{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:47:18Z","timestamp":1760150838499,"version":"build-2065373602"},"reference-count":57,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2022,1,28]],"date-time":"2022-01-28T00:00:00Z","timestamp":1643328000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"BioCubaFarma\/IBM 3051-280-II","award":["3051-280"],"award-info":[{"award-number":["3051-280"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Lower-extremity arterial disease is a major health problem with increasing prevalence, often leading to non-traumatic amputation, disability and mortality. The molecular mechanisms underpinning abnormal vascular wall remodeling are not fully understood. We hypothesized on the existence of a vascular tissue memory that may be transmitted through soluble signaling messengers, transferred from humans to healthy recipient animals, and consequently drive the recapitulation of arterial wall thickening and other vascular pathologies. We examined the effects of the intralesional infiltration for 6 days of arteriosclerotic popliteal artery-derived homogenates (100 \u00b5g of protein) into rats\u2019 full-thickness wounds granulation tissue. Animals infiltrated with normal saline solution or healthy brachial arterial tissue homogenate obtained from traumatic amputation served as controls. The significant thickening of arteriolar walls was the constant outcome in two independent experiments for animals receiving arteriosclerotic tissue homogenates. This material induced other vascular morphological changes including an endothelial cell phenotypic reprogramming that mirrored the donor\u2019s vascular histopathology. The immunohistochemical expression pattern of relevant vascular markers appeared to match between the human tissue and the corresponding recipient rats. These changes occurred within days of administration, and with no cross-species limitation. The identification of these \u201cvascular disease drivers\u201d may pave novel research avenues for atherosclerosis pathobiology.<\/jats:p>","DOI":"10.3390\/ijms23031511","type":"journal-article","created":{"date-parts":[[2022,1,29]],"date-time":"2022-01-29T05:26:17Z","timestamp":1643433977000},"page":"1511","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Intralesional Infiltrations of Arteriosclerotic Tissue Cells-Free Filtrate Reproduce Vascular Pathology in Healthy Recipient Rats"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9797-1986","authenticated-orcid":false,"given":"Jorge","family":"Berlanga-Acosta","sequence":"first","affiliation":[{"name":"Tissue Repair, Wound Healing and Cytoprotection Research Group, Biomedical Research Direction, Center for Genetic Engineering and Biotechnology, Ave. 31 S\/N. e\/158 and 190, Cubanac\u00e1n, Playa, Havana 10600, Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0818-1972","authenticated-orcid":false,"given":"Maday","family":"Fern\u00e1ndez-Mayola","sequence":"additional","affiliation":[{"name":"Tissue Repair, Wound Healing and Cytoprotection Research Group, Biomedical Research Direction, Center for Genetic Engineering and Biotechnology, Ave. 31 S\/N. e\/158 and 190, Cubanac\u00e1n, Playa, Havana 10600, Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2788-0701","authenticated-orcid":false,"given":"Yssel","family":"Mendoza-Mar\u00ed","sequence":"additional","affiliation":[{"name":"Tissue Repair, Wound Healing and Cytoprotection Research Group, Biomedical Research Direction, Center for Genetic Engineering and Biotechnology, Ave. 31 S\/N. e\/158 and 190, Cubanac\u00e1n, Playa, Havana 10600, Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9519-0139","authenticated-orcid":false,"given":"Ariana","family":"Garc\u00eda-Ojalvo","sequence":"additional","affiliation":[{"name":"Tissue Repair, Wound Healing and Cytoprotection Research Group, Biomedical Research Direction, Center for Genetic Engineering and Biotechnology, Ave. 31 S\/N. e\/158 and 190, Cubanac\u00e1n, Playa, Havana 10600, Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3503-5874","authenticated-orcid":false,"given":"Indira","family":"Martinez-Jimenez","sequence":"additional","affiliation":[{"name":"Tissue Repair, Wound Healing and Cytoprotection Research Group, Biomedical Research Direction, Center for Genetic Engineering and Biotechnology, Ave. 31 S\/N. e\/158 and 190, Cubanac\u00e1n, Playa, Havana 10600, Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadia","family":"Rodriguez-Rodriguez","sequence":"additional","affiliation":[{"name":"Tissue Repair, Wound Healing and Cytoprotection Research Group, Biomedical Research Direction, Center for Genetic Engineering and Biotechnology, Ave. 31 S\/N. e\/158 and 190, Cubanac\u00e1n, Playa, Havana 10600, Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1235-8504","authenticated-orcid":false,"given":"Raymond J.","family":"Playford","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences, University of West London, St Marys Rd, Ealing, London W5 5RF, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osvaldo","family":"Reyes-Acosta","sequence":"additional","affiliation":[{"name":"Tissue Repair, Wound Healing and Cytoprotection Research Group, Biomedical Research Direction, Center for Genetic Engineering and Biotechnology, Ave. 31 S\/N. e\/158 and 190, Cubanac\u00e1n, Playa, Havana 10600, Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0251-5812","authenticated-orcid":false,"given":"Laura","family":"Lopez-Mar\u00edn","sequence":"additional","affiliation":[{"name":"Department of Pathology, Institute for Arteriosclerosis Research, Institute of Nephrology \u201cDr. Abelardo Buch\u201d, Calle 26 y L\u00ednea del Ferrocarril, Vedado, Havana 10400, Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3098-0970","authenticated-orcid":false,"given":"Gerardo","family":"Guill\u00e9n-Nieto","sequence":"additional","affiliation":[{"name":"Tissue Repair, Wound Healing and Cytoprotection Research Group, Biomedical Research Direction, Center for Genetic Engineering and Biotechnology, Ave. 31 S\/N. e\/158 and 190, Cubanac\u00e1n, Playa, Havana 10600, Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1056\/NEJMcp1507631","article-title":"Clinical Practice. 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