{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:20:09Z","timestamp":1788481209250,"version":"build-2803163510"},"reference-count":101,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2022,1,21]],"date-time":"2022-01-21T00:00:00Z","timestamp":1642723200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001736","name":"German-Israeli Foundation for Scientific Research and Development","doi-asserted-by":"publisher","award":["I-1469-414.13\/2018"],"award-info":[{"award-number":["I-1469-414.13\/2018"]}],"id":[{"id":"10.13039\/501100001736","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Mast cells are involved in allergic and other inflammatory diseases. The polyphenol resveratrol is known for its anti-inflammatory properties and may be used as nutraceutical in mast cell associated diseases. We analyzed the effect of resveratrol on mast cells in vivo in ovalbumin-induced allergic enteritis as well as experimental colitis in IL-10\u2212\/\u2212 mice which received resveratrol via drinking water. Treatment with resveratrol prevented the increase in mast cells in both allergic enteritis and chronic colitis in duodenum as well as in colon. Further, it delayed the onset of diseases symptoms and ameliorated diseases associated parameters such as tissue damage as well as inflammatory cell infiltration in affected colon sections. In addition to the findings in vivo, resveratrol inhibited IgE-dependent degranulation and expression of pro-inflammatory cytokines such as TNF-\u03b1 in IgE\/DNP-activated as well as in LPS-activated bone marrow-derived mast cells. These results indicate that resveratrol may be considered as an anti-allergic and anti-inflammatory plant-derived component for the prevention or treatment of mast cell-associated disorders of the gastrointestinal tract.<\/jats:p>","DOI":"10.3390\/ijms23031213","type":"journal-article","created":{"date-parts":[[2022,1,23]],"date-time":"2022-01-23T20:32:52Z","timestamp":1642969972000},"page":"1213","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Resveratrol Treatment Prevents Increase of Mast Cells in Both Murine OVA Enteritis and IL-10\u2212\/\u2212 Colitis"],"prefix":"10.3390","volume":"23","author":[{"given":"Sabrina","family":"Bilotta","sequence":"first","affiliation":[{"name":"Institute of Nutritional Medicine, University of Hohenheim, Fruwirthstra\u00dfe 12, 70599 Stuttgart, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Arbogast","sequence":"additional","affiliation":[{"name":"Institute of Nutritional Medicine, University of Hohenheim, Fruwirthstra\u00dfe 12, 70599 Stuttgart, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine","family":"Schart","sequence":"additional","affiliation":[{"name":"Institute of Nutritional Medicine, University of Hohenheim, Fruwirthstra\u00dfe 12, 70599 Stuttgart, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurice","family":"Frei","sequence":"additional","affiliation":[{"name":"Institute of Nutritional Medicine, University of Hohenheim, Fruwirthstra\u00dfe 12, 70599 Stuttgart, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Lorentz","sequence":"additional","affiliation":[{"name":"Institute of Nutritional Medicine, University of Hohenheim, Fruwirthstra\u00dfe 12, 70599 Stuttgart, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e185630","DOI":"10.1001\/jamanetworkopen.2018.5630","article-title":"Prevalence and Severity of Food Allergies Among US Adults","volume":"2","author":"Gupta","year":"2019","journal-title":"JAMA Netw. 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