{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T14:55:08Z","timestamp":1774796108560,"version":"3.50.1"},"reference-count":35,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2022,1,25]],"date-time":"2022-01-25T00:00:00Z","timestamp":1643068800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002261","name":"Russian Foundation for Basic Research","doi-asserted-by":"publisher","award":["18-29-17069"],"award-info":[{"award-number":["18-29-17069"]}],"id":[{"id":"10.13039\/501100002261","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["16-14-00061"],"award-info":[{"award-number":["16-14-00061"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016971","name":"Lomonosov Moscow State University","doi-asserted-by":"publisher","award":["AAAA-A21-121041500039-8"],"award-info":[{"award-number":["AAAA-A21-121041500039-8"]}],"id":[{"id":"10.13039\/501100016971","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>To obtain fiber materials with pronounced chemical-biological protection, metal (Zn or Ta) nanoparticles were jointly applied with polyelectrolyte complexes of enzymes and polypeptides being their stabilizers. Computer modeling revealed the preferences between certain polyelectrolyte partners for N-acyl-homoserine lactone acylase and hexahistidine-tagged organophosphorus hydrolase (His6-OPH) possessing the quorum quenching (QQ) behavior with bacterial cells. The combinations of metal nanoparticles and enzymes appeared to function better as compared to the combinations of the same QQ-enzymes with antibiotics (polymyxins), making it possible to decrease the applied quantities by orders of magnitude while giving the same effect. The elimination of Gram-positive and Gram-negative bacterial cells from doubly modified fiber materials notably increased (up to 2.9-fold), whereas His6-OPH retained its hydrolytic activity in reaction with organophosphorus compounds (up to 74% of initially applied activity). Materials with the certain enzyme and Zn nanoparticles were more efficient against Bacillus subtilis cells (up to 2.1-fold), and Ta nanoparticles acted preferentially against Escherichia coli (up to 1.5-fold). Some materials were proved to be more suitable for combined modification by metal nanoparticles and His6-OPH complexes as antimicrobial protectants.<\/jats:p>","DOI":"10.3390\/ijms23031359","type":"journal-article","created":{"date-parts":[[2022,1,25]],"date-time":"2022-01-25T20:40:18Z","timestamp":1643143218000},"page":"1359","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Combined Modification of Fiber Materials by Enzymes and Metal Nanoparticles for Chemical and Biological Protection"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3970-4334","authenticated-orcid":false,"given":"Ilya","family":"Lyagin","sequence":"first","affiliation":[{"name":"Faculty of Chemistry, Lomonosov Moscow State University, Lenin Hills 1\/3, 119991 Moscow, Russia"},{"name":"N.M. Emanuel Institute of Biochemical Physics RAS, Kosygin str. 4, 119334 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolay","family":"Stepanov","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry, Lomonosov Moscow State University, Lenin Hills 1\/3, 119991 Moscow, Russia"},{"name":"N.M. Emanuel Institute of Biochemical Physics RAS, Kosygin str. 4, 119334 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Frolov","sequence":"additional","affiliation":[{"name":"Department of Physical Chemistry, National University of Science and Technology \u201cMISIS\u201d, Leninsky ave. 4, 119049 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6992-854X","authenticated-orcid":false,"given":"Elena","family":"Efremenko","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry, Lomonosov Moscow State University, Lenin Hills 1\/3, 119991 Moscow, Russia"},{"name":"N.M. Emanuel Institute of Biochemical Physics RAS, Kosygin str. 4, 119334 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e109444","DOI":"10.1016\/j.envres.2020.109444","article-title":"Factors affecting use of personal protective equipment and pesticide safety practices: A systematic review","volume":"185","author":"Sapbamrer","year":"2020","journal-title":"Environ. Res."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e141382","DOI":"10.1016\/j.scitotenv.2020.141382","article-title":"Occupational exposure to pesticides: Genetic danger to farmworkers and manufacturing workers-A meta-analytical review","volume":"748","author":"Pinto","year":"2020","journal-title":"Sci. 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