Protein of Group A Streptococcus To Initiate Autophagy during Infection","volume":"11","author":"Wang","year":"2020","journal-title":"mBio"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1080\/15548627.2019.1628539","article-title":"Group A Streptococcus modulates RAB1- and PIK3C3 complex-dependent autophagy","volume":"2","author":"Toh","year":"2020","journal-title":"Autophagy"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1186\/s13071-017-2528-3","article-title":"Targeting the master regulator mTOR: A new approach to prevent the neurological of consequences of parasitic infections?","volume":"10","author":"Donnelly","year":"2017","journal-title":"Parasites Vectors"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"e00725","DOI":"10.1128\/mBio.00725-15","article-title":"Inhibiting the Mammalian target of rapamycin blocks the development of experimental cerebral malaria","volume":"6","author":"Gordon","year":"2015","journal-title":"mBio"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Shuid, A.N., Jayusman, P.A., Shuid, N., Ismail, J., Kamal Nor, N., and Naina Mohamed, I. (2020). Update on Atypicalities of Central Nervous System in Autism Spectrum Disorder. Brain Sci., 10.","DOI":"10.3390\/brainsci10050309"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"50","DOI":"10.3109\/08830185.2014.933957","article-title":"mTOR signaling in T cell immunity and autoimmunity","volume":"34","author":"Liu","year":"2015","journal-title":"Int. Rev. Immunol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/ni.2005","article-title":"The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 andmTORC2","volume":"12","author":"Delgoffe","year":"2011","journal-title":"Nat. Immunol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"320","DOI":"10.4049\/jimmunol.178.1.320","article-title":"Selective survival of naturally occurring human CD4+CD25+Foxp3+ regulatory T cells cultured with rapamycin","volume":"178","author":"Strauss","year":"2007","journal-title":"J. Immunol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s12974-019-1644-8","article-title":"Lipopolysaccharide induces neuroinflammation in microglia by activating the MTOR pathway and downregulating Vps34 to inhibit autophagosome formation","volume":"17","author":"Ye","year":"2020","journal-title":"J. Neuroinflamm."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1080\/15548627.2016.1277310","article-title":"Using tuberous sclerosis complex to understand the impact of MTORC1 signaling on mitochondrial dynamics and mitophagy in neurons","volume":"13","author":"Saffari","year":"2017","journal-title":"Autophagy"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Lenzi, P., Ferese, R., Biagioni, F., Fulceri, F., Busceti, C., Falleni, A., Gambardella, S., Frati, A., and Fornai, F. (2021). Rapamycin Ameliorates Defects in Mitochondrial Fission and Mitophagy in Glioblastoma Cells. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22105379"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"101481","DOI":"10.1016\/j.tice.2020.101481","article-title":"Rapamycin alleviates cognitive impairment in murine vascular dementia: The enhancement of mitophagy by PI3K\/AKT\/mTOR axis","volume":"69","author":"Zheng","year":"2021","journal-title":"Tissue Cell"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1016\/j.cell.2019.05.004","article-title":"Human Gut Microbiota from Autism Spectrum Disorder Promote Behavioral Symptoms in Mice","volume":"177","author":"Sharon","year":"2019","journal-title":"Cell"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1016\/j.bbalip.2010.07.007","article-title":"Biological effects of propionic acid in humans; metabolism, potential applications and underlying mechanisms","volume":"1801","author":"Peppelenbosch","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"8824","DOI":"10.1038\/s41598-019-45348-z","article-title":"Propionic Acid Induces Gliosis and Neuro-inflammation through Modulation of PTEN\/AKT Pathway in Autism Spectrum Disorder","volume":"9","author":"Abdelli","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1038\/s41398-017-0089-z","article-title":"Butyrate enhances mitochondrial function during oxidative stress in cell lines from boys with autism","volume":"8","author":"Rose","year":"2018","journal-title":"Transl. Psychiatry"},{"key":"ref_63","first-page":"28177","article-title":"Enteric short-chain fatty acids: Microbial messengers of metabolism, mitochondria, and mind: Implications in autism spectrum disorders","volume":"26","author":"MacFabe","year":"2015","journal-title":"Microb. Ecol. Health Dis."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Trifonova, E.A., Klimenko, A.I., Mustafin, Z.S., Lashin, S.A., and Kochetov, A.V. (2019). The mTOR Signaling Pathway Activity and Vitamin D Availability Control the Expression of Most Autism Predisposition Genes. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20246332"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1096\/fj.10-172577","article-title":"Gene targeting by the vitamin D response element binding protein reveals a role for vitamin D in osteoblast mTOR signaling","volume":"25","author":"Lisse","year":"2011","journal-title":"FASEB J."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"102350","DOI":"10.1016\/j.autrev.2019.102350","article-title":"Emerging role of vitamin D in autoimmune diseases: An update on evidence and therapeutic implications","volume":"18","author":"Murdaca","year":"2019","journal-title":"Autoimmun. Rev."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Trifonova, E.A., Klimenko, A.I., Mustafin, Z.S., Lashin, S.A., and Kochetov, A.V. (2021). Do Autism Spectrum and Autoimmune Disorders Share Predisposition Gene Signature Due to mTOR Signaling Pathway Controlling Expression?. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22105248"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/msb.2010.108","article-title":"A comprehensive map of the mTOR signaling network","volume":"6","author":"Caron","year":"2010","journal-title":"Mol. Syst. Biol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1101\/gr.197566.115","article-title":"nanoCAGE reveals 50 UTR features that define specific modes of translation of functionally related MTOR-sensitive mRNAs","volume":"26","author":"Gandin","year":"2016","journal-title":"Genome Res."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.3389\/fimmu.2019.01474","article-title":"Antigenic Targets of Patient and Maternal Autoantibodies in Autism Spectrum Disorder","volume":"10","author":"Vandormael","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/bpa.12299","article-title":"The regulation and function of lactate dehydrogenase a: Therapeutic potential in brain tumor","volume":"26","author":"Valvona","year":"2016","journal-title":"Brain Pathol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"17551","DOI":"10.1073\/pnas.0507856102","article-title":"Regulation of RNA splicing by the methylation-dependent transcriptional repressor methyl-CpG binding protein 2","volume":"102","author":"Young","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"4243","DOI":"10.1007\/s12035-016-0005-1","article-title":"CRMPs function in neurons and glial cells: Potential therapeutic targets for neurodegenerative diseases and CNS injury","volume":"54","author":"Nagai","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"14939","DOI":"10.1074\/jbc.M900097200","article-title":"p90 ribosomal S6 kinase and p70 ribosomal S6 kinase link phosphorylation of the eukaryotic chaperonin containing TCP-1 to growth factor, insulin, and nutrient signaling","volume":"284","author":"Abe","year":"2009","journal-title":"J. Biol. Chem."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/s41582-019-0174-4","article-title":"Immunoneuropsychiatry\u2014Novel perspectives on brain disorders","volume":"15","author":"Pape","year":"2019","journal-title":"Nat. Rev. Neurol."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/2\/967\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T14:02:21Z","timestamp":1760364141000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/2\/967"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,16]]},"references-count":75,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2022,1]]}},"alternative-id":["ijms23020967"],"URL":"https:\/\/doi.org\/10.3390\/ijms23020967","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,16]]}}}