{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:23:11Z","timestamp":1791296591576,"version":"4.1.0"},"reference-count":139,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2022,1,17]],"date-time":"2022-01-17T00:00:00Z","timestamp":1642377600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["DFG grant RU816\/12-1"],"award-info":[{"award-number":["DFG grant RU816\/12-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Cytokines and their receptors have a vital function in regulating various processes such as immune function, inflammation, haematopoiesis, cell growth and differentiation. The interaction between a cytokine and its specific receptor triggers intracellular signalling cascades that lead to altered gene expression in the target cell and consequent changes in its proliferation, differentiation, or activation. In this review, we highlight the role of the soluble type I cytokine receptor CRLF1 (cytokine receptor-like factor-1) and the Interleukin (IL)-6 cytokine CLCF1 (cardiotrophin-like cytokine factor 1) during development in physiological and pathological conditions with particular emphasis on Crisponi\/cold-induced sweating syndrome (CS\/CISS) and discuss new insights, challenges and possibilities arising from recent studies.<\/jats:p>","DOI":"10.3390\/ijms23020992","type":"journal-article","created":{"date-parts":[[2022,1,17]],"date-time":"2022-01-17T08:20:42Z","timestamp":1642407642000},"page":"992","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["CRLF1 and CLCF1 in Development, Health and Disease"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9128-8537","authenticated-orcid":false,"given":"Laura","family":"Crisponi","sequence":"first","affiliation":[{"name":"Institute of Genetic and Biomedical Research (IRGB), National Research Council, 09042 Monserrato, CA, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Insa","family":"Buers","sequence":"additional","affiliation":[{"name":"Department of General Pediatrics, Muenster University Children\u2019s Hospital, Albert-Schweitzer-Campus 1, Gbde. A1, D-48149 M\u00fcnster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2385-4159","authenticated-orcid":false,"given":"Frank","family":"Rutsch","sequence":"additional","affiliation":[{"name":"Department of General Pediatrics, Muenster University Children\u2019s Hospital, Albert-Schweitzer-Campus 1, Gbde. A1, D-48149 M\u00fcnster, Germany"},{"name":"Center for Rare Diseases, Muenster University Hospital, D-48149 M\u00fcnster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Khan, M.M. (2016). Immunopharmacology, Springer. 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